Nutrition, the gut microbiome and the metabolic syndrome

Best Practice and Research: Clinical Gastroenterology

Volumn 27, Issue 1, 2013, Pages 59-72

  Kovatcheva Datchary, Petia ^a   Arora, Tulika ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Gut microbiota; Metabolic syndrome; Obesity; Prebiotic; Probiotic

Indexed keywords

PREBIOTIC AGENT; PROBIOTIC AGENT;

ARTICLE; DIET; HUMAN; INTESTINE FLORA; LIFESTYLE; LIVER FUNCTION; METABOLIC SYNDROME X; MICROBIOME; NONHUMAN; NUTRITION; OBESITY;

EID: 84879090469     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2013.03.017     Document Type: Review

References (114)

1. R.H. Eckel, S.M. Grundy, and P.Z. Zimmet The metabolic syndrome The Lancet 365 9468 2005 1415 1428
2. H. Tilg, and A. Kaser Gut microbiome, obesity, and metabolic dysfunction The Journal of Clinical Investigation 121 6 2011 2126 2132
3. C.F. Semenkovich Insulin resistance and atherosclerosis The Journal of Clinical Investigation 116 7 2006 1813 1822
4. A. Astrup Dietary management of obesity Journal of Parenteral and Enteral Nutrition 32 5 2008 575 577
5. J. Qin, R. Li, J. Raes, M. Arumugam, K.S. Burgdorf, and C. Manichanh A human gut microbial gene catalogue established by metagenomic sequencing Nature 464 7285 2010 59 65
6. A.M. O'Hara, and F. Shanahan The gut flora as a forgotten organ EMBO Reports 7 2006 688 693
7. R. Wall, R.P. Ross, C.A. Ryan, S. Hussey, B. Murphy, and G.F. Fitzgerald Role of gut microbiota in early infant development Clinical Medicine Insights: Pediatrics 3 2009 45 54
8. C. Palmer, E.M. Bik, D.B. DiGiulio, D.A. Relman, and P.O. Brown Development of the human infant intestinal microbiota PLoS Biology 5 7 2007 e177
9. J.E. Koenig, A. Spor, N. Scalfone, A.D. Fricker, J. Stombaugh, and R. Knight Succession of microbial consortia in the developing infant gut microbiome Proceedings of the National Academy of Sciences 108 Suppl. 1 2011 4578 4585
10. C. De Filippo, D. Cavalieri, M. Di Paola, M. Ramazzotti, J.B. Poullet, and S. Massart Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa Proceedings of the National Academy of Sciences 107 33 2010 14691 14696
11. T. Yatsunenko, F.E. Rey, M.J. Manary, I. Trehan, M.G. Dominguez-Bello, and M. Contreras Human gut microbiome viewed across age and geography Nature 486 7402 2012 222 227
12. B.D. Muegge, J. Kuczynski, D. Knights, J.C. Clemente, A. González, and L. Fontana Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans Science 332 6032 2011 970 974
13. F. Bäckhed, H. Ding, T. Wang, L.V. Hooper, G.Y. Koh, and A. Nagy The gut microbiota as an environmental factor that regulates fat storage Proceedings of the National Academy of Sciences 101 44 2004 15718 15723
14. F. Backhed, J.K. Manchester, C.F. Semenkovich, and J.I. Gordon Mechanisms underlying the resistance to diet-induced obesity in germ-free mice Proceedings of the National Academy of Sciences 104 3 2007 979 984
15. R.E. Ley, F. Bäckhed, P. Turnbaugh, C.A. Lozupone, R.D. Knight, and J.I. Gordon Obesity alters gut microbial ecology Proceedings of the National Academy of Sciences 102 31 2005 11070 11075
16. P.J. Turnbaugh, F. Bäckhed, L. Fulton, and J.I. Gordon Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome Cell Host & Microbe 3 4 2008 213 223
17. R.E. Ley, P.J. Turnbaugh, S. Klein, and J.I. Gordon Microbial ecology: human gut microbes associated with obesity Nature 444 7122 2006 1022 1023
18. F. Armougom, M. Henry, B. Vialettes, D. Raccah, and D. Raoult Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients PLoS One 4 9 2009 e7125
19. A. Santacruz, M.C. Collado, L. García-Valdés, M.T. Segura, J.A. Martín-Lagos, and T. Anjos Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women British Journal of Nutrition 104 01 2010 83 92
20. H. Zhang, J.K. DiBaise, A. Zuccolo, D. Kudrna, M. Braidotti, and Y. Yu Human gut microbiota in obesity and after gastric bypass Proceedings of the National Academy of Sciences 106 7 2009 2365 2370
21. S.H. Duncan, G.E. Lobley, G. Holtrop, J. Ince, A.M. Johnstone, and P. Louis Human colonic microbiota associated with diet, obesity and weight loss International Journal of Obesity 32 11 2008 1720 1724
