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Volumn 5, Issue 7, 2016, Pages

Improving cancer immunotherapy by targeting the STATe of MDSCs

Author keywords

Drugs; immunotherapy; MDSCs; STAT signaling; tumor microenvironment

Indexed keywords

AMILORIDE; AXITINIB; BEVACIZUMAB; CALCIDIOL 1 MONOOXYGENASE; CIMETIDINE; CUCURBITACIN; CURCUMIN; DECITABINE; DOCETAXEL; ICARIIN; IPILIMUMAB; PACLITAXEL; ROSIGLITAZONE; SILDENAFIL; SORAFENIB; STAT PROTEIN; SUNITINIB; TADALAFIL; VEMURAFENIB;

EID: 84982908724     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1196312     Document Type: Review
Times cited : (54)

References (88)
  • 2
    • 84925453223 scopus 로고    scopus 로고
    • Immunotherapy of melanoma: present options and future promises
    • 25589384
    • A.Rotte, M.Bhandaru, Y.Zhou, K.J.McElwee. Immunotherapy of melanoma:present options and future promises. Cancer Metastasis Rev 2015; 34:115-28; PMID:25589384; http://dx.doi.org/10.1007/s10555-014-9542-0
    • (2015) Cancer Metastasis Rev , vol.34 , pp. 115-128
    • Rotte, A.1    Bhandaru, M.2    Zhou, Y.3    McElwee, K.J.4
  • 3
    • 84879515584 scopus 로고    scopus 로고
    • Immune-suppressive properties of the tumor microenvironment
    • 23666510
    • J.C.Becker, M.H.Andersen, D.Schrama, P.Thor Straten. Immune-suppressive properties of the tumor microenvironment. Cancer Immunol Immunother 2013; 62:1137-48; PMID:23666510; http://dx.doi.org/10.1007/s00262-013-1434-6
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1137-1148
    • Becker, J.C.1    Andersen, M.H.2    Schrama, D.3    Thor Straten, P.4
  • 4
    • 84864662070 scopus 로고    scopus 로고
    • Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    • 22842478
    • S.Walter, T.Weinschenk, A.Stenzl, R.Zdrojowy, A.Pluzanska, C.Szczylik, M.Staehler, W.Brugger, P.Y.Dietrich, R.Mendrzyk et al. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med 2012; 18:1254-61; PMID:22842478; http://dx.doi.org/10.1038/nm.2883
    • (2012) Nat Med , vol.18 , pp. 1254-1261
    • Walter, S.1    Weinschenk, T.2    Stenzl, A.3    Zdrojowy, R.4    Pluzanska, A.5    Szczylik, C.6    Staehler, M.7    Brugger, W.8    Dietrich, P.Y.9    Mendrzyk, R.10
  • 5
    • 84880924329 scopus 로고    scopus 로고
    • Increase in CD14+HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
    • 23764929
    • F.Arihara, E.Mizukoshi, M.Kitahara, Y.Takata, K.Arai, T.Yamashita, Y.Nakamoto, S.Kaneko. Increase in CD14+HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. Cancer Immunol Immunother 2013; 62:1421-30; PMID:23764929; http://dx.doi.org/10.1007/s00262-013-1447-1
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1421-1430
    • Arihara, F.1    Mizukoshi, E.2    Kitahara, M.3    Takata, Y.4    Arai, K.5    Yamashita, T.6    Nakamoto, Y.7    Kaneko, S.8
  • 6
    • 84900839768 scopus 로고    scopus 로고
    • Cancer vaccines in the world of immune suppressive monocytes (CD14(+)HLA-DR(lo/neg) Cells): the gateway to improved responses
    • 24772111
    • R.R.Laborde, Y.Lin, M.P.Gustafson, P.A.Bulur, A.B.Dietz. Cancer vaccines in the world of immune suppressive monocytes (CD14(+)HLA-DR(lo/neg) Cells):the gateway to improved responses. Front Immunol 2014; 5:147; PMID:24772111; http://dx.doi.org/10.3389/fimmu.2014.00147
    • (2014) Front Immunol , vol.5 , pp. 147
    • Laborde, R.R.1    Lin, Y.2    Gustafson, M.P.3    Bulur, P.A.4    Dietz, A.B.5
  • 7
    • 84869791457 scopus 로고    scopus 로고
    • Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma
    • 23100512
    • K.N.Kodumudi, A.Weber, A.A.Sarnaik, S.Pilon-Thomas. Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. J Immunol 2012; 189:5147-54; PMID:23100512; http://dx.doi.org/10.4049/jimmunol.1200274
    • (2012) J Immunol , vol.189 , pp. 5147-5154
    • Kodumudi, K.N.1    Weber, A.2    Sarnaik, A.A.3    Pilon-Thomas, S.4
  • 10
    • 63949088142 scopus 로고    scopus 로고
    • Adoptive transfer of HER2/neu-specific T cells expanded with alternating gamma chain cytokines mediate tumor regression when combined with the depletion of myeloid-derived suppressor cells
    • 18979098
    • J.K.Morales, M.Kmieciak, L.Graham, M.Feldmesser, H.D.Bear, M.H.Manjili. Adoptive transfer of HER2/neu-specific T cells expanded with alternating gamma chain cytokines mediate tumor regression when combined with the depletion of myeloid-derived suppressor cells. Cancer Immunol Immunother 2009; 58:941-53; PMID:18979098; http://dx.doi.org/10.1007/s00262-008-0609-z
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 941-953
