Hsp90 inhibition suppresses NF-ĸB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 10, 2016, Pages L964-L974

  Thangjam, Gagan S ^a   Birmpas, Charalampos ^a   Barabutis, Nektarios ^a   Gregory, Betsy W ^a   Clemens, Mary Ann ^b   Newton, Joseph R ^b   Fulton, David ^c   Catravas, John D ^a,d  

^a OLD DOMINION UNIVERSITY   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d OLD DOMINION UNIVERSITY   (United States)

Author keywords

Histone h3; Hsp90; Human lung endothelial cells; NF B; Sirt 2

Indexed keywords

HEAT SHOCK PROTEIN 90; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA POLYMERASE II; SIRTUIN 2; TANESPIMYCIN; BENZOQUINONE DERIVATIVE; IL8 PROTEIN, HUMAN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROCYCLIC LACTAM; RELA PROTEIN, HUMAN; SIRT2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ACUTE LUNG INJURY; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; IMMUNOLOGY; LUNG; MALE; METABOLISM; MICROVASCULATURE; PATHOLOGY; PROTEIN PROCESSING; PROTEIN TRANSPORT; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ACETYLATION; ANIMALS; BENZOQUINONES; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-8; LACTAMS, MACROCYCLIC; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE, INBRED C57BL; MICROVESSELS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SIRTUIN 2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION;

EID: 84984596990     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00054.2016     Document Type: Article

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