Roles of thrombelastography and thromboelastometry for patient blood management in cardiac surgery

Transfusion Medicine Reviews

Volumn 27, Issue 4, 2013, Pages 213-220

  Bolliger, Daniel ^a   Tanaka, Kenichi A ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR CONCENTRATE; FIBRINOGEN CONCENTRATE; FRESH FROZEN PLASMA; HEMOGLOBIN; HEMOSTATIC AGENT; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOCYTE CONCENTRATE;

ARTICLE; BLEEDING; BLOOD TRANSFUSION; CASE CONTROL STUDY; COMPARATIVE STUDY; CRYOPRECIPITATE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; HEART SURGERY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; SYSTEMATIC REVIEW (TOPIC); THROMBOCYTE COUNT; THROMBOCYTE FUNCTION ANALYZER; THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY;

ALGORITHMS; BLOOD COAGULATION FACTORS; BLOOD PLATELETS; BLOOD TRANSFUSION; CARDIAC SURGICAL PROCEDURES; CLINICAL TRIALS AS TOPIC; ELASTICITY; ERYTHROCYTES; HEMATOCRIT; HEMODILUTION; HEMOGLOBINS; HEMOSTASIS; HUMANS; ODDS RATIO; PLASMA; PLATELET COUNT; PLATELET TRANSFUSION; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RETROSPECTIVE STUDIES; THROMBELASTOGRAPHY; TREATMENT OUTCOME; VISCOSITY;

EID: 84886749024     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2013.08.004     Document Type: Article

References (62)

