Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 2, 2015, Pages

  Hunt, Harriet ^a   Stanworth, Simon ^b,c   Curry, Nicola ^d   Woolley, Tom ^e   Cooper, Chris ^a   Ukoumunne, Obioha ^a   Zhelev, Zhivko ^a   Hyde, Chris ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d CHURCHILL HOSPITAL   (United Kingdom)

^e QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLEEDING; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; HEMATOLOGICAL PROCEDURE; HOSPITAL ADMISSION; HUMAN; INJURY; INJURY SCALE; INTERMETHOD COMPARISON; INTERNATIONAL NORMALIZED RATIO; PRIORITY JOURNAL; PROTHROMBIN TIME; REVIEW; ROTATIONAL THROMBOELASTOMETRY; SENSITIVITY AND SPECIFICITY; STANDARD; SYSTEMATIC REVIEW; THROMBOELASTOGRAPHY; TRAUMA INDUCED COAGULOPATHY; ADULT; BLOOD; BLOOD COAGULATION DISORDERS; COMPLICATION; CROSS-SECTIONAL STUDY; HEMORRHAGE; META ANALYSIS; PROCEDURES; STANDARDS;

ADULT; BLOOD COAGULATION DISORDERS; CROSS-SECTIONAL STUDIES; HEMORRHAGE; HUMANS; THROMBELASTOGRAPHY; WOUNDS AND INJURIES;

EID: 84934344293     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD010438.pub2     Document Type: Review

References (97)

1. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, et al. Functional definition and characterization of acute traumatic coagulopathy. Critical Care Medicine 2011;39(12):2652-8.
2. Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. Journal of Thrombosis and Haemostasis 2007;5(2):289-95.
3. Woolley T, Midwinter M, Spencer P, Watts S, Doran C, Kirkman E. Utility of interim ROTEM values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients. Injury 2013;44:593-9.
4. Afshari A. Evidence based evaluation of immuno-coagulatory interventions in critical care. Danish Medical Bulletin 2011;58:B4316.
5. Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD007871.pub2]
6. Anonymous Abstracts of Papers to be Presented at the Annual Scientific Meeting of the Trauma Association of Canada, May 10-12, 2007, Ottowa, Ontario, Canada. The Journal of TRAUMA - Injury, Infection & Critical Care 2007;62(3):787-804.
7. Anonymous Congress of the German Interdisciplinary Association of Intensive Care and Emergency Medicine 3-6 December 2008 CCH Congress Centre, Hamburg [Kongress der Deutschen Interdisziplinären Vereinigung für Intensivmedizin und Notfallmedizin 3-6 Dezember 2008 CCH Congress Center, Hamburg]. Intensivmedizin und Notfallmedizin. 2008; Vol. 45 supplement:1-100.
8. Avikainen V. Coagulation disorders in severely and critically injured patients. Annales Chirurgiae et Gynaecologiae 1977;66:269-77.
9. Blackbourne LH, Baer DG, Eastridge BJ, Renz EM, Chung KK, DuBose J, et al. Military medical revolution: deployed hospital and en route care. Journal of Trauma and Acute Care Surgery 2012;73:S378-87.
10. Cap AP, Spinella PC. Severity of head injury is associated with increased risk of coagulopathy in combat casualties. The Journal of TRAUMA - Injury, Infection & Critical Care 2011;71:S78-81.
11. Carroll R C, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, et al. Early evaluation of acute traumatic coagulopathy by thrombelastography. Translational Research 2009;154:34-9.
12. Chandler WL, Ferrell C, Trimble S, Moody S. Development of a rapid emergency hemorrhage panel. Transfusion 2010;50:2547-52.
13. Cheng L, Yao X. Significance of thrombelastogram in the study on coagulation disorder of patients with severe traumatic brain injury. [Chinese]. Chinese Journal of Contemporary Neurology and Neurosurgery 2009;9:270-4.
14. Cotton BA, Faz G, Hatch QM, Radwan ZA, Podbielski J, Wade C, et al. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. The Journal of TRAUMA - Injury, Infection & Critical Care 2011;71:407-14.
