-
1
-
-
0033210507
-
Graphic representation of the results of kinetic analyses
-
Andersen, O.S. 1999. Graphic representation of the results of kinetic analyses. J. Gen. Physiol. 114:589-590. http://dx.doi.org/10.1085/ jgp.114.589
-
(1999)
J. Gen. Physiol
, vol.114
, pp. 589-590
-
-
Andersen, O.S.1
-
2
-
-
36549084005
-
How to turn the reaction coordinate into time
-
Auerbach, A. 2007. How to turn the reaction coordinate into time. J. Gen. Physiol. 130:543-546. http://dx.doi.org/10.1085/jgp .200709898
-
(2007)
J. Gen. Physiol.
, vol.130
, pp. 543-546
-
-
Auerbach, A.1
-
3
-
-
84855175213
-
Thinking in cycles: MWC is a good model for acetylcholine receptor-channels
-
Auerbach, A. 2012. Thinking in cycles: MWC is a good model for acetylcholine receptor-channels. J. Physiol. 590:93-98.
-
(2012)
J. Physiol.
, vol.590
, pp. 93-98
-
-
Auerbach, A.1
-
4
-
-
10044248233
-
Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens
-
Burzomato, V., M. Beato, P.J. Groot-Kormelink, D. Colquhoun, and L.G. Sivilotti. 2004. Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. J. Neurosci. 24:10924-10940. http://dx.doi.org/10.1523/JNEUROSCI.3424-04.2004
-
(2004)
J. Neurosci.
, vol.24
, pp. 10924-10940
-
-
Burzomato, V.1
Beato, M.2
Groot-Kormelink, P.J.3
Colquhoun, D.4
Sivilotti, L.G.5
-
5
-
-
0027665006
-
Allosteric proteins: from regulatory enzymes to receptors-personal recollections
-
Changeux, J.P. 1993. Allosteric proteins: from regulatory enzymes to receptors-personal recollections. Bioessays. 15:625-634. http:// dx.doi.org/10.1002/bies.950150909
-
(1993)
Bioessays
, vol.15
, pp. 625-634
-
-
Changeux, J.P.1
-
6
-
-
0032199006
-
Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
-
Colquhoun, D. 1998. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol. 125:923-947.http://dx.doi.org/10.1038/sj.bjp.0702164
-
(1998)
Br. J. Pharmacol.
, vol.125
, pp. 923-947
-
-
Colquhoun, D.1
-
7
-
-
30444460582
-
The quantitative analysis of drug-receptor interactions: a short history
-
Colquhoun, D. 2006. The quantitative analysis of drug-receptor interactions: a short history. Trends Pharmacol. Sci. 27:149-157. http://dx.doi.org/10.1016/j.tips.2006.01.008
-
(2006)
Trends Pharmacol. Sci
, vol.27
, pp. 149-157
-
-
Colquhoun, D.1
-
8
-
-
0017743694
-
Relaxation and fluctuations of membrane currents that flow through drug-operated channels
-
Colquhoun, D., and A.G. Hawkes. 1977. Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proc. R. Soc. Lond. B Biol. Sci. 199:231-262. http:// dx.doi.org/10.1098/rspb.1977.0137
-
(1977)
Proc. R. Soc. Lond. B Biol. Sci.
, vol.199
, pp. 231-262
-
-
Colquhoun, D.1
Hawkes, A.G.2
-
9
-
-
0020490146
-
On the stochastic properties of bursts of single ion channel openings and of clusters of bursts
-
Colquhoun, D., and A.G. Hawkes. 1982. On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Philos. Trans. R. Soc. Lond. B Biol. Sci. 300:1-59. http:// dx.doi.org/10.1098/rstb.1982.0156
-
(1982)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.300
, pp. 1-59
-
-
Colquhoun, D.1
Hawkes, A.G.2
-
10
-
-
0000410893
-
A Q-matrix Cookbook. In Single Channel Recording. B. Sakmann and E. Neher, editors
-
Colquhoun, D., and A.G. Hawkes. 1995a. A Q-matrix Cookbook. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 589-633.
-
(1995)
Plenum Press, New York
, pp. 589-633
-
-
Colquhoun, D.1
Hawkes, A.G.2
-
11
-
-
0000410893
-
The principles of the stochastic interpretation of ion channel mechanisms
-
B. Sakmann and E. Neher, editors. Plenum Press, New York
-
Colquhoun, D., and A.G. Hawkes. 1995b. The principles of the stochastic interpretation of ion channel mechanisms. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 397-482.
