Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response

Circulation

Volumn 134, Issue 14, 2016, Pages 1039-1051

  Clément, Marc ^a   Basatemur, Gemma ^a   Masters, Leanne ^a   Baker, Lauren ^a   Bruneval, Patrick ^b   Iwawaki, Takao ^c   Kneilling, Manfred ^d   Yamasaki, Sho ^e   Goodall, Jane ^a   Mallat, Ziad ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSERM   (France)

^c GUNMA UNIVERSITY   (Japan)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e KYUSHU UNIVERSITY   (Japan)

Author keywords

atherosclerosis; cell proliferation; inflammation; necrosis

Indexed keywords

C TYPE LECTIN RECEPTOR 4E; CHOLESTEROL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LECTIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN KINASE SYK; UNCLASSIFIED DRUG; AUTACOID; CLEC4D PROTEIN, HUMAN; CLECSF8 PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LECTIN; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN;

ANIMAL CELL; ARTERY LESION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BONE MARROW; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID STORAGE; MACROPHAGE; MACROPHAGE FUNCTION; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ATHEROSCLEROSIS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LECTINS, C-TYPE; LIPOPROTEINS, LDL; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NECROSIS; PHENOTYPE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; UNFOLDED PROTEIN RESPONSE;

EID: 84986207731     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.022668     Document Type: Article

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