15. Cotton BA, Minei KM, Radwan ZA, Matijevic N, Pivalizza E, Podbielski J, et al. Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients. Journal of Trauma and Acute Care Surgery 2012;72:1470-7.
16. Cotton BA, Harvin JA, Kostousouv V, Minei KM, Radwan ZA, Schoechl H, et al. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. Journal of Trauma and Acute Care Surgery 2012;73:365-70.
17. Craft R, Carroll R, Langdon R, Clanton C, Snider C, Lawson C, et al. Point-of-care thrombelastography assays for coagulopathy in trauma patients. Transfusion 2008;48:81A.
18. Curry NS, Rourke C, Khan S, Beavis J, Kingsland S, Brohi K, et al. Fibrinogen replacement in traumatic bleeding. Journal of Thrombosis and Haemostasis 2011;9:938.
19. Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, et al. Trauma haemorrhage: evolving role of ROTEM for predicting transfusion requirements. Shock 2009;32:15.
20. Davenport R, Rourke C, Manson J, De'Ath H, Platton S, Coates A, et al. Activated protein C is a principle mediator of acute traumatic coagulopathy. Journal of Thrombosis and Haemostasis 2011;9:51-2.
21. David J-S, Marchal V, Levrat A, Inaba K. Which is the most effective strategy: early detection of coagulopathy with thromboelastometry or use of hemostatic factors or both?. Critical Care (London, England) 2011;15:433; author reply 433.
22. Differding JA, Underwood SJ, Van PY, Khaki RA, Spoerke NJ, Schreiber MA. First Place Residents' Competition: trauma induces a hypercoagulable state that is resistant to hypothermia as measured by thrombelastogram. American Journal of Surgery 2011;201:585-9.
23. Ettinger MG. Coagulation abnormalities in subarachnoid hemorrhage. Stroke; a journal of cerebral circulation 1970;1:139-42.
24. Floccard B, Rugeri L, Faure A, Saint Denis M, Boyle EM, Peguet O, et al. Early coagulopathy in trauma patients: an on-scene and hospital admission study. Injury 2012;43:26-32.
25. Franschman G, Boer C, Andriessen TM, van der Naalt J, Horn J, Haitsma I, et al. Multicenter evaluation of the course of coagulopathy in patients with isolated traumatic brain injury: relation to CT characteristics and outcome. Journal of Neurotrauma 2012;29:128-36.
26. Frink M, Zeckey C, Mommsen P, Haasper C, Krettek C, Hildebrand F. Polytrauma management - a single centre experience. Injury 2009;40:S5-S11.
27. Hagemo JS. Prehospital detection of traumatic coagulopathy. Transfusion 2013;53:48S-51S.
28. Hagemo JS, Naess PA, Johansson P, Windeløv NA, Cohen MJ, Røislien J, et al. Evaluation of TEG and RoTEM inter-changeability in trauma patients. Injury 2013;44:600-5.
29. Jambor C, Heindl B, Spannagl M, Rolfes C, Dinges G K, Frietsch T. Blood transfusion haemostaseological management in polytrauma - status of patient-oriented diagnostic methods. Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie 2009;44:200-9.
30. Jeger V, Zimmermann H, Exadaktylos AK. Can RapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?. The Journal of TRAUMA - Injury, Infection & Critical Care 2009;66:1253-7.
31. Jeger V, Zimmermann H, Exadaktylos AK. Thrombelastography in trauma, the closer the better. The Journal of TRAUMA - Injury, Infection & Critical Care 2010;68:508.
32. Jeger V, Willi S, Liu T, Omert L, Orr A, Popovsky MA, et al. A comparison of point of care thrombelastography (TEG) versus conventional coagulation tests (CCT) in the emergency department management of trauma. British Journal of Surgery 2011;98:15.
33. Jeger V, Willi S, Liu T, Omert L, Orr A, Popovsky MA, et al. Comparison of point-of-care thrombelastography versus conventional coagulation tests in the emergency department management of trauma. Critical Care 2011;15:S154.
