Tissue inhibitor of metalloproteinases 3-dependent microvascular endothelial cell barrier function is disrupted under septic conditions

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 11, 2016, Pages H1455-H1467

  Arpino, Valerie ^a,b   Mehta, Sanjay ^a,b   Wang, Lefeng ^a,b   Bird, Ryan ^a,b   Rohan, Marta ^a   Pape, Cynthia ^a,b   Gill, Sean E ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

Sepsis; Tissue inhibitor of metalloproteinases; Vascular leak

Indexed keywords

ALBUMIN; DEXTRAN; EVANS BLUE; FLUORESCEIN; GAMMA INTERFERON; ILOMASTAT; INTERLEUKIN 1BETA; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR; VASCULAR ENDOTHELIAL CADHERIN; CADHERIN; CYTOKINE; DIPEPTIDE; LEUKOCYTE ANTIGEN; MATRIX METALLOPROTEINASE INHIBITOR; N-(2(R)-2-(HYDROXAMIDOCARBONYLMETHYL)-4-METHYLPENTANOYL)-L-TRYPTOPHAN METHYLAMIDE;

ADHERENS JUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIAL CELL; CAPILLARY LEAK SYNDROME; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELL FUNCTION; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC RESISTANCE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; LUNG BLOOD VESSEL; LUNG INJURY; MALE; MONOLAYER CULTURE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSENDOTHELIAL ELECTRICAL RESISTANCE; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; GENOTYPE; KNOCKOUT MOUSE; LUNG; LUNG EDEMA; METABOLISM; MICROVASCULATURE; PATHOPHYSIOLOGY; PHENOTYPE; SEPSIS; TIME FACTOR; VASCULARIZATION;

ADHERENS JUNCTIONS; ANIMALS; ANTIGENS, CD; CADHERINS; CAPILLARY PERMEABILITY; CELLS, CULTURED; CYTOKINES; DIPEPTIDES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENOTYPE; LUNG; MALE; MATRIX METALLOPROTEINASE INHIBITORS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROVESSELS; PHENOTYPE; PULMONARY EDEMA; SEPSIS; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 84983748528     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00796.2015     Document Type: Article

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