Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer

Medical Oncology

Volumn 31, Issue 4, 2014, Pages

  Wu, Xuan Di ^a   Song, Yong Chun ^a   Cao, Pei Long ^a   Zhang, Hao ^a   Guo, Qi ^a   Yan, Rong ^a   Diao, Dong Mei ^a   Cheng, Yao ^a   Dang, Cheng Xue ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Biomarker; CRC; Methylation; miR 34a; miR 34b c; Stool DNA

Indexed keywords

BIOLOGICAL MARKER; MICRORNA 34A; MICRORNA 34B; UNCLASSIFIED DRUG; MICRORNA; MIRN34 MICRORNA, HUMAN; TUMOR MARKER;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER DIAGNOSIS; CANCER SCREENING; CANCER STAGING; CANCER TISSUE; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DNA DETERMINATION; DNA METHYLATION; FECES; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NON INVASIVE PROCEDURE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; AGED; COLORECTAL TUMOR; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA METHYLATION; FECES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEALTHY VOLUNTEERS; HUMANS; LYMPHATIC METASTASIS; MALE; MICRORNAS; MIDDLE AGED; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; TUMOR MARKERS, BIOLOGICAL;

EID: 84894274025     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0894-7     Document Type: Article

References (28)

1. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843-54.
2. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281-97.
3. Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, et al. Combinatorial microRNA target predictions. Nat Genet. 2005;37(5):495-500. doi: 10.1038/ng1536.
4. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20. doi: 10.1016/j.cell.2004.12.035.
5. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5(7):522-31. doi: 10.1038/nrg1379.
6. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10(10):704-14. doi: 10.1038/nrg2634.
7. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006;9(6):435-43. doi: 10.1016/j.ccr.2006.04.020.
8. Lehmann U, Hasemeier B, Christgen M, Muller M, Romermann D, Langer F, et al. Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol. 2008;214(1):17-24. doi: 10.1002/path.2251.
9. Feng B, Dong TT, Wang LL, Zhou HM, Zhao HC, Dong F, et al. Colorectal cancer migration and invasion initiated by microRNA-106a. PLoS ONE. 2012;7(8):e43452. doi: 10.1371/journal.pone.0043452.
10. Faber C, Kirchner T, Hlubek F. The impact of microRNAs on colorectal cancer. Virchows Archiv Int J Pathol. 2009;454(4):359-67. doi: 10.1007/s00428-009-0751-9.
11. Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008;68(11):4123-32. doi: 10.1158/0008-5472.CAN-08-0325.
12. Vogt M, Munding J, Gruner M, Liffers ST, Verdoodt B, Hauk J, et al. Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Archiv Int J Pathol. 2011;458(3):313-22. doi: 10.1007/s00428-010-1030-5.
13. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 2007;17(15):1298-307. doi: 10.1016/j.cub.2007.06.068.
14. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 2007;67(18):8433-8. doi: 10.1158/0008-5472.CAN-07-1585.
15. Siemens H, Neumann J, Jackstadt R, Mansmann U, Horst D, Kirchner T, et al. Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and -catenin predicts distant metastasis of colon cancer. Clin Cancer Res. 2012;19(3):710-20. doi: 10.1158/1078-0432.ccr-12-1703.
16. Lujambio A, Calin GA, Villanueva A, Ropero S, Sanchez-Cespedes M, Blanco D, et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA. 2008;105(36):13556-61. doi: 10.1073/pnas.0803055105.
17. Li J-M, Zhao R-H, Li S-T, Xie C-X, Jiang H-H, Ding W-J, et al. Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer. Saudi Med J. 2012;33(1):24-9.
18. Ahmed FE, Ahmed NC, Vos PW, Bonnerup C, Atkins JN, Casey M, et al. Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle. Cancer Genomics Proteomics. 2013;10(3):93-113.
19. Zhang H, Song YC, Dang CX. Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer. Int J Med Sci. 2013;10(3):230-4. doi: 10.7150/ijms.5278.
20. Guo Q, Song Y, Zhang H, Wu X, Xia P, Dang C. Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients. Med Oncol. 2013;30(4):695. doi: 10.1007/s12032-013-0695-4.
21. Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Korner H et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle (Georgetown, Tex). 2008;7(16):2591-600.
22. Rodriguez-Moranta F, Azuara D, Soriano-Izquierdo A, Blanco I, Sanjuan X, de Oca J et al. Stool DNA melting curve analysis of methylated promoters is sensitive and specific for the non-invasive early diagnostic tool for colorectal tumors. Gastroenterology 2009;136(5):A768.
23. Klaassen CH, Jeunink MA, Prinsen CF, Ruers TJ, Tan AC, Strobbe LJ, et al. Quantification of human DNA in feces as a diagnostic test for the presence of colorectal cancer. Clin Chem. 2003;49(7):1185-7.
24. Kalimutho M, Di Cecilia S, Del Vecchio Blanco G, Roviello F, Sileri P, Cretella M et al. Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br J Cancer 2011;104(11):1770-8. doi: 10.1038/bjc.2011.82.
25. Wu CW, Ng SS, Dong YJ, Ng SC, Leung WW, Lee CW, et al. Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps. Gut. 2012;61(5):739-45. doi: 10.1136/gut.2011. 239236.
26. Wang Z, Chen Z, Gao Y, Li N, Li B, Tan F, et al. DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer. Cancer Biol Ther. 2011;11(5):490-6. doi: 10.4161/cbt.11.5.14550.
27. Cao W, Fan R, Wang L, Cheng S, Li H, Jiang J, et al. Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells. Tumour Biol J Int Soc Oncodev Biol Med. 2013;34(2):963-71. doi: 10.1007/s13277-012-0632-8.
28. Bosch LJ, Mongera S, Terhaar Sive Droste JS, Oort FA, van Turenhout ST, Penning MT et al. Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection. Cell Oncol. (Dordrecht) 2012;35(4):309-15. doi: 10.1007/s13402-012-0092-6.