메뉴 건너뛰기




Volumn 16, Issue 4, 2016, Pages 1-7

Cerebral Lactate Metabolism After Traumatic Brain Injury

Author keywords

Cerebral metabolism; Energetic dysfunction; Glucose; Lactate; Traumatic brain injury

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCOSE TRANSPORTER; HYDROXYCARBOXYLIC ACID RECEPTOR 1; HYPERTONIC SOLUTION; LACTIC ACID; UNCLASSIFIED DRUG; GLUCOSE;

EID: 84982843937     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-016-0638-5     Document Type: Review
Times cited : (71)

References (56)
  • 1
    • 46849094295 scopus 로고    scopus 로고
    • Moderate and severe traumatic brain injury in adults
    • PID: 18635021
    • Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008;7(8):728–41. doi:10.1016/S1474-4422(08)70164-9.
    • (2008) Lancet Neurol , vol.7 , Issue.8 , pp. 728-741
    • Maas, A.I.1    Stocchetti, N.2    Bullock, R.3
  • 2
    • 84904396161 scopus 로고    scopus 로고
    • Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care
    • PID: 25071702
    • Rostami E, Engquist H, Enblad P. Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care. Front Neurol. 2014;5:114. doi:10.3389/fneur.2014.00114.
    • (2014) Front Neurol , vol.5 , pp. 114
    • Rostami, E.1    Engquist, H.2    Enblad, P.3
  • 3
    • 0038692191 scopus 로고    scopus 로고
    • Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study
    • COI: 1:CAS:528:DC%2BD3sXmsVSktb8%3D, PID: 12843790
    • Vespa PM, McArthur D, O'Phelan K, Glenn T, Etchepare M, Kelly D, et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23(7):865–77. doi:10.1097/01.WCB.0000076701.45782.EF.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.7 , pp. 865-877
    • Vespa, P.M.1    McArthur, D.2    O'Phelan, K.3    Glenn, T.4    Etchepare, M.5    Kelly, D.6
  • 4
    • 84896401893 scopus 로고    scopus 로고
    • Metabolic crisis in severely head-injured patients: is ischemia just the tip of the iceberg?
    • PID: 24130548
    • Carre E, Ogier M, Boret H, Montcriol A, Bourdon L, Jean-Jacques R. Metabolic crisis in severely head-injured patients: is ischemia just the tip of the iceberg? Front Neurol. 2013;4:146. doi:10.3389/fneur.2013.00146.
    • (2013) Front Neurol , vol.4 , pp. 146
    • Carre, E.1    Ogier, M.2    Boret, H.3    Montcriol, A.4    Bourdon, L.5    Jean-Jacques, R.6
  • 5
    • 18944405433 scopus 로고    scopus 로고
    • Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    • COI: 1:CAS:528:DC%2BD2MXlsFegsro%3D, PID: 15716852
    • Vespa P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab. 2005;25(6):763–74. doi:10.1038/sj.jcbfm.9600073.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.6 , pp. 763-774
    • Vespa, P.1    Bergsneider, M.2    Hattori, N.3    Wu, H.M.4    Huang, S.C.5    Martin, N.A.6
  • 6
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • COI: 1:CAS:528:DyaK2cXmvFentr8%3D, PID: 7938003
    • Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A. 1994;91(22):10625–9.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.22 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 7
    • 84890447871 scopus 로고    scopus 로고
    • Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study
    • PID: 23968221
    • Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon DK, Carpenter KL, et al. Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study. J Neurotrauma. 2013;30(24):2031–7. doi:10.1089/neu.2013.2947.
    • (2013) J Neurotrauma , vol.30 , Issue.24 , pp. 2031-2037
