Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer

FASEB Journal

Volumn 26, Issue 3, 2012, Pages 1052-1063

  Bortolussi, Giulia ^a   Zentilin, Lorena ^a   Baj, Gabriele ^b   Giraudi, Pablo ^c   Bellarosa, Cristina ^c   Giacca, Mauro ^a   Tiribelli, Claudio ^b,c   Muro, Andrés F ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c Centro Studi Fegato   (Italy)

Author keywords

Kernicterus; Phototherapy; UGT1A1

Indexed keywords

BILIRUBIN; GLUCURONOSYLTRANSFERASE 1A1; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CEREBELLUM DISEASE; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; DISEASE SEVERITY; FEMALE; GENE THERAPY; GENE TRANSFER; HOMOZYGOSITY; HYPERBILIRUBINEMIA; JAUNDICE; LETHALITY; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PHOTOTHERAPY; POINT MUTATION; PRIORITY JOURNAL; STOP CODON;

ANIMALS; ANIMALS, NEWBORN; BILIRUBIN; BLOTTING, NORTHERN; BLOTTING, WESTERN; CEREBELLUM; CRIGLER-NAJJAR SYNDROME; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLUCURONOSYLTRANSFERASE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE;

MUS;

EID: 84857744956     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-195461     Document Type: Article

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