    • Morales, J.K.1    Kmieciak, M.2    Graham, L.3    Feldmesser, M.4    Bear, H.D.5    Manjili, M.H.6
  • 12
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • 22437938
    • D.I.Gabrilovich, S.Ostrand-Rosenberg, V.Bronte. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012; 12:253-68; PMID:22437938; http://dx.doi.org/10.1038/nri3175
    • (2012) Nat Rev Immunol , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 13
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • 19197294
    • D.I.Gabrilovich, S.Nagaraj. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009; 9:162-74; PMID:19197294; http://dx.doi.org/10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 14
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • 18832739
    • J.I.Youn, S.Nagaraj, M.Collazo, D.I.Gabrilovich. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 2008; 181:5791-802; PMID:18832739; http://dx.doi.org/10.4049/jimmunol.181.8.5791
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 15
    • 84902959977 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity in human cancers
    • 24965257
    • S.Solito, I.Marigo, L.Pinton, V.Damuzzo, S.Mandruzzato, V.Bronte. Myeloid-derived suppressor cell heterogeneity in human cancers. Ann N Y Acad Sci 2014; 1319:47-65; PMID:24965257; http://dx.doi.org/10.1111/nyas.12469
    • (2014) Ann N Y Acad Sci , vol.1319 , pp. 47-65
    • Solito, S.1    Marigo, I.2    Pinton, L.3    Damuzzo, V.4    Mandruzzato, S.5    Bronte, V.6
  • 16
    • 84865715288 scopus 로고    scopus 로고
    • Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology
    • 22692756
    • C.A.Dumitru, K.Moses, S.Trellakis, S.Lang, S.Brandau. Neutrophils and granulocytic myeloid-derived suppressor cells:immunophenotyping, cell biology and clinical relevance in human oncology. Cancer Immunol Immunother 2012; 61:1155-67; PMID:22692756; http://dx.doi.org/10.1007/s00262-012-1294-5
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1155-1167
    • Dumitru, C.A.1    Moses, K.2    Trellakis, S.3    Lang, S.4    Brandau, S.5
  • 17
    • 84912081252 scopus 로고    scopus 로고
    • A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients
    • 25436215
    • E.K.Vetsika, F.Koinis, M.Gioulbasani, D.Aggouraki, A.Koutoulaki, E.Skalidaki, D.Mavroudis, V.Georgoulias, A.Kotsakis. A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients. J Immunol Res 2014; 2014:659294; PMID:25436215; http://dx.doi.org/10.1155/2014/659294
    • (2014) J Immunol Res , vol.2014 , pp. 659294
    • Vetsika, E.K.1    Koinis, F.2    Gioulbasani, M.3    Aggouraki, D.4    Koutoulaki, A.5    Skalidaki, E.6    Mavroudis, D.7    Georgoulias, V.8    Kotsakis, A.9
  • 18
    • 84899104324 scopus 로고    scopus 로고
    • Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
    • 24800171
    • A.Martens, H.Zelba, C.Garbe, G.Pawelec, B.Weide. Monocytic myeloid-derived suppressor cells in advanced melanoma patients:Indirect impact on prognosis through inhibition of tumor-specific T-cell responses? Oncoimmunology 2014; 3:e27845; PMID:24800171
    • (2014) Oncoimmunology , vol.3 , pp. e27845
    • Martens, A.1    Zelba, H.2    Garbe, C.3    Pawelec, G.4    Weide, B.5
  • 19
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • 17617589
    • P.Sinha, V.K.Clements, S.K.Bunt, S.M.Albelda, S.Ostrand-Rosenberg. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 2007; 179:977-83; PMID:17617589; http://dx.doi.org/10.4049/jimmunol.179.2.977
    • (2007) J Immunol , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 20
    • 84865407523 scopus 로고    scopus 로고
    • TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy
    • 22863752
    • J.P.Marcoe, J.R.Lim, K.L.Schaubert, N.Fodil-Cornu, M.Matka, A.L.McCubbrey, A.R.Farr, S.M.Vidal, Y.Laouar. TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nat Immunol 2012; 13:843-50; PMID:22863752; http://dx.doi.org/10.1038/ni.2388
    • (2012) Nat Immunol , vol.13 , pp. 843-850
    • Marcoe, J.P.1    Lim, J.R.2    Schaubert, K.L.3    Fodil-Cornu, N.4    Matka, M.5    McCubbrey, A.L.6    Farr, A.R.7    Vidal, S.M.8    Laouar, Y.9
  • 22
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • 20028852
    • M.K.Srivastava, P.Sinha, V.K.Clements, P.Rodriguez, S.Ostrand-Rosenberg. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res 2010; 70:68-77; PMID:20028852; http://dx.doi.org/10.1158/0008-5472.CAN-09-2587
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 24
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients
    • 11406548
