-
1
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
Ionov Y, Peinado M, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363: 558-61.
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
-
2
-
-
0027314411
-
Microsatellite instability in cancer of the proximal colon
-
Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-19.
-
(1993)
Science
, vol.260
, pp. 816-819
-
-
Thibodeau, S.N.1
Bren, G.2
Schaid, D.3
-
3
-
-
0027158031
-
Clues to the pathogenesis of familial colorectal cancer
-
Aaltonen LA, Peltomäki P, Leach FS et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260: 812-16.
-
(1993)
Science
, vol.260
, pp. 812-816
-
-
Aaltonen, L.A.1
Peltomäki, P.2
Leach, F.S.3
-
4
-
-
0027137935
-
Hypermutability and mismatch repair deficiency in RER+ tumor cells
-
Parsons R, Li GM, Longley M et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993; 75: 1227-36.
-
(1993)
Cell
, vol.75
, pp. 1227-1236
-
-
Parsons, R.1
Li, G.M.2
Longley, M.3
-
5
-
-
0028152314
-
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
-
Hemminki A, Peltomäki P, Mecklin JP et al. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet 1994; 8: 405-10.
-
(1994)
Nat Genet
, vol.8
, pp. 405-410
-
-
Hemminki, A.1
Peltomäki, P.2
Mecklin, J.P.3
-
6
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane MF, Loda M, Gaida GM et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997; 57: 808-11.
-
(1997)
Cancer Res
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
-
7
-
-
0029066689
-
Inactivation of the type II TGF-II receptor in colon cancer cells with microsatellite instability
-
Markowitz S, Wang J, Myeroff L et al. Inactivation of the type II TGF-II receptor in colon cancer cells with microsatellite instability. Science 1995; 268: 1336-38.
-
(1995)
Science
, vol.268
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
-
8
-
-
0036569940
-
Mutations at coding repeat sequences in mismatch repair deficient human cancers: toward a new concept of target genes for instability
-
Duval A, Hamelin R. Mutations at coding repeat sequences in mismatch repair deficient human cancers: toward a new concept of target genes for instability. Cancer Res 2002; 62: 2447-54.
-
(2002)
Cancer Res
, vol.62
, pp. 2447-2454
-
-
Duval, A.1
Hamelin, R.2
-
9
-
-
0036494106
-
Mutation profiling of mismatch repair-deficient colorectal cancers using an in silico genome scan to identify coding microsatellites
-
Park J, Betel D, Gryfe R et al. Mutation profiling of mismatch repair-deficient colorectal cancers using an in silico genome scan to identify coding microsatellites. Cancer Res 2002; 62: 1284-8.
-
(2002)
Cancer Res
, vol.62
, pp. 1284-1288
-
-
Park, J.1
Betel, D.2
Gryfe, R.3
-
10
-
-
33751087779
-
Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
-
Hugo H, Cures A, Suraweera N et al. Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer 2006; 45: 1143-54.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 1143-1154
-
-
Hugo, H.1
Cures, A.2
Suraweera, N.3
-
11
-
-
2342467382
-
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability
-
Giannini G, Rinaldi C, Ristori E et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene 2004; 23: 2640-7.
-
(2004)
Oncogene
, vol.23
, pp. 2640-2647
-
-
Giannini, G.1
Rinaldi, C.2
Ristori, E.3
-
12
-
-
0032534069
-
A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer
-
Boland CR, Thibodeau SN, Hamilton SR et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248-57.
-
(1998)
Cancer Res
, vol.58
, pp. 5248-5257
-
-
Boland, C.R.1
Thibodeau, S.N.2
Hamilton, S.R.3
-
13
-
-
12844262940
-
Development of a fluorescent multiplex assay for detection of MSI-high tumors
-
Bacher JW, Flanagan LA, Smalley RL et al. Development of a fluorescent multiplex assay for detection of MSI-high tumors. Dis Markers 2004; 20: 237-50.