-
(1995)
Single Channel Recording
, pp. 397-482
-
-
Colquhoun, D.1
Hawkes, A.G.2
-
12
-
-
0019856889
-
Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels
-
Colquhoun, D., and B. Sakmann. 1981. Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels. Nature. 294:464-466. http://dx.doi .org/10.1038/294464a0
-
(1981)
Nature
, vol.294
, pp. 464-466
-
-
Colquhoun, D.1
Sakmann, B.2
-
13
-
-
0022272338
-
Fast events in singlechannel currents activated by acetylcholine and its analogues at the frog muscle end-plate
-
Colquhoun, D., and B. Sakmann. 1985. Fast events in singlechannel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J. Physiol. 369:501-557.
-
(1985)
J. Physiol.
, vol.369
, pp. 501-557
-
-
Colquhoun, D.1
Sakmann, B.2
-
14
-
-
0001774017
-
Fitting and statistical analysis of single-channel records
-
B. Sakmann and E. Neher, editors. Plenum Press, New York
-
Colquhoun, D., and F.J. Sigworth. 1995. Fitting and statistical analysis of single-channel records. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 483-587.
-
(1995)
Single Channel Recording
, pp. 483-587
-
-
Colquhoun, D.1
Sigworth, F.J.2
-
15
-
-
84870985510
-
The conductance of ion channels opened by different cholinomimetic agonists in cultured rat muscle
-
Colquhoun, D., P. Gardner, and D.C. Ogden. 1983. The conductance of ion channels opened by different cholinomimetic agonists in cultured rat muscle. J. Physiol. 345:139P.
-
(1983)
J. Physiol.
, vol.345
, pp. 139
-
-
Colquhoun, D.1
Gardner, P.2
Ogden, D.C.3
-
16
-
-
3042869077
-
Properties of single ion channel currents elicited by a pulse of agonist concentration or voltage
-
Colquhoun, D., A.G. Hawkes, A. Merlushkin, and B. Edmonds. 1997. Properties of single ion channel currents elicited by a pulse of agonist concentration or voltage. Philos. Trans. R. Soc. Lond. A. 355:1743-1786. http://dx.doi.org/10.1098/rsta.1997.0090
-
(1997)
Philos. Trans. R. Soc. Lond. A.
, vol.355
, pp. 1743-1786
-
-
Colquhoun, D.1
Hawkes, A.G.2
Merlushkin, A.3
Edmonds, B.4
-
17
-
-
0037444604
-
The quality of maximum likelihood estimates of ion channel rate constants
-
Colquhoun, D., C.J. Hatton, and A.G. Hawkes. 2003. The quality of maximum likelihood estimates of ion channel rate constants. J. Physiol. 547:699-728. http://dx.doi.org/10.1113/jphysiol .2002.034165
-
(2003)
J. Physiol.
, vol.547
, pp. 699-728
-
-
Colquhoun, D.1
Hatton, C.J.2
Hawkes, A.G.3
-
18
-
-
2942694522
-
How to impose microscopic reversibility in complex reaction mechanisms
-
Colquhoun, D., K.A. Dowsland, M. Beato, and A.J. Plested. 2004. How to impose microscopic reversibility in complex reaction mechanisms. Biophys. J. 86:3510-3518. http://dx.doi.org/10 .1529/biophysj.103.038679
-
(2004)
Biophys. J.
, vol.86
, pp. 3510-3518
-
-
Colquhoun, D.1
Dowsland, K.A.2
Beato, M.3
Plested, A.J.4
-
19
-
-
84861963413
-
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
-
Corringer, P.J., F. Poitevin, M.S. Prevost, L. Sauguet, M. Delarue, and J.-P. Changeux. 2012. Structure and pharmacology of pentameric receptor channels: from bacteria to brain. Structure. 20: 941-956. http://dx.doi.org/10.1016/j.str.2012.05.003
-
(2012)
Structure
, vol.20
, pp. 941-956
-
-
Corringer, P.J.1
Poitevin, F.2
Prevost, M.S.3
Sauguet, L.4
Delarue, M.5
Changeux, J.-P.6
-
20
-
-
70449143838
-
Interaction at end-plate receptors between different choline derivatives
-
Del Castillo, J., and B. Katz. 1957. Interaction at end-plate receptors between different choline derivatives. Proc. R. Soc. Lond. B Biol. Sci. 146:369-381. http://dx.doi.org/10.1098/rspb.1957.0018
-
(1957)
Proc. R. Soc. Lond. B Biol. Sci.