22. A. Schwiertz, D. Taras, K. Schafer, S. Beijer, N.A. Bos, and C. Donus Microbiota and SCFA in lean and overweight healthy subjects Obesity 18 1 2009 190 195
23. P.J. Turnbaugh, and J.I. Gordon The core gut microbiome, energy balance and obesity The Journal of Physiology 587 17 2009 4153 4158
24. P.J. Turnbaugh, M. Hamady, T. Yatsunenko, B.L. Cantarel, A. Duncan, and R.E. Ley A core gut microbiome in obese and lean twins Nature 457 7228 2009 480 484
25. S. Greenblum, P.J. Turnbaugh, and E. Borenstein Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease Proceedings of the National Academy of Sciences 109 2 2012 594 599
26. O. Koren, J.K. Goodrich, T.C. Cullender, A. Spor, K. Laitinen, and H. Kling Bäckhed Host remodeling of the gut microbiome and metabolic changes during pregnancy Cell 150 3 2012 470 480
27. FAO/WHO Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria 2001 WHO
28. A. Lan, D. Lagadic-Gossmann, C. Lemaire, C. Brenner, and G. Jan Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria Apoptosis 12 3 2007 573 591
29. F. Girard-Pipau, A. Pompei, S. Schneider, J. Nano, X. Hebuterne, and P. Boquet Intestinal microflora, short chain and cellular fatty acids, influence of a probiotic Saccharomyces boulardii Microbial Ecology in Health and Disease 14 4 2002 220 227
30. J.L. Sonnenburg, C.T. Chen, and J.I. Gordon Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host PLoS Biology 4 12 2006 e413
31. M.L. Marco, T.H. Peters, R.S. Bongers, D. Molenaar, S. van Hemert, and J.L. Sonnenburg Lifestyle of Lactobacillus plantarum in the mouse caecum Environmental Microbiology 11 10 2009 2747 2757
32. E. Denou, R.D. Pridmore, B. Berger, J.M. Panoff, F. Arigoni, and H. Brussow Identification of genes associated with the long-gut-persistence phenotype of the probiotic Lactobacillus johnsonii strain NCC533 using a combination of genomics and transcriptome analysis Journal of Bacteriology 190 9 2008 3161 3168
33. N.P. McNulty, T. Yatsunenko, A. Hsiao, J.J. Faith, B.D. Muegge, and A.L. Goodman The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins Science Translational Medicine 3 106 2011 106ra
34. F.P. Martin, Y. Wang, N. Sprenger, E. Holmes, J.C. Lindon, and S. Kochhar Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy Journal of Proteome Research 6 4 2007 1471 1481
35. F.P. Martin, Y. Wang, N. Sprenger, I.K. Yap, T. Lundstedt, and P. Lek Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model Molecular Systems Biology 4 2008 157
36. D.B. West, J.P. Delany, P.M. Camet, F. Blohm, A.A. Truett, and J. Scimeca Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 275 3 1998 R667 R672
37. H.Y. Lee, J.H. Park, S.H. Seok, M.W. Baek, D.J. Kim, and K.E. Lee Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice Biochimica Biophysica Acta 1761 2006 736 744
38. K. Lee, K. Paek, H.Y. Lee, J.H. Park, and Y. Lee Antiobesity effect of trans-10, cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice Journal of Applied Microbiology 103 4 2007 1140 1146
39. M. Sato, K. Uzu, T. Yoshida, E.M. Hamad, H. Kawakami, and H. Matsuyama Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats British Journal of Nutrition 99 5 2008 1013 1017
40. N. Takemura, T. Okubo, and K. Sonoyama Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet Experimental Biology and Medicine 235 7 2010 849 856
41. E.M. Hamad, M. Sato, K. Uzu, T. Yoshida, S. Higashi, and H. Kawakami Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats British Journal of Nutrition 101 5 2009 716 724
42. Y. Kadooka, A. Ogawa, K. Ikuyama, and M. Sato The probiotic Lactobacillus gasseri SBT2055 inhibits enlargement of visceral adipocytes and upregulation of serum soluble adhesion molecule (sICAM-1) in rats International Dairy Journal 21 9 2011 623 627
43. D.Y. Park, Y.T. Ahn, C.S. Huh, S.M. Jeon, and M.S. Choi The inhibitory effect of Lactobacillus plantarum KY1032 cell extract on the adipogenesis of 3T3-L1 Cells Journal of Medicinal Food 14 6 2011 670 675
44. J.N. Ho, J.W. Choi, W.C. Lim, M.K. Kim, I.Y. Lee, and H.Y. Cho Kefir inhibits 3T3-L1 adipocyte differentiation through down-regulation of adipogenic transcription factor expression Journal of The Science of Food and Agriculture 93 3 2013 485 490