    • Jalloh, I.1    Helmy, A.2    Shannon, R.J.3    Gallagher, C.N.4    Menon, D.K.5    Carpenter, K.L.6
  • 8
    • 0141891196 scopus 로고    scopus 로고
    • Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism
    • COI: 1:CAS:528:DC%2BD3sXnslaqsbc%3D, PID: 14526234
    • Glenn TC, Kelly DF, Boscardin WJ, McArthur DL, Vespa P, Oertel M, et al. Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab. 2003;23(10):1239–50. doi:10.1097/01.WCB.0000089833.23606.7F.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.10 , pp. 1239-1250
    • Glenn, T.C.1    Kelly, D.F.2    Boscardin, W.J.3    McArthur, D.L.4    Vespa, P.5    Oertel, M.6
  • 9
    • 84899412718 scopus 로고    scopus 로고
    • Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain
    • COI: 1:CAS:528:DC%2BC2cXhs1GqsLs%3D, PID: 24477453, This recent pilot phase II investigational study examined the effect of a short infusion of hypertonic lactate in TBI patients monitored with CMD. It was found a significant and clinically relevant increase of CMD glucose, suggesting a beneficial cerebral glucose sparing-effect. Additional positive effects of hypertonic lactate were the decrease of glutamate (reduced excitotoxicity) and of ICP
    • Bouzat P, Sala N, Suys T, Zerlauth JB, Marques-Vidal P, Feihl F, et al. Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain. Intensive Care Med. 2014;40(3):412–21. doi:10.1007/s00134-013-3203-6. This recent pilot phase II investigational study examined the effect of a short infusion of hypertonic lactate in TBI patients monitored with CMD. It was found a significant and clinically relevant increase of CMD glucose, suggesting a beneficial cerebral glucose sparing-effect. Additional positive effects of hypertonic lactate were the decrease of glutamate (reduced excitotoxicity) and of ICP.
    • (2014) Intensive Care Med , vol.40 , Issue.3 , pp. 412-421
    • Bouzat, P.1    Sala, N.2    Suys, T.3    Zerlauth, J.B.4    Marques-Vidal, P.5    Feihl, F.6
  • 10
    • 0037154801 scopus 로고    scopus 로고
    • Lactate administration attenuates cognitive deficits following traumatic brain injury
    • COI: 1:CAS:528:DC%2BD38Xht1ahsLk%3D, PID: 11844482
    • Rice AC, Zsoldos R, Chen T, Wilson MS, Alessandri B, Hamm RJ, et al. Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res. 2002;928(1–2):156–9.
    • (2002) Brain Res , vol.928 , Issue.1-2 , pp. 156-159
    • Rice, A.C.1    Zsoldos, R.2    Chen, T.3    Wilson, M.S.4    Alessandri, B.5    Hamm, R.J.6
  • 11
    • 34548225552 scopus 로고    scopus 로고
    • Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat
    • COI: 1:STN:280:DC%2BD2svpvFCkug%3D%3D, PID: 17660938, discussion 27
    • Holloway R, Zhou Z, Harvey HB, Levasseur JE, Rice AC, Sun D, et al. Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. Acta Neurochir. 2007;149(9):919–27. doi:10.1007/s00701-007-1241-y. discussion 27.
    • (2007) Acta Neurochir , vol.149 , Issue.9 , pp. 919-927
    • Holloway, R.1    Zhou, Z.2    Harvey, H.B.3    Levasseur, J.E.4    Rice, A.C.5    Sun, D.6
  • 12
    • 58149214725 scopus 로고    scopus 로고
    • Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study
    • COI: 1:CAS:528:DC%2BD1cXhtl2qt7zK, PID: 18936695
    • Oddo M, Schmidt JM, Carrera E, Badjatia N, Connolly ES, Presciutti M, et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36(12):3233–8. doi:10.1097/CCM.0b013e31818f4026.
    • (2008) Crit Care Med , vol.36 , Issue.12 , pp. 3233-3238
