Corticosteroids found ineffective for phosgene-induced acute lung injury in rats

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 85-92

  Luo, Sa ^a,b   Pauluhn, Jürgen ^b   Trübel, Hubert ^b   Wang, Chen ^c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BAYER PHARMA AG   (Germany)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Acute lung injury; Biomarkers in exhaled air; Chlorine; Corticosteroid; Phosgene

Indexed keywords

BUDESONIDE; CARBON DIOXIDE; CHLORINE; DEXAMETHASONE; MOMETASONE FUROATE; NITRIC OXIDE; PHOSGENE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATH ANALYSIS; BREATHING RATE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFICACY; DRUG TREATMENT FAILURE; EXPIRED AIR; LUNG ALVEOLUS; LUNG EDEMA; LUNG FUNCTION; LUNG LAVAGE; LUNG WEIGHT; MALE; MORBIDITY; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SURVIVAL;

ACUTE LUNG INJURY; BIOMARKERS IN EXHALED AIR; CHLORINE; CORTICOSTEROID; PHOSGENE;

ACUTE LUNG INJURY; ADRENAL CORTEX HORMONES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; BUDESONIDE; CARBON DIOXIDE; CHEMICAL WARFARE AGENTS; DEXAMETHASONE; DIET; MALE; NITRIC OXIDE; ORGAN SIZE; PHOSGENE; PREGNADIENEDIOLS; RATS; RATS, WISTAR; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS;

EID: 84902356785     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.011     Document Type: Article

References (32)

