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Volumn 113, Issue 34, 2016, Pages 9587-9592

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein

(21)  Wang, Wei a   Nguyen, Linh T T a   Burlak, Christopher b   Chegini, Fariba c   Guo, Feng c   Chataway, Tim c   Ju, Shulin d,k   Fisher, Oriana S d,l   Miller, David W e   Datta, Debajyoti f   Wu, Fang d,m   Wu, Chun Xiang a   Landeru, Anuradha a   Wells, James A f,g   Cookson, Mark R e   Boxer, Matthew B h   Thomas, Craig J h   Gai, Wei Ping c   Ringe, Dagmar d,i,j   Petsko, Gregory A d,i,j,n   more..


Author keywords

Aggregation; Caspase; Inflammasome; Parkinson's disease; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; SHORT HAIRPIN RNA; 1-(2-((1-(4-AMINO-3-CHLOROPHENYL)METHANOYL)AMINO)-3,3-DIMETHYLBUTANOYL)PYRROLIDINE-2-CARBOXYLIC ACID; 4 AMINOBENZOIC ACID DERIVATIVE; ALUMINUM POTASSIUM SULFATE; ALUMINUM SULFATE; DIPEPTIDE; IL1B PROTEIN, HUMAN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MENADIONE; NIGERICIN; PROTEIN AGGREGATE; SMALL INTERFERING RNA; SNCA PROTEIN, HUMAN;

EID: 84983688506     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1610099113     Document Type: Article
Times cited : (206)

References (57)
  • 1
    • 0031469711 scopus 로고    scopus 로고
    • The epidemiology of Parkinson's disease
    • Ben-Shlomo Y (1997) The epidemiology of Parkinson's disease.Baillieres Clin Neurol 6(1):55-68.
    • (1997) Baillieres Clin Neurol , vol.6 , Issue.1 , pp. 55-68
    • Ben-Shlomo, Y.1
  • 2
    • 79955557808 scopus 로고    scopus 로고
    • Rotenone, paraquat, and Parkinson's disease
    • Tanner CM, et al. (2011) Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 119(6):866-872.
    • (2011) Environ Health Perspect , vol.119 , Issue.6 , pp. 866-872
    • Tanner, C.M.1
  • 3
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease
    • Lang AE, Lozano AM (1998) Parkinson's disease. N Engl J Med 339:1130-1143.
    • (1998) N Engl J Med , vol.339 , pp. 1130-1143
    • Lang, A.E.1    Lozano, A.M.2
  • 5
    • 68249157080 scopus 로고    scopus 로고
    • Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
    • McKee AC, et al. (2009) Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68(7):709-735.
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.7 , pp. 709-735
    • McKee, A.C.1
  • 6
    • 1942454250 scopus 로고    scopus 로고
    • Inflammation and neurodegeneration in Parkinson's disease
    • McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord 10(Suppl 1):S3-S7.
    • (2004) Parkinsonism Relat Disord , vol.10 , pp. S3-S7
    • McGeer, P.L.1    McGeer, E.G.2
  • 7
  • 8
    • 84864772346 scopus 로고    scopus 로고
    • Association of Parkinson's disease with infections and occupational exposure to possible vectors
    • Harris MA, Tsui JK, Marion SA, Shen H, Teschke K (2012) Association of Parkinson's disease with infections and occupational exposure to possible vectors. Mov Disord 27(9):1111-1117.
    • (2012) Mov Disord , vol.27 , Issue.9 , pp. 1111-1117
    • Harris, M.A.1    Tsui, J.K.2    Marion, S.A.3    Shen, H.4    Teschke, K.5
  • 9
    • 0019517567 scopus 로고
    • Post-encephalitic Parkinsonism: Current experience
    • Rail D, Scholtz C, Swash M (1981) Post-encephalitic Parkinsonism: Current experience. J Neurol Neurosurg Psychiatr 44(8):670-676.
    • (1981) J Neurol Neurosurg Psychiatr , vol.44 , Issue.8 , pp. 670-676
    • Rail, D.1    Scholtz, C.2    Swash, M.3
  • 10
    • 77958152812 scopus 로고    scopus 로고
    • Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries
    • Henry J, Smeyne RJ, Jang H, Miller B, Okun MS (2010) Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. Parkinsonism Relat Disord 16(9):566-571.
    • (2010) Parkinsonism Relat Disord , vol.16 , Issue.9 , pp. 566-571
    • Henry, J.1    Smeyne, R.J.2    Jang, H.3    Miller, B.4    Okun, M.S.5
  • 11
    • 69549120391 scopus 로고    scopus 로고
    • Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
    • Jang H, et al. (2009) Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci USA 106(33):14063-14068.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.33 , pp. 14063-14068
    • Jang, H.1
  • 12
    • 0021921441 scopus 로고
    • Why was the 1918 influenza pandemic so lethal? The possible role of a neurovirulent neuraminidase
    • Maurizi CP (1985) Why was the 1918 influenza pandemic so lethal? The possible role of a neurovirulent neuraminidase. Med Hypotheses 16(1):1-5.
