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Volumn 5, Issue AUG, 2014, Pages

Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection

Author keywords

Biomarkers; Cell free nucleic acids; CFNA; Colorectal cancer; DNA methylation; DNA mutation; MiRNAs; Noninvasive tests

Indexed keywords

MICRORNA; PROTEIN P53;

EID: 84987788950     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00182     Document Type: Review
Times cited : (25)

References (92)
  • 1
    • 34247598254 scopus 로고    scopus 로고
    • Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran
    • Abbaszadegan, M. R., Tavasoli, A., Velayati, A., Sima, H. R., Vosooghinia, H., Farzadnia, M., et al. (2007). Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran. World J. Gastroenterol. 13, 10528-10533.
    • (2007) World J. Gastroenterol , vol.13 , pp. 10528-10533
    • Abbaszadegan, M.R.1    Tavasoli, A.2    Velayati, A.3    Sima, H.R.4    Vosooghinia, H.5    Farzadnia, M.6
  • 2
    • 84904269291 scopus 로고    scopus 로고
    • The detection of the methylated wif-1 gene is more accurate than a fecal occult blood test for colorectal cancer screening
    • Amiot, A., Mansour, H., Baumgaertner, I., Delchier, J. C., Tournigand, C., Furet, J. P., et al. (2014). The detection of the methylated wif-1 gene is more accurate than a fecal occult blood test for colorectal cancer screening. PLoS ONE 9:e99233. doi: 10.1371/journal.pone.0099233
    • (2014) PLoS ONE , vol.9
    • Amiot, A.1    Mansour, H.2    Baumgaertner, I.3    Delchier, J.C.4    Tournigand, C.5    Furet, J.P.6
  • 4
    • 68149181469 scopus 로고    scopus 로고
    • Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients
    • discussion: 9-63
    • Baek, Y. H., Chang, E., Kim, Y. J., Kim, B. K., Sohn, J. H., and Park, D. I. (2009). Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients. Dis. Colon Rectum. 52, 8452-8459. discussion: 9-63. doi: 10.1007/DCR.0b013e3181a79533
    • (2009) Dis. Colon Rectum , vol.52 , pp. 8452-8459
    • Baek, Y.H.1    Chang, E.2    Kim, Y.J.3    Kim, B.K.4    Sohn, J.H.5    Park, D.I.6
  • 5
    • 84869491009 scopus 로고    scopus 로고
    • Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma
    • Baraniskin, A., Nopel-Dunnebacke, S., Ahrens, M., Jensen, S. G., Zollner, H., Maghnouj, A., et al. (2013). Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma. Int. J. Cancer 132, E48-E57. doi: 10.1002/ijc.27791
    • (2013) Int. J. Cancer , vol.132 , pp. E48-E57
    • Baraniskin, A.1    Nopel-Dunnebacke, S.2    Ahrens, M.3    Jensen, S.G.4    Zollner, H.5    Maghnouj, A.6
  • 7
    • 0344420252 scopus 로고    scopus 로고
    • Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer
    • Berger, B. M., Robison, L., and Glickman, J. (2003). Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer. Diagn. Mol. Pathol. 12, 487-492. doi: 10.1097/00019606-200312000-00002
    • (2003) Diagn. Mol. Pathol , vol.12 , pp. 487-492
    • Berger, B.M.1    Robison, L.2    Glickman, J.3
  • 8
    • 84885703210 scopus 로고    scopus 로고
    • Combining position weight matrices and document-term matrix for efficient extraction of associations of methylated genes and diseases from free text
    • Bin Raies, A., Mansour, H., Incitti, R., and Bajic, V. B. (2013). Combining position weight matrices and document-term matrix for efficient extraction of associations of methylated genes and diseases from free text. PLoS ONE 8:e77848. doi: 10.1371/journal.pone.0077848
    • (2013) PLoS ONE , vol.8
    • Bin Raies, A.1    Mansour, H.2    Incitti, R.3    Bajic, V.B.4
  • 9
    • 0035990182 scopus 로고    scopus 로고
    • K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease
    • Borchers, R., Heinzlmann, M., Zahn, R., Witter, K., Martin, K., Loeschke, K., et al. (2002). K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease. Scand. J. Gastroenterol. 37, 615-618. doi: 10.1080/00365520212505
    • (2002) Scand. J. Gastroenterol , vol.37 , pp. 615-618
    • Borchers, R.1    Heinzlmann, M.2    Zahn, R.3    Witter, K.4    Martin, K.5    Loeschke, K.6
  • 10
    • 85007738202 scopus 로고    scopus 로고
    • ABC of colorectal cancer: epidemiology
    • Boyle, P., and Langman, J. S. (2000). ABC of colorectal cancer: epidemiology. BMJ 321, 726405-726408. doi: 10.1136/bmj.321.7264.805