-
(2004)
Dis Markers
, vol.20
, pp. 237-250
-
-
Bacher, J.W.1
Flanagan, L.A.2
Smalley, R.L.3
-
14
-
-
33745977120
-
Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers
-
Murphy KM, Zhang S, Geiger T et al. Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers. J Mol Diagn 2006; 8: 305-11.
-
(2006)
J Mol Diagn
, vol.8
, pp. 305-311
-
-
Murphy, K.M.1
Zhang, S.2
Geiger, T.3
-
15
-
-
0036234167
-
Does MSI-low exist?
-
Tomlinson I, Halford S, Aaltonen L, Hawkins N, Ward R. Does MSI-low exist? J Pathol 2002; 197: 6-13.
-
(2002)
J Pathol
, vol.197
, pp. 6-13
-
-
Tomlinson, I.1
Halford, S.2
Aaltonen, L.3
Hawkins, N.4
Ward, R.5
-
16
-
-
0032952309
-
A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer
-
Perucho M, Correspondence RE, Boland CR et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1999; 59: 249-56.
-
(1999)
Cancer Res
, vol.59
, pp. 249-256
-
-
Perucho, M.1
Correspondence, R.E.2
Boland, C.R.3
-
17
-
-
0031938045
-
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
-
Zhou XP, Hoang JM, Li YJ et al. Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites. Genes Chromosomes Cancer 1998; 21: 101-7.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 101-107
-
-
Zhou, X.P.1
Hoang, J.M.2
Li, Y.J.3
-
18
-
-
0031015728
-
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
-
Hoang JM, Cottu PH, Thuille B, Salmon RJ, Thomas G, Hamelin R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res 1997; 57: 300-3.
-
(1997)
Cancer Res
, vol.57
, pp. 300-303
-
-
Hoang, J.M.1
Cottu, P.H.2
Thuille, B.3
Salmon, R.J.4
Thomas, G.5
Hamelin, R.6
-
19
-
-
0032778898
-
Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin. Implications for microsatellite instability testing
-
Pyatt R, Chadwick RB, Johnson CK, Adebamowo C, De La Chapelle A, Prior TW. Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin. Implications for microsatellite instability testing. Am J Pathol 1999; 155: 349-53.
-
(1999)
Am J Pathol
, vol.155
, pp. 349-353
-
-
Pyatt, R.1
Chadwick, R.B.2
Johnson, C.K.3
Adebamowo, C.4
De La Chapelle, A.5
Prior, T.W.6
-
20
-
-
29644441530
-
Stability of BAT26 in tumours of hereditary nonpolyposis colorectal cancer patients with MSH2 intragenic deletion
-
Pastrello C, Baglioni S, Tibiletti MG et al. Stability of BAT26 in tumours of hereditary nonpolyposis colorectal cancer patients with MSH2 intragenic deletion. Eur J Hum Genet 2006; 14: 63-8.
-
(2006)
Eur J Hum Genet
, vol.14
, pp. 63-68
-
-
Pastrello, C.1
Baglioni, S.2
Tibiletti, M.G.3
-
21
-
-
0036893598
-
Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR
-
Suraweera N, Duval A, Reperant M et al. Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology 2002; 123: 1804-11.
-
(2002)
Gastroenterology
, vol.123
, pp. 1804-1811
-
-
Suraweera, N.1
Duval, A.2
Reperant, M.3
-
22
-
-
33847712926
-
Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors
-
Xicola RM, Llor X, Pons E et al. Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. J Natl Cancer Inst 2007; 7: 244-52.
-
(2007)
J Natl Cancer Inst
, vol.7
, pp. 244-252
-
-
Xicola, R.M.1
Llor, X.2
Pons, E.3
-
23
-
-
0034852772
-
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level
-
Samowitz WS, Curtin K, Ma KN et al. Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level. Cancer Epidemiol Biomarkers Prev 2001; 10: 917-23.
-
(2001)
Cancer Epidemiol Biomarkers Prev
, vol.10
, pp. 917-923
-
-
Samowitz, W.S.1
Curtin, K.2
Ma, K.N.3
-
24
-
-
29744465560
-
Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified
-
Ward RL, Turner J, Williams R et al. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol 2005; 207: 377-84.