    • (1985) Med Hypotheses , vol.16 , Issue.1 , pp. 1-5
    • Maurizi, C.P.1
  • 13
    • 77955366745 scopus 로고    scopus 로고
    • Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: Implications for Parkinson's disease pathogenesis and therapies
    • Oueslati A, Fournier M, Lashuel HA (2010) Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: Implications for Parkinson's disease pathogenesis and therapies. Prog Brain Res 183:115-145.
    • (2010) Prog Brain Res , vol.183 , pp. 115-145
    • Oueslati, A.1    Fournier, M.2    Lashuel, H.A.3
  • 15
    • 34548341065 scopus 로고    scopus 로고
    • The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease
    • Michell AW, et al. (2007) The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant 16(5):461-474.
    • (2007) Cell Transplant , vol.16 , Issue.5 , pp. 461-474
    • Michell, A.W.1
  • 16
    • 77955141273 scopus 로고    scopus 로고
    • Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
    • Ulusoy A, Febbraro F, Jensen PH, Kirik D, Romero-Ramos M (2010) Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. Eur J Neurosci 32(3):409-422.
    • (2010) Eur J Neurosci , vol.32 , Issue.3 , pp. 409-422
    • Ulusoy, A.1    Febbraro, F.2    Jensen, P.H.3    Kirik, D.4    Romero-Ramos, M.5
  • 17
    • 39749196233 scopus 로고    scopus 로고
    • Selective loss of nigral dopamine neurons induced by over-expression of truncated human alpha-synuclein in mice
    • Wakamatsu M, et al. (2008) Selective loss of nigral dopamine neurons induced by over-expression of truncated human alpha-synuclein in mice. Neurobiol Aging 29(4):574-585.
    • (2008) Neurobiol Aging , vol.29 , Issue.4 , pp. 574-585
    • Wakamatsu, M.1
  • 18
    • 84867571567 scopus 로고    scopus 로고
    • Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease
    • Prasad K, Beach TG, Hedreen J, Richfield EK (2012) Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease. Brain Pathol 22(6):811-825.
    • (2012) Brain Pathol , vol.22 , Issue.6 , pp. 811-825
    • Prasad, K.1    Beach, T.G.2    Hedreen, J.3    Richfield, E.K.4
  • 19
    • 13844320376 scopus 로고    scopus 로고
    • Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
    • Li W, et al. (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci USA 102(6):2162-2167.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.6 , pp. 2162-2167
    • Li, W.1
  • 20
    • 0142154275 scopus 로고    scopus 로고
    • Alpha-synuclein degradation by serine protease neurosin: Implication for pathogenesis of synucleinopathies
    • Iwata A, et al. (2003) Alpha-synuclein degradation by serine protease neurosin: Implication for pathogenesis of synucleinopathies. Hum Mol Genet 12(20):2625-2635.
    • (2003) Hum Mol Genet , vol.12 , Issue.20 , pp. 2625-2635
    • Iwata, A.1
  • 21
    • 77950021983 scopus 로고    scopus 로고
    • Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations
    • Lewis KA, Yaeger A, DeMartino GN, Thomas PJ (2010) Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations. J Bioenerg Biomembr 42(1):85-95.
    • (2010) J Bioenerg Biomembr , vol.42 , Issue.1 , pp. 85-95
    • Lewis, K.A.1    Yaeger, A.2    DeMartino, G.N.3    Thomas, P.J.4
  • 22
    • 78650221707 scopus 로고    scopus 로고
    • Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology
    • Lewis KA, et al. (2010) Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology. Am J Pathol 177(6):3037-3050.
    • (2010) Am J Pathol , vol.177 , Issue.6 , pp. 3037-3050
    • Lewis, K.A.1
  • 23
    • 0043233011 scopus 로고    scopus 로고
    • Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro
    • Mishizen-Eberz AJ, et al. (2003) Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J Neurochem 86(4):836-847.
    • (2003) J Neurochem , vol.86 , Issue.4 , pp. 836-847
    • Mishizen-Eberz, A.J.1
  • 24
    • 21644446495 scopus 로고    scopus 로고
    • Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases
    • Sung JY, et al. (2005) Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. J Biol Chem 280(26):25216-25224.
    • (2005) J Biol Chem , vol.280 , Issue.26 , pp. 25216-25224
    • Sung, J.Y.1
  • 25
    • 51549106105 scopus 로고    scopus 로고
    • Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
    • Sevlever D, Jiang P, Yen SH (2008) Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Biochemistry 47(36):9678-9687.