    • (2000) BMJ , vol.321
    • Boyle, P.1    Langman, J.S.2
  • 13
    • 84868649500 scopus 로고    scopus 로고
    • Label-free serum ribonucleic acid analysis for colorectal cancer detection by surface-enhanced Raman spectroscopy and multivariate analysis
    • Chen, Y., Chen, G., Feng, S., Pan, J., Zheng, X., Su, Y., et al. (2012). Label-free serum ribonucleic acid analysis for colorectal cancer detection by surface-enhanced Raman spectroscopy and multivariate analysis. J. Biomed. Opt. 17:667003. doi: 10.1117/1.JBO.17.6.067003
    • (2012) J. Biomed. Opt , vol.17
    • Chen, Y.1    Chen, G.2    Feng, S.3    Pan, J.4    Zheng, X.5    Su, Y.6
  • 14
    • 79952752337 scopus 로고    scopus 로고
    • Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis
    • Cheng, H., Zhang, L., Cogdell, D. E., Zheng, H., Schetter, A. J., Nykter, M., et al. (2011). Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS ONE 6:e17745. doi: 10.1371/journal.pone.0017745
    • (2011) PLoS ONE , vol.6
    • Cheng, H.1    Zhang, L.2    Cogdell, D.E.3    Zheng, H.4    Schetter, A.J.5    Nykter, M.6
  • 15
    • 33846228264 scopus 로고    scopus 로고
    • Correlation of K-ras codon 12 mutations in human feces and ages of patients with colorectal cancer (CRC)
    • Chien, C. C., Chen, S. H., Liu, C. C., Lee, C. L., Yang, R. N., Yang, S. H., et al. (2007). Correlation of K-ras codon 12 mutations in human feces and ages of patients with colorectal cancer (CRC). Transl. Res. 149, 26-102. doi: 10.1016/j.trsl.2006.09.006
    • (2007) Transl. Res , vol.149 , pp. 26-102
    • Chien, C.C.1    Chen, S.H.2    Liu, C.C.3    Lee, C.L.4    Yang, R.N.5    Yang, S.H.6
  • 16
    • 80052783071 scopus 로고    scopus 로고
    • Epigenetic alteration of microRNAs in feces of colorectal cancer and its clinical significance
    • Cho, W. C. (2011). Epigenetic alteration of microRNAs in feces of colorectal cancer and its clinical significance. Expert Rev. Mol. Diagn. 11, 791-794. doi: 10.1586/erm.11.57
    • (2011) Expert Rev. Mol. Diagn , vol.11 , pp. 791-794
    • Cho, W.C.1
  • 18
    • 84863456744 scopus 로고    scopus 로고
    • Digital detection of multiple minority mutants in stool DNA for noninvasive colorectal cancer diagnosis
    • Deng, L., Qi, Z., Zou, B., Wu, H., Huang, H., Kajiyama, T., et al. (2012). Digital detection of multiple minority mutants in stool DNA for noninvasive colorectal cancer diagnosis. Anal. Chem. 84, 13645-13652. doi: 10.1021/ac3008016
    • (2012) Anal. Chem , vol.84 , pp. 13645-13652
    • Deng, L.1    Qi, Z.2    Zou, B.3    Wu, H.4    Huang, H.5    Kajiyama, T.6
  • 20
    • 28044468634 scopus 로고    scopus 로고
    • Detection and quantification of mutations in the plasma of patients with colorectal tumors
    • Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., et al. (2005). Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc. Natl. Acad. Sci. U.S.A. 102, 456368-456373. doi: 10.1073/pnas.0507904102
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102
    • Diehl, F.1    Li, M.2    Dressman, D.3    He, Y.4    Shen, D.5    Szabo, S.6
  • 21
    • 0035815919 scopus 로고    scopus 로고
    • Detecting colorectal cancer in stool with the use of multiple genetic targets
    • Dong, S. M., Traverso, G., Johnson, C., Geng, L., Favis, R., Boynton, K., et al. (2001). Detecting colorectal cancer in stool with the use of multiple genetic targets. J. Natl. Cancer Inst. 93, 1158-1165. doi: 10.1093/jnci/93.11.858
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 1158-1165
    • Dong, S.M.1    Traverso, G.2    Johnson, C.3    Geng, L.4    Favis, R.5    Boynton, K.6
  • 22
    • 0034964458 scopus 로고    scopus 로고
    • Detection of the mutated K-Ras biomarker in colorectal carcinoma
    • Doolittle, B. R., Emanuel, J., Tuttle, C., and Costa, J. (2001). Detection of the mutated K-Ras biomarker in colorectal carcinoma. Exp. Mol. Pathol. 70, 389-301. doi: 10.1006/exmp.2001.2364
    • (2001) Exp. Mol. Pathol , vol.70 , pp. 389-301
    • Doolittle, B.R.1    Emanuel, J.2    Tuttle, C.3    Costa, J.4
  • 23
    • 33750701826 scopus 로고    scopus 로고
    • Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas
    • Ebert, M. P., Model, F., Mooney, S., Hale, K., Lograsso, J., Tonnes-Priddy, L., et al. (2006). Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas. Gastroenterology 131, 5418-5430. doi: 10.1053/j.gastro.2006.08.034
