Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 36, 2016, Pages 10186-10191

  Chung, Won Suk ^a,d   Verghese, Philip B ^b,e   Chakraborty, Chandrani ^a   Joung, Julia ^a,f,g,h   Hyman, Bradley T ^c   Ulrich, Jason D ^b   Holtzman, David M ^b   Barres, Ben A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^e Center for Emerging Technologies   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h Massachusetts Institute of Technology   (United States)

Author keywords

Apoe allele; Astrocytes|synapse elimination|phagocytosis |c1q

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; COMPLEMENT COMPONENT C1Q; OPSONIN; PROTEIN S;

ADULT; ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ASTROCYTE; CELL AGING; CONFERENCE PAPER; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; MOUSE; NERVE ENDING; NONHUMAN; PHAGOCYTOSIS; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETINA GANGLION CELL; SYNAPSE; SYNAPSE PRUNING; SYNAPTOSOME; TURNOVER TIME; ALZHEIMER DISEASE; ANIMAL; GENE EXPRESSION REGULATION; GENE KNOCK-IN; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; IMMUNOLOGY; NERVE CELL PLASTICITY; PATHOLOGY; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALLELES; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ASTROCYTES; COMPLEMENT C1Q; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; PHAGOCYTOSIS; SYNAPSES;

EID: 84986000940     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1609896113     Document Type: Article

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