    • (2008) Biochemistry , vol.47 , Issue.36 , pp. 9678-9687
    • Sevlever, D.1    Jiang, P.2    Yen, S.H.3
  • 26
    • 84928050252 scopus 로고    scopus 로고
    • Mechanisms of inflammasome activation: Recent advances and novel insights
    • Vanaja SK, Rathinam VAK, Fitzgerald KA (2015) Mechanisms of inflammasome activation: Recent advances and novel insights. Trends Cell Biol 25(5):308-315.
    • (2015) Trends Cell Biol , vol.25 , Issue.5 , pp. 308-315
    • Vanaja, S.K.1    Rathinam, V.A.K.2    Fitzgerald, K.A.3
  • 27
    • 0345189364 scopus 로고    scopus 로고
    • Yeast cells provide insight into alpha-synuclein biology and pathobiology
    • Outeiro TF, Lindquist S (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302(5651):1772-1775.
    • (2003) Science , vol.302 , Issue.5651 , pp. 1772-1775
    • Outeiro, T.F.1    Lindquist, S.2
  • 28
    • 13844320376 scopus 로고    scopus 로고
    • Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
    • Li W, et al. (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci USA 102(6):2162-2167.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.6 , pp. 2162-2167
    • Li, W.1
  • 29
  • 30
    • 77951683942 scopus 로고    scopus 로고
    • A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
    • Boxer MB, et al. (2010) A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety. ChemMedChem 5(5):730-738.
    • (2010) ChemMedChem , vol.5 , Issue.5 , pp. 730-738
    • Boxer, M.B.1
  • 31
    • 80055078029 scopus 로고    scopus 로고
    • A soluble α-synuclein construct forms a dynamic tetramer
    • Wang W, et al. (2011) A soluble α-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci USA 108(43):17797-17802.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.43 , pp. 17797-17802
    • Wang, W.1
  • 32
    • 84904961684 scopus 로고    scopus 로고
    • Potential pharmacological chaperones targeting cancer-Associated MCL-1 and Parkinson disease-associated α-synuclein
    • Oh M, et al. (2014) Potential pharmacological chaperones targeting cancer-Associated MCL-1 and Parkinson disease-associated α-synuclein. Proc Natl Acad Sci USA 111(30):11007-11012.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.30 , pp. 11007-11012
    • Oh, M.1
  • 33
    • 34548341065 scopus 로고    scopus 로고
    • The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease
    • Michell AW, et al. (2007) The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant 16(5):461-474.
    • (2007) Cell Transplant , vol.16 , Issue.5 , pp. 461-474
    • Michell, A.W.1
  • 34
    • 20744442130 scopus 로고    scopus 로고
    • A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: Implications for pathogenesis of Parkinson disease
    • Liu CW, et al. (2005) A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: Implications for pathogenesis of Parkinson disease. J Biol Chem 280(24):22670-22678.
    • (2005) J Biol Chem , vol.280 , Issue.24 , pp. 22670-22678
    • Liu, C.W.1
  • 35
    • 1942454250 scopus 로고    scopus 로고
    • Inflammation and neurodegeneration in Parkinson's disease
    • McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord 10(Suppl 1):S3-S7.
    • (2004) Parkinsonism Relat Disord , vol.10 , pp. S3-S7
    • McGeer, P.L.1    McGeer, E.G.2
  • 36
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer PL, Itagaki S, McGeer EG (1988) Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol 76(6):550-557.
    • (1988) Acta Neuropathol , vol.76 , Issue.6 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 37
    • 36249003354 scopus 로고    scopus 로고
    • Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]-PK11195 PET
    • Bartels AL, Leenders KL (2007) Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]-PK11195 PET. Mov Disord 22(13):1852-1856.
    • (2007) Mov Disord , vol.22 , Issue.13 , pp. 1852-1856
    • Bartels, A.L.1    Leenders, K.L.2
  • 38
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D, et al. (1995) Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 202(1-2):17-20.
    • (1995) Neurosci Lett , vol.202 , Issue.1-2 , pp. 17-20
    • Blum-Degen, D.1
  • 39
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M, et al. (1996) Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett 211(1):13-16.
    • (1996) Neurosci Lett , vol.211 , Issue.1 , pp. 13-16
    • Mogi, M.1
  • 40
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • Mogi M, et al. (1994) Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett 165 (1-2):208-210.
    • (1994) Neurosci Lett , vol.165 , Issue.1-2 , pp. 208-210
    • Mogi, M.1
  • 41
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi M, et al. (1994) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 180(2):147-150.
