Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro

Biomedicine and Pharmacotherapy

Volumn 80, Issue , 2016, Pages 227-235

  Li, Yali ^a   Yang, Fangfang ^a   Zheng, Weidong ^b   Hu, Mingxing ^a   Wang, Juanxiu ^a   Ma, Sisi ^a   Deng, Yuanle ^a   Luo, Yi ^a   Ye, Tinghong ^a   Yin, Wenya ^a  

^a SICHUAN UNIVERSITY   (China)

^b Sichuan Food and Drug Inspection and Testing Institute   (China)

Author keywords

Apoptosis; Migration and invasion; Non small cell lung carcinoma; P. granatum leaves extract (PLE); Reactive oxygen species

Indexed keywords

BETA ACTIN; ELLAGIC ACID; GELATINASE A; GELATINASE B; PLANT MEDICINAL PRODUCT; POMEGRANATE EXTRACT; PUNICALAGIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PLANT EXTRACT; TANNIN;

A-549 CELL LINE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APOPTOSIS RATE; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHRONOPHARMACOLOGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ETHNOPHARMACOLOGY; FLOW CYTOMETRY; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INTRINSIC ACTIVITY; L-02 CELL LINE; LL/2 (LLC1) CELL LINE; MIGRATION INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NCI-H1299 CELL LINE; NON SMALL CELL LUNG CANCER; NONHUMAN; NORMAL HUMAN; PLANT LEAF; POMEGRANATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VERO CELL LINE; ANIMAL; CELL CYCLE; CELL MOTION; CELL SHAPE; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; ENZYMOLOGY; LUNG TUMOR; LYTHRACEAE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; STATISTICAL MODEL; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; ELLAGIC ACID; HEK293 CELLS; HUMANS; HYDROLYZABLE TANNINS; LINEAR MODELS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NEOPLASM INVASIVENESS; PLANT EXTRACTS; PLANT LEAVES; PUNICACEAE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VERO CELLS;

EID: 84983448817     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.03.023     Document Type: Article

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