Platelet apoptosis in adult immune thrombocytopenia: Insights into the mechanism of damage triggered by auto-antibodies

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Goette, Nora P ^a   Glembotsky, Ana C ^a   Lev, Paola R ^a   Grodzielski, Matías ^a   Contrufo, Geraldine ^a   Pierdominici, Marta S ^b   Espasandin, Yesica R ^a   Riveros, Dardo ^c   García, Alejandro J ^c   Molinas, Felisa C ^a   Heller, Paula G ^a   Marta, Rosana F ^a  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b HOSPITAL RAMOS MEJÍA   (Argentina)

^c CEMIC   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CASPASE 3; DUAL SPECIFICITY PHOSPHATASE 2; GLYCOPROTEIN IB; LEUPEPTIN; PADGEM PROTEIN; PHOSPHATIDYLSERINE; CALCIMYCIN; CD3 ANTIGEN;

ADULT; AGED; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; EXPOSURE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INTERNALIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN BINDING; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; VERY ELDERLY; BLOOD; DRUG EFFECTS; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MIDDLE AGED; PATHOLOGY; PLASMA; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; AUTOANTIBODIES; BLOOD PLATELETS; CALCIMYCIN; CASPASE 3; HUMANS; LYMPHOCYTES; MIDDLE AGED; PHOSPHATIDYLSERINES; PLASMA; PLATELET ACTIVATION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; YOUNG ADULT;

EID: 84983050083     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160563     Document Type: Article

References (26)

1. McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol. 2013; 163:10-23. doi: 10.1111/bjh.12480 PMID: 23937260
2. McMillan R, Wang L, Tomer A, Nichol J, Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood. 2004; 103:1364-1369. PMID: 14576051
3. Lev PR, Grodzielski M, Goette NP, Glembotsky AC, Espasandin YR, Pierdominici MS, et al. Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count. Br J Haematol. 2014; 165:854-864. doi: 10.1111/bjh.12832 PMID: 24673454
4. Woods VL Jr, Kurata Y, Montgomery RR, Tani P, Mason D, Oh EH, et al. Autoantibodies against platelet glycoprotein Ib in patients with chronic idiopathic thrombocytopenic purpura. Blood. 1984; 64:156-160. PMID: 6234034
5. Woods VL Jr, Oh EH, Mason D, McMillan R. Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood. 1984; 63:368-375. PMID: 6229297
6. He R, Reid DM, Jones CE, Shulman NR. Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood. 1994; 83:1024-1032. PMID: 8111044
7. McMillan R. The pathogenesis of chronic immune thrombocytopenic purpura. Semin Hematol. 2007; 44:S3-S11. doi: 10.1053/j.seminhematol.2007.11.002 PMID: 18096470
8. Najaoui A, Bakchoul T, Stoy J, Bein G, Rummel MJ, Santoso S, et al. Autoantibody-mediated complement activation on platelets is a common finding in patients with immune thrombocytopenic purpura (ITP). Eur J Haematol. 2012; 88:167-174. doi: 10.1111/j.1600-0609.2011.01718.x PMID: 21985182
9. Olsson B, Andersson PO, Jernås M, Jacobsson S, Carlsson B, Carlsson LM, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003; 9:1123-1124. PMID: 12937414
10. Zhao Ch, Li X, Zhang F, Wang L, Peng J, Hou M. Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies. Haematologica. 2008; 93:1428-1430. doi: 10.3324/haematol.12889 PMID: 18757854
11. Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007; 128:1173-1186. PMID: 17382885
12. Kile BT. The role of apoptosis in megakaryocytes and platelets. Br J Haematol. 2014; 165:217-226. doi: 10.1111/bjh.12757 PMID: 24467740
13. Leytin V, Mykhaylov S, Starkey AF, Allen DJ, Lau H, Ni H, et al. Intravenous immunoglobulin inhibits anti-IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia. Br J Haematol. 2006; 133:78-82. PMID: 16512832
14. Winkler J, Kroiss S, Rand M, Azzouzi I, Annie Bang KW, Speer O, et al. Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin. Br J Haematol. 2012; 156:508-515. doi: 10.1111/j.1365-2141.2011.08973.x PMID: 22171764
15. Catani L. Dendritic cells of immune thrombocytopenic purpura (ITP) show increased capacity to present apoptotic platelets to T lymphocytes. Exp Hematol. 2006; 34:879-887. PMID: 16797415
16. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009; 113:2386-2393. doi: 10.1182/blood-2008-07-162503 PMID: 19005182
17. Page L, Psaila B, Provan D, Michael Hamilton J, Jenkins JM, Elish AS, et al. The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP. Br J Haematol. 2007; 138:245-248. PMID: 17542983
18. Hulkower KI, Butler CC, Linebaugh BE, Klaus JL, Keppler D, Giranda VL, et al. Fluorescent microplate assay for cancer cell-associated cathepsin B. Eur J Biochem. 2000; 267:4165-4170. PMID: 10866820
19. Beigier-Bompadre M, Barrionuevo P, Alves-Rosa F, Rubel CJ, Palermo MS, Isturiz MA. The formyl peptide N-formyl-methionyl-leucyl-phenylalanine downregulates the expression of FcgammaRs in interferon-gamma-activated monocytes/macrophages in vitro and in vivo. Scand J Immunol. 2003; 57:221-228. PMID: 12641650
20. Glembotsky AC, Bluteau D, Espasandin YR, Goette NP, Marta RF, Marin Oyarzun CP et al. Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets. J Thromb Haemost. 2014; 12:761-772. doi: 10.1111/jth.12550 PMID: 24606315
21. Mutlu A, Gyulkhandanyan AV, Freedman J, Leytin V. Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors. Br J Haematol. 2012; 159:565-571. doi: 10.1111/bjh.12066 PMID: 23025479
22. Álvarez Román MT, Fernández Bello I, Arias-Salgado EG, Rivas Pollmar MI, Jiménez Yuste V, Martín Salces M. Effects of thrombopoietin receptor agonists on procoagulant state in patients with immune thrombocytopenia. J Thromb Haemost. 2014; 112:65-72.
23. Zhan Y, Zou S, Hua F, Li F, Ji L, Wang W, et al. High-dose dexamethasone modulates serum cytokine profile in patients with primary immune thrombocytopenia. Immunol Lett. 2014; 160:33-38. doi: 10.1016/j.imlet.2014.03.002 PMID: 24657323
24. McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol. 2000; 37:239-248. PMID: 10942218
25. Couzi L, Pitard V, Sicard X, Garrigue I, Hawchar O, Merville P, et al. Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa) Blood. 2012; 119:1418-1427. doi: 10.1182/blood-2011-06-363655 PMID: 22180442
26. Beau Mitchell W, Pinheiro MP, Boulad N, Kaplan D, Edison MN, Psaila B, et al. Effect of TPO receptor agonists on the apoptotic profile of platelets in patients with chronic ITP. Am J Hematol. 2014; 89: E228-E234. doi: 10.1002/ajh.23832 PMID: 25132654