Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus

PLoS Pathogens

Volumn 12, Issue 7, 2016, Pages

  Ren, Ying ^a   Zhao, Peng ^a   Liu, Jin ^a   Yuan, Yukang ^a   Cheng, Qiao ^a   Zuo, Yibo ^a   Qian, Liping ^a   Liu, Chang ^a   Guo, Tingting ^a   Zhang, Liting ^a   Wang, Xiaofang ^a   Qian, Guanghui ^a   Li, Lemin ^a   Ge, Jun ^a   Dai, Jianfeng ^a   Xiong, Sidong ^a   Zheng, Hui ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLOHEXIMIDE; DEUBIQUITINASE; IMMUNOGLOBULIN G ANTIBODY; JANUS KINASE 1; PROTEIN KINASE TYK2; STAT1 PROTEIN; INTERFERON; PROTEINASE; STAT1 PROTEIN, HUMAN; USP2 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; LUCIFERASE ASSAY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; CELL LINE; CELL NUCLEUS; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; SENDAI VIRUS; VESICULOVIRUS; VIRUS INFECTION;

CELL LINE; CELL NUCLEUS; ENDOPEPTIDASES; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERFERONS; MICROSCOPY, FLUORESCENCE; PROTEIN TRANSPORT; REAL-TIME POLYMERASE CHAIN REACTION; SENDAI VIRUS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANSFECTION; UBIQUITINATION; VESICULOVIRUS; VIRUS DISEASES;

EID: 84982921071     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005764     Document Type: Article

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