-
(2005)
J Pathol
, vol.207
, pp. 377-384
-
-
Ward, R.L.1
Turner, J.2
Williams, R.3
-
25
-
-
34447121322
-
Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer
-
Malesci A, Laghi L, Bianchi P et al. Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. Clin Cancer Res 2007; 13: 3831-9.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3831-3839
-
-
Malesci, A.1
Laghi, L.2
Bianchi, P.3
-
26
-
-
0033862311
-
Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women
-
Malkhosyan SR, Yamamoto H, Piao Z, Perucho M. Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women. Gastroenterology 2000; 119: 598.
-
(2000)
Gastroenterology
, vol.119
, pp. 598
-
-
Malkhosyan, S.R.1
Yamamoto, H.2
Piao, Z.3
Perucho, M.4
-
27
-
-
16544364390
-
HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences
-
Jass JR. HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences. Fam Cancer 2004; 3: 93-100.
-
(2004)
Fam Cancer
, vol.3
, pp. 93-100
-
-
Jass, J.R.1
-
28
-
-
16544371133
-
Prognosis in DNA mismatch repair deficient colorectal cancer: are all MSI tumours equivalent?
-
Clark AJ, Barnetson R, Farrington SM, Dunlop MG. Prognosis in DNA mismatch repair deficient colorectal cancer: are all MSI tumours equivalent? Fam Cancer 2004; 3: 85-91.
-
(2004)
Fam Cancer
, vol.3
, pp. 85-91
-
-
Clark, A.J.1
Barnetson, R.2
Farrington, S.M.3
Dunlop, M.G.4
-
29
-
-
0030812206
-
Association between CpG island methylation and microsatellite instability in colorectal cancer
-
Ahuja N, Mohan AL, Li Q et al. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 1997; 57: 3370-4.
-
(1997)
Cancer Res
, vol.57
, pp. 3370-3374
-
-
Ahuja, N.1
Mohan, A.L.2
Li, Q.3
-
30
-
-
33750372629
-
Predictive value of microsatellite instability for benefit from adjuvant fluorouracil chemotherapy in colorectal cancer
-
Iacopetta B, Watanabe T. Predictive value of microsatellite instability for benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut 2006; 55: 1671-2.
-
(2006)
Gut
, vol.55
, pp. 1671-1672
-
-
Iacopetta, B.1
Watanabe, T.2
-
31
-
-
55849140517
-
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
-
Poynter JN, Siegmund KD, Weisenberger DJ et al. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev 2008; 17: 3208-15.
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 3208-3215
-
-
Poynter, J.N.1
Siegmund, K.D.2
Weisenberger, D.J.3
-
32
-
-
9144226978
-
Screening for defective DNA mismatch repair in stage II and III colorectal cancer patients
-
Chai SM, Zeps N, Shearwood AM et al. Screening for defective DNA mismatch repair in stage II and III colorectal cancer patients. Clin Gastroenterol Hepatol 2004; 2: 1017-25.
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, pp. 1017-1025
-
-
Chai, S.M.1
Zeps, N.2
Shearwood, A.M.3
-
33
-
-
0037265479
-
Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer
-
Wang C, Van Rijnsoever M, Grieu F et al. Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer. Oncology 2003; 64: 259-65.
-
(2003)
Oncology
, vol.64
, pp. 259-265
-
-
Wang, C.1
Van Rijnsoever, M.2
Grieu, F.3
-
34
-
-
14544300998
-
Systematic review of microsatellite instability and colorectal cancer prognosis
-
Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 2005; 23: 609-18.
-
(2005)
J Clin Oncol
, vol.23
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
35
-
-
33745828302
-
Population-based study of prognostic factors in stage II colonic cancer
-
Morris M, Platell C, De Boer B, McCaul K, Iacopetta B. Population-based study of prognostic factors in stage II colonic cancer. Br J Surg 2006; 93: 866-71.
-
(2006)
Br J Surg
, vol.93
, pp. 866-871
-
-
Morris, M.1
Platell, C.2
De Boer, B.3
McCaul, K.4
Iacopetta, B.5
-
36
-
-
34948846004
-
Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? The need for high quality pathology
-
Morris EJ, Maughan NJ, Forman D, Quirke P. Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? The need for high quality pathology. Gut 2007; 56: 1419-25.