    • J.Schmielau, O.J.Finn. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients. Cancer Res 2001; 61:4756-60; PMID:11406548
    • (2001) Cancer Res , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 27
    • 46049098560 scopus 로고    scopus 로고
    • A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
    • 18485901
    • B.Hoechst, L.A.Ormandy, M.Ballmaier, F.Lehner, C.Kruger, M.P.Manns, T.F.Greten, F.Korangy. A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology 2008; 135:234-43; PMID:18485901; http://dx.doi.org/10.1053/j.gastro.2008.03.020
    • (2008) Gastroenterology , vol.135 , pp. 234-243
    • Hoechst, B.1    Ormandy, L.A.2    Ballmaier, M.3    Lehner, F.4    Kruger, C.5    Manns, M.P.6    Greten, T.F.7    Korangy, F.8
  • 28
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • 18593947
    • P.Serafini, S.Mgebroff, K.Noonan, I.Borrello. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 2008; 68:5439-49; PMID:18593947; http://dx.doi.org/10.1158/0008-5472.CAN-07-6621
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 29
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • 16424049
    • B.Huang, P.Y.Pan, Q.Li, A.I.Sato, D.E.Levy, J.Bromberg, C.M.Divino, S.H.Chen. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 2006; 66:1123-31; PMID:16424049; http://dx.doi.org/10.1158/0008-5472.CAN-05-1299
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.H.8
  • 30
    • 84921325808 scopus 로고    scopus 로고
    • The JAK-STAT pathway: impact on human disease and therapeutic intervention
    • 25587654
    • J.J.O'Shea, D.M.Schwartz, A.V.Villarino, M.Gadina, I.B.McInnes, A.Laurence. The JAK-STAT pathway:impact on human disease and therapeutic intervention. Annu Rev Med 2015; 66:311-28; PMID:25587654; http://dx.doi.org/10.1146/annurev-med-051113-024537
    • (2015) Annu Rev Med , vol.66 , pp. 311-328
    • O'Shea, J.J.1    Schwartz, D.M.2    Villarino, A.V.3    Gadina, M.4    McInnes, I.B.5    Laurence, A.6
  • 31
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • 21067974
    • T.Condamine, D.I.Gabrilovich. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol 2011; 32:19-25; PMID:21067974; http://dx.doi.org/10.1016/j.it.2010.10.002
    • (2011) Trends Immunol , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 34
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • 18809714
    • P.Cheng, C.A.Corzo, N.Luetteke, B.Yu, S.Nagaraj, M.M.Bui, M.Ortiz, W.Nacken, C.Sorg, T.Vogl et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008; 205:2235-49; PMID:18809714; http://dx.doi.org/10.1084/jem.20080132
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6    Ortiz, M.7    Nacken, W.8    Sorg, C.9    Vogl, T.10
  • 36
    • 84876921278 scopus 로고    scopus 로고
    • Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells
    • 23486482
    • L.M.Hix, J.Karavitis, M.W.Khan, Y.H.Shi, K.Khazaie, M.Zhang. Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J Biol Chem 2013; 288:11676-88; PMID:23486482; http://dx.doi.org/10.1074/jbc.M112.441402
    • (2013) J Biol Chem , vol.288 , pp. 11676-11688
    • Hix, L.M.1    Karavitis, J.2    Khan, M.W.3    Shi, Y.H.4    Khazaie, K.5    Zhang, M.6
  • 37
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • 18272812
    • K.Movahedi, M.Guilliams, J.Van den Bossche, R.Van den Bergh, C.Gysemans, A.Beschin, P.De Baetselier, J.A.Van Ginderachter. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 2008; 111:4233-44; PMID:18272812; http://dx.doi.org/10.1182/blood-2007-07-099226
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van den Bossche, J.3    Van den Bergh, R.4    Gysemans, C.5    Beschin, A.6    De Baetselier, P.7    Van Ginderachter, J.A.8
  • 39
    • 74049097839 scopus 로고    scopus 로고
    • Stat 6-dependent induction of myeloid derived suppressor cells after physical injury regulates nitric oxide response to endotoxin
    • 20032720
    • V.Munera, P.J.Popovic, J.Bryk, J.Pribis, D.Caba, B.M.Matta, M.Zenati, J.B.Ochoa. Stat 6-dependent induction of myeloid derived suppressor cells after physical injury regulates nitric oxide response to endotoxin. Ann Surg 2010; 251:120-6; PMID:20032720; http://dx.doi.org/10.1097/SLA.0b013e3181bfda1c
    • (2010) Ann Surg , vol.251 , pp. 120-126
    • Munera, V.1    Popovic, P.J.2    Bryk, J.3    Pribis, J.4    Caba, D.5    Matta, B.M.6    Zenati, M.7    Ochoa, J.B.8
  • 40
    • 11844277698 scopus 로고    scopus 로고
    • Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease
    • 15634881
