Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 35, 2016, Pages E5182-E5191

  Bakeer, Nihal ^a   James, Jeanne ^a   Roy, Swarnava ^a   Wansapura, Janaka ^a,b   Shanmukhappa, Shiva Kumar ^a   Lorenz, John N ^c   Osinska, Hanna ^a   Backer, Kurt ^a   Huby, Anne Cecile ^a   Shrestha, Archana ^a   Niss, Omar ^a   Fleck, Robert ^a   Quinn, Charles T ^a   Taylor, Michael D ^a   Purevjav, Enkhsaikhan ^a   Aronow, Bruce J ^a   Towbin, Jeffrey A ^a   Malik, Punam ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLOMBO   (Sri Lanka)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Arrhythmias; Cardiomyopathy; Restrictive physiology; Sickle cell anemia; Sudden death

Indexed keywords

HYDROXYPROLINE; ION CHANNEL; TRANSCRIPTOME;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE CELL; CARDIOVASCULAR MAGNETIC RESONANCE; CELL LOSS; CELL ULTRASTRUCTURE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DOWN REGULATION; ELECTROCARDIOGRAPHY; EXTRACELLULAR MATRIX; EXTRACELLULAR SPACE; GENE ONTOLOGY; HEART CONDUCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEMATOPOIESIS; HISTOPATHOLOGY; HYPOXIA; LONGITUDINAL STUDY; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QRS COMPLEX; QT PROLONGATION; RESTRICTIVE CARDIOMYOPATHY; SARCOMERE LENGTH; SICKLE CELL ANEMIA; SUDDEN CARDIAC DEATH; TISSUE DOPPLER IMAGING; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CARDIOMYOPATHY; COMPLICATION; DIASTOLIC HEART FAILURE; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; HEART ARRHYTHMIA; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; PULMONARY HYPERTENSION; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOMYOPATHIES; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; GENE EXPRESSION PROFILING; HEART FAILURE, DIASTOLIC; HUMANS; HYPERTENSION, PULMONARY; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIUM;

EID: 84984669517     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600311113     Document Type: Article

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