    • (2006) Gastroenterology , vol.131 , pp. 5418-5430
    • Ebert, M.P.1    Model, F.2    Mooney, S.3    Hale, K.4    Lograsso, J.5    Tonnes-Priddy, L.6
  • 24
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008, GLOBOCAN 2008
    • Ferlay, J., Shin, H. R., Bray, F., Forman, D., Mathers, C., and Parkin, D. M., (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127, 12893-12917. doi: 10.1002/ijc.25516
    • (2010) Int. J. Cancer , vol.127 , pp. 12893-12917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 25
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel, R., Lescoe, M. K., Rao, M. R., Copeland, N. G., Jenkins, N. A., Garber, J., et al. (1993). The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 5027-5038. doi: 10.1016/0092-8674(93)90546-3
    • (1993) Cell , vol.75 , pp. 5027-5038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3    Copeland, N.G.4    Jenkins, N.A.5    Garber, J.6
  • 26
    • 84883779712 scopus 로고    scopus 로고
    • Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene
    • Gerecke, C., Mascher, C., Gottschalk, U., Kleuser, B., and Scholtka, B. (2013). Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene. Cancer Prev. Res. 6, 998-907. doi: 10.1158/1940-6207.CAPR-13-0145
    • (2013) Cancer Prev. Res , vol.6 , pp. 997-998
    • Gerecke, C.1    Mascher, C.2    Gottschalk, U.3    Kleuser, B.4    Scholtka, B.5
  • 27
    • 84878318144 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
    • Giraldez, M. D., Lozano, J. J., Ramirez, G., Hijona, E., Bujanda, L., Castells, A., et al. (2013). Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study. Clin. Gastroenterol. Hepatol. 11, 681-8 e3. doi: 10.1016/j.cgh.2012.12.009
    • (2013) Clin. Gastroenterol. Hepatol , vol.11
    • Giraldez, M.D.1    Lozano, J.J.2    Ramirez, G.3    Hijona, E.4    Bujanda, L.5    Castells, A.6
  • 28
    • 66349102768 scopus 로고    scopus 로고
    • Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer
    • Glockner, S. C., Dhir, M., Yi, J. M., McGarvey, K. E., Van Neste, L., Louwagie, J., et al. (2009). Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res. 69, 11691-11699. doi: 10.1158/0008-5472.CAN-08-0142
    • (2009) Cancer Res , vol.69 , pp. 11691-11699
    • Glockner, S.C.1    Dhir, M.2    Yi, J.M.3    McGarvey, K.E.4    Van Neste, L.5    Louwagie, J.6
  • 29
    • 84881512893 scopus 로고    scopus 로고
    • Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients
    • Guo, Q., Song, Y., Zhang, H., Wu, X., Xia, P., and Dang, C. (2013). Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients. Med. Oncology. 30, 495. doi: 10.1007/s12032-013-0695-4
    • (2013) Med. Oncology , vol.30 , pp. 495
    • Guo, Q.1    Song, Y.2    Zhang, H.3    Wu, X.4    Xia, P.5    Dang, C.6
  • 30
    • 78049332872 scopus 로고    scopus 로고
    • Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors
    • Haggar, F. A., and Boushey, R. P. (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin. Colon Rectal Surg. 22, 491-497. doi: 10.1055/s-0029-1242458
    • (2009) Clin. Colon Rectal Surg , vol.22 , pp. 491-497
    • Haggar, F.A.1    Boushey, R.P.2
  • 31
    • 84939552146 scopus 로고    scopus 로고
    • A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes
    • Hansen, M. F., Neckmann, U., Lavik, L. A., Vold, T., Gilde, B., Toft, R. K., et al. (2014). A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes. Mol Genet Genomic Med. 2, 286-200. doi: 10.1002/mgg3.62
    • (2014) Mol Genet Genomic Med , vol.2 , pp. 286-300
    • Hansen, M.F.1    Neckmann, U.2    Lavik, L.A.3    Vold, T.4    Gilde, B.5    Toft, R.K.6
  • 32
    • 27144552677 scopus 로고    scopus 로고
    • Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein
    • Hanson, C. A., and Miller, J. R. (2005). Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. Gene 361, 1-12. doi: 10.1016/j.gene.2005.07.024
    • (2005) Gene , vol.361 , pp. 1-12
    • Hanson, C.A.1    Miller, J.R.2
  • 33
    • 0028932967 scopus 로고
    • Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA)
    • Hasegawa, Y., Takeda, S., Ichii, S., Koizumi, K., Maruyama, M., Fujii, A., et al. (1995). Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA). Oncogene 10, 7441-7445.