    • P.Sinha, V.K.Clements, S.Ostrand-Rosenberg. Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol 2005; 174:636-45; PMID:15634881; http://dx.doi.org/10.4049/jimmunol.174.2.636
    • (2005) J Immunol , vol.174 , pp. 636-645
    • Sinha, P.1    Clements, V.K.2    Ostrand-Rosenberg, S.3
  • 41
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression
    • 22282665
    • F.Roth, A.C.De La Fuente, J.L.Vella, A.Zoso, L.Inverardi, P.Serafini. Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression. Cancer Res 2012; 72:1373-83; PMID:22282665; http://dx.doi.org/10.1158/0008-5472.CAN-11-2772
    • (2012) Cancer Res , vol.72 , pp. 1373-1383
    • Roth, F.1    De La Fuente, A.C.2    Vella, J.L.3    Zoso, A.4    Inverardi, L.5    Serafini, P.6
  • 42
    • 84901744815 scopus 로고    scopus 로고
    • Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics
    • 24879823
    • S.V.Hato, A.Khong, I.J.de Vries, W.J.Lesterhuis. Molecular pathways:the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res 2014; 20:2831-7; PMID:24879823; http://dx.doi.org/10.1158/1078-0432.CCR-13-3141
    • (2014) Clin Cancer Res , vol.20 , pp. 2831-2837
    • Hato, S.V.1    Khong, A.2    de Vries, I.J.3    Lesterhuis, W.J.4
  • 44
    • 84885761143 scopus 로고    scopus 로고
    • Immunological consequences of selective BRAF inhibitors in malignant melanoma: neutralization of myeloid-derived suppressor cells
    • 24167759
    • B.Schilling, A.Paschen. Immunological consequences of selective BRAF inhibitors in malignant melanoma:neutralization of myeloid-derived suppressor cells. Oncoimmunology 2013; 2:e25218; PMID:24167759
    • (2013) Oncoimmunology , vol.2 , pp. e25218
    • Schilling, B.1    Paschen, A.2
  • 45
    • 79955829332 scopus 로고    scopus 로고
    • Development of second-generation VEGFR tyrosine kinase inhibitors: current status
    • 21318618
    • P.Bhargava, M.O.Robinson. Development of second-generation VEGFR tyrosine kinase inhibitors:current status. Curr Oncol Rep 2011; 13:103-11; PMID:21318618; http://dx.doi.org/10.1007/s11912-011-0154-3
    • (2011) Curr Oncol Rep , vol.13 , pp. 103-111
    • Bhargava, P.1    Robinson, M.O.2
  • 46
    • 84908089640 scopus 로고    scopus 로고
    • Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation
    • 25081318
    • H.Yuan, P.Cai, Q.Li, W.Wang, Y.Sun, Q.Xu, Y.Gu. Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation. Biomed Pharmacother 2014; 68:751-6; PMID:25081318; http://dx.doi.org/10.1016/j.biopha.2014.07.002
    • (2014) Biomed Pharmacother , vol.68 , pp. 751-756
    • Yuan, H.1    Cai, P.2    Li, Q.3    Wang, W.4    Sun, Y.5    Xu, Q.6    Gu, Y.7
  • 47
    • 84860780501 scopus 로고    scopus 로고
    • Combined vaccine+axitinib therapy yields superior antitumor efficacy in a murine melanoma model
    • 22504156
    • A.Bose, D.B.Lowe, A.Rao, W.J.Storkus. Combined vaccine+axitinib therapy yields superior antitumor efficacy in a murine melanoma model. Melanoma Res 2012; 22:236-43; PMID:22504156; http://dx.doi.org/10.1097/CMR.0b013e3283538293
    • (2012) Melanoma Res , vol.22 , pp. 236-243
    • Bose, A.1    Lowe, D.B.2    Rao, A.3    Storkus, W.J.4
  • 48
    • 79953221190 scopus 로고    scopus 로고
    • Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model
    • 21321535
    • M.Cao, Y.Xu, J.I.Youn, R.Cabrera, X.Zhang, D.Gabrilovich, D.R.Nelson, C.Liu. Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Lab Invest 2011; 91:598-608; PMID:21321535; http://dx.doi.org/10.1038/labinvest.2010.205
    • (2011) Lab Invest , vol.91 , pp. 598-608
    • Cao, M.1    Xu, Y.2    Youn, J.I.3    Cabrera, R.4    Zhang, X.5    Gabrilovich, D.6    Nelson, D.R.7    Liu, C.8
  • 49
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • 19276286
    • J.S.Ko, A.H.Zea, B.I.Rini, J.L.Ireland, P.Elson, P.Cohen, A.Golshayan, P.A.Rayman, L.Wood, J.Garcia et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res 2009; 15:2148-57; PMID:19276286; http://dx.doi.org/10.1158/1078-0432.CCR-08-1332
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3    Ireland, J.L.4    Elson, P.5    Cohen, P.6    Golshayan, A.7    Rayman, P.A.8    Wood, L.9    Garcia, J.10
  • 50
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
    • 21315783
    • J.Finke, J.Ko, B.Rini, P.Rayman, J.Ireland, P.Cohen. MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int Immunopharmacol 2011; 11:856-61; PMID:21315783; http://dx.doi.org/10.1016/j.intimp.2011.01.030
    • (2011) Int Immunopharmacol , vol.11 , pp. 856-861
    • Finke, J.1    Ko, J.2    Rini, B.3    Rayman, P.4    Ireland, J.5    Cohen, P.6
  • 51
