Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4α2 nicotinic acetylcholine receptor: Antagonist binding site and mode of receptor inhibition revealed

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26521-26532

  Absalom, Nathan L ^a   Quek, Gracia ^a   Lewis, Trevor M ^b   Qudah, Taima ^a   Von Arenstorff, Ida ^a   Ambrus, Joseph I ^c   Harpsøe, Kasper ^d   Karim, Nasiara ^a   Balle, Thomas ^a   McLeod, Malcolm D ^c   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINIC ACETYLCHOLINE RECEPTORS;

AMINO ACIDS;

ACETYLCHOLINE; METHYLLYCACONITINE; NICOTINIC RECEPTOR ALPHA4BETA2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; FEMALE; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR PROBE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BLOCKING; STOICHIOMETRY; STRUCTURAL HOMOLOGY; VOLTAGE CLAMP; XENOPUS LAEVIS;

EID: 84884193367     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.475053     Document Type: Article

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