    • (1995) Oncogene , vol.10 , pp. 7441-7445
    • Hasegawa, Y.1    Takeda, S.2    Ichii, S.3    Koizumi, K.4    Maruyama, M.5    Fujii, A.6
  • 34
    • 77956143206 scopus 로고    scopus 로고
    • Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer
    • He, Q., Chen, H. Y., Bai, E. Q., Luo, Y. X., Fu, R. J., He, Y. S., et al. (2010). Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. Cancer Genetics Cytogenet. 202, 1-10. doi: 10.1016/j.cancergencyto.2010.05.018
    • (2010) Cancer Genetics Cytogenet , vol.202 , pp. 1-10
    • He, Q.1    Chen, H.Y.2    Bai, E.Q.3    Luo, Y.X.4    Fu, R.J.5    He, Y.S.6
  • 35
    • 67449128445 scopus 로고    scopus 로고
    • GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer
    • Hellebrekers, D. M., Lentjes, M. H., van den Bosch, S. M., Melotte, V., Wouters, K. A., Daenen, K. L., et al. (2009). GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin. Cancer Res. 15, 12990-12997. doi: 10.1158/1078-0432.CCR-09-0055
    • (2009) Clin. Cancer Res , vol.15 , pp. 12990-12997
    • Hellebrekers, D.M.1    Lentjes, M.H.2    van den Bosch, S.M.3    Melotte, V.4    Wouters, K.A.5    Daenen, K.L.6
  • 36
    • 77953192081 scopus 로고    scopus 로고
    • Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer
    • Huang, Z., Huang, D., Ni, S., Peng, Z., Sheng, W., and Du, X. (2010). Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int. J. Cancer 127, 118-126. doi: 10.1002/ijc.25007
    • (2010) Int. J. Cancer , vol.127 , pp. 118-126
    • Huang, Z.1    Huang, D.2    Ni, S.3    Peng, Z.4    Sheng, W.5    Du, X.6
  • 37
    • 34547851719 scopus 로고    scopus 로고
    • Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions
    • Huang, Z., Li, L., and Wang, J. (2007). Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. Dig. Dis. Sci. 52, 9287-9291. doi: 10.1007/s10620-007-9755-y
    • (2007) Dig. Dis. Sci , vol.52 , pp. 9287-9291
    • Huang, Z.1    Li, L.2    Wang, J.3
  • 38
    • 78649766938 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • Iacopetta, B., Grieu, F., and Amanuel, B. (2010). Microsatellite instability in colorectal cancer. Asia Pac. J. Clin. Oncol. 6, 460-469. doi: 10.1111/j.1743-7563.2010.01335.x
    • (2010) Asia Pac. J. Clin. Oncol , vol.6 , pp. 460-469
    • Iacopetta, B.1    Grieu, F.2    Amanuel, B.3
  • 42
    • 84860391473 scopus 로고    scopus 로고
    • Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer
    • Kalimutho, M., Del Vecchio Blanco, G., Di Cecilia, S., Sileri, P., Cretella, M., Pallone, F., et al. (2011a). Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer. J. Gastroenterol. 46, 12391-12402. doi: 10.1007/s00535-011-0456-0
    • (2011) J. Gastroenterol , vol.46 , pp. 12391-12402
    • Kalimutho, M.1    Del Vecchio Blanco, G.2    Di Cecilia, S.3    Sileri, P.4    Cretella, M.5    Pallone, F.6
  • 43
    • 79957603048 scopus 로고    scopus 로고
    • Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
    • Kalimutho, M., Di Cecilia, S., Del Vecchio Blanco, G., Roviello, F., Sileri, P., Cretella, M., et al. (2011b). Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br. J. Cancer. 104, 11770-11778. doi: 10.1038/bjc.2011.82
    • (2011) Br. J. Cancer , vol.104 , pp. 11770-11778
    • Kalimutho, M.1    Di Cecilia, S.2    Del Vecchio Blanco, G.3    Roviello, F.4    Sileri, P.5    Cretella, M.6
  • 44
    • 84865503318 scopus 로고    scopus 로고
    • Plasma miR-21: a potential diagnostic marker of colorectal cancer
    • Kanaan, Z., Rai, S. N., Eichenberger, M. R., Roberts, H., Keskey, B., Pan, J., et al. (2012). Plasma miR-21: a potential diagnostic marker of colorectal cancer. Ann. Surg. 256, 344-351. doi: 10.1097/SLA.0b013e318265bd6f
    • (2012) Ann. Surg , vol.256 , pp. 344-351
    • Kanaan, Z.1    Rai, S.N.2    Eichenberger, M.R.3    Roberts, H.4    Keskey, B.5    Pan, J.6
  • 45
    • 84884503872 scopus 로고    scopus 로고
    • A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer
    • Kanaan, Z., Roberts, H., Eichenberger, M. R., Billeter, A., Ocheretner, G., Pan, J., et al. (2013). A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer. Ann. Surg. 258, 300-308. doi: 10.1097/SLA.0b013e3182a15bcc
    • (2013) Ann. Surg , vol.258 , pp. 300-308
    • Kanaan, Z.1    Roberts, H.2    Eichenberger, M.R.3    Billeter, A.4    Ocheretner, G.5    Pan, J.6
  • 46
    • 85061174001 scopus 로고    scopus 로고
    • Gene methylation in stool for the screening of colorectal cancer and pre-malignant lesions
    • Kang, Y. P., Cao, F. A., Chang, W. J., Lou, Z., Wang, H., Wu, L. L., et al. (2011). [Gene methylation in stool for the screening of colorectal cancer and pre-malignant lesions]. Zhonghua Wei Chang Wai Ke Za Zhi 14, 12-16.
    • (2011) Zhonghua Wei Chang Wai Ke Za Zhi , vol.14 , pp. 12-16
    • Kang, Y.P.1    Cao, F.A.2    Chang, W.J.3    Lou, Z.4    Wang, H.5    Wu, L.L.6
  • 47
    • 0033822891 scopus 로고    scopus 로고
    • P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients
    • Khan, Z. A., Jonas, S. K., Le-Marer, N., Patel, H., Wharton, R. Q., Tarragona, A., et al. (2000). P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients. Clin. Cancer Res. 6, 9499-9504.