34. Jeger V, Willi S, Liu T, Yeh DD, De Moya M, Zimmermann H, et al. The rapid TEG alpha-angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients. ScientificWorldJournal 2012;2012:821794.
35. Kashuk J, Moore E, Wohlauer M, Johnson J, Pezold M, Lawrence J, et al. Initial experiences with point of care (POC) rapid thrombelastography (TEG) for management of life threatening postinjury coagulopathy (PIC). Shock 2010;33:27-8.
36. Kashuk JL, Moore EE, Wohlauer M, Johnson JL, Pezold M, Lawrence J, et al. Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathy. Transfusion 2012;52:23-33.
37. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL. Usefulness of thromboelastography in assessment of trauma patient coagulation. Journal of Trauma 1995;39:170.
38. McCann K, Walsh M, Castellino F, Yount R, Thomas S, Evans E, et al. Expanding role of platelet mapping in traumatic brain injury. Journal of Neurotrauma 2011;28 (6):A51.
39. Messenger BM, Craft RM, Carroll RC, Daley BJ, Enderson B, Snider CG. TEG-guided massive transfusion in trauma patients. Anesthesia and Analgesia. 2011; Vol. 112 Suppl 5:S-90.
40. Nystrup KB, Windelov NA, Thomsen AB, Johansson PI. Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine 2011;19. [DOI: 10.1186/1757-7241-19-52.]
41. Ostrowski SR, Sorensen AM, Larsen CF, Johansson PI. Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study. Scandinavian Journal of Trauma, Resuscitation & Emergency Medicine 2011;19:64.
42. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. Journal of Trauma and Acute Care Surgery 2012;73:60-6.
43. Ostrowski SR, Sorensen AM, Windelov NA, Perner A, Welling KL, Wanscher M, et al. High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine 2012;20:27. [DOI: 10.1186/1757-7241-20-27.]
44. Park MS, Salinas J, Wade CE, Wang JF, Martini WJ, Pusateri AE, et al. Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients. The Journal of TRAUMA - Injury, Infection & Critical Care 2008;64:S188-94.
45. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, et al. Thromboelastography as a better Indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. The Journal of Trauma 2009;67(2):266-76.
46. Pezold M, Moore EE, Wohlauer M, Sauaia A, Gonzalez E, Banerjee A, et al. Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes. Surgery 2012;151:48-54.
47. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. The Journal of TRAUMA - Injury, Infection & Critical Care 2008;64:S64-8.
48. Raza I, Davenport R, Brohi K, Rourke C, Platton S, Khan S, et al. Dilutional coagulopathy following blood transfusion in trauma. Journal of Thrombosis and Haemostasis 2011;9:692-3.
49. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. Occult activation of fibrinolysis in trauma. Journal of Thrombosis and Haemostasis 2011;9:848.
50. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. Journal of Thrombosis and Haemostasis 2013;11:307-14.
51. Rizoli SB, Scarpelini S, Callum J, Nascimento B, Mann KG, Pinto R, et al. Clotting factor deficiency in early trauma-associated coagulopathy. The Journal of TRAUMA - Injury, Infection & Critical Care 2011;71:S427-34.
52. Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. Journal of Thrombosis and Haemostasis 2012;10:1342-51.
53. Schochl H. Intraoperative coagulation management in polytrauma. [German]. Journal fur Anasthesie und Intensivbehandlung 2005;12:119-22.
54. Schochl H, Frietsch T, Drews P, Jambor C. 21st Annual Meeting of the Eastern Association for the Surgery of Trauma, Jacksonville, FL, USA, January 15-19, 2008. The Journal of TRAUMA - Injury, Infection & Critical Care. 2007; Vol. 63:1426-40.
55. Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. The Journal of TRAUMA - Injury, Infection & Critical Care 2009;67:125-31.
56. Schochl H, Solomon C, Redl H, Bahrami S. Rotational thromboelastometry in patients with severe traumatic brain injury: possible risk stratification?. Shock 2011;36:31.
57. Schochl H, Solomon C, Redl H, Bahrami S. Rotational thromboelastometric (rotem (r)) test results in the emergency room predicts massive transfusion in major trauma patients. Shock 2011;36:30.