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • 20406969
    • J.S.Ko, P.Rayman, J.Ireland, S.Swaidani, G.Li, K.D.Bunting, B.Rini, J.H.Finke, P.A.Cohen. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res 2010; 70:3526-36; PMID:20406969; http://dx.doi.org/10.1158/0008-5472.CAN-09-3278
    • (2010) Cancer Res , vol.70 , pp. 3526-3536
    • Ko, J.S.1    Rayman, P.2    Ireland, J.3    Swaidani, S.4    Li, G.5    Bunting, K.D.6    Rini, B.7    Finke, J.H.8    Cohen, P.A.9
  • 52
    • 84874456244 scopus 로고    scopus 로고
    • Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells
    • 23497256
    • D.J.Panka, Q.Liu, A.K.Geissler, J.W.Mier. Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells. Mol Cancer 2013; 12:17; PMID:23497256; http://dx.doi.org/10.1186/1476-4598-12-17
    • (2013) Mol Cancer , vol.12 , pp. 17
    • Panka, D.J.1    Liu, Q.2    Geissler, A.K.3    Mier, J.W.4
  • 54
    • 84874112910 scopus 로고    scopus 로고
    • Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer
    • 22864396
    • S.K.Bunt, A.M.Mohr, J.M.Bailey, P.M.Grandgenett, M.A.Hollingsworth. Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. Cancer Immunol Immunother 2013; 62:225-36; PMID:22864396; http://dx.doi.org/10.1007/s00262-012-1324-3
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 225-236
    • Bunt, S.K.1    Mohr, A.M.2    Bailey, J.M.3    Grandgenett, P.M.4    Hollingsworth, M.A.5
  • 55
    • 84872240349 scopus 로고    scopus 로고
    • Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells
    • 23220070
    • Y.Zheng, M.Xu, X.Li, J.Jia, K.Fan, G.Lai. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol 2013; 54:74-83; PMID:23220070; http://dx.doi.org/10.1016/j.molimm.2012.10.035
    • (2013) Mol Immunol , vol.54 , pp. 74-83
    • Zheng, Y.1    Xu, M.2    Li, X.3    Jia, J.4    Fan, K.5    Lai, G.6
  • 56
    • 84896523643 scopus 로고    scopus 로고
    • Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
    • 24777678
    • Y.Pico de Coana, I.Poschke, G.Gentilcore, Y.Mao, M.Nystrom, J.Hansson, G.V.Masucci, R.Kiessling. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol Res 2013; 1:158-62; PMID:24777678; http://dx.doi.org/10.1158/2326-6066.CIR-13-0016
    • (2013) Cancer Immunol Res , vol.1 , pp. 158-162
    • Pico de Coana, Y.1    Poschke, I.2    Gentilcore, G.3    Mao, Y.4    Nystrom, M.5    Hansson, J.6    Masucci, G.V.7    Kiessling, R.8
  • 57
    • 84894639687 scopus 로고    scopus 로고
    • Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
    • 24498358
    • A.A.Tarhini, H.Edington, L.H.Butterfield, Y.Lin, Y.Shuai, H.Tawbi, C.Sander, Y.Yin, M.Holtzman, J.Johnson et al. Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab. PLoS One 2014; 9:e87705; PMID:24498358; http://dx.doi.org/10.1371/journal.pone.0087705
    • (2014) PLoS One , vol.9 , pp. e87705
    • Tarhini, A.A.1    Edington, H.2    Butterfield, L.H.3    Lin, Y.4    Shuai, Y.5    Tawbi, H.6    Sander, C.7    Yin, Y.8    Holtzman, M.9    Johnson, J.10
  • 59
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    • 17101732
    • P.Serafini, K.Meckel, M.Kelso, K.Noonan, J.Califano, W.Koch, L.Dolcetti, V.Bronte, I.Borrello. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 2006; 203:2691-702; PMID:17101732; http://dx.doi.org/10.1084/jem.20061104
    • (2006) J Exp Med , vol.203 , pp. 2691-2702
    • Serafini, P.1    Meckel, K.2    Kelso, M.3    Noonan, K.4    Califano, J.5    Koch, W.6    Dolcetti, L.7    Bronte, V.8    Borrello, I.9
  • 60
    • 80054730389 scopus 로고    scopus 로고
    • Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
    • 21969559
    • C.Meyer, A.Sevko, M.Ramacher, A.V.Bazhin, C.S.Falk, W.Osen, I.Borrello, M.Kato, D.Schadendorf, M.Baniyash et al. Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. Proc Natl Acad Sci U S A 2011; 108:17111-6; PMID:21969559; http://dx.doi.org/10.1073/pnas.1108121108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17111-17116
    • Meyer, C.1    Sevko, A.2    Ramacher, M.3    Bazhin, A.V.4    Falk, C.S.5    Osen, W.6    Borrello, I.7    Kato, M.8    Schadendorf, D.9    Baniyash, M.10
  • 61
    • 84920666147 scopus 로고    scopus 로고
    • Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma
    • 25320361
    • D.T.Weed, J.L.Vella, I.M.Reis, A.C.De la Fuente, C.Gomez, Z.Sargi, R.Nazarian, J.Califano, I.Borrello, P.Serafini. Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res 2015; 21:39-48; PMID:25320361; http://dx.doi.org/10.1158/1078-0432.CCR-14-1711
    • (2015) Clin Cancer Res , vol.21 , pp. 39-48