, vol.146
, pp. 369-381
-
-
Del Castillo, J.1
Katz, B.2
-
21
-
-
77952682080
-
Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors
-
Edelstein, S.J., and J.P. Changeux. 2010. Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors. Biophys. J. 98:2045-2052. http://dx.doi.org/ 10.1016/j.bpj.2010.01.050
-
(2010)
Biophys. J.
, vol.98
, pp. 2045-2052
-
-
Edelstein, S.J.1
Changeux, J.P.2
-
22
-
-
0021530285
-
Some unexpected consequences of a simple physical mechanism for voltage-dependent gating in biological membranes
-
Finkelstein, A., and C.S. Peskin. 1984. Some unexpected consequences of a simple physical mechanism for voltage-dependent gating in biological membranes. Biophys. J. 46:549-558. http:// dx.doi.org/10.1016/S0006-3495(84)84053-9
-
(1984)
Biophys. J.
, vol.46
, pp. 549-558
-
-
Finkelstein, A.1
Peskin, C.S.2
-
23
-
-
0025889070
-
Kinetic constants of the acetylcholine (ACh) receptor reaction deduced from the rise in open probability after steps in ACh concentration
-
Franke, C., H. Hatt, H. Parnas, and J. Dudel. 1991. Kinetic constants of the acetylcholine (ACh) receptor reaction deduced from the rise in open probability after steps in ACh concentration. Biophys. J. 60:1008-1016. http://dx.doi.org/10.1016/S0006-3495(91)82138-5
-
(1991)
Biophys. J
, vol.60
, pp. 1008-1016
-
-
Franke, C.1
Hatt, H.2
Parnas, H.3
Dudel, J.4
-
24
-
-
0442279279
-
Structure and function of AMPA receptors
-
Gouaux, E. 2004. Structure and function of AMPA receptors. J. Physiol. 554:249-253. http://dx.doi.org/10.1113/jphysiol.2003 .054320
-
(2004)
J. Physiol.
, vol.554
, pp. 249-253
-
-
Gouaux, E.1
-
25
-
-
0346365092
-
Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels
-
Grosman, C. 2003. Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels. Biochemistry. 42:14977-14987. http://dx.doi.org/10.1021/bi0354334
-
(2003)
Biochemistry
, vol.42
, pp. 14977-14987
-
-
Grosman, C.1
-
26
-
-
0034100847
-
Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants
-
Grosman, C., and A. Auerbach. 2000. Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants. J. Gen. Physiol. 115:621-635. http://dx.doi .org/10.1085/jgp.115.5.621
-
(2000)
J. Gen. Physiol.
, vol.115
, pp. 621-635
-
-
Grosman, C.1
Auerbach, A.2
-
27
-
-
0035923695
-
The dissociation of acetylcholine from open nicotinic receptor channels
-
Grosman, C., and A. Auerbach. 2001. The dissociation of acetylcholine from open nicotinic receptor channels. Proc. Natl. Acad. Sci. USA. 98:14102-14107. http://dx.doi.org/10.1073/pnas.251402498
-
(2001)
Proc. Natl. Acad. Sci. USA.
, vol.98
, pp. 14102-14107
-
-
Grosman, C.1
Auerbach, A.2
-
28
-
-
0034677524
-
Mapping the conformational wave of acetylcholine receptor channel gating
-
Grosman, C., M. Zhou, and A. Auerbach. 2000. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 403:773-776. http://dx.doi.org/10.1038/35001586
-
(2000)
Nature
, vol.403
, pp. 773-776
-
-
Grosman, C.1
Zhou, M.2
Auerbach, A.3
-
29
-
-
0037444682
-
Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits
-
Hatton, C.J., C. Shelley, M. Brydson, D. Beeson, and D. Colquhoun. 2003. Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits. J. Physiol. 547:729-760. http:// dx.doi.org/10.1113/jphysiol.2002.034173
-
(2003)
J. Physiol.
, vol.547
, pp. 729-760
-
-
Hatton, C.J.1
Shelley, C.2
Brydson, M.3
Beeson, D.4
Colquhoun, D.5
-
30
-
-
84864009008
-
An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors
-
Jadey, S., and A. Auerbach. 2012. An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors. J. Gen. Physiol. 140:17-28. http://dx.doi.org/10.1085/jgp.201210801
-
(2012)
