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Volumn 31, Issue 8, 2016, Pages 1462-1469

Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice

Author keywords

betacyanins; gut microbiota; hepatic steatosis; insulin resistance; obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETACYANIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RIBOSOME RNA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; ANTIOBESITY AGENT; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; GLUCOSE BLOOD LEVEL; INSULIN; LIPID;

EID: 84984598130     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.13278     Document Type: Article
Times cited : (117)

References (42)
  • 1
    • 33746133962 scopus 로고    scopus 로고
    • Measuring the full economic costs of diet, physical activity and obesity-related chronic diseases
    • Popkin BM, Kim S, Rusev ER, Du S, Zizza C. Measuring the full economic costs of diet, physical activity and obesity-related chronic diseases. Obes. Rev. 2006; 7: 271–93.
    • (2006) Obes. Rev. , vol.7 , pp. 271-293
    • Popkin, B.M.1    Kim, S.2    Rusev, E.R.3    Du, S.4    Zizza, C.5
  • 2
    • 84879072840 scopus 로고    scopus 로고
    • Diabetes, obesity and gut microbiota
    • Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Cl Ga. 2013; 27: 73–83.
    • (2013) Best Pract Res Cl Ga. , vol.27 , pp. 73-83
    • Everard, A.1    Cani, P.D.2
  • 3
    • 84860163107 scopus 로고    scopus 로고
    • Anti-obesity drugs: a review about their effects and their safety
    • Derosa G, Maffioli P. Anti-obesity drugs: a review about their effects and their safety. Expert Opin. Drug Saf. 2012; 11: 459–71.
    • (2012) Expert Opin. Drug Saf. , vol.11 , pp. 459-471
    • Derosa, G.1    Maffioli, P.2
  • 4
    • 34447516925 scopus 로고    scopus 로고
    • Evolution of symbiotic bacteria in the distal human intestine
    • Xu J, Mahowald MA, Ley RE et al. Evolution of symbiotic bacteria in the distal human intestine. Plos Biol. 2007; 5: 1574–86.
    • (2007) Plos Biol. , vol.5 , pp. 1574-1586
    • Xu, J.1    Mahowald, M.A.2    Ley, R.E.3
  • 6
    • 84879090469 scopus 로고    scopus 로고
    • Nutrition, the gut microbiome and the metabolic syndrome
    • Kovatcheva-Datchary P, Arora T. Nutrition, the gut microbiome and the metabolic syndrome. Best Pract Res Cl Ga. 2013; 27: 59–72.
    • (2013) Best Pract Res Cl Ga. , vol.27 , pp. 59-72
    • Kovatcheva-Datchary, P.1    Arora, T.2
  • 7
    • 70350110294 scopus 로고    scopus 로고
    • High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
    • Hildebrandt MA, Hoffmann C, Sherrill-Mix SA et al. High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity. Gastroenterology 2009; 137: 1716–24.
    • (2009) Gastroenterology , vol.137 , pp. 1716-1724
    • Hildebrandt, M.A.1    Hoffmann, C.2    Sherrill-Mix, S.A.3
  • 8
    • 34848912627 scopus 로고    scopus 로고
    • Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    • Cani PD, Neyrinck AM, Fava F et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007; 50: 2374–83.
    • (2007) Diabetologia , vol.50 , pp. 2374-2383
    • Cani, P.D.1    Neyrinck, A.M.2    Fava, F.3
  • 9
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57: 1470–81.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3
  • 10
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • Everard A, Lazarevic V, Derrien M et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011; 60: 2775–86.
    • (2011) Diabetes , vol.60 , pp. 2775-2786
    • Everard, A.1    Lazarevic, V.2    Derrien, M.3
  • 11
    • 84970872356 scopus 로고    scopus 로고
    • Hypocholesterolemic effect of fermented red pitaya (hylocereus polyrhizus) juice in diet-induced Hypercholesterolemic Rats
    • Yusof RM, Akhiruddin MA. Hypocholesterolemic effect of fermented red pitaya (hylocereus polyrhizus) juice in diet-induced Hypercholesterolemic Rats. Ann. Nutr. Metab. 2009; 55: 92–101.
