Viscoelastic methods of blood clotting assessment - a multidisciplinary review

Frontiers in Medicine

Volumn 2, Issue SEP, 2015, Pages

  Benes, Jan ^a,b   Zatloukal, Jan ^a   Kletecka, Jakub ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Coagulation; Point of care testing; Thrombosis; Transfusion; Trauma induced coagulopathy; Viscoelastic methods

Indexed keywords

EID: 85015139188     PISSN: None     EISSN: 2296858X     Source Type: Journal    
DOI: 10.3389/fmed.2015.00062     Document Type: Review

References (58)

1. Hartert H. Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klin Wochenschr (1948) 26(37):577-83. doi:10.1007/BF01697545
2. Lier H, Böttiger BW, Hinkelbein J, Krep H, Bernhard M. Coagulation management in multiple trauma: a systematic review. Intensive Care Med (2011) 37(4):572-82. doi:10.1007/s00134-011-2139-y
3. Woolley T, Midwinter M, Spencer P, Watts S, Doran C, Kirkman E. Utility of interim ROTEM(®) values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients. Injury (2013) 44(5):593-9. doi:10.1016/j.injury.2012.03.018
4. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med (2011) 39(12):2652-8. doi:10.1097/CCM.0b013e3182281af5
5. Hincker A, Feit J, Sladen RN, Wagener G. Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery. Crit Care (2014) 18(5):549. doi:10.1186/s13054-014-0549-2
6. Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg (2008) 106(5):1366-75. doi:10.1213/ane.0b013e318168b367
7. Keene DD, Nordmann GR, Woolley T. Rotational thromboelastometry-guided trauma resuscitation. Curr Opin Crit Care (2013) 19(6):605-12. doi:10.1097/MCC.0000000000000021
8. Gonzalez E, Kashuk JL, Moore EE, Silliman CC. Differentiation of enzymatic from platelet hypercoagulability using the novel thrombelastography parameter delta (delta). J Surg Res (2010) 163(1):96-101. doi:10.1016/j.jss.2010.03.058
9. Schaden E, Schober A, Hacker S, Kozek-Langenecker S. Ecarin modified rotational thrombelastometry: a point-of-care applicable alternative to monitor the direct thrombin inhibitor argatroban. Wien Klin Wochenschr (2013) 125(5-6):156-9. doi:10.1007/s00508-013-0327-1
10. Schaden E, Schober A, Hacker S, Spiss C, Chiari A, Kozek-Langenecker S. Determination of enoxaparin with rotational thrombelastometry using the prothrombinase-induced clotting time reagent. Blood Coagul Fibrinolysis (2010) 21(3):256-61. doi:10.1097/MBC.0b013e328337014c
11. Dutton RP. Haemostatic resuscitation. Br J Anaesth (2012) 109(Suppl 1):i39-46. doi:10.1093/bja/aes389
12. Ho AMH, Dion PW, Yeung JHH, Holcomb JB, Critchley LAH, Ng CSH, et al. Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion. Anesthesiology (2012) 116(3):716-28. doi:10.1097/ALN.0b013e318245c47b
13. Miller TE. New evidence in trauma resuscitation-is 1:1:1 the answer? Perioper Med (Lond) (2013) 2(1):13. doi:10.1186/2047-0525-2-13
14. Dutton RP. Management of traumatic haemorrhage-the US perspective. Anaesthesia (2015) 70(Suppl 1):108-11,e38. doi:10.1111/anae.12894
15. Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, et al. Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. J Trauma Acute Care Surg (2014) 76(3):561-7. doi:10.1097/TA.0000000000000146 discussion 567
16. Khan S, Davenport R, Raza I, Glasgow S, De'Ath HD, Johansson PI, et al. Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Med (2015) 41(2):239-47. doi:10.1007/s00134-014-3584-1
17. Seghatchian J, Samama MM. Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathy. Transfus Apher Sci (2012) 47(2):235-43. doi:10.1016/j.transci.2012.06.001