J. Gen. Physiol.
, vol.140
, pp. 17-28
-
-
Jadey, S.1
Auerbach, A.2
-
31
-
-
79951621335
-
The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates ("flip")
-
Krashia, P., R. Lape, F. Lodesani, D. Colquhoun, and L.G. Sivilotti. 2011. The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates ("flip"). J. Gen. Physiol. 137:197-216. http://dx.doi.org/10.1085/jgp.201010521
-
(2011)
J. Gen. Physiol.
, vol.137
, pp. 197-216
-
-
Krashia, P.1
Lape, R.2
Lodesani, F.3
Colquhoun, D.4
Sivilotti, L.G.5
-
32
-
-
49649102025
-
On the nature of partial agonism in the nicotinic receptor superfamily
-
Lape, R., D. Colquhoun, and L.G. Sivilotti. 2008. On the nature of partial agonism in the nicotinic receptor superfamily. Nature. 454: 722-727.
-
(2008)
Nature
, vol.454
, pp. 722-727
-
-
Lape, R.1
Colquhoun, D.2
Sivilotti, L.G.3
-
33
-
-
70450217002
-
Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors
-
Lape, R., P. Krashia, D. Colquhoun, and L.G. Sivilotti. 2009. Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors. J. Physiol. 587:5045-5072. http://dx.doi.org/10.1113/jphysiol.2009.176305
-
(2009)
J. Physiol.
, vol.587
, pp. 5045-5072
-
-
Lape, R.1
Krashia, P.2
Colquhoun, D.3
Sivilotti, L.G.4
-
34
-
-
84856289577
-
The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors
-
Lape, R., A.J. Plested, M. Moroni, D. Colquhoun, and L.G. Sivilotti. 2012. The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors. J. Neurosci. 32:1336-1352. http://dx.doi.org/10.1523/JNEUROSCI.4346-11 .2012
-
(2012)
J. Neurosci.
, vol.32
, pp. 1336-1352
-
-
Lape, R.1
Plested, A.J.2
Moroni, M.3
Colquhoun, D.4
Sivilotti, L.G.5
-
35
-
-
0021843692
-
Ionic channels with conformational substates
-
Läuger, P. 1985. Ionic channels with conformational substates. Biophys. J. 47:581-590. http://dx.doi.org/10.1016/S0006-3495(85) 83954-0
-
(1985)
Biophys. J.
, vol.47
, pp. 581-590
-
-
Läuger, P.1
-
36
-
-
2542432136
-
Cys-loop receptors: new twists and turns
-
Lester, H.A., M.I. Dibas, D.S. Dahan, J.F. Leite, and D.A. Dougherty. 2004. Cys-loop receptors: new twists and turns. Trends Neurosci. 27:329-336. http://dx.doi.org/10.1016/j.tins.2004.04.002
-
(2004)
Trends Neurosci
, vol.27
, pp. 329-336
-
-
Lester, H.A.1
Dibas, M.I.2
Dahan, D.S.3
Leite, J.F.4
Dougherty, D.A.5
-
37
-
-
17844405808
-
Maximum likelihood estimation of ion channel kinetics from macroscopic currents
-
Milescu, L.S., G. Akk, and F. Sachs. 2005. Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys. J. 88:2494-2515. http://dx.doi.org/10.1529/biophysj.104 .053256
-
(2005)
Biophys. J.
, vol.88
, pp. 2494-2515
-
-
Milescu, L.S.1
Akk, G.2
Sachs, F.3
-
38
-
-
73049167504
-
Teleonomic mechanisms in cellular metabolism, growth, and differentiation
-
Monod, J., and F. Jacob. 1961. Teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harb. Symp. Quant. Biol. 26:389-401. http://dx.doi.org/10.1101/SQB.1961.026 .01.048
-
(1961)
Cold Spring Harb. Symp. Quant. Biol.
