Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy

Journal of Biological Chemistry

Volumn 282, Issue 13, 2007, Pages 10068-10078

  Parsons, Stephanie A ^a,e   Millay, Douglas P ^a   Sargent, Michelle A ^a   Naya, Francisco J ^b   McNally, Elizabeth M ^c   Sweeney, H Lee ^d   Molkentin, Jeffery D ^a,f,g  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Boston University   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e PFIZER INC   (United States)

^f AMERICAN HEART ASSOCIATION   (United States)

^g American Heart Association ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN (CN); CARDIAC FIBROSIS; MUSCULAR DYSTROPHY; UTROPHIN;

BIOLOGICAL ORGANS; DISEASES; GENE EXPRESSION; MUSCLE; PHYSIOLOGICAL MODELS; RATS;

ENZYMES;

CALCINEURIN; SARCOGLYCAN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE DELETION; GENE DISRUPTION; GENE TARGETING; GENOTYPE; HEART; HEART DISEASE; HEART MUSCLE FIBROSIS; HEART VENTRICLE; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIMB GIRDLE MUSCULAR DYSTROPHY; LOXP SITE; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE CELL; MYOPATHY; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; TRANSGENE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; ENZYMOLOGY; GENETICS; MOUSE MUTANT; PATHOLOGY;

MUS;

ANIMALS; CALCINEURIN; DISEASE MODELS, ANIMAL; HEART DISEASES; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES, LIMB-GIRDLE; SARCOGLYCANS;

EID: 34248227847     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609368200     Document Type: Article

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