-
(2007)
Gut
, vol.56
, pp. 1419-1425
-
-
Morris, E.J.1
Maughan, N.J.2
Forman, D.3
Quirke, P.4
-
37
-
-
58249089749
-
Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
-
Salama P, Phillips M, Grieu F et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27: 186-92.
-
(2009)
J Clin Oncol
, vol.27
, pp. 186-192
-
-
Salama, P.1
Phillips, M.2
Grieu, F.3
-
38
-
-
77951217044
-
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
-
Frey DM, Droeser RA, Viehl CT et al. High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int J Cancer 2010; 126: 2635-43.
-
(2010)
Int J Cancer
, vol.126
, pp. 2635-2643
-
-
Frey, D.M.1
Droeser, R.A.2
Viehl, C.T.3
-
39
-
-
0030819872
-
Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells
-
Aebi S, Fink D, Gordon R et al. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells. Clin Cancer Res 1997; 3: 1763-7.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1763-1767
-
-
Aebi, S.1
Fink, D.2
Gordon, R.3
-
40
-
-
0035392965
-
Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses
-
Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 2001; 61: 5193-201.
-
(2001)
Cancer Res
, vol.61
, pp. 5193-5201
-
-
Meyers, M.1
Wagner, M.W.2
Hwang, H.S.3
Kinsella, T.J.4
Boothman, D.A.5
-
41
-
-
0034690610
-
Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
-
Elsaleh H, Joseph D, Grieu F, Zeps N, Spry N, Iacopetta B. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet 2000; 355: 1745-50.
-
(2000)
Lancet
, vol.355
, pp. 1745-1750
-
-
Elsaleh, H.1
Joseph, D.2
Grieu, F.3
Zeps, N.4
Spry, N.5
Iacopetta, B.6
-
42
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
-
Ribic CM, Sargent DJ, Moore MJ et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003; 349: 247-57.
-
(2003)
N Engl J Med
, vol.349
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
-
43
-
-
66949113291
-
Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis
-
Des Guetz G, Schischmanoff O, Nicolas P, Perret GY, Morere JF, Uzzan B. Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis. Eur J Cancer 2009; 45: 1890-6.
-
(2009)
Eur J Cancer
, vol.45
, pp. 1890-1896
-
-
Des Guetz, G.1
Schischmanoff, O.2
Nicolas, P.3
Perret, G.Y.4
Morere, J.F.5
Uzzan, B.6
-
44
-
-
33947546541
-
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
-
Kim GP, Colangelo LH, Wieand HS et al. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol 2007; 25: 767-72.
-
(2007)
J Clin Oncol
, vol.25
, pp. 767-772
-
-
Kim, G.P.1
Colangelo, L.H.2
Wieand, H.S.3
-
45
-
-
33646798052
-
Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer
-
Jover R, Zapater P, Castells A et al. Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut 2006; 55: 848-55.
-
(2006)
Gut
, vol.55
, pp. 848-855
-
-
Jover, R.1
Zapater, P.2
Castells, A.3
-
46
-
-
24644515996
-
Prognostic and predictive relevance of microsatellite instability in colorectal cancer
-
Storojeva I, Boulay JL, Heinimann K et al. Prognostic and predictive relevance of microsatellite instability in colorectal cancer. Oncol Rep 2005; 14: 241-9.
-
(2005)
Oncol Rep
, vol.14
, pp. 241-249
-
-
Storojeva, I.1
Boulay, J.L.2
Heinimann, K.3
-
47
-
-
10744228074
-
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
-
Carethers JM, Smith EJ, Behling CA et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology 2004; 126: 394-401.
-
(2004)
Gastroenterology
, vol.126
, pp. 394-401
-
-
Carethers, J.M.1
Smith, E.J.2
Behling, C.A.3
-
48
-
-
33947505886
-
Clinical uses of microsatellite instability testing in colorectal cancer: an ongoing challenge
-
Boland CR. Clinical uses of microsatellite instability testing in colorectal cancer: an ongoing challenge. J Clin Oncol 2007; 25: 754-6.