58. Schochl H, Cotton B, Inaba K, Nienaber U, Fischer H, Voelckel W, et al. FIBTEM provides early prediction of massive transfusion in trauma. Critical Care (London, England) 2011;15:R265.
59. Schochl H, Solomon C, Voelckel W. Goal-directed coagulation management in trauma-related bleeding. Shock 2012;38:32-3.
60. Schochl H, Solomon C, Voelckel W, Redl H, Bahrami S. Hyperfibrinolysis in trauma. Shock 2012;38:7-8.
61. Schreiber MA, Differding J, Thorborg P, Mayberry JC, Mullins RJ, Timberlake GA, et al. Hypercoagulability is most prevalent early after injury and in female patients. The Journal of TRAUMA - Injury, Infection & Critical Care 2005;58:475-81.
62. Schreiber M, Park M, Kashuk J, Park M. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time: discussion. The Journal of TRAUMA - Injury, Infection & Critical Care 2009;67:275-6.
63. Shah B, Subramanium A, Agrawal D, Mukhopadhyay A. Thromboelastography-viscoelastic haemostatic assay (VHA) as an indicator of overt disseminated intravascular coagulation in brain injury patients within 24 hours after injury. Brain Injury 2012;26(4-5):586-7.
64. Sharma P, Saxena R. A novel thromboelastographic score to identify overt disseminated intravascular coagulation resulting in a hypocoagulable state. American Journal of Clinical Pathology 2010;134:97-102.
65. Sixta SL, Schreiber M, Cohen M, Wade CE, Holcomb JB, Cotton BA. Coagulopathy after head injury: uncommon by conventional coagulation testing and associated with platelet-fibrinogen dysfunction. Journal of Surgical Research 2013;179(2):272-3.
66. Solomon C, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, et al. Platelet function following trauma. A multiple electrode aggregometry study. Thrombosis and Haemostasis 2011;106:322-30.
67. Spoors C, Rourke C, Manson J, De'Ath H, Raza I, Khan S, et al. Rotem indices of platelet function in acute traumatic coagulopathy. British Journal of Surgery. 2011; Vol. 98 (S2):8:O24.
68. Tanaka KA, Bolliger D, Vadlamudi R, Nimmo A. Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma. Journal of Cardiothoracic and Vascular Anesthesia 2012;26:1083-93.
69. Tapia NM, Chang A, Norman M, Welsh F, Scott B, Wall M J Jr, et al. TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. Journal of Trauma and Acute Care Surgery 2013;74:378-86.
70. Theusinger OM, Wanner GA, Emmert MY, Billeter A, Eismon J, Seifert B, et al. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM (R)) Is associated with higher mortality in patients with severe trauma. Anesthesia and Analgesia 2011;113:1003-12.
71. Theusinger OM, Levy JH. Point of care devices for assessing bleeding and coagulation in the trauma patient. Anesthesiology Clinics 2013;31:55-65.
72. Watters JM, Sambasivan CN, Zink K, Kremenevskiy I, Englehart MS, Underwood SJ, et al. Splenectomy leads to a persistent hypercoagulable state after trauma. American Journal of Surgery 2010;199:646-51.
73. Weiss G, Lison S, Glaser M, Herberger S, Johanning K, Strasser T, et al. Observational study of fibrinogen concentrate in massive hemorrhage: evaluation of a multicenter register. Blood Coagulation & Fibrinolysis 2011;22:727-34.
74. Windelov NA, Welling KL, Ostrowski SR, Johansson PI. The prognostic value of thrombelastography in identifying neurosurgical patients with worse prognosis. Blood Coagulation and Fibrinolysis 2011;22:416-9.
75. Wohlauer MV, Thomas SG, Moore EE, Walsh M, Musunuru H, Davis PK, et al. Platelet dysfunction as an early marker for traumatic brain induced coagulopathy in the absence of platelet inhibitors. Journal of the American College of Surgeons 2012;1:S60.
