MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis

PLoS Pathogens

Volumn 5, Issue 6, 2009, Pages

  Bowdish, Dawn M E ^a,e   Sakamoto, Kaori ^b   Kim, Mi Jeong ^c   Kroos, Mariliis ^a   Mukhopadhyay, Subhankar ^a   Leifer, Cynthia A ^c   Tryggvason, Karl ^d   Gordon, Siamon ^a   Russell, David G ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF GEORGIA   (United States)

^c Animal Health Diagnostic Center   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CORD FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MARCO RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MD 2; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; IMMUNOGLOBULIN RECEPTOR; MARCO PROTEIN, HUMAN; MARCO PROTEIN, MOUSE; MICROSPHERE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOSOME; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHO CELL; CRICETULUS; CYTOPLASM; FLUORESCENCE MICROSCOPY; GENETICS; HAMSTER; IMMUNOLOGY; MACROPHAGE; METABOLISM;

MUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTIGENS, CD14; CHO CELLS; CORD FACTORS; CRICETINAE; CRICETULUS; CYTOKINES; CYTOPLASM; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MICROSPHERES; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; RECEPTORS, IMMUNOLOGIC; SCAVENGER RECEPTORS, CLASS A; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 67650904929     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000474     Document Type: Article

References (39)

1. Kaufmann SH (2000) Is the development of a new tuberculosis vaccine possible? Nat Med 6: 955-960.
2. Bekierkunst A (1968) Acute granulomatous response produced in mice by trehalose-6,6-dimycolate. J Bacteriol 96: 958-961.
3. Gilleron M, Ronet C, Mempel M, Monsarrat B, Gachelin G, et al. (2001) Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette Guerin and ability to induce granuloma and recruit natural killer T cells. J Biol Chem 276: 34896-34904. (Pubitemid 37384492)
4. Apostolou I, Takahama Y, Belmant C, Kawano T, Huerre M, et al. (1999) Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc Natl Acad Sci U S A 96: 5141-5146.
5. Yamagami H, Matsumoto T, Fujiwara N, Arakawa T, Kaneda K, et al. (2001) Trehalose 6,6′-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in mice. Infect Immun 69: 810-815. (Pubitemid 32109543)
6. Noll H, Bloch H, Asselineau J, Lederer E (1956) The chemical structure of the cord factor of Mycobacterium tuberculosis. Biochim Biophys Acta 20: 299-309.
7. Bekierkunst A, Levij IS, Yarkoni E, Vilkas E, Adam A, et al. (1969) Granuloma formation induced in mice by chemically defined mycobacterial fractions. J Bacteriol 100: 95-102.
8. Yarkoni E, Rapp HJ (1977) Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6′-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets. Infect Immun 18: 552-554. (Pubitemid 8231937)
9. Geisel RE, Sakamoto K, Russell DG, Rhoades ER (2005) In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174: 5007-5015.
10. Retzinger GS, Meredith SC, Hunter RL, Takayama K, Kezdy FJ (1982) Identification of the physiologically active state of the mycobacterial glycolipid trehalose 6,6′-dimycolate and the role of fibrinogen in the biologic activities of trehalose 6,6′-dimycolate monolayers. J Immunol 129: 735-744.
11. Underhill DM, Gantner B (2004) Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect 6: 1368-1373.
12. Peiser L, Makepeace K, Pluddemann A, Savino S, Wright JC, et al. (2006) Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay. Infect Immun 74: 5191-5199. (Pubitemid 44300438)
13. Dahl M, Bauer AK, Arredouani M, Soininen R, Tryggvason K, et al. (2007) Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest 117: 757-764. (Pubitemid 46348534)
14. Haworth R, Platt N, Keshav S, Hughes D, Darley E, et al. (1997) The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 186: 1431-1439. (Pubitemid 27479802)
15. Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, et al. (1997) A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386: 292. (Pubitemid 27142516)