-
(2007)
J Clin Oncol
, vol.25
, pp. 754-756
-
-
Boland, C.R.1
-
49
-
-
67650284737
-
Clinical implications of microsatellite instability in sporadic colon cancers
-
Sinicrope FA, Sargent DJ. Clinical implications of microsatellite instability in sporadic colon cancers. Curr Opin Oncol 2009; 21: 369-73.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 369-373
-
-
Sinicrope, F.A.1
Sargent, D.J.2
-
50
-
-
0041524111
-
CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer
-
Van Rijnsoever M, Elsaleh H, Joseph D, McCaul K, Iacopetta B. CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer. Clin Cancer Res 2003; 9: 2898-903.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2898-2903
-
-
Van Rijnsoever, M.1
Elsaleh, H.2
Joseph, D.3
McCaul, K.4
Iacopetta, B.5
-
51
-
-
77954748953
-
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
-
Sargent D, Marsoni S, Monges G et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol 2010; 28: 3219-26.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3219-3226
-
-
Sargent, D.1
Marsoni, S.2
Monges, G.3
-
52
-
-
77954710907
-
Microsatellite instability and adjuvant fluorouracil chemotherapy: a mismatch?
-
Ng K, Schrag D. Microsatellite instability and adjuvant fluorouracil chemotherapy: a mismatch? J Clin Oncol 2010; 28: 3207-10.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3207-3210
-
-
Ng, K.1
Schrag, D.2
-
53
-
-
0029904811
-
The role of DNA mismatch repair in platinum drug resistance
-
Fink D, Nebel S, Aebi S et al. The role of DNA mismatch repair in platinum drug resistance. Cancer Res 1996; 56: 4881-6.
-
(1996)
Cancer Res
, vol.56
, pp. 4881-4886
-
-
Fink, D.1
Nebel, S.2
Aebi, S.3
-
54
-
-
15444350120
-
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
-
Fink D, Zheng H, Nebel S et al. In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res 1997; 57: 1841-5.
-
(1997)
Cancer Res
, vol.57
, pp. 1841-1845
-
-
Fink, D.1
Zheng, H.2
Nebel, S.3
-
55
-
-
54049146248
-
Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group
-
Müller CI, Schulmann K, Reinacher-Schick A et al. Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group. Int J Colorectal Dis 2008; 23: 1033-9.
-
(2008)
Int J Colorectal Dis
, vol.23
, pp. 1033-1039
-
-
Müller, C.I.1
Schulmann, K.2
Reinacher-Schick, A.3
-
56
-
-
0035418619
-
The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
-
Jacob S, Aguado M, Fallik D, Praz F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001; 61: 6555-62.
-
(2001)
Cancer Res
, vol.61
, pp. 6555-6562
-
-
Jacob, S.1
Aguado, M.2
Fallik, D.3
Praz, F.4
-
57
-
-
0141731323
-
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
-
Fallik D, Borrini F, Boige V et al. Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res 2003; 63: 5738-44.
-
(2003)
Cancer Res
, vol.63
, pp. 5738-5744
-
-
Fallik, D.1
Borrini, F.2
Boige, V.3
-
58
-
-
55949099916
-
Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines
-
Vilar E, Scaltriti M, Balmaña J et al. Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. Br J Cancer 2008; 99: 1607-12.
-
(2008)
Br J Cancer
, vol.99
, pp. 1607-1612
-
-
Vilar, E.1
Scaltriti, M.2
Balmaña, J.3
-
59
-
-
0033973828
-
Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status
-
Bras-Gonçalves RA, Rosty C, Laurent-Puig P, Soulié P, Dutrillaux B, Poupon MF. Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status. Br J Cancer 2000; 82: 913-23.