, vol.26
, pp. 389-401
-
-
Monod, J.1
Jacob, F.2
-
39
-
-
73649152457
-
Allosteric proteins and cellular control systems
-
Monod, J., J.P. Changeux, and F. Jacob. 1963. Allosteric proteins and cellular control systems. J. Mol. Biol. 6:306-329. http://dx.doi .org/10.1016/S0022-2836(63)80091-1
-
(1963)
J. Mol. Biol.
, vol.6
, pp. 306-329
-
-
Monod, J.1
Changeux, J.P.2
Jacob, F.3
-
40
-
-
78651189765
-
On the nature of allosteric transitions: A plausible model
-
Monod, J., J. Wyman, and J.P. Changeux. 1965. On the nature of allosteric transitions: A plausible model. J. Mol. Biol. 12:88-118.http://dx.doi.org/10.1016/S0022-2836(65)80285-6
-
(1965)
J. Mol. Biol.
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
41
-
-
67349279395
-
Detection and trapping of intermediate states priming nicotinic receptor channel opening
-
Mukhtasimova, N., W.Y. Lee, H.L. Wang, and S.M. Sine. 2009. Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature. 459:451-454. http://dx.doi.org/ 10.1038/nature07923
-
(2009)
Nature
, vol.459
, pp. 451-454
-
-
Mukhtasimova, N.1
Lee, W.Y.2
Wang, H.L.3
Sine, S.M.4
-
42
-
-
58549118250
-
Unliganded gating of acetylcholine receptor channels
-
Purohit, P., and A. Auerbach. 2009. Unliganded gating of acetylcholine receptor channels. Proc. Natl. Acad. Sci. USA. 106:115-120. http://dx.doi.org/10.1038/pnas.0809272106
-
(2009)
Proc. Natl. Acad. Sci. USA.
, vol.106
, pp. 115-120
-
-
Purohit, P.1
Auerbach, A.2
-
43
-
-
0025270712
-
Steady-state coupling of ionchannel conformations to a transmembrane ion gradient
-
Richard, E.A., and C. Miller. 1990. Steady-state coupling of ionchannel conformations to a transmembrane ion gradient. Science. 247:1208-1210. http://dx.doi.org/10.1126/science.2156338
-
(1990)
Science
, vol.247
, pp. 1208-1210
-
-
Richard, E.A.1
Miller, C.2
-
44
-
-
0035010215
-
Testing for detailed balance (microscopic reversibility in ion channel gating
-
Rothberg, B.S., and K.L. Magleby. 2001. Testing for detailed balance (microscopic reversibility in ion channel gating. Biophys. J. 80: 3025-3026. http://dx.doi.org/10.1016/S0006-3495(01)76268-6
-
(2001)
Biophys. J.
, vol.80
, pp. 3025-3026
-
-
Rothberg, B.S.1
Magleby, K.L.2
-
45
-
-
0033561222
-
A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics
-
Salamone, F.N., M. Zhou, and A. Auerbach. 1999. A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J. Physiol. 516:315-330. http://dx.doi.org/10.1111/ j.1469-7793.1999.0315v.x
-
(1999)
J. Physiol.
, vol.516
, pp. 315-330
-
-
Salamone, F.N.1
Zhou, M.2
Auerbach, A.3
-
46
-
-
0031017261
-
Coupling of permeation and gating in an NMDA-channel pore mutant
-
Schneggenburger, R., and P. Ascher. 1997. Coupling of permeation and gating in an NMDA-channel pore mutant. Neuron. 18:167-177. http://dx.doi.org/10.1016/S0896-6273(01)80055-6
-
(1997)
Neuron
, vol.18
, pp. 167-177
-
-
Schneggenburger, R.1
Ascher, P.2
-
47
-
-
0029797664
-
Single-channel currents from recombinant NMDA NR1a/ NR2D receptors expressed in Xenopus oocytes
-
Wyllie, D.J.A., P. Béhé, M. Nassar, R. Schoepfer, and D. Colquhoun. 1996. Single-channel currents from recombinant NMDA NR1a/ NR2D receptors expressed in Xenopus oocytes. Proc. Biol. Sci. 263:1079-1086. http://dx.doi.org/10.1098/rspb.1996.0159
-
(1996)
Proc. Biol. Sci.
, vol.263
, pp. 1079-1086
-
-
Wyllie, D.J.A.1
Béhé, P.2
Nassar, M.3
Schoepfer, R.4
Colquhoun, D.5
-
48
-
-
0000095559
-
The problem of the heme Interactions in hemoglobin and the basis of the Bohr effect
-
Wyman, J., and D.W. Allen. 1951. The problem of the heme Interactions in hemoglobin and the basis of the Bohr effect. J. Polym. Sci., Polym. Phys. Ed. VII:499-518.
-
(1951)
J. Polym. Sci., Polym. Phys. Ed. VII
, pp. 499-518
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-
Wyman, J.1
Allen, D.W.2
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