Non-equivalent ligand selectivity of agonist sites in (α4β2) 2α4 nicotinic acetylcholine receptors: A key determinant of agonist efficacy

Journal of Biological Chemistry

Volumn 289, Issue 31, 2014, Pages 21795-21806

  Mazzaferro, Simone ^a   Gasparri, Federica ^a   New, Karina ^a   Alcaino, Constanza ^b   Faundez, Manuel ^b   Vasquez, Patricio Iturriaga ^b   Vijayan, Ranjit ^c   Biggin, Philip C ^d   Bermudez, Isabel ^a  

^a OXFORD BROOKES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CHILE   (Chile)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; TOBACCO;

AGONIST BINDING SITE; COVALENT MODIFICATIONS; LIGAND-GATED ION CHANNELS; METHANESULFONATES; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR); STRUCTURAL MECHANISMS; WHETHER DIFFERENCES;

LIGANDS;

ACETYLCHOLINE; CYSTEINE; CYTISINE; MESYLIC ACID; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2 2ALPHA2; SAZETIDINE A; TC 2559; UNCLASSIFIED DRUG; VARENICLINE; LIGAND; NICOTINIC RECEPTOR ALPHA4BETA2;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FEMALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN MODIFICATION; XENOPUS LAEVIS; ANIMAL; GENETICS; METABOLISM;

ANIMALS; LIGANDS; NICOTINIC AGONISTS; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84905393947     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.555136     Document Type: Article

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