Novel mechanism of attenuation of LPS-induced NF-κB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 5, 2014, Pages 942-952

  Thangjam, Gagan S ^a,c   Dimitropoulou, Chistiana ^a   Joshi, Atul D ^a,c   Barabutis, Nektarios ^a,c   Shaw, Mary C ^a   Kovalenkov, Yevgeniy ^a   Wallace, Chistopher M ^a   Fulton, David J ^a   Patel, Vijay ^b   Catravas, John D ^a,c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b AUGUSTA UNIVERSITY   (United States)

^c OLD DOMINION UNIVERSITY   (United States)

Author keywords

CAMP response element binding protein binding protein; Heat shock protein 90 inhibitor; Human lung microvascular endothelial cells; LPS; NF B

Indexed keywords

17 N ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEOXYRIBONUCLEASE; ESCHERICHIA COLI ENDOTOXIN; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CELL CULTURE; DEACETYLATION; DNA BINDING; ENZYME ASSAY; ENZYME INHIBITION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ENDOTHELIUM; MICROVASCULAR ENDOTHELIAL CELL; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; BENZOQUINONES; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HISTONE DEACETYLASES; HISTONES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B PROTEINS; LACTAMS, MACROCYCLIC; LIPOPOLYSACCHARIDES; LUNG; MICROVESSELS; NF-KAPPA B; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; UBIQUITINATION;

EID: 84899732608     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0214OC     Document Type: Article

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