    • (2009) Ann. Nutr. Metab. , vol.55 , pp. 92-101
    • Yusof, R.M.1    Akhiruddin, M.A.2
  • 12
    • 24344479101 scopus 로고    scopus 로고
    • Generation of decarboxylated and dehydrogenated betacyanins in thermally treated purified fruit extract from purple pitaya (Hylocereus polyrhizus) monitored by LC-MS/MS
    • Wybraniec S, Mizrahi Y. Generation of decarboxylated and dehydrogenated betacyanins in thermally treated purified fruit extract from purple pitaya (Hylocereus polyrhizus) monitored by LC-MS/MS. J Agr Food Chem. 2005; 53: 6704–12.
    • (2005) J Agr Food Chem. , vol.53 , pp. 6704-6712
    • Wybraniec, S.1    Mizrahi, Y.2
  • 13
    • 84925654587 scopus 로고    scopus 로고
    • Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia
    • Han JY, Ma DS, Zhang M, Yang XL, Tan DH. Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia. Biomed Res Int. 2015; 2015: 1–9.
    • (2015) Biomed Res Int. , vol.2015 , pp. 1-9
    • Han, J.Y.1    Ma, D.S.2    Zhang, M.3    Yang, X.L.4    Tan, D.H.5
  • 14
    • 80053937226 scopus 로고    scopus 로고
    • Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats
    • Wroblewska M, Juskiewicz J, Wiczkowski W. Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats. Lipids Health Dis. 2011; 10.
    • (2011) Lipids Health Dis. , vol.10
    • Wroblewska, M.1    Juskiewicz, J.2    Wiczkowski, W.3
  • 16
    • 84970873616 scopus 로고    scopus 로고
    • Effects of red pitaya fruit (hylocereus polyrhizus) consumption on blood glucose level and lipidprofile in type 2 diabetic subjects
    • Abd Hadi N, Mohamad M, Rohin MAK, Mohd YR. Effects of red pitaya fruit (hylocereus polyrhizus) consumption on blood glucose level and lipidprofile in type 2 diabetic subjects. Borneo Science Journal. 2012; 31: 113–29.
    • (2012) Borneo Science Journal. , vol.31 , pp. 113-129
    • Abd Hadi, N.1    Mohamad, M.2    Rohin, M.A.K.3    Mohd, Y.R.4
  • 17
    • 70349423741 scopus 로고    scopus 로고
    • Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
    • Rohin MAK, Abd Hadi N, Mohd Yusof R, Rahmat A, Mansor SM, Ali AM. Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats. Int Food Res J. 2009; 16: 431–40.
    • (2009) Int Food Res J. , vol.16 , pp. 431-440
    • Rohin, M.A.K.1    Abd Hadi, N.2    Mohd Yusof, R.3    Rahmat, A.4    Mansor, S.M.5    Ali, A.M.6
  • 18
    • 0034877013 scopus 로고    scopus 로고
    • Identification and distribution of simple and acylated betacyanins in the amaranthaceae
    • Cai YZ, Sun M, Corke H. Identification and distribution of simple and acylated betacyanins in the amaranthaceae. J Agr Food Chem. 2001; 49: 1971–8.
    • (2001) J Agr Food Chem. , vol.49 , pp. 1971-1978
    • Cai, Y.Z.1    Sun, M.2    Corke, H.3
  • 19
    • 70449158340 scopus 로고
    • A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues
    • Folch J, Lees M, Stanley GHS. A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues. J. Biol. Chem. 1957; 226: 497–509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.H.S.3
  • 20
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313–21.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 21
    • 0035861327 scopus 로고    scopus 로고
    • Betacyanins from vine cactus Hylocereus polyrhizus
    • Wybraniec S, Platzner I, Geresh S et al. Betacyanins from vine cactus Hylocereus polyrhizus. Phytochemistry 2001; 58: 1209–12.