1. Johnson J.L., Moore E.E., Kashuk J.L., Banerjee A., Cothren C.C., Biffl W.L., et al. Effect of blood products transfusion on the development of postinjury multiple organ failure. Arch Surg 2010, 145:973-977.
2. Karkouti K., Wijeysundera D.N., Yau T.M., Beattie W.S., Abdelnaem E., McCluskey S.A., et al. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004, 44:1453-1462.
3. Koch C.G., Li L., Duncan A.I., Mihaljevic T., Loop F.D., Starr N.J., et al. Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg 2006, 81:1650-1657.
4. Spiess B.D., Royston D., Levy J.H., Fitch J., Dietrich W., Body S., et al. Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 2004, 44:1143-1148.
5. Isbister J.P., Shander A., Spahn D.R., Erhard J., Farmer S.L., Hofmann A. Adverse blood transfusion outcomes: establishing causation. Transfus Med Rev 2011, 25:89-101.
6. Vamvakas E.C., Blajchman M.A. Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality. Transfus Med Rev 2010, 24:77-124.
7. Ferraris V.A., Saha S.P., Oestreich J.H., Song H.K., Rosengart T., Reece T.B., et al. 2012 Update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations. Ann Thorac Surg 2012, 94:1761-1781.
8. Carroll R.C., Chavez J.J., Snider C.C., Meyer D.S., Muenchen R.A. Correlation of perioperative platelet function and coagulation tests with bleeding after cardiopulmonary bypass surgery. J Lab Clin Med 2006, 147:197-204.
9. Crowther M.A., Warkentin T.E. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood 2008, 111:4871-4879.
10. Karlsson M., Ternstrom L., Hyllner M., Baghaei F., Flinck A., Skrtic S., et al. Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. Thromb Haemost 2009, 102:137-144.
11. Sniecinski R.M., Chen E.P., Makadia S.S., Kikura M., Bolliger D., Tanaka K.A. Changing from aprotinin to tranexamic acid results in increased use of blood products and recombinant factor VIIa for aortic surgery requiring hypothermic arrest. J Cardiothorac Vasc Anesth 2010, 24:959-963.
12. Fassl J., Matt P., Eckstein F., Filipovic M., Gregor M., Zenklusen U., et al. Transfusion of allogeneic blood products in proximal aortic surgery with hyopthermic circulatory arrest: effects of thromboelastometry-guided transfusion management. J Cardiothorac Vasc Anesth 2013, 10.1053/j.jvca.2013.02.009.
13. Spahn D.R., Goodnough L.T. Alternatives to blood transfusion. Lancet 2013, 381:1855-1865.
14. Avidan M.S., Alcock E.L., Da Fonseca J., Ponte J., Desai J.B., Despotis G.J., et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 2004, 92:178-186.
15. Nuttall G.A., Oliver W.C., Santrach P.J., Bryant S., Dearani J.A., Schaff H.V., et al. Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass. Anesthesiology 2001, 94:773-781.
16. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006;105:198-208.
17. O'Shaughnessy D.F., Atterbury C., Bolton Maggs P., Murphy M., Thomas D., Yates S., et al. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol 2004, 126:11-28.
18. Rossaint R., Bouillon B., Cerny V., Coats T.J., Duranteau J., Fernandez-Mondejar E., et al. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010, 14:R52.
19. Nuttall G.A., Oliver W.C., Ereth M.H., Santrach P.J. Coagulation tests predict bleeding after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 1997, 11:815-823.
20. Bolliger D., Görlinger K., Tanaka K.A. Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution. Anesthesiology 2010, 113:1205-1219.
21. Bolliger D., Seeberger M.D., Tanaka K.A. Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev 2012, 26:1-13.
22. Lee G.C., Kicza A.M., Liu K.Y., Nyman C.B., Kaufman R.M., Body S.C. Does rotational thromboelastometry (ROTEM) improve prediction of bleeding after cardiac surgery?. Anesth Analg 2012, 115:499-506.
23. Tanaka K.A., Bolliger D., Vadlamudi R., Nimmo A. Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma. J Cardiothorac Vasc Anesth 2012, 26:1083-1093.
24. Ak K., Isbir C.S., Tetik S., Atalan N., Tekeli A., Aljodi M., et al. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. J Card Surg 2009, 24:404-410.
25. Anderson L., Quasim I., Soutar R., Steven M., Macfie A., Korte W. An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. Transfus Med 2006, 16:31-39.
26. Girdauskas E., Kempfert J., Kuntze T., Borger M.A., Enders J., Fassl J., et al. Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. J Thorac Cardiovasc Surg 2010, 140:1117-1124.
27. Görlinger K., Dirkmann D., Hanke A.A., Kamler M., Kottenberg E., Thielmann M., et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 2011, 115:1179-1191.
28. Romlin B.S., Wahlander H., Berggren H., Synnergren M., Baghaei F., Nilsson K., et al. Intraoperative thromboelastometry is associated with reduced transfusion prevalence in pediatric cardiac surgery. Anesth Analg 2011, 112:30-36.
29. Shore-Lesserson L., Manspeizer H.E., DePerio M., Francis S., Vela-Cantos F., Ergin M.A. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999, 88:312-319.
30. Spiess B.D., Gillies B.S., Chandler W., Verrier E. Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. J Cardiothorac Vasc Anesth 1995, 9:168-173.
31. Weber C.F., Görlinger K., Meininger D., Herrmann E., Bingold T., Moritz A., et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012, 117:531-547.