    • (2000) Clin. Cancer Res , vol.6 , pp. 9499-9504
    • Khan, Z.A.1    Jonas, S.K.2    Le-Marer, N.3    Patel, H.4    Wharton, R.Q.5    Tarragona, A.6
  • 48
    • 84908335830 scopus 로고    scopus 로고
    • Circulating miR-18a: a sensitive cancer screening biomarker in human cancer
    • Komatsu, S., Ichikawa, D., Takeshita, H., Morimura, R., Hirajima, S., Tsujiura, M., et al. (2014). Circulating miR-18a: a sensitive cancer screening biomarker in human cancer. In Vivo 28, 393-397.
    • (2014) In Vivo , vol.28 , pp. 393-397
    • Komatsu, S.1    Ichikawa, D.2    Takeshita, H.3    Morimura, R.4    Hirajima, S.5    Tsujiura, M.6
  • 49
    • 0036244675 scopus 로고    scopus 로고
    • Microsatellite analysis of fecal DNA for colorectal cancer detection
    • Koshiji, M., Yonekura, Y., Saito, T., and Yoshioka, K. (2002). Microsatellite analysis of fecal DNA for colorectal cancer detection. J. Surg. Oncol. 80, 14-40. doi: 10.1002/jso.10096
    • (2002) J. Surg. Oncol , vol.80 , pp. 14-40
    • Koshiji, M.1    Yonekura, Y.2    Saito, T.3    Yoshioka, K.4
  • 50
    • 28844481452 scopus 로고    scopus 로고
    • The KRAS oncogene: past, present, and future
    • Kranenburg, O. (2005). The KRAS oncogene: past, present, and future. Biochim. Biophys. Acta. 1756, 21-22. doi: 10.1016/j.bbcan.2005.10.001
    • (2005) Biochim. Biophys. Acta , vol.1756 , pp. 21-22
    • Kranenburg, O.1
  • 51
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • Leary, R. J., Sausen, M., Kinde, I., Papadopoulos, N., Carpten, J. D., Craig, D., et al. (2012). Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci. Transl. Med. 4:16262ra54. doi: 10.1126/scitranslmed.3004742
    • (2012) Sci. Transl. Med , vol.4
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3    Papadopoulos, N.4    Carpten, J.D.5    Craig, D.6
  • 52
    • 27744526931 scopus 로고    scopus 로고
    • Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer
    • Leung, W. K., To, K. F., Man, E. P., Chan, M. W., Bai, A. H., Hui, A. J., et al. (2005). Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. Am. J. Gastroenterol. 100, 10274-10279. doi: 10.1111/j.1572-0241.2005.50412.x
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 10274-10279
    • Leung, W.K.1    To, K.F.2    Man, E.P.3    Chan, M.W.4    Bai, A.H.5    Hui, A.J.6
  • 54
    • 3242655683 scopus 로고    scopus 로고
    • Real time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA in patients with colorectal cancer
    • Lledo, S. M., Garcia-Granero, E., Dasi, F., Ripoli, R., Garcia, S. A., Cervantes, A., et al. (2004). Real time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA in patients with colorectal cancer. Colorectal Dis. 6, 436-442. doi: 10.1111/j.1463-1318.2004.00627.x
    • (2004) Colorectal Dis , vol.6 , pp. 436-442
    • Lledo, S.M.1    Garcia-Granero, E.2    Dasi, F.3    Ripoli, R.4    Garcia, S.A.5    Cervantes, A.6
  • 55
    • 84877781097 scopus 로고    scopus 로고
    • Identification and evaluation of plasma microRNAs for early detection of colorectal cancer
    • Luo, X., Stock, C., Burwinkel, B., and Brenner, H. (2013). Identification and evaluation of plasma microRNAs for early detection of colorectal cancer. PLoS ONE 8:e62880. doi: 10.1371/journal.pone.0062880
    • (2013) PLoS ONE , vol.8
    • Luo, X.1    Stock, C.2    Burwinkel, B.3    Brenner, H.4
  • 56
    • 84957852098 scopus 로고
    • Les acides nucléiques du plasma sanguin chezl'homme
    • Mandel, P., and Metais, P. (1948). Les acides nucléiques du plasma sanguin chezl'homme. C. R. Seances Soc. Biol. Fil. 142, 241-243.
    • (1948) C. R. Seances Soc. Biol. Fil , vol.142 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 59
    • 84893202189 scopus 로고    scopus 로고
    • MicroRNAs and human diseases: diagnostic and therapeutic potential
    • [Epub ahead of print]
    • Maqbool, R., and Hussain, M. U. (2014). MicroRNAs and human diseases: diagnostic and therapeutic potential. Cell Tissue Res. doi: 10.1007/s00441-013-1787-3. [Epub ahead of print].
    • (2014) Cell Tissue Res
    • Maqbool, R.1    Hussain, M.U.2
  • 60
    • 67649635452 scopus 로고    scopus 로고
    • N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer
    • Melotte, V., Lentjes, M. H., van den Bosch, S. M., Hellebrekers, D. M., de Hoon, J. P., Wouters, K. A., et al. (2009). N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer. J. Natl. Cancer Inst. 101, 1316-1327. doi: 10.1093/jnci/djp131
    • (2009) J. Natl. Cancer Inst , vol.101 , pp. 1316-1327
    • Melotte, V.1    Lentjes, M.H.2    van den Bosch, S.M.3    Hellebrekers, D.M.4    de Hoon, J.P.5    Wouters, K.A.6
  • 61
    • 34047246471 scopus 로고    scopus 로고
    • Noninvasive detection through REMS-PCR technique of K-ras mutations in stool DNA of patients with colorectal cancer
    • Mixich, F., Ioana, M., Voinea, F., Saftoiu, A., and Ciurea, T. (2007). Noninvasive detection through REMS-PCR technique of K-ras mutations in stool DNA of patients with colorectal cancer. J. Gastrointestin. Liver Dis. 16, 1-10.