45. M. Tanida, J. Shen, K. Maeda, Y. Horii, T. Yamano, and Y. Fukushima High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats Obesity Research & Clinical Practice 2 3 2008 159 169
46. L. Aronsson, Y. Huang, P. Parini, M. Korach-Andre, J. Hakansson, and J.A. Gustafsson Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4) PloS One 5 9 2010 e13087
47. A. Nerstedt, E.C. Nilsson, K. Ohlson, J. Hakansson, L. Thomas Svensson, and B. Lowenadler Administration of Lactobacillus evokes coordinated changes in the intestinal expression profile of genes regulating energy homeostasis and immune phenotype in mice British Journal of Nutrition 97 6 2007 1117 1127
48. -/- mice PLoS One 7 10 2012 e46837
49. Y.S. Ji, H.N. Kim, H.J. Park, J.E. Lee, S.Y. Yeo, and J.S. Yang Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28 Beneficial Microbes 3 1 2012 13 22
50. T. Arora, J. Anastasovska, G. Gibson, K. Tuohy, R.K. Sharma, and J. Bell Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice British Journal of Nutrition 108 8 2012 1382 1389
51. E. Angelakis, D. Bastelica, A. Ben Amara, A. El Filali, A. Dutour, and J.L. Mege An evaluation of the effects of Lactobacillus ingluviei on body weight, the intestinal microbiome and metabolism in mice Microbial Pathogenesis 52 1 2012 61 68
52. Y. Kadooka, M. Sato, K. Imaizumi, A. Ogawa, K. Ikuyama, and Y. Akai Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial European Journal of Clinical Nutrition 64 6 2010 636 643
53. N. Vendt, H. Grünberg, T. Tuure, O. Malminiemi, E. Wuolijoki, and V. Tillmann Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial Journal of Human Nutrition and Dietetics 19 1 2006 51 58
54. R. Luoto, M. Kalliomaki, K. Laitinen, and E. Isolauri The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years International Journal of Obesity 34 10 2010 1531 1537
55. H.C. Xing, L.J. Li, K.J. Xu, T. Shen, Y.B. Chen, and J.F. Sheng Intestinal microflora in rats with ischemia/reperfusion liver injury Journal of Zhejiang University Science B 6 1 2005 14 21
56. T. Le Roy, M. Llopis, P. Lepage, A. Bruneau, S. Rabot, and C. Bevilacqua Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice Gut 2012 10.1136/gutjnl-2012-303816
57. A. Iacono, G.M. Raso, R.B. Canani, A. Calignano, and R. Meli Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms The Journal of Nutritional Biochemistry 22 8 2011 699 711
58. G. Nardone, D. Compare, E. Liguori, V. Di Mauro, A. Rocco, and M. Barone Protective effects of Lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury American Journal of Physiology Gastrointestinal and Liver Physiology 299 3 2010 G669 G676
59. D. Adawi, S. Ahrne, and G. Molin Effects of different probiotic strains of Lactobacillus and Bifidobacterium on bacterial translocation and liver injury in an acute liver injury model International Journal of Food Microbiology 70 3 2001 213 220
60. H.C. Xing, L.J. Li, K.J. Xu, T. Shen, Y.B. Chen, and J.F. Sheng Protective role of supplement with foreign Bifidobacterium and Lactobacillus in experimental hepatic ischemia-reperfusion injury Journal of Gastroenterology and Hepatology 21 4 2006 647 656
61. C.B. Forsyth, A. Farhadi, S.M. Jakate, Y. Tang, M. Shaikh, and A. Keshavarzian Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis Alcohol 43 2 2009 163 172
62. Y. Wang, Y. Liu, A. Sidhu, Z. Ma, C. McClain, and W. Feng Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury American Journal of Physiology Gastrointestinal and Liver Physiology 303 1 2012 G32 G41
63. Y. Wang, I. Kirpich, Y. Liu, Z. Ma, S. Barve, and C.J. McClain Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury The American Journal of Pathology 179 6 2011 2866 2875
64. X. Ma, J. Hua, and Z. Li Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells Journal of Hepatology 49 5 2008 821 830
65. Z. Li, S. Yang, H. Lin, J. Huang, P.A. Watkins, and A.B. Moser Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2 2003 343 350
66. E. Esposito, A. Iacono, G. Bianco, G. Autore, S. Cuzzocrea, and P. Vajro Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats The Journal of Nutrition 139 5 2009 905 911
67. M. Roberfroid, G.R. Gibson, L. Hoyles, A.L. McCartney, R. Rastall, and I. Rowland Prebiotic effects: metabolic and health benefits British Journal of Nutrition 104 Suppl. S2 2010 S1 S63