32. Royston D., von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. Br J Anaesth 2001, 86:575-578.
33. Görlinger K., Dirkmann D., Solomon C., Hanke A.A. Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability. Br J Anaesth 2013, 110:222-230.
34. Khan H., Belsher J., Yilmaz M., Afessa B., Winters J.L., Moore S.B., et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007, 131:1308-1314.
35. Murphy G.J., Reeves B.C., Rogers C.A., Rizvi S.I., Culliford L., Angelini G.D. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007, 116:2544-2552.
36. Sarani B., Dunkman W.J., Dean L., Sonnad S., Rohrbach J.I., Gracias V.H. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008, 36:1114-1118.
37. Watson G.A., Sperry J.L., Rosengart M.R., Minei J.P., Harbrecht B.G., Moore E.E., et al. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma 2009, 67:221-227.
38. Kozek-Langenecker S.A., Afshari A., Albaladejo P., Santullano C.A., De Robertis E., Filipescu D.C., et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013, 30:270-382.
39. Spalding G.J., Hartrumpf M., Sierig T., Oesberg N., Kirschke C.G., Albes J.M. Cost reduction of perioperative coagulation management in cardiac surgery: value of "bedside" thrombelastography (ROTEM). Eur J Cardiothorac Surg 2007, 31:1052-1057.
40. Wikkelsoe A.J., Afshari A., Wetterslev J., Brok J., Moeller A.M. Monitoring patients at risk of massive transfusion with thrombelastography or thromboelastometry: a systematic review. Acta Anaesthesiol Scand 2011, 55:1174-1189.
41. Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J: Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011:CD007871.
42. Roback J.D., Caldwell S., Carson J., Davenport R., Drew M.J., Eder A., et al. Evidence-based practice guidelines for plasma transfusion. Transfusion 2010, 50:1227-1239.
43. Toulon P., Ozier Y., Ankri A., Fleron M.H., Leroux G., Samama C.M. Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery. A multicenter study. Thromb Haemost 2009, 101:394-401.
44. Ogawa S., Szlam F., Chen E.P., Nishimura T., Kim H., Roback J.D., et al. A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion 2012, 52:14-22.
45. Bolliger D., Szlam F., Molinaro R.J., Rahe-Meyer N., Levy J.H., Tanaka K.A. Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: an in vitro model. Br J Anaesth 2009, 102:793-799.
46. Nielsen V.G., Cohen B.M., Cohen E. Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII. Acta Anaesthesiol Scand 2005, 49:222-231.
47. Rumph B., Bolliger D., Narang N., Molinaro R.J., Levy J.H., Szlam F., et al. In vitro comparative study of hemostatic components in warfarin-treated and fibrinogen-deficient plasma. J Cardiothorac Vasc Anesth 2010, 24:408-412.
48. Nascimento B., Al Mahoos M., Callum J., Capone A., Pacher J., Tien H., et al. Vitamin K-dependent coagulation factor deficiency in trauma: a comparative analysis between international normalized ratio and thromboelastography. Transfusion 2012, 52:7-13.
49. Casutt M., Konrad C., Schuepfer G. Effect of rivaroxaban on blood coagulation using the viscoelastic coagulation test ROTEM. Anaesthesist 2012, 61:948-953.
50. Larsen O.H., Fenger-Eriksen C., Christiansen K., Ingerslev J., Sorensen B. Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology 2011, 115:294-302.
51. Kozek-Langenecker S., Sorensen B., Hess J.R., Spahn D.R. Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review. Crit Care 2011, 15:R239.
52. Lin D.M., Murphy L.S., Tran M.H. Use of prothrombin complex concentrates and fibrinogen concentrates in the perioperative setting: a systematic review. Transfus Med Rev 2013, 27:91-104.
53. Ogawa S., Szlam F., Bolliger D., Nishimura T., Chen E.P., Tanaka K.A. The impact of hematocrit on fibrin clot formation assessed by rotational thromboelastometry. Anesth Analg 2012, 115:16-21.
54. Karkouti K., Callum J., Crowther M.A., McCluskey S.A., Pendergrast J., Tait G., et al. The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study. Anesth Analg 2013, 117:14-22.
55. Bolliger D., Seeberger M.D., Tanaka K.A., Dell-Kuster S., Gregor M., Zenklusen U., et al. Pre-analytical effects of pneumatic tube transport on impedance platelet aggregometry. Platelets 2009, 20:458-465.
56. Demeyere R., Gillardin S., Arnout J., Strengers P.F. Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study. Vox Sang 2010, 99:251-260.
57. Ereth M.H. Decision to transfuse comfort zones: move out or get pushed out. Transfusion 2012, 52:2-3.
58. Wang S.C., Shieh J.F., Chang K.Y., Chu Y.C., Liu C.S., Loong C.C., et al. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc 2010, 42:2590-2593.
59. Schochl H., Nienaber U., Maegele M., Hochleitner G., Primavesi F., Steitz B., et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care 2011, 15:R83.
60. Coakley M., Reddy K., Mackie I., Mallett S. Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. J Cardiothorac Vasc Anesth 2006, 20:548-553.
61. Bolliger D., Szlam F., Levy J.H., Molinaro R.J., Tanaka K.A. Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage. Br J Anaesth 2010, 104:318-325.
62. Ker K., Edwards P., Perel P., Shakur H., Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012, 344:e3054.