-
(2000)
Br J Cancer
, vol.82
, pp. 913-923
-
-
Bras-Gonçalves, R.A.1
Rosty, C.2
Laurent-Puig, P.3
Soulié, P.4
Dutrillaux, B.5
Poupon, M.F.6
-
60
-
-
64649096900
-
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and Leukemia Group B Protocol 89803
-
Bertagnolli MM, Niedzwiecki D, Compton CC et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and Leukemia Group B Protocol 89803. J Clin Oncol 2009; 27: 1814-21.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1814-1821
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Compton, C.C.3
-
61
-
-
65249150218
-
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
-
Vilar E, Mukherjee B, Kuick R et al. Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. Clin Cancer Res 2009; 15: 2829-39.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2829-2839
-
-
Vilar, E.1
Mukherjee, B.2
Kuick, R.3
-
62
-
-
77949270273
-
Microsatellite instability in colorectal cancer - the stable evidence
-
Vilar E, Gruber SB. Microsatellite instability in colorectal cancer - the stable evidence. Nat Rev Clin Oncol 2010; 7: 153-62.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 153-162
-
-
Vilar, E.1
Gruber, S.B.2
-
63
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005; 5: 689-98.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 689-698
-
-
Kaelin Jr, W.G.1
-
64
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
65
-
-
77949261297
-
Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer
-
(abstract).
-
Vilar E, Chow A, Raskin L et al. Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer. J Clin Oncol 2009; 27: 11028 (abstract).
-
(2009)
J Clin Oncol
, vol.27
, pp. 11028
-
-
Vilar, E.1
Chow, A.2
Raskin, L.3
-
66
-
-
77953658106
-
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
-
Martin SA, McCarthy A, Barber LJ et al. Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol Med 2009; 1: 323-37.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 323-337
-
-
Martin, S.A.1
McCarthy, A.2
Barber, L.J.3
-
67
-
-
67349248619
-
Molecular classification of solid tumours: towards pathway-driven therapeutics
-
Swanton C, Caldas C. Molecular classification of solid tumours: towards pathway-driven therapeutics. Br J Cancer 2009; 100: 1517-22.
-
(2009)
Br J Cancer
, vol.100
, pp. 1517-1522
-
-
Swanton, C.1
Caldas, C.2
-
68
-
-
0032555020
-
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
-
Aaltonen LA, Salovaara R, Kristo P et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998; 338: 1481-7.
-
(1998)
N Engl J Med
, vol.338
, pp. 1481-1487
-
-
Aaltonen, L.A.1
Salovaara, R.2
Kristo, P.3
-
69
-
-
0034129240
-
Population-based molecular detection of hereditary nonpolyposis colorectal cancer
-
Salovaara R, Loukola A, Kristo P et al. Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000; 18: 2193-200.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2193-2200
-
-
Salovaara, R.1
Loukola, A.2
Kristo, P.3
-
70
-
-
0034799747
-
The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer
-
Samowitz WS, Curtin K, Lin HH et al. The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. Gastroenterology 2001; 121: 830-8.
-
(2001)
Gastroenterology
, vol.121
, pp. 830-838
-
-
Samowitz, W.S.1
Curtin, K.2
Lin, H.H.3
-
71
-
-
0035478506
-
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study
-
Percesepe A, Borghi F, Menigatti M et al. Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study. J Clin Oncol 2001; 19: 3944-50.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3944-3950
-
-
Percesepe, A.1
Borghi, F.2
Menigatti, M.3
-
72
-
-
0034827025
-
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas
-
Cunningham JM, Kim CY, Christensen ER et al. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet 2001; 69: 780-90.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 780-790
-
-
Cunningham, J.M.1
Kim, C.Y.2
Christensen, E.R.3
-
73
-
-
20244386395
-
Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer
-
Pi-nol V, Castells A, Andreu M et al. Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA 2005; 293: 1986-94.
-
(2005)
JAMA
, vol.293
, pp. 1986-1994
-
-
Pi-nol, V.1
Castells, A.2
Andreu, M.3
-
74
-
-
17944362664
-
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
-
Hampel H, Frankel WL, Martin E et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 2005; 352: 1851-60.
-
(2005)
N Engl J Med
, vol.352
, pp. 1851-1860
-
-
Hampel, H.1
Frankel, W.L.2
Martin, E.3
-
75
-
-
58749101712
-
Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
-
Schofield L, Watson N, Grieu F et al. Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test. Int J Cancer 2009; 124: 1097-102.