    • Weed, D.T.1    Vella, J.L.2    Reis, I.M.3    De la Fuente, A.C.4    Gomez, C.5    Sargi, Z.6    Nazarian, R.7    Califano, J.8    Borrello, I.9    Serafini, P.10
  • 63
    • 84910071057 scopus 로고    scopus 로고
    • Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma
    • 24878583
    • K.A.Noonan, N.Ghosh, L.Rudraraju, M.Bui, I.Borrello. Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma. Cancer Immunol Res 2014; 2:725-31; PMID:24878583; http://dx.doi.org/10.1158/2326-6066.CIR-13-0213
    • (2014) Cancer Immunol Res , vol.2 , pp. 725-731
    • Noonan, K.A.1    Ghosh, N.2    Rudraraju, L.3    Bui, M.4    Borrello, I.5
  • 64
    • 84878242670 scopus 로고    scopus 로고
    • Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
    • 23389111
    • D.Salvemini, S.F.Kim, V.Mollace. Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology:relevance and clinical implications. Am J Physiol Regul Integr Comp Physiol 2013; 304:R473-87; PMID:23389111; http://dx.doi.org/10.1152/ajpregu.00355.2012
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.304 , pp. R473-R487
    • Salvemini, D.1    Kim, S.F.2    Mollace, V.3
  • 65
    • 81555228400 scopus 로고    scopus 로고
    • Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
    • 21972293
    • N.Obermajer, R.Muthuswamy, J.Lesnock, R.P.Edwards, P.Kalinski. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood 2011; 118:5498-505; PMID:21972293; http://dx.doi.org/10.1182/blood-2011-07-365825
    • (2011) Blood , vol.118 , pp. 5498-5505
    • Obermajer, N.1    Muthuswamy, R.2    Lesnock, J.3    Edwards, R.P.4    Kalinski, P.5
  • 66
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • 20093776
    • F.Chalmin, S.Ladoire, G.Mignot, J.Vincent, M.Bruchard, J.P.Remy-Martin, W.Boireau, A.Rouleau, B.Simon, D.Lanneau et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 2010; 120:457-71; PMID:20093776; http://dx.doi.org/10.1172/JCI40483DS1
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6    Boireau, W.7    Rouleau, A.8    Simon, B.9    Lanneau, D.10
  • 67
    • 79958061935 scopus 로고    scopus 로고
    • Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions
    • 21244860
    • J.Zhou, J.Wu, X.Chen, N.Fortenbery, E.Eksioglu, K.N.Kodumudi, E.B.Pk, J.Dong, J.Y.Djeu, S.Wei. Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int Immunopharmacol 2011; 11:890-8; PMID:21244860; http://dx.doi.org/10.1016/j.intimp.2011.01.007
    • (2011) Int Immunopharmacol , vol.11 , pp. 890-898
    • Zhou, J.1    Wu, J.2    Chen, X.3    Fortenbery, N.4    Eksioglu, E.5    Kodumudi, K.N.6    Pk, E.B.7    Dong, J.8    Djeu, J.Y.9    Wei, S.10
  • 68
    • 77950498798 scopus 로고    scopus 로고
    • Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine
    • 19882154
    • I.Daurkin, E.Eruslanov, J.Vieweg, S.Kusmartsev. Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine. Cancer Immunol Immunother 2010; 59:697-706; PMID:19882154; http://dx.doi.org/10.1007/s00262-009-0786-4
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 697-706
    • Daurkin, I.1    Eruslanov, E.2    Vieweg, J.3    Kusmartsev, S.4
  • 69
    • 84861577263 scopus 로고    scopus 로고
    • The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment
    • 21898392
    • J.M.Lee, J.H.Seo, Y.J.Kim, Y.S.Kim, H.J.Ko, C.Y.Kang. The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment. Int J Cancer 2012; 131:741-51; PMID:21898392; http://dx.doi.org/10.1002/ijc.26411
    • (2012) Int J Cancer , vol.131 , pp. 741-751
    • Lee, J.M.1    Seo, J.H.2    Kim, Y.J.3    Kim, Y.S.4    Ko, H.J.5    Kang, C.Y.6
  • 70
    • 58149332680 scopus 로고    scopus 로고
    • Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma
    • 19088044
    • S.Kusmartsev, Z.Su, A.Heiser, J.Dannull, E.Eruslanov, H.Kubler, D.Yancey, P.Dahm, J.Vieweg. Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin Cancer Res 2008; 14:8270-8; PMID:19088044; http://dx.doi.org/10.1158/1078-0432.CCR-08-0165
    • (2008) Clin Cancer Res , vol.14 , pp. 8270-8278
    • Kusmartsev, S.1    Su, Z.2    Heiser, A.3    Dannull, J.4    Eruslanov, E.5    Kubler, H.6    Yancey, D.7    Dahm, P.8    Vieweg, J.9
  • 71
    • 84877825407 scopus 로고    scopus 로고
    • Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
    • 23589106
    • C.Iclozan, S.Antonia, A.Chiappori, D.T.Chen, D.Gabrilovich. Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother 2013; 62:909-18; PMID:23589106; http://dx.doi.org/10.1007/s00262-013-1396-8
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 909-918
