Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles

Toxicology

Volumn 326, Issue , 2014, Pages 74-85

  Gustafsson, Åsa ^a,b   Jonasson, Sofia ^a   Sandström, Thomas ^b   Lorentzen, Johnny C ^c   Bucht, Anders ^a,b  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aerosol inhalation; Asthma; Immune response; Inflammation; Ovalbumin; Titanium dioxide

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; OVALBUMIN; T LYMPHOCYTE RECEPTOR; TITANIUM DIOXIDE NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; AEROSOL; AUTACOID; CYTOKINE; METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

AEROSOL; ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; EOSINOPHIL COUNT; FLOW CYTOMETRY; GENETIC VARIABILITY; HELPER CELL; IMMUNE RESPONSE; LIMULUS LYSATE TEST; LUNG RESISTANCE; LYMPHOCYTE COUNT; MACROPHAGE; MALE; NEUTROPHIL COUNT; NONHUMAN; RAT; RESPIRATORY FUNCTION; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; ANIMAL; BLOOD; BRONCHUS HYPERREACTIVITY; BROWN NORWAY RAT; CHEMICALLY INDUCED; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; EXPOSURE; GENETICS; GENOTYPE; IMMUNOLOGY; LOEFFLER PNEUMONIA; LUNG; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; PHENOTYPE; PNEUMONIA; RISK FACTOR; SPECIES DIFFERENCE; TH1 CELL; TOXICITY;

AEROSOLS; ANIMALS; BRONCHIAL HYPERREACTIVITY; CYTOKINES; DISEASE MODELS, ANIMAL; GENETIC VARIATION; GENOTYPE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; LUNG; MALE; METAL NANOPARTICLES; NEUTROPHILS; OVALBUMIN; PHENOTYPE; PNEUMONIA; PULMONARY EOSINOPHILIA; RATS, INBRED BN; RISK FACTORS; SPECIES SPECIFICITY; TH1 CELLS; TITANIUM;

EID: 84908448302     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.10.004     Document Type: Article

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