    • (2001) Phytochemistry , vol.58 , pp. 1209-1212
    • Wybraniec, S.1    Platzner, I.2    Geresh, S.3
  • 22
    • 0036128032 scopus 로고    scopus 로고
    • Betacyanins in fruits from red-purple pitaya, Hylocereus polyrhizus (Weber) Britton & Rose (vol 77, pg 101, 2001)
    • Stintzing FC, Schieber A, Carle R. Betacyanins in fruits from red-purple pitaya, Hylocereus polyrhizus (Weber) Britton & Rose (vol 77, pg 101, 2001). Food Chem. 2002; 77: 101–6.
    • (2002) Food Chem. , vol.77 , pp. 101-106
    • Stintzing, F.C.1    Schieber, A.2    Carle, R.3
  • 23
    • 52649144812 scopus 로고    scopus 로고
    • Betalains in red and yellow varieties of the Andean tuber crop ulluco (Ullucus tuberosus)
    • Svenson J, Smallfield BM, Joyce NI, Sanson CE, Perry NB. Betalains in red and yellow varieties of the Andean tuber crop ulluco (Ullucus tuberosus). J Agr Food Chem. 2008; 56: 7730–7.
    • (2008) J Agr Food Chem. , vol.56 , pp. 7730-7737
    • Svenson, J.1    Smallfield, B.M.2    Joyce, N.I.3    Sanson, C.E.4    Perry, N.B.5
  • 24
    • 77952151217 scopus 로고    scopus 로고
    • Profiles of betacyanins in epidermal layers of grafted and light-stressed cacti studied by LC-DAD-ESI-MS/MS
    • Wybraniec S, Stalica P, Sporna A, Mizrahi Y. Profiles of betacyanins in epidermal layers of grafted and light-stressed cacti studied by LC-DAD-ESI-MS/MS. J Agr Food Chem. 2010; 58: 5347–54.
    • (2010) J Agr Food Chem. , vol.58 , pp. 5347-5354
    • Wybraniec, S.1    Stalica, P.2    Sporna, A.3    Mizrahi, Y.4
  • 25
    • 79957867318 scopus 로고    scopus 로고
    • Anthocyanins: Natural Colorants with Health-Promoting Properties
    • He JA, Giusti MM. Anthocyanins: Natural Colorants with Health-Promoting Properties. Annu Rev Food Sci T. 2010; 1: 163–87.
    • (2010) Annu Rev Food Sci T. , vol.1 , pp. 163-187
    • He, J.A.1    Giusti, M.M.2
  • 26
    • 84884389488 scopus 로고    scopus 로고
    • Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications
    • Munir KM, Chandrasekaran S, Gao F, Quon MJ. Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol-Endoc M. 2013; 305: E679–E86.
    • (2013) Am J Physiol-Endoc M. , vol.305 , pp. E679-E686
    • Munir, K.M.1    Chandrasekaran, S.2    Gao, F.3    Quon, M.J.4
  • 27
    • 84880349078 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?
    • Timmers S, Hesselink MKC, Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? Ann Ny Acad Sci. 2013; 1290: 83–9.
    • (2013) Ann Ny Acad Sci. , vol.1290 , pp. 83-89
    • Timmers, S.1    Hesselink, M.K.C.2    Schrauwen, P.3
  • 28
    • 0027362079 scopus 로고
    • chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
    • Zarjevski N, Cusin I, Vettor R, Rohnerjeanrenaud F, Jeanrenaud B. chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993; 133: 1753–8.
    • (1993) Endocrinology , vol.133 , pp. 1753-1758
    • Zarjevski, N.1    Cusin, I.2    Vettor, R.3    Rohnerjeanrenaud, F.4    Jeanrenaud, B.5
  • 29
    • 33745106645 scopus 로고    scopus 로고
    • Drug Insight: the role of leptin in human physiology and pathophysiology - emerging clinical applications
    • Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology - emerging clinical applications. Nat Clin Pract Endoc. 2006; 2: 318–27.