    • Iclozan, C.1    Antonia, S.2    Chiappori, A.3    Chen, D.T.4    Gabrilovich, D.5
  • 72
    • 36348989162 scopus 로고    scopus 로고
    • Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells
    • 18006848
    • Y.Nefedova, M.Fishman, S.Sherman, X.Wang, A.A.Beg, D.I.Gabrilovich. Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res 2007; 67:11021-8; PMID:18006848; http://dx.doi.org/10.1158/0008-5472.CAN-07-2593
    • (2007) Cancer Res , vol.67 , pp. 11021-11028
    • Nefedova, Y.1    Fishman, M.2    Sherman, S.3    Wang, X.4    Beg, A.A.5    Gabrilovich, D.I.6
  • 73
    • 84862120892 scopus 로고    scopus 로고
    • Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner
    • 22283566
    • T.Michels, G.V.Shurin, H.Naiditch, A.Sevko, V.Umansky, M.R.Shurin. Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner. J Immunotoxicol 2012; 9:292-300; PMID:22283566; http://dx.doi.org/10.3109/1547691X.2011.642418
    • (2012) J Immunotoxicol , vol.9 , pp. 292-300
    • Michels, T.1    Shurin, G.V.2    Naiditch, H.3    Sevko, A.4    Umansky, V.5    Shurin, M.R.6
  • 74
    • 77952549994 scopus 로고    scopus 로고
    • Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice
    • 20346445
    • L.W.Pfannenstiel, S.S.Lam, L.A.Emens, E.M.Jaffee, T.D.Armstrong. Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice. Cell Immunol 2010; 263:79-87; PMID:20346445; http://dx.doi.org/10.1016/j.cellimm.2010.03.001
    • (2010) Cell Immunol , vol.263 , pp. 79-87
    • Pfannenstiel, L.W.1    Lam, S.S.2    Emens, L.A.3    Jaffee, E.M.4    Armstrong, T.D.5
  • 75
    • 84874232680 scopus 로고    scopus 로고
    • Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model
    • 23359505
    • A.Sevko, T.Michels, M.Vrohlings, L.Umansky, P.Beckhove, M.Kato, G.V.Shurin, M.R.Shurin, V.Umansky. Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model. J Immunol 2013; 190:2464-71; PMID:23359505; http://dx.doi.org/10.4049/jimmunol.1202781
    • (2013) J Immunol , vol.190 , pp. 2464-2471
    • Sevko, A.1    Michels, T.2    Vrohlings, M.3    Umansky, L.4    Beckhove, P.5    Kato, M.6    Shurin, G.V.7    Shurin, M.R.8    Umansky, V.9
  • 76
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers
    • 20702612
    • K.N.Kodumudi, K.Woan, D.L.Gilvary, E.Sahakian, S.Wei, J.Y.Djeu. A novel chemoimmunomodulating property of docetaxel:suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 2010; 16:4583-94; PMID:20702612; http://dx.doi.org/10.1158/1078-0432.CCR-10-0733
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3    Sahakian, E.4    Wei, S.5    Djeu, J.Y.6
  • 77
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    • 16230418
    • Y.Nefedova, S.Nagaraj, A.Rosenbauer, C.Muro-Cacho, S.M.Sebti, D.I.Gabrilovich. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 2005; 65:9525-35; PMID:16230418; http://dx.doi.org/10.1158/0008-5472.CAN-05-0529
    • (2005) Cancer Res , vol.65 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3    Muro-Cacho, C.4    Sebti, S.M.5    Gabrilovich, D.I.6
  • 78
    • 84867512289 scopus 로고    scopus 로고
    • Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer
    • 22746287
    • P.Lu, B.Yu, J.Xu. Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer. Cancer Biother Radiopharm 2012; 27:495-503; PMID:22746287; http://dx.doi.org/10.1089/cbr.2012.1219
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 495-503
    • Lu, P.1    Yu, B.2    Xu, J.3
  • 79
    • 84958652204 scopus 로고    scopus 로고
    • CD45 Phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation
    • 26885857
    • V.Kumar, P.Cheng, T.Condamine, S.Mony, L.R.Languino, J.C.McCaffrey, N.Hockstein, M.Guarino, G.Masters, E.Penman et al. CD45 Phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation. Immunity 2016; 44:303-15; PMID:26885857; http://dx.doi.org/10.1016/j.immuni.2016.01.014
    • (2016) Immunity , vol.44 , pp. 303-315
    • Kumar, V.1    Cheng, P.2    Condamine, T.3    Mony, S.4    Languino, L.R.5    McCaffrey, J.C.6    Hockstein, N.7    Guarino, M.8    Masters, G.9    Penman, E.10
  • 80
    • 84863248624 scopus 로고    scopus 로고
    • Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
    • 22030090
    • S.P.Tu, H.Jin, J.D.Shi, L.M.Zhu, Y.Suo, G.Lu, A.Liu, T.C.Wang, C.S.Yang. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila) 2012; 5:205-15; PMID:22030090; http://dx.doi.org/10.1158/1940-6207.CAPR-11-0247
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 205-215
    • Tu, S.P.1    Jin, H.2    Shi, J.D.3    Zhu, L.M.4    Suo, Y.5    Lu, G.6    Liu, A.7    Wang, T.C.8    Yang, C.S.9