    • (2007) J. Gastrointestin. Liver Dis , vol.16 , pp. 1-10
    • Mixich, F.1    Ioana, M.2    Voinea, F.3    Saftoiu, A.4    Ciurea, T.5
  • 62
    • 84878734930 scopus 로고    scopus 로고
    • Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load
    • Mouliere, F., El Messaoudi, S., Gongora, C., Guedj, A. S., Robert, B., Del Rio, M., et al. (2013). Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load. Transl. Oncol. 6, 319-328. doi: 10.1593/tlo.12445
    • (2013) Transl. Oncol , vol.6 , pp. 319-328
    • Mouliere, F.1    El Messaoudi, S.2    Gongora, C.3    Guedj, A.S.4    Robert, B.5    Del Rio, M.6
  • 63
    • 11144356831 scopus 로고    scopus 로고
    • Methylation changes in faecal DNA: a marker for colorectal cancer screening?
    • Muller, H. M., Oberwalder, M., Fiegl, H., Morandell, M., Goebel, G., Zitt, M., et al. (2004). Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet 363, 9417283-9417285. doi: 10.1016/S0140-6736(04)16002-9
    • (2004) Lancet , vol.363
    • Muller, H.M.1    Oberwalder, M.2    Fiegl, H.3    Morandell, M.4    Goebel, G.5    Zitt, M.6
  • 64
    • 70349251628 scopus 로고    scopus 로고
    • Analysis of fecal DNA methylation to detect gastrointestinal neoplasia
    • Nagasaka, T., Tanaka, N., Cullings, H. M., Sun, D. S., Sasamoto, H., Uchida, T., et al. (2009). Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J. Natl. Cancer Inst. 101, 18244-18258. doi: 10.1093/jnci/djp265
    • (2009) J. Natl. Cancer Inst , vol.101 , pp. 18244-18258
    • Nagasaka, T.1    Tanaka, N.2    Cullings, H.M.3    Sun, D.S.4    Sasamoto, H.5    Uchida, T.6
  • 65
    • 66049112674 scopus 로고    scopus 로고
    • Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening
    • Ng, E. K., Chong, W. W., Jin, H., Lam, E. K., Shin, V. Y., Yu, J., et al. (2009). Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 58, 10375-10381. doi: 10.1136/gut.2008.167817
    • (2009) Gut , vol.58 , pp. 10375-10381
    • Ng, E.K.1    Chong, W.W.2    Jin, H.3    Lam, E.K.4    Shin, V.Y.5    Yu, J.6
  • 66
    • 84899431845 scopus 로고    scopus 로고
    • Circulating exosomal microRNAs as biomarkers of colon cancer
    • Ogata-Kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., et al. (2014). Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS ONE 9:e92921. doi: 10.1371/journal.pone.0092921
    • (2014) PLoS ONE , vol.9
    • Ogata-Kawata, H.1    Izumiya, M.2    Kurioka, D.3    Honma, Y.4    Yamada, Y.5    Furuta, K.6
  • 67
    • 77957600558 scopus 로고    scopus 로고
    • Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression
    • Pu, X. X., Huang, G. L., Guo, H. Q., Guo, C. C., Li, H., Ye, S., et al. (2010). Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression. J. Gastroenterol. Hepatol. 25, 10674-10680. doi: 10.1111/j.1440-1746.2010.06417.x
    • (2010) J. Gastroenterol. Hepatol , vol.25 , pp. 10674-10680
    • Pu, X.X.1    Huang, G.L.2    Guo, H.Q.3    Guo, C.C.4    Li, H.5    Ye, S.6
  • 68
    • 10544229336 scopus 로고    scopus 로고
    • Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces
    • Ratto, C., Flamini, G., Sofo, L., Nucera, P., Ippoliti, M., Curigliano, G., et al. (1996). Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces. Dis. Colon Rectum. 39, 11238-11244. doi: 10.1007/BF02055116
    • (1996) Dis. Colon Rectum , vol.39 , pp. 11238-11244
    • Ratto, C.1    Flamini, G.2    Sofo, L.3    Nucera, P.4    Ippoliti, M.5    Curigliano, G.6
  • 70
    • 84888356699 scopus 로고    scopus 로고
    • Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer
    • Roperch, J. P., Incitti, R., Forbin, S., Bard, F., Mansour, H., Mesli, F., et al. (2013). Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer. BMC Cancer 13:566. doi: 10.1186/1471-2407-13-566
    • (2013) BMC Cancer , vol.13 , pp. 566
    • Roperch, J.P.1    Incitti, R.2    Forbin, S.3    Bard, F.4    Mansour, H.5    Mesli, F.6
  • 71
    • 84861573867 scopus 로고    scopus 로고
    • Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up
    • Scholefield, J. H., Moss, S. M., Mangham, C. M., Whynes, D. K., and Hardcastle, J. D. (2012). Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up. Gut 61, 7036-7040. doi: 10.1136/gutjnl-2011-300774
    • (2012) Gut , vol.61 , pp. 7036-7040
