Optimization of amino acid thioesters as inhibitors of metallo-β-lactamase L1

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 19, 2016, Pages 4698-4701

  Liu, Xiao Long ^a   Yang, Ke Wu ^a   Zhang, Yue Juan ^a   Ge, Ying ^a   Xiang, Yang ^a   Chang, Ya Nan ^a   Oelschlaeger, Peter ^b  

^a NORTHWEST UNIVERSITY   (China)

^b WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Antibiotic resistance; Inhibitor; L1; Mercaptoacetic acid thioester; Metallo lactamase

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; FUNCTIONAL GROUP; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE L1 INHIBITOR; METHIONINE; THIOESTER; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE L1; ESTER;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; IC50; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS;

AMINO ACIDS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; ESTERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84985952480     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.048     Document Type: Article

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