68. P.D. Cani, C. Knauf, M.A. Iglesias, D.J. Drucker, N.M. Delzenne, and R.G. Burcelin Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor Diabetes 55 5 2006 1484 1490
69. E. Delmée, P.D. Cani, G. Gual, C. Knauf, R. Burcelin, and N. Maton Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice Life Sciences 79 10 2006 1007 1013
70. P.D. Cani, C.A. Daubioul, B. Reusens, C. Remacle, G. Catillon, and N.M. Delzenne Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats Journal of Endocrinology 185 3 2005 457 465
71. P.D. Cani, A.M. Neyrinck, F. Fava, C. Knauf, R.G. Burcelin, and K.M. Tuohy Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia Diabetologia 50 11 2007 2374 2383
72. P.D. Cani, S. Possemiers, T. Van de Wiele, Y. Guiot, A. Everard, and O. Rottier Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability Gut 58 8 2009 1091 1103
73. A. Everard, V. Lazarevic, M. Derrien, M. Girard, G.G. Muccioli, and A.M. Neyrinck Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice Diabetes 60 11 2011 2775 2786
74. J.A. Parnell, and R.A. Reimer Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats British Journal of Nutrition 107 04 2012 601 613
75. A.M. Neyrinck, S. Possemiers, W. Verstraete, F. De Backer, P.D. Cani, and N.M. Delzenne Dietary modulation of Clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice The Journal of Nutritional Biochemistry 23 1 2012 51 59
76. A.M. Neyrinck, S. Possemiers, C. Druart, T. Van de Wiele, F. De Backer, and P.D. Cani Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice PloS One 6 6 2011 e20944
77. S. Hooda, B.M.V. Boler, M.C.R. Serao, J.M. Brulc, M.A. Staeger, and T.W. Boileau 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber The Journal of Nutrition 142 7 2012 1259 1265
78. E.M. Dewulf, P.D. Cani, S.P. Claus, S. Fuentes, P.G.B. Puylaert, and A.M. Neyrinck Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women Gut 2012 10.1136/gutjnl-2012-303304
79. L.M.G. Davis, I. Martínez, J. Walter, C. Goin, and R.W. Hutkins Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans PLoS One 6 9 2011 e25200
80. P.D. Cani, A.M. Neyrinck, N. Maton, and N.M. Delzenne Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1 Obesity 13 6 2005 1000 1007
81. P.D. Cani, E. Lecourt, E.M. Dewulf, F.M. Sohet, B.D. Pachikian, and D. Naslain Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal The American Journal of Clinical Nutrition 90 5 2009 1236 1243
82. J.A. Parnell, and R.A. Reimer Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults The American Journal of Clinical Nutrition 89 6 2009 1751 1759
83. S.P.M. Verhoef, D. Meyer, and K.R. Westerterp Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake British Journal of Nutrition 106 11 2011 1757 1762
84. G. Tolhurst, H. Heffron, Y.S. Lam, H.E. Parker, A.M. Habib, and E. Diakogiannaki Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2 Diabetes 61 2 2012 364 371
85. P.D. Cani, S. Hoste, Y. Guiot, and N.M. Delzenne Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats British Journal of Nutrition 98 01 2007 32 37
86. E.M. Dewulf, P.D. Cani, A.M. Neyrinck, S. Possemiers, A.V. Holle, and G.G. Muccioli Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice The Journal of Nutritional Biochemistry 22 8 2011 712 722
87. D.M. Lambert, and G.G. Muccioli Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players Current Opinion in Clinical Nutrition and Metabolic Care 10 6 2007 735 744
88. G.G. Muccioli, D. Naslain, F. Backhed, C.S. Reigstad, D.M. Lambert, and N.M. Delzenne The endocannabinoid system links gut microbiota to adipogenesis Molecular System Biology 6 2010 392
89. F.-P.J. Martin, Y. Wang, N. Sprenger, I.K.S. Yap, S. Rezzi, and Z. Ramadan Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model Molecular System Biology 4 2008 205
90. F.P. Martin, N. Sprenger, I. Montoliu, S. Rezzi, S. Kochhar, and J.K. Nicholson Dietary modulation of gut functional ecology studied by fecal metabonomics Journal of Proteome Research 9 10 2010 5284 5295
91. T. Arora, R.L. Loo, J. Anastasovska, G.R. Gibson, K.M. Tuohy, and R.K. Sharma Differential effects of two fermentable carbohydrates on central appetite regulation and body composition PLoS One 7 8 2012 e43263