  • 81
    • 0032881792 scopus 로고    scopus 로고
    • Skewed differentiation of bone marrow CD34+ cells of tumor bearers from dendritic toward monocytic cells, and the redirection of differentiation toward dendritic cells by 1alpha,25-dihydroxyvitamin D3
    • 12609462
    • M.R.Young, M.A.Wright, K.Vellody, D.M.Lathers. Skewed differentiation of bone marrow CD34+ cells of tumor bearers from dendritic toward monocytic cells, and the redirection of differentiation toward dendritic cells by 1alpha,25-dihydroxyvitamin D3. Int J Immunopharmacol 1999; 21:675-88; PMID:12609462; http://dx.doi.org/10.1016/S0192-0561(99)00044-2
    • (1999) Int J Immunopharmacol , vol.21 , pp. 675-688
    • Young, M.R.1    Wright, M.A.2    Vellody, K.3    Lathers, D.M.4
  • 82
    • 59249090694 scopus 로고    scopus 로고
    • 1alpha,25-Dihydroxyvitamin D(3) to skew intratumoral levels of immune inhibitory CD34(+) progenitor cells into dendritic cells
    • 19201295
    • J.S.Kulbersh, T.A.Day, M.B.Gillespie, M.R.Young. 1alpha,25-Dihydroxyvitamin D(3) to skew intratumoral levels of immune inhibitory CD34(+) progenitor cells into dendritic cells. Otolaryngol Head Neck Surg 2009; 140:235-40; PMID:19201295; http://dx.doi.org/10.1016/j.otohns.2008.11.011
    • (2009) Otolaryngol Head Neck Surg , vol.140 , pp. 235-240
    • Kulbersh, J.S.1    Day, T.A.2    Gillespie, M.B.3    Young, M.R.4
  • 83
    • 77953916257 scopus 로고    scopus 로고
    • Use of α,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma
    • 20438786
    • J.E.Walsh, A.M.Clark, T.A.Day, M.B.Gillespie, M.R.Young. Use of α,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma. Hum Immunol 2010; 71:659-65; PMID:20438786; http://dx.doi.org/10.1016/j.humimm.2010.04.008
    • (2010) Hum Immunol , vol.71 , pp. 659-665
    • Walsh, J.E.1    Clark, A.M.2    Day, T.A.3    Gillespie, M.B.4    Young, M.R.5
  • 84
    • 84921904953 scopus 로고    scopus 로고
    • Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials
    • 25624439
    • M.Di Maio, C.Gallo, N.B.Leighl, M.C.Piccirillo, G.Daniele, F.Nuzzo, C.Gridelli, V.Gebbia, F.Ciardiello, S.De Placido et al. Symptomatic toxicities experienced during anticancer treatment:agreement between patient and physician reporting in three randomized trials. J Clin Oncol 2015; 33:910-5; PMID:25624439; http://dx.doi.org/10.1200/JCO.2014.57.9334
    • (2015) J Clin Oncol , vol.33 , pp. 910-915
    • Di Maio, M.1    Gallo, C.2    Leighl, N.B.3    Piccirillo, M.C.4    Daniele, G.5    Nuzzo, F.6    Gridelli, C.7    Gebbia, V.8    Ciardiello, F.9    De Placido, S.10
  • 85
    • 84902000342 scopus 로고    scopus 로고
    • Chemotherapy-induced neuropathy: A comprehensive survey
    • 24830939
    • N.C.Miltenburg, W.Boogerd. Chemotherapy-induced neuropathy:A comprehensive survey. Cancer Treat Rev 2014; 40:872-82; PMID:24830939; http://dx.doi.org/10.1016/j.ctrv.2014.04.004
    • (2014) Cancer Treat Rev , vol.40 , pp. 872-882
    • Miltenburg, N.C.1    Boogerd, W.2
  • 86
    • 84897890387 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an “innocent bystander
    • 24594636
    • L.Gelao, C.Criscitiello, A.Esposito, A.Goldhirsch, G.Curigliano. Immune checkpoint blockade in cancer treatment:a double-edged sword cross-targeting the host as an “innocent bystander”. Toxins (Basel) 2014; 6:914-33; PMID:24594636; http://dx.doi.org/10.3390/toxins6030914
    • (2014) Toxins (Basel) , vol.6 , pp. 914-933
    • Gelao, L.1    Criscitiello, C.2    Esposito, A.3    Goldhirsch, A.4    Curigliano, G.5
  • 87
    • 84925797532 scopus 로고    scopus 로고
    • Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice
    • 25545152
    • K.Nishimura, J.Saegusa, F.Matsuki, K.Akashi, G.Kageyama, A.Morinobu. Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice. Arthritis Rheumatol 2015; 67:893-902; PMID:25545152; http://dx.doi.org/10.1002/art.39007
    • (2015) Arthritis Rheumatol , vol.67 , pp. 893-902
    • Nishimura, K.1    Saegusa, J.2    Matsuki, F.3    Akashi, K.4    Kageyama, G.5    Morinobu, A.6
  • 88
    • 84907068048 scopus 로고    scopus 로고
    • AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells
    • 25149535
    • S.K.Maenhout, S.Du Four, J.Corthals, B.Neyns, K.Thielemans, J.L.Aerts. AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells. Oncotarget 2014; 5:6801-15; PMID:25149535
    • (2014) Oncotarget , vol.5 , pp. 6801-6815
    • Maenhout, S.K.1    Du Four, S.2    Corthals, J.3    Neyns, B.4    Thielemans, K.5    Aerts, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.