Ligand binding at the 4-4 agonist-binding site of the 42 nAChR triggers receptor activation through a pre-activated conformational state

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Indurthi, Dinesh C ^a   Lewis, Trevor M ^b   Ahring, Philip K ^a   Balle, Thomas ^a   Chebib, Mary ^a   Absalom, Nathan L ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4ALPHA4; NICOTINIC RECEPTOR ALPHA4BETA2; NS 9283; SAZETIDINE A; TC 2559; UNCLASSIFIED DRUG; 3-(3-(PYRIDINE-3-YL)-1,2,4-OXADIAZOL-5-YL)BENZONITRILE; ACETYLCHOLINE; AZETIDINE DERIVATIVE; ISOPROTEIN; OXADIAZOLE DERIVATIVE; PROTEIN BINDING; PYRIDINE DERIVATIVE; SAZETIDINE-A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHANNEL GATING; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; LIGAND BINDING; NONHUMAN; XENOPUS LAEVIS; ANIMAL; CELL MEMBRANE; CONFORMATION; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; OOCYTE;

ACETYLCHOLINE; ANIMALS; AZETIDINES; BINDING SITES; CELL MEMBRANE; HUMANS; ION CHANNEL GATING; LIGANDS; MOLECULAR CONFORMATION; OOCYTES; OXADIAZOLES; PROTEIN BINDING; PROTEIN ISOFORMS; PYRIDINES; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84984817991     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0161154     Document Type: Article

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