92. P.W. So, W.S. Yu, Y.T. Kuo, C. Wasserfall, A.P. Goldstone, and J.D. Bell Impact of resistant starch on body fat patterning and central appetite regulation PLoS One 2 12 2007 e1309
93. J. Anastasovska, T. Arora, G.J. Sanchez Canon, J.R.C. Parkinson, K. Touhy, and G.R. Gibson Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment Obesity 20 5 2012 1016 1023
94. J.A. Parnell, M. Raman, K.P. Rioux, and R.A. Reimer The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance Liver International: Official Journal of the International Association for the Study of the Liver 32 5 2012 701 711
95. N. Agheli, M. Kabir, S. Berni-Canani, E. Petitjean, A. Boussairi, and J. Luo Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-öligosaccharides in sucrose-fed insulin-resistant rats The Journal of Nutrition 128 8 1998 1283 1288
96. N.M. Delzenne, and N.N. Kok Biochemical basis of oligofructose-induced hypolipidemia in animal models The Journal of Nutrition 129 7 1999 1467S 1470S
97. N. Kok, M. Roberfroid, A. Robert, and N. Delzenne Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats British Journal of Nutrition 76 06 1996 881 890
98. J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, and T. Takahashi Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet European Journal of Nutrition 47 4 2008 192 200
99. C.A. Daubioul, H.S. Taper, L.D. De Wispelaere, and N.M. Delzenne Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese zucker rats The Journal of Nutrition 130 5 2000 1314 1319
100. J.A. Parnell, and R.A. Reimer Effect of prebiotic fibre supplementation on hepatic gene expression and serum lipids: a dose-response study in JCR:LA-cp rats British Journal of Nutrition 103 11 2010 1577 1584
101. M. Fiordaliso, N. Kok, J.P. Desager, F. Goethals, D. Deboyser, and M. Roberfroid Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats Lipids 30 2 1995 163 167
102. J. Busserolles, E. Gueux, E. Rock, C. Demigné, A. Mazur, and Y. Rayssiguier Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats The Journal of Nutrition 133 6 2003 1903 1908
103. C.A. Daubioul, N. Rousseau, R. Demeure, B. Gallez, H. Taper, and B. Declerck Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese zucker fa/fa rats The Journal of Nutrition 132 5 2002 967 973
104. J.-H. Kang, S.-I. Yun, and H.-O. Park Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats Journal of Microbiology 48 5 2010 712 714
105. S.I. Yun, H.O. Park, and J.H. Kang Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes Journal of Applied Microbiology 107 5 2009 1681 1686
106. H. An, S. Park, D. Lee, J. Kim, M. Cha, and S. Lee Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats Lipids in Health and Disease 10 1 2011 116
107. J.J. Chen, R. Wang, X.-f. Li, and R.-l. Wang Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal Reg I gene expression Experimental Biology and Medicine 236 7 2011 823 831
108. C.L.J. Karlsson, G. Molin, F. Fåk, M.-L. Johansson Hagslätt, M. Jakesevic, and Å. Håkansson Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age British Journal of Nutrition 106 06 2011 887 895
109. A.M. Neyrinck, V.F. Van Hee, N. Piront, F. De Backer, O. Toussaint, and P.D. Cani Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice Nutrition and Diabetes 2 2012 e28
110. P.D. Cani, E. Joly, Y. Horsmans, and N.M. Delzenne Oligofructose promotes satiety in healthy human: a pilot study European Journal of Clinical Nutrition 60 5 2005 567 572
111. L. Cloetens, W.F. Broekaert, Y. Delaedt, F. Ollevier, C.M. Courtin, and J.A. Delcour Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study British Journal of Nutrition 103 05 2010 703 713
112. H.E. Bays, J.L. Evans, K.C. Maki, M. Evans, V. Maquet, and R. Cooper Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial European Journal of Clinical Nutrition 67 2013 2 7
113. K.C. Maki, G.R. Gibson, R.S. Dickmann, C.W.C. Kendall, C.Y.O. Chen, and A. Costabile Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal Nutrition 28 11-12 2012 1115 1121
114. G.E. Walton, E.G.H.M. van den Heuvel, M.H.W. Kosters, R.A. Rastall, K.M. Tuohy, and G.R. Gibson A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age British Journal of Nutrition 107 10 2012 1466 1475