Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 24911-24921

  Olsen, Jeppe A ^a,b,c   Ahring, Philip K ^c,d   Kastrup, Jette S ^b   Gajhede, Michael ^b   Balle, Thomas ^c  

^a NEUROSEARCH A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Saniona AB   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CHEMICAL ACTIVATION; MODULATION; QUANTUM THEORY;

ACETYLCHOLINE-BINDING PROTEINS; CONCENTRATION RANGES; COORDINATED ACTIONS; FAVORABLE INTERACTIONS; GAMMA-AMINOBUTYRIC ACIDS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); QUANTUM-MECHANICAL CALCULATION;

BINDING SITES;

3 [3 (PYRIDINE 3 YL) 1,2,4 OXADIAZOL 5 YL]BENZONITRILE; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE BINDING PROTEIN; BINDING PROTEIN; HISTIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; UNCLASSIFIED DRUG; 3-(3-(PYRIDINE-3-YL)-1,2,4-OXADIAZOL-5-YL)BENZONITRILE; ACETYLCHOLINE; CARRIER PROTEIN; NICOTINIC RECEPTOR; OXADIAZOLE DERIVATIVE; PROTEIN BINDING; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; GENE MUTATION; HUMAN; HUMAN CELL; LYMNAEA STAGNALIS; MOLECULAR MODEL; NONHUMAN; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; MEMBRANE POTENTIAL; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HISTIDINE; HUMANS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NICOTINIC AGONISTS; OOCYTES; OXADIAZOLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RECEPTORS, NICOTINIC; SEQUENCE HOMOLOGY, AMINO ACID; STATIC ELECTRICITY; XENOPUS LAEVIS;

EID: 84906984055     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.568097     Document Type: Article

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