    • Scholefield, J.H.1    Moss, S.M.2    Mangham, C.M.3    Whynes, D.K.4    Hardcastle, J.D.5
  • 74
    • 0026537986 scopus 로고
    • Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors
    • Sidransky, D., Tokino, T., Hamilton, S. R., Kinzler, K. W., Levin, B., Frost, P., et al. (1992). Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256, 505302-505305. doi: 10.1126/science.1566048
    • (1992) Science , vol.256
    • Sidransky, D.1    Tokino, T.2    Hamilton, S.R.3    Kinzler, K.W.4    Levin, B.5    Frost, P.6
  • 76
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    • Toledo, F., and Wahl, G. M. (2006). Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6, 1209-1223. doi: 10.1038/nrc2012
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 1209-1223
    • Toledo, F.1    Wahl, G.M.2
  • 77
    • 0037204202 scopus 로고    scopus 로고
    • Detection of APC mutations in fecal DNA from patients with colorectal tumors
    • Traverso, G., Shuber, A., Levin, B., Johnson, C., Olsson, L., Schoetz, D. J. Jr., et al. (2002). Detection of APC mutations in fecal DNA from patients with colorectal tumors. N. Engl. J. Med. 346, 511-520. doi: 10.1056/NEJMoa012294
    • (2002) N. Engl. J. Med , vol.346 , pp. 511-520
    • Traverso, G.1    Shuber, A.2    Levin, B.3    Johnson, C.4    Olsson, L.5    Schoetz, D.J.6
  • 78
    • 36649023930 scopus 로고    scopus 로고
    • The origin of circulating free DNa
    • van der Vaart, M., and Pretorius, P. J. (2007). The origin of circulating free DNa. Clin. Chem. 53, 12215. doi: 10.1373/clinchem.2007.092734
    • (2007) Clin. Chem , vol.53 , pp. 12215
    • van der Vaart, M.1    Pretorius, P.J.2
  • 79
    • 0029970487 scopus 로고    scopus 로고
    • Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool
    • Villa, E., Dugani, A., Rebecchi, A. M., Vignoli, A., Grottola, A., Buttafoco, P., et al. (1996). Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool. Gastroenterology 110, 5346-5353. doi: 10.1053/gast.1996.v110.pm8613038
    • (1996) Gastroenterology , vol.110 , pp. 5346-5353
    • Villa, E.1    Dugani, A.2    Rebecchi, A.M.3    Vignoli, A.4    Grottola, A.5    Buttafoco, P.6
  • 80
    • 40049096639 scopus 로고    scopus 로고
    • Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening
    • Wang, D. R., and Tang, D. (2008). Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening. World J. Gastroenterol. 14, 424-431.
    • (2008) World J. Gastroenterol , vol.14 , pp. 424-431
    • Wang, D.R.1    Tang, D.2
  • 81
    • 84899451999 scopus 로고    scopus 로고
    • Identification of a circulating microRNA signature for colorectal cancer detection
    • Wang, J., Huang, S. K., Zhao, M., Yang, M., Zhong, J. L., Gu, Y. Y., et al. (2014). Identification of a circulating microRNA signature for colorectal cancer detection. PLoS ONE 9:e87451. doi: 10.1371/journal.pone.0087451
    • (2014) PLoS ONE , vol.9
    • Wang, J.1    Huang, S.K.2    Zhao, M.3    Yang, M.4    Zhong, J.L.5    Gu, Y.Y.6
  • 82
    • 84866113596 scopus 로고    scopus 로고
    • Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer
    • Wang, Q., Huang, Z., Ni, S., Xiao, X., Xu, Q., Wang, L., et al. (2012). Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer. PLoS ONE 7:e44398. doi: 10.1371/journal.pone.0044398
    • (2012) PLoS ONE , vol.7
    • Wang, Q.1    Huang, Z.2    Ni, S.3    Xiao, X.4    Xu, Q.5    Wang, L.6
  • 83
    • 84901793311 scopus 로고    scopus 로고
    • Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma
    • Wu, C. W., Ng, S. C., Dong, Y., Tian, L., Ng, S. S., Leung, W. W., et al. (2014b). Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma. Clin. Cancer Res. 20, 11994-13002. doi: 10.1158/1078-0432.CCR-13-1750
    • (2014) Clin. Cancer Res , vol.20 , pp. 11994-13002
    • Wu, C.W.1    Ng, S.C.2    Dong, Y.3    Tian, L.4    Ng, S.S.5    Leung, W.W.6
  • 84
    • 84894274025 scopus 로고    scopus 로고
    • Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer
    • Wu, X. D., Song, Y. C., Cao, P. L., Zhang, H., Guo, Q., Yan, R., et al. (2014a). Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer. Med. Oncol. 31, 494. doi: 10.1007/s12032-014-0894-7
    • (2014) Med. Oncol , vol.31 , pp. 494
    • Wu, X.D.1    Song, Y.C.2    Cao, P.L.3    Zhang, H.4    Guo, Q.5    Yan, R.6
  • 85