    • (2006) Nat Clin Pract Endoc. , vol.2 , pp. 318-327
    • Brennan, A.M.1    Mantzoros, C.S.2
  • 30
    • 11144264156 scopus 로고    scopus 로고
    • nonalcoholic fatty liver disease: A review of current understanding and future impact
    • Charlton M. nonalcoholic fatty liver disease: A review of current understanding and future impact. Clin Gastroenterol H. 2004; 2: 1048–58.
    • (2004) Clin Gastroenterol H. , vol.2 , pp. 1048-1058
    • Charlton, M.1
  • 31
    • 84859091966 scopus 로고    scopus 로고
    • Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation
    • Jang HH, Park MY, Kim HW et al. Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. Nutr. Metab. 2012; 9.
    • (2012) Nutr. Metab. , vol.9
    • Jang, H.H.1    Park, M.Y.2    Kim, H.W.3
  • 32
    • 84879039234 scopus 로고    scopus 로고
    • Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats
    • Zhang S, Zheng LL, Dong DS et al. Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats. Food Chem. 2013; 141: 2108–16.
    • (2013) Food Chem. , vol.141 , pp. 2108-2116
    • Zhang, S.1    Zheng, L.L.2    Dong, D.S.3
  • 33
    • 84902094667 scopus 로고    scopus 로고
    • Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats
    • Song Y, Lee SJ, Jang SH et al. Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats. Nutrients 2014; 6: 2179–95.
    • (2014) Nutrients , vol.6 , pp. 2179-2195
    • Song, Y.1    Lee, S.J.2    Jang, S.H.3
  • 34
    • 0030253348 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus
    • Kruszynska YT, Olefsky JM. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J. Invest. Med. 1996; 44: 413–28.
    • (1996) J. Invest. Med. , vol.44 , pp. 413-428
    • Kruszynska, Y.T.1    Olefsky, J.M.2
  • 35
    • 0030938616 scopus 로고    scopus 로고
    • Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis
    • DeFronzo RA. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis. Neth. J. Med. 1997; 50: 191–7.
    • (1997) Neth. J. Med. , vol.50 , pp. 191-197
    • DeFronzo, R.A.1
  • 36
    • 0037356826 scopus 로고    scopus 로고
    • The role of the novel adipocyte-derived hormone adiponectin in human disease
    • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. Endocrinol. 2003; 148: 293–300.
    • (2003) Eur. J. Endocrinol. , vol.148 , pp. 293-300
    • Diez, J.J.1    Iglesias, P.2
  • 37
    • 14044257221 scopus 로고    scopus 로고
    • The evolving role of inflammation in obesity and the metabolic syndrome
    • Lee YH, Pratley RE. The evolving role of inflammation in obesity and the metabolic syndrome. Curr. Diab. Rep. 2005; 5: 70–5.
    • (2005) Curr. Diab. Rep. , vol.5 , pp. 70-75
    • Lee, Y.H.1    Pratley, R.E.2
  • 38
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard JP, Maachi M, Lagathu C et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 2006; 17: 4–12.
    • (2006) Eur. Cytokine Netw. , vol.17 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3
  • 39
    • 23644450775 scopus 로고    scopus 로고
    • Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    • Cancello R, Henegar C, Viguerie N et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54: 2277–86.
    • (2005) Diabetes , vol.54 , pp. 2277-2286
    • Cancello, R.1    Henegar, C.2    Viguerie, N.3
  • 40
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Backhed F, Ding H, Wang T et al. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U. S. A. 2004; 101: 15718–23.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding, H.2    Wang, T.3
  • 41
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin NR, Lee JC, Lee HY et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 2014; 63: 727–35.
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.1    Lee, J.C.2    Lee, H.Y.3
  • 42
    • 84934451277 scopus 로고    scopus 로고
    • A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice
    • Anhe FF, Roy D, Pilon G et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 2015; 64: 872–83.
    • (2015) Gut , vol.64 , pp. 872-883
    • Anhe, F.F.1    Roy, D.2    Pilon, G.3


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