-
(2009)
Int J Cancer
, vol.124
, pp. 1097-1102
-
-
Schofield, L.1
Watson, N.2
Grieu, F.3
-
76
-
-
42049113883
-
Value of database linkage: are patients at risk of familial colorectal cancer being referred for genetic counselling and testing?
-
Wong C, Gibbs P, Johns J et al. Value of database linkage: are patients at risk of familial colorectal cancer being referred for genetic counselling and testing? Intern Med J 2008; 38: 328-33.
-
(2008)
Intern Med J
, vol.38
, pp. 328-333
-
-
Wong, C.1
Gibbs, P.2
Johns, J.3
-
77
-
-
0348108292
-
Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: problems in diagnosis, surveillance, and management
-
Lynch HT, Riley BD, Weissman SM et al. Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: problems in diagnosis, surveillance, and management. Cancer 2004; 100: 53-64.
-
(2004)
Cancer
, vol.100
, pp. 53-64
-
-
Lynch, H.T.1
Riley, B.D.2
Weissman, S.M.3
-
78
-
-
23244455418
-
It is time to get serious about diagnosing Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) in the general population
-
Terdiman JP. It is time to get serious about diagnosing Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) in the general population. Gastroenterology 2005; 129: 741-4.
-
(2005)
Gastroenterology
, vol.129
, pp. 741-744
-
-
Terdiman, J.P.1
-
79
-
-
1842477266
-
Current clinical selection strategies for identification of hereditary non-polyposis colorectal cancer families are inadequate: a meta-analysis
-
Kievit W, De Bruin JH, Adang EM et al. Current clinical selection strategies for identification of hereditary non-polyposis colorectal cancer families are inadequate: a meta-analysis. Clin Genet 2004; 65: 308-16.
-
(2004)
Clin Genet
, vol.65
, pp. 308-316
-
-
Kievit, W.1
De Bruin, J.H.2
Adang, E.M.3
-
80
-
-
34548765471
-
Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancer
-
Watson N, Grieu F, Morris M et al. Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancer. J Mol Diagn 2007; 9: 472-8.
-
(2007)
J Mol Diagn
, vol.9
, pp. 472-478
-
-
Watson, N.1
Grieu, F.2
Morris, M.3
-
81
-
-
29744435357
-
Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining
-
Mangold E, Pagenstecher C, Friedl W et al. Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining. J Pathol 2005; 207: 385-95.
-
(2005)
J Pathol
, vol.207
, pp. 385-395
-
-
Mangold, E.1
Pagenstecher, C.2
Friedl, W.3
-
82
-
-
11144279281
-
Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms
-
Shia J, Klimstra DS, Nafa K et al. Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. Am J Surg Pathol 2005; 29: 96-104.
-
(2005)
Am J Surg Pathol
, vol.29
, pp. 96-104
-
-
Shia, J.1
Klimstra, D.S.2
Nafa, K.3
-
83
-
-
1642535480
-
BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
-
Deng G, Bell I, Crawley S et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res 2004; 10: 191-5.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 191-195
-
-
Deng, G.1
Bell, I.2
Crawley, S.3
-
84
-
-
4444311092
-
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing
-
Domingo E, Laiho P, Ollikainen M et al. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet 2004; 41: 664-8.
-
(2004)
J Med Genet
, vol.41
, pp. 664-668
-
-
Domingo, E.1
Laiho, P.2
Ollikainen, M.3
-
86
-
-
77951218531
-
-
Letter in response to "Identifying Lynch syndrome" by de la Chapelle
-
Jenkins MA, Dowty JG, Hopper JL, Tucker K, Southey MC. Letter in response to "Identifying Lynch syndrome" by de la Chapelle et al. Int J Cancer 2010; 126: 2757-8.
-
(2010)
Int J Cancer
, vol.126
, pp. 2757-2758
-
-
Jenkins, M.A.1
Dowty, J.G.2
Hopper, J.L.3
Tucker, K.4
Southey, M.C.5
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