76. Woolley T, Midwinter M, Spencer P, Doran C, Kirkman E. Early determination of hypocoagulopathy based on interim ROTEM values for clot strength. British Journal of Surgery 2010;97:21.
77. Barts, The London School of Medicine, Dentistry The science of the bleeding obvious! Trauma surgery. Summer Science Exhibition 2011, The Royal Society 5-10 July 2011.
78. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CE, Glasziou PE, Irwig LE, et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Annals of Internal Medicine 2003;138(1):W1-12.
79. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. The Journal of TRAUMA - Injury, Infection & Critical Care 2003;54(6):1127-30.
80. Brohi, K Query concerning 2003 paper [personal communication]. email to: H Hunt 14 September 2013.
81. Deeks JJ, Bossuyt PM, Gatsonis M, Constantine A [editors]. Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. The Cochrane Collaboration, 2010, issue Version 1.0.
82. Doran CM, Woolley T, Midwinter MJ. Surgeon General's Operational Policy Letter 10/07 - Management of massive haemorrhage on operations. Defence Medical Services Department 05/01/02, dated June 14, 2007 quoted in Feasibility of using rotational thromboelastometry to assess coagulation status of combat casualties in a deployed setting. The Journal of TRAUMA - Injury, Infection & Critical Care 2010; Vol. 69 Suppl 1 July:40-8.
83. Dzik WH. Predicting hemorrhage using preoperative coagulation screening assays. Current Hematology Reports 2004;3(5):324-30.
84. Frith D, Goslings JC, Gaardner C, Maegele M, Cohen MJ, Allard S, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. Journal of Thrombosis and Haemostasis 2010;8:1919-25.
85. Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point of care coagulation devices. International Anaesthesia Research Society 2008;106(5):1366-75.
86. Hess JR, Lindell AL, Stansbury LG, Dutton RP, Scalea TM. The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. Transfusion 2009;49(1):34-9.
87. Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, et al. Causes of death in U.S. Special Operations forces in the global war on terrorism. Annals of Surgery 2007;245(6):968-91.
88. Hunt H, Hyde C, Stanworth S, Curry N, Perel P, Woolley T, et al. Thromboelastography (TEG) and thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding. Cochrane Database of Systematic Reviews 2013, Issue 3. [DOI: 10.1002/14651858.CD010438]
89. Hunt H, Hyde CJ, Stanworth S, Curry N, Perel P, Woolley T, et al. A systematic review of studies indicating the additional prognostic value of tests of global haemostasis (TEG/ROTEM) in the immediate care of adult trauma patients. PROSPERO-registered protocol 7 April 2014; Vol. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014009060.
90. Macaskill P, Gatsonis C, Deeks JJ, Harbord RM, Takwoingi Y. Chapter 10: Analysing and Presenting Results. In: Deeks JJ, Bossuyt PM, Gatsonis C editor(s). Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. 1.0. The Cochrane Collaboration, 2010.
91. MacLeod JB, Lynn M, McKenney MG, Dohn SM, Murthda M. Early coagulopathy predicts mortality in trauma. The Journal of TRAUMA - Injury, Infection & Critical Care 2003;55(1):39-44.
92. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 2007;38(3):298-304.
93. Reitsma JB, Rutjes AWS, Whiting P, Vlassov VV, Leeflang MMG, Deeks JJ. Chapter 9: Assessing methodological quality. In: Deeks JJ, Bossuyt PM, Gatsonis C (editors), Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version1.0.0. The Cochrane Collaboration, 2009. Available from: http://srdta.cochrane.org/.
94. The Nordic Cochrane Centre. Review Manager (RevMan). 5.2. Copenhagen: The Cochrane Collaboration, 2012.
95. Sankarankutty A, Nascimento B, da Luz LT, Rizoli S. TEG and ROTEM in trauma: similar test but different results. World Journal of Emergency Surgery 2012;Suppl 1:S3.
96. Spinella PC, Holcomb JB. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Reviews 2009;23:231-40.
97. Stainsby D, MacLennan S, Thomas D, Isaac J, Hamilton PJ. Guidelines on the management of massive blood loss. British Journal of Haematology 2006;135:634-41.