    • (1994) Neurosci Lett , vol.180 , Issue.2 , pp. 147-150
    • Mogi, M.1
  • 42
    • 49149125924 scopus 로고    scopus 로고
    • Immunotherapy for neurological diseases
    • Villoslada P, et al. (2008) Immunotherapy for neurological diseases. Clin Immunol 128(3):294-305.
    • (2008) Clin Immunol , vol.128 , Issue.3 , pp. 294-305
    • Villoslada, P.1
  • 43
    • 33747505812 scopus 로고    scopus 로고
    • Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy
    • Schwartz M, Butovsky O, Kipnis J (2006) Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy. J Neuroimmune Pharmacol 1(1):4-10.
    • (2006) J Neuroimmune Pharmacol , vol.1 , Issue.1 , pp. 4-10
    • Schwartz, M.1    Butovsky, O.2    Kipnis, J.3
  • 44
    • 33644854500 scopus 로고    scopus 로고
    • Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
    • Dinarello CA (2006) Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am J Clin Nutr 83(2):447S-455S.
    • (2006) Am J Clin Nutr , vol.83 , Issue.2 , pp. 447S-455S
    • Dinarello, C.A.1
  • 45
    • 79955557808 scopus 로고    scopus 로고
    • Rotenone, paraquat, and Parkinson's disease
    • Tanner CM, et al. (2011) Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 119(6):866-872.
    • (2011) Environ Health Perspect , vol.119 , Issue.6 , pp. 866-872
    • Tanner, C.M.1
  • 46
    • 0036799487 scopus 로고    scopus 로고
    • Multiple caspases are activated after traumatic brain injury: Evidence for involvement in functional outcome
    • Knoblach SM, et al. (2002) Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. J Neurotrauma 19(10):1155-1170.
    • (2002) J Neurotrauma , vol.19 , Issue.10 , pp. 1155-1170
    • Knoblach, S.M.1
  • 47
    • 1442275733 scopus 로고    scopus 로고
    • Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Furuya T, et al. (2004) Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci 24(8):1865-1872.
    • (2004) J Neurosci , vol.24 , Issue.8 , pp. 1865-1872
    • Furuya, T.1
  • 48
    • 79956199921 scopus 로고    scopus 로고
    • Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing
    • Cullen V, et al. (2011) Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. Ann Neurol 69(6):940-953.
    • (2011) Ann Neurol , vol.69 , Issue.6 , pp. 940-953
    • Cullen, V.1
  • 49
    • 0037677549 scopus 로고    scopus 로고
    • Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation
    • Liu B, Gao HM, Hong JS (2003) Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation. Environ Health Perspect 111(8):1065-1073.
    • (2003) Environ Health Perspect , vol.111 , Issue.8 , pp. 1065-1073
    • Liu, B.1    Gao, H.M.2    Hong, J.S.3
  • 50
    • 0033601995 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity
    • Klevenyi P, et al. (1999) Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport 10(3):635-638.
    • (1999) Neuroreport , vol.10 , Issue.3 , pp. 635-638
    • Klevenyi, P.1
  • 51
    • 0036460861 scopus 로고    scopus 로고
    • In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain
    • Ling Z, et al. (2002) In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov Disord 17(1):116-124.
    • (2002) Mov Disord , vol.17 , Issue.1 , pp. 116-124
    • Ling, Z.1
  • 52
    • 79955921784 scopus 로고    scopus 로고
    • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
    • Gao H-M, et al. (2011) Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 119(6):807-814.
    • (2011) Environ Health Perspect , vol.119 , Issue.6 , pp. 807-814
    • Gao, H.-M.1
  • 53
    • 0037677549 scopus 로고    scopus 로고
    • Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation
    • Liu B, Gao HM, Hong JS (2003) Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation. Environ Health Perspect 111(8):1065-1073.
    • (2003) Environ Health Perspect , vol.111 , Issue.8 , pp. 1065-1073
    • Liu, B.1    Gao, H.M.2    Hong, J.S.3
  • 54
    • 0033601995 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity
    • Klevenyi P, et al. (1999) Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport 10(3):635-638.
    • (1999) Neuroreport , vol.10 , Issue.3 , pp. 635-638
    • Klevenyi, P.1
  • 55
    • 0036460861 scopus 로고    scopus 로고
    • In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain
    • Ling Z, et al. (2002) In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov Disord 17(1):116-124.
    • (2002) Mov Disord , vol.17 , Issue.1 , pp. 116-124
    • Ling, Z.1
  • 56
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y, et al. (2001) Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 98(25):14669-14674.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.25 , pp. 14669-14674
    • Du, Y.1
  • 57
    • 84983651724 scopus 로고    scopus 로고
    • Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
    • Bassil F, et al. (2016) Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy. Proc Natl Acad Sci USA 113:9593-9598.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 9593-9598
    • Bassil, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.