1. AEGL Acute exposure guideline levels for selected airborne chemicals. National Research Council. Chlorine: Acute Exposure Guideline Levels 13-76 2014, vol. 4. National Academies Press, http://www.nap.edu (accessed 04.14).
2. Borak J., Diller W.F. Phosgene exposure: mechanisms of injury and treatment strategies. J. Occup. Environ. Med. 2000, 43:110-119.
3. Büch T., Schäfer E., Steinritz D., Dietrich A., Gudermann T. Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as "sweet spots" for targeted therapies. Rev. Physiol. Biochem. Pharmacol. 2013, 165:31-65.
4. Chen J., Mo Y., Schlueter C.F., Hoyle G.W. Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 2013, 272:408-413.
5. de Lange D.W., Meulenbelt J. Do corticosteroids have a role in preventing or reducing acute toxic lung injury caused by inhalation of chemical agents?. Clin. Toxicol. (Phila) 2011, 49:61-71.
6. Diller W.F., Zante R. Dose-response relations in the phosgene effect on humans and animals literature study. Zbl. Arbeitsmed. 1982, 32:360-368.
7. Diller W.F. Pathogenesis of phosgene poisoning. Toxicol. Ind. Health 1985, 1:7-15.
8. Dinis-Oliveira R.J., Duarte J.A., Remiao F., Sanchez-Navarro A., Bastos M.L., Carvalho F. Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats. Toxicology 2006, 227:73-85.
9. Directive 2010/63/EEC Guideline of the council dated September 22, 2010 on the reconciliation of legal and administrative regulations of the member countries for the protection of animals used for studies and other scientific purposes. J. European Community 2010, 33-76. Legal specifications L276.
10. Grainge C., Rice P. Management of phosgene-induced acute lung injury. Clin. Toxicol. 2010, 48:497-508.
11. Gunnarsson M., Walther S.M., Seidal T., Lennquist S. Effects of inhalation of corticosteroids immediately after experimental chlorine gas lung injury. J. Trauma 2000, 48:101-107.
12. 2 distinguish between ventilation and perfusion defects during exercise testing in patients with lung and heart diseases. Chest 2007, 132:977-983.
13. Jonasson S., Koch B., Bucht A. Inhalation of chlorine causes long-standing lung inflammation and airway hyperresponsiveness in a murine model of chemical-induced lung injury. Toxicology 2013, 303:34-42.
14. Jonasson S., Wigenstam E., Koch B., Bucht A. Early treatment of chlorine-induced airway hyperresponsiveness and inflammation with corticosteroids. Toxicol. Appl. Pharmacol. 2013, 271:168-174.
15. Layne E. Total protein, "spectrophotometric and turbidimetric methods for measuring proteins, II. Protein estimation with the folinciocalteu reagent". Method Enzymol. 1957, 3:447-454.
16. Leikauf G.D., Varsalona Pope-, Concel H., Liu V.J., P Bein.K., Berndt A., Martin T.M., Ganguly K., Jang A.S., Brant K.A., Dopico R.A.J.r., Upadhyay S., Di Y.P., Li Q., Hu Z., Vuga L.J., Medvedovic M., Kaminski N., You M., Alexander D.C., Dunn Mc, Prows J.E., Knoell D.R., Fabisiak D.L., J.P Integrative assessment of chlorine-induced acute lung injury in mice. Am. J. Respir. Cell Mol. Biol. 2012, 2:234-244.
17. Li W.L., Pomprapa A., Lachmann B., Leonhardt S., Czupalla O., Rosenbruch M., Pauluhn J. Effect of PEEP on phosgene-induced lung edema: pilot study on dogs using protective ventilation strategies. Toxicology (submitted) 2014.
18. Li W.L., Hai C.X., Pauluhn J. Inhaled nitric oxide aggravates phosgene model of acute lung injury. Inhal. Toxicol. 2011, 23:842-852.
19. Li W.L., Liu F.F., Wang C., Truebel H., Pauluhn J. Novel insights into phosgene-induced acute lung lnjury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis. Toxicol. Sci. 2013, 131:612-628.
20. Liu F., Li W., Pauluhn J., Trübel H., Wang C. Lipopolysaccharide-induced acute lung injury in rats: comparative assessment of intratracheal instillation and aerosol inhalation. Toxicology 2013, 304:158-166.
21. Liu F., Li W., Pauluhn J., Trübel H., Wang C. Rat models of acute lung injury: exhaled nitric oxide as a sensitive, noninvasive real-time biomarker of prognosis and efficacy of intervention. Toxicology 2013, 310:104-114.
22. Liu F., Pauluhn J., Trübel H., Wang C. Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats. Toxicology 2014, 315:17-23.
23. Massa C.B., Scott P., Abramova E., Gardner C., Laskin D.L., Gow A.J. Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol. Appl. Pharmacol. 2014, 278:53-64.
24. OECD, 2009. Organization for economic cooperation and development OECD - environment, health and safety publications, series on testing and assessment No. 39: guidance document for acute inhalation toxicity testing, [ENV/JM/MONO 28; July 21, 2009]. (accessed 04.14.). http://oberon.sourceoecd.org.
25. Pauluhn J., Thiel A. A simple approach to validation of directed-flow nose-only inhalation chambers. J. Appl. Toxicol. 2007, 27:160-167.
26. Pauluhn J. Acute nose-only exposure of rats to phosgene. Part I: concentration×time dependence of LC(50)s, nonlethal-threshold concentrations, and analysis of breathing patterns. Inhal. Toxicol. 2006, 18:423-435.
27. Pauluhn J. Acute nose-only exposure of rats to phosgene. Part II. concentration×time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months. Inhal. Toxicol. 2006, 18:595-607.
28. Pauluhn J., Carson A., Costa D.L., Gordon T., Kodavanti U., Last J.A., Matthay M.A., Pinkerton K.E., Sciuto A.M. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal. Toxicol. 2007, 19:789-810.
29. Russell D., Blain P.G., Rice P. Clinical management of casualties exposed to lung damaging agents: a critical review. Emerg. Med. J. 2006, 23:421-424.
30. Underhill F.P. The physiology and experimental treatment of poisoning with the lethal war gases. Arch. Int. Med. 1919, 23:753-770. Cited in WHO, 1997, 1998.
31. Yadav A.K., Bracher A., Doran S.F., Leustik M., Squadrito G.L., Postlethwait E.M., Matalon S. Mechanisms and modification of chlorine-induced lung injury in animals. Proc. Am. Thorac. Soc. 2010, 7:278-283.
32. Zwart A., Woutersen R.A. Acute inhalation toxicity of chlorine in rats and mice: time-concentration-mortality relationships and effects on respiration. J. Hazard Mat. 1988, 19:195-208.