Inhaled sulfur dioxide causes pulmonary and systemic inflammation leading to fibrotic respiratory disease in a rat model of chemical-induced lung injury

Toxicology

Volumn 368-369, Issue , 2016, Pages 28-36

  Wigenstam, Elisabeth ^a   Elfsmark, Linda ^a   Bucht, Anders ^a,b   Jonasson, Sofia ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Chemical induced lung injury; Corticosteroids; Inflammation; Respiratory mechanics; Sulfur dioxide

Indexed keywords

COLLAGEN; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; METHACHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SULFUR DIOXIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; VASCULOTROPIN; ANTIINFLAMMATORY AGENT; METHACHOLINE CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATHING; BREATHING MECHANICS; BRONCHUS; BRONCHUS INJURY; BRONCHUS MUCOSA; CELL ACTIVATION; CHEMICALLY INDUCED DISORDER; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MEGADOSE; EOSINOPHIL; FEMALE; GRANULOCYTE; HELPER CELL; HISTOPATHOLOGY; IMMUNOREGULATION; LONG TERM CARE; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG INJURY; LUNG PARENCHYMA; LUNG RESISTANCE; MACROPHAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY TRACT ALLERGY; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; TH1 CELL; TH2 CELL; ANIMAL; BRONCHIAL HYPERREACTIVITY; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; RESPIRATORY HYPERSENSITIVITY;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHIAL HYPERREACTIVITY; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; FEMALE; INFLAMMATION; LUNG; LUNG INJURY; MACROPHAGES; METHACHOLINE CHLORIDE; NEUTROPHILS; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY HYPERSENSITIVITY; SULFUR DIOXIDE; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84984793117     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.08.018     Document Type: Article

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