Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies

Haematologica

Volumn 93, Issue 9, 2008, Pages 1428-1430

  Zhao, Chunhong ^a   Li, Xiaofang ^a   Zhang, Feng ^b   Wang, Lin ^a   Peng, Jun ^a   Hou, Ming ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cytotoxic T lymphocyte; Dexamethasone; Idiopathic thrombocytopenic purpura

Indexed keywords

AUTOANTIBODY; DEXAMETHASONE; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; LIPOCORTIN 5;

BLOOD ANALYSIS; CELL DESTRUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG EFFECT; DRUG MEGADOSE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LETTER; THROMBOCYTE;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; BLOOD PLATELETS; CHILD; FEMALE; HUMANS; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 50849101392     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.12889     Document Type: Letter

References (12)

1. McMillan R, Wang L, Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost 2003;1:485-91.
2. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med 2002;346:995-1008.
3. Chang M, Nakagawa PA, Williams SA, Schwartz MR, Imfeld KL, Buzby JS, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003;102:887-95.
4. McMillan R, Wang L, Tomer A, Nichol J, Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult chronic ITP patients. Blood 2004;103:1364-9.
5. Brighton TA, Evans S, Castaldi PA, Chesterman CN, Chong BH. Prospective evaluation of the clinical usefulness of an antigen specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 1996;88:194-201.
6. Olsson B, Andersson PO, Jernas M, Jacobsson S, Carlsson B, Carlsson LM, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9:1123-4.
7. Zhang F, Chu X, Wang L, Zhu Y, Li L, Ma D, et al. Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura. Eur J Haematol 2006; 76: 427-31.
8. British Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003;120:574-96.
9. Cheng Y, Wong RS, Soo YO, Chui CH, Lau FY, Chan NP, et al. Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone. N Engl J Med 2003;349:831-6.
10. Hou M, Peng J, Shi Y, Zhang CQ, Qin P, Zhao CL, et al. Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol 2003;70:353-7.
11. Goldberg JE, Sherwood SW, Clayberger C. A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry. J Immunol Methods 1999;224:1-9.
12. Guo C, Chu X, Shi Y, He W, Li L, Wang L, et al. Correction of Th1-dominant cytokine profiles by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. J Clin Immunol 2007;27:557-62.