16. Jozefowski S, Arredouani M, Sulahian T, Kobzik L (2005) Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol 175: 8032-8041. (Pubitemid 41798365)
17. Arredouani M, Yang Z, Ning Y, Qin G, Soininen R, et al. (2004) The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med 200: 267-272. (Pubitemid 38982186)
18. Pedroza-Gonzalez A, Garcia-Romo GS, Aguilar-Leon D, Calderon-Amador J, Hurtado-Ortiz R, et al. (2004) In situ analysis of lung antigen-presenting cells during murine pulmonary infection with virulent Mycobacterium tuberculosis. Int J Exp Pathol 85: 135-145.
19. Ito S, Naito M, Kobayashi Y, Takatsuka H, Jiang S, et al. (1999) Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. Arch Histol Cytol 62: 83-95. (Pubitemid 29197741)
20. Kanno S, Furuyama A, Hirano S (2007) A murine scavenger receptor MARCO recognizes polystyrene nanoparticles. Toxicol Sci 97: 398-406. (Pubitemid 47073855)
21. Perera PY, Vogel SN, Detore GR, Haziot A, Goyert SM (1997) CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol. J Immunol 158: 4422-4429. (Pubitemid 127483946)
22. Schlesinger LS (1993) Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol 150: 2920-2930.
23. Maeda N, Nigou J, Herrmann JL, Jackson M, Amara A, et al. (2003) The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J Biol Chem 278: 5513-5516. (Pubitemid 36800791)
24. Schlesinger LS, Bellinger-Kawahara CG, Payne NR, Horwitz MA (1990) Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3. J Immunol 144: 2771-2780. (Pubitemid 20136689)
25. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285: 732-736. (Pubitemid 129505076)
26. Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, et al. (2007) Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J Immunol 179: 3463-3471.
27. Nakata T, Yasuda M, Fujita M, Kataoka H, Kiura K, et al. (2006) CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex. Cell Microbiol 8: 1899-1909. (Pubitemid 44680872)
28. Manukyan M, Triantafilou K, Triantafilou M, Mackie A, Nilsen N, et al. (2005) Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1. Eur J Immunol 35: 911-921. (Pubitemid 40425547)
29. Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130: 1071-1082.
30. Seimon TA, Obstfeld A, Moore KJ, Golenbock DT, Tabas I (2006) Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103: 19794-19799. (Pubitemid 46037510)
31. Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, et al. (2005) Cholesterolinduced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol 171: 61-73. (Pubitemid 41434602)
32. Ozeki Y, Tsutsui H, Kawada N, Suzuki H, Kataoka M, et al. (2006) Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. Microb Pathog 40: 171-176.
33. de Paula L, Silva CL, Carlos D, Matias-Peres C, Sorgi CA, et al. (2007) Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs. Genet Vaccines Ther 5: 2. (Pubitemid 46322123)
34. Lima VM, Bonato VL, Lima KM, Dos Santos SA, Dos Santos RR, et al. (2001) Role of trehalose dimycolate in recruitment of cells and modulation of production of cytokines and NO in tuberculosis. Infect Immun 69: 5305-5312.
35. Lima KM, Santos SA, Lima VM, Coelho-Castelo AA, Rodrigues JM Jr, et al. (2003) Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis. Gene Ther 10: 678-685.
36. Axelrod S, Oschkinat H, Enders J, Schlegel B, Brinkmann V, et al. (2008) Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide. Cell Microbiol. (Pubitemid 351837272)
37. Chen Y, Pikkarainen T, Elomaa O, Soininen R, Kodama T, et al. (2005) Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol 175: 8173-8180. (Pubitemid 41798381)
38. Gough PJ, Greaves DR, Gordon S (1998) A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake. J Lipid Res 39: 531-543.
39. Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, et al. (1998) Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. J Biol Chem 273: 4530-4538. (Pubitemid 28103194)