18. Frith D, Brohi K. The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care (2012) 18(6):631-6. doi:10.1097/MCC.0b013e3283599ab9
19. Cap A, Hunt B. Acute traumatic coagulopathy. Curr Opin Crit Care (2014) 20(6):638-45. doi:10.1097/MCC.0000000000000158
20. Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost (2012) 10(7):1342-51. doi:10.1111/j.1538-7836.2012.04752.x
21. Rizoli SB, Scarpelini S, Callum J, Nascimento B, Mann KG, Pinto R, et al. Clotting factor deficiency in early trauma-associated coagulopathy. J Trauma (2011) 71(5 Suppl 1):S427-34. doi:10.1097/TA.0b013e318232e5ab
22. Inaba K, Karamanos E, Lustenberger T, Schöchl H, Shulman I, Nelson J, et al. Impact of fibrinogen levels on outcomes after acute injury in patients requiring a massive transfusion. J Am Coll Surg (2013) 216(2):290-7. doi:10.1016/j.jamcollsurg.2012.10.017
23. Hagemo JS, Stanworth S, Juffermans NP, Brohi K, Cohen M, Johansson PI, et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Crit Care (2014) 18(2):R52. doi:10.1186/cc13798
24. Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost (2010) 8(9):1919-25. doi:10.1111/j.1538-7836.2010.03945.x
25. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg (2011) 254(2):194-200. doi:10.1097/SLA.0b013e318226113d
26. Gando S, Tedo I, Kubota M. Posttrauma coagulation and fibrinolysis. Crit Care Med (1992) 20(5):594-600. doi:10.1097/00003246-199205000-00009
27. Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg (2012) 255(2):379-85. doi:10.1097/SLA.0b013e318235d9e6
28. Schöchl H, Voelckel W, Maegele M, Solomon C. Trauma-associated hyperfibrinolysis. Hamostaseologie (2012) 32(1):22-7. doi:10.5482/ha-1178
29. Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, Chin TL, et al. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg (2013) 75(6):961-7. doi:10.1097/TA.0b013e3182aa9c9f discussion 967
30. Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth (2008) 100(6):792-7. doi:10.1093/bja/aen083
31. Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, et al. Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res (2009) 154(1):34-9. doi:10.1016/j.trsl.2009.04.001
32. Schöchl H, Frietsch T, Pavelka M, Jámbor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma (2009) 67(1):125-31. doi:10.1097/TA.0b013e31818b2483
33. Tauber H, Innerhofer P, Breitkopf R, Westermann I, Beer R, El Attal R, et al. Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'. Br J Anaesth (2011) 107(3):378-87. doi:10.1093/bja/aer158
34. Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg (2010) 252(3):434-42. doi:10.1097/SLA.0b013e3181f09191 discussion 443
35. Spahn DR. TEG®-or ROTEM®-based individualized goal-directed coagulation algorithms: don't wait-act now! Crit Care (2014) 18(6):637. doi:10.1186/s13054-014-0637-3
36. Schöchl H, Maegele M, Solomon C, Görlinger K, Voelckel W. Early and individualized goal-directed therapy for trauma-induced coagulopathy. Scand J Trauma Resusc Emerg Med (2012) 20:15. doi:10.1186/1757-7241-20-15
37. Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care (2010) 14(2):R55. doi:10.1186/cc8948
38. Schöchl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care (2011) 15(2):R83. doi:10.1186/cc10078
39. Kashuk JL, Moore EE, Le T, Lawrence J, Pezold M, Johnson JL, et al. Noncitrated whole blood is optimal for evaluation of postinjury coagulopathy with point-of-care rapid thrombelastography. J Surg Res (2009) 156(1):133-8. doi:10.1016/j.jss.2009.03.046
40. Nardi G, Agostini V, Rondinelli B, Russo E, Bastianini B, Bini G, et al. Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs. Crit Care (2015) 19(1):83. doi:10.1186/s13054-015-0817-9
41. Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK. Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Crit Care (2014) 18(5):518. doi:10.1186/s13054-014-0518-9
42. Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 17(2):R76. doi:10.1186/cc12685
43. Johansson PI, Sølbeck S, Genet G, Stensballe J, Ostrowski SR. Coagulopathy and hemostatic monitoring in cardiac surgery: an update. Scand Cardiovasc J (2012) 46(4):194-202. doi:10.3109/14017431.2012.671487
44. Lisman T, Porte RJ. Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood (2010) 116(6):878-85. doi:10.1182/blood-2010-02-261891
45. Clevenger B, Mallett SV. Transfusion and coagulation management in liver transplantation. World J Gastroenterol (2014) 20(20):6146-58. doi:10.3748/wjg.v20.i20.6146
46. Wikkelsoe AJ, Afshari A, Wetterslev J, Brok J, Moeller AM. Monitoring patients at risk of massive transfusion with thrombelastography or thromboelastometry: a systematic review. Acta Anaesthesiol Scand (2011) 55(10):1174-89. doi:10.1111/j.1399-6576.2011.02534.x
47. Weber CF, Görlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology (2012) 117(3):531-47. doi:10.1097/ALN.0b013e318264c644
48. National Institute for Health and Care Excellence. Detecting, Managing and Monitoring Haemostasis: Viscoelastometric Point-of-Care Testing (ROTEM, TEG and Sonoclot Systems) [Internet]. (2014). Available from: http://www.nice.org.uk/guidance/dg13
49. Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth (2012) 109(6):851-63. doi:10.1093/bja/aes361
50. Brenner T, Schmidt K, Delang M, Mehrabi A, Bruckner T, Lichtenstern C, et al. Viscoelastic and aggregometric point-of-care testing in patients with septic shock-cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand (2012) 56(10):1277-90. doi:10.1111/j.1399-6576.2012.02750.x
51. Haase N, Ostrowski SR, Wetterslev J, Lange T, Møller MH, Tousi H, et al. Thromboelastography in patients with severe sepsis: a prospective cohort study. Intensive Care Med (2015) 41(1):77-85. doi:10.1007/s00134-014-3552-9
52. Müller MC, Meijers JCM, Vroom MB, Juffermans NP. Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review. Crit Care (2014) 18(1):R30. doi:10.1186/cc13721
53. Yang Y, Yao Z, Dai W, Shi P, Luo L, Zhang C. Changes of thrombelastography in patients undergoing elective primary total knee and total hip replacement with low molecular heparin prophylaxis. J Orthop Surg Res (2014) 9:52. doi:10.1186/s13018-014-0052-0
54. Bai J, Zheng QW, Fu SH, Li XX, Li YR, Zhou Y, et al. Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people. Int J Clin Exp Med (2013) 6(4):310-9
55. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, et al. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma (2009) 67(2):266-75; discussion 275-6. doi:10.1097/TA.0b013e3181ae6f1c
56. Müller M, Balvers K, Binnekade JM, Curry N, Stanworth S, Gaarder C, et al. Thromboelastometry and organ failure in trauma patients: a prospective cohort study. Crit Care (2014) 18(6):687. doi:10.1186/s13054-014-0687-6
57. Patel R, Cook DJ, Meade MO, Griffith LE, Mehta G, Rocker GM, et al. Burden of illness in venous thromboembolism in critical care: a multicenter observational study. J Crit Care (2005) 20(4):341-7. doi:10.1016/j.jcrc.2005.09.014
58. Eller T, Busse J, Dittrich M, Flieder T, Alban S, Knabbe C, et al. Dabigatran, rivaroxaban, apixaban, argatroban and fondaparinux and their effects on coagulation POC and platelet function tests. Clin Chem Lab Med (2014) 52(6):835-44. doi:10.1515/cclm-2013-0936