    • 0031777844 scopus 로고    scopus 로고
    • Abnormal expression of CD44 variants in the exfoliated cells in the feces of patients with colorectal cancer
    • Yamao, T., Matsumura, Y., Shimada, Y., Moriya, Y., Sugihara, K., Akasu, T., et al. (1998). Abnormal expression of CD44 variants in the exfoliated cells in the feces of patients with colorectal cancer. Gastroenterology 114, 6196-6205. doi: 10.1016/S0016-5085(98)70425-1
    • (1998) Gastroenterology , vol.114 , pp. 6196-6205
    • Yamao, T.1    Matsumura, Y.2    Shimada, Y.3    Moriya, Y.4    Sugihara, K.5    Akasu, T.6
  • 86
    • 84894354513 scopus 로고    scopus 로고
    • Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer
    • Zanutto, S., Pizzamiglio, S., Ghilotti, M., Bertan, C., Ravagnani, F., Perrone, F., et al. (2014). Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer. Br. J. Cancer. 110, 4001-4007. doi: 10.1038/bjc.2013.819
    • (2014) Br. J. Cancer , vol.110 , pp. 4001-4007
    • Zanutto, S.1    Pizzamiglio, S.2    Ghilotti, M.3    Bertan, C.4    Ravagnani, F.5    Perrone, F.6
  • 87
    • 84907708556 scopus 로고    scopus 로고
    • Plasma miR-200c and miR-18a as potential biomarkers for the detection of colorectal carcinoma
    • Zhang, G. J., Zhou, T., Liu, Z. L., Tian, H. P., and Xia, S. S. (2013b). Plasma miR-200c and miR-18a as potential biomarkers for the detection of colorectal carcinoma. Mol. Clin. Oncol. 1, 279-284. doi: 10.3892/mco.2013.61
    • (2013) Mol. Clin. Oncol , vol.1 , pp. 279-284
    • Zhang, G.J.1    Zhou, T.2    Liu, Z.L.3    Tian, H.P.4    Xia, S.S.5
  • 88
    • 84873326080 scopus 로고    scopus 로고
    • Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer
    • Zhang, H., Song, Y. C., and Dang, C. X. (2013a). Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer. Int. J. Med. Sci. 10, 330-334. doi: 10.7150/ijms.5278
    • (2013) Int. J. Med. Sci , vol.10 , pp. 330-334
    • Zhang, H.1    Song, Y.C.2    Dang, C.X.3
  • 89
    • 79955549712 scopus 로고    scopus 로고
    • Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis
    • Zhang, H., Wang, X., Ma, Q., Zhou, Z., and Fang, J. (2011a). Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis. Lab. Invest. 91, 588-598. doi: 10.1038/labinvest.2010.200
    • (2011) Lab. Invest , vol.91 , pp. 588-598
    • Zhang, H.1    Wang, X.2    Ma, Q.3    Zhou, Z.4    Fang, J.5
  • 90
    • 84855826568 scopus 로고    scopus 로고
    • Detection of methylated tissue factor pathway inhibitor 2 and human long DNA in fecal samples of patients with colorectal cancer in China
    • Zhang, J., Yang, S., Xie, Y., Chen, X., Zhao, Y., He, D., et al. (2012). Detection of methylated tissue factor pathway inhibitor 2 and human long DNA in fecal samples of patients with colorectal cancer in China. Cancer Epidemiol. 36, 13-17. doi: 10.1016/j.canep.2011.04.006
    • (2012) Cancer Epidemiol , vol.36 , pp. 13-17
    • Zhang, J.1    Yang, S.2    Xie, Y.3    Chen, X.4    Zhao, Y.5    He, D.6
  • 91
    • 84870429364 scopus 로고    scopus 로고
    • Human stool vimentin, oncostatin M receptor and tissue factor pathway inhibitor 2 gene methylation analysis for the detection of colorectal neoplasms
    • Zhang, J. P., Wang, J., Gui, Y. L., Zhu, Q. Q., Xu, Z. W., and Li, J. S. (2011b). [Human stool vimentin, oncostatin M receptor and tissue factor pathway inhibitor 2 gene methylation analysis for the detection of colorectal neoplasms]. Zhonghua Yi Xue Za Zhi 91, 35482-35484.
    • (2011) Zhonghua Yi Xue Za Zhi , vol.91 , pp. 35482-35484
    • Zhang, J.P.1    Wang, J.2    Gui, Y.L.3    Zhu, Q.Q.4    Xu, Z.W.5    Li, J.S.6
  • 92
    • 35348831351 scopus 로고    scopus 로고
    • DNA stool test for colorectal cancer: hypermethylation of the secreted frizzled-related protein-1 gene
    • discussion: 26-27
    • Zhang, W., Bauer, M., Croner, R. S., Pelz, J. O., Lodygin, D., Hermeking, H., et al. (2007). DNA stool test for colorectal cancer: hypermethylation of the secreted frizzled-related protein-1 gene. Dis. Colon Rectum 50, 10618-10626. discussion: 26-27. doi: 10.1007/s10350-007-0286-6
    • (2007) Dis. Colon Rectum , vol.50 , pp. 10618-10626
    • Zhang, W.1    Bauer, M.2    Croner, R.S.3    Pelz, J.O.4    Lodygin, D.5    Hermeking, H.6


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