    • Oddo, M.1    Schmidt, J.M.2    Carrera, E.3    Badjatia, N.4    Connolly, E.S.5    Presciutti, M.6
  • 13
    • 34547624611 scopus 로고    scopus 로고
    • Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    • COI: 1:CAS:528:DC%2BD2sXhtF2rur7J, PID: 17579656
    • Simpson IA, Carruthers A, Vannucci SJ. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab. 2007;27(11):1766–91. doi:10.1038/sj.jcbfm.9600521.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.11 , pp. 1766-1791
    • Simpson, I.A.1    Carruthers, A.2    Vannucci, S.J.3
  • 15
    • 84920640012 scopus 로고    scopus 로고
    • Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose
    • COI: 1:CAS:528:DC%2BC2cXhvVWntbjL, PID: 25335801
    • Jalloh I, Carpenter KL, Grice P, Howe DJ, Mason A, Gallagher CN, et al. Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose. J Cereb Blood Flow Metab. 2015;35(1):111–20. doi:10.1038/jcbfm.2014.177.
    • (2015) J Cereb Blood Flow Metab , vol.35 , Issue.1 , pp. 111-120
    • Jalloh, I.1    Carpenter, K.L.2    Grice, P.3    Howe, D.J.4    Mason, A.5    Gallagher, C.N.6
  • 17
    • 0342963103 scopus 로고
    • Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects
    • COI: 1:STN:280:DyaL287kvFagsw%3D%3D, PID: 3485282
    • Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A. 1986;83(4):1140–4.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , Issue.4 , pp. 1140-1144
    • Fox, P.T.1    Raichle, M.E.2
  • 18
    • 33745726895 scopus 로고    scopus 로고
    • Fuelling cerebral activity in exercising man
    • COI: 1:CAS:528:DC%2BD28XmtVOhtrk%3D, PID: 16395281
    • Dalsgaard MK. Fuelling cerebral activity in exercising man. J Cereb Blood Flow Metab. 2006;26(6):731–50. doi:10.1038/sj.jcbfm.9600256.
    • (2006) J Cereb Blood Flow Metab , vol.26 , Issue.6 , pp. 731-750
    • Dalsgaard, M.K.1
  • 19
    • 0030997119 scopus 로고    scopus 로고
    • Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study
    • COI: 1:STN:280:DyaK2s7mtlKiuw%3D%3D, PID: 9010426
    • Bergsneider M, Hovda DA, Shalmon E, Kelly DF, Vespa PM, Martin NA, et al. Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg. 1997;86(2):241–51. doi:10.3171/jns.1997.86.2.0241.
    • (1997) J Neurosurg , vol.86 , Issue.2 , pp. 241-251
    • Bergsneider, M.1    Hovda, D.A.2    Shalmon, E.3    Kelly, D.F.4    Vespa, P.M.5    Martin, N.A.6
  • 20
    • 84891871611 scopus 로고    scopus 로고
    • Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
    • COI: 1:CAS:528:DC%2BC2cXksV2mtw%3D%3D, PID: 24411938
    • Goyal MS, Hawrylycz M, Miller JA, Snyder AZ, Raichle ME. Aerobic glycolysis in the human brain is associated with development and neotenous gene expression. Cell Metab. 2014;19(1):49–57. doi:10.1016/j.cmet.2013.11.020.
    • (2014) Cell Metab , vol.19 , Issue.1 , pp. 49-57
    • Goyal, M.S.1    Hawrylycz, M.2    Miller, J.A.3    Snyder, A.Z.4    Raichle, M.E.5
  • 21
    • 58849104345 scopus 로고    scopus 로고
    • A combined microdialysis and FDG-PET study of glucose metabolism in head injury
    • PID: 19099177, discussion
    • Hutchinson PJ, O'Connell MT, Seal A, Nortje J, Timofeev I, Al-Rawi PG, et al. A combined microdialysis and FDG-PET study of glucose metabolism in head injury. Acta Neurochir. 2009;151(1):51–61. doi:10.1007/s00701-008-0169-1. discussion.
    • (2009) Acta Neurochir , vol.151 , Issue.1 , pp. 51-61
    • Hutchinson, P.J.1    O'Connell, M.T.2    Seal, A.3    Nortje, J.4    Timofeev, I.5    Al-Rawi, P.G.6
  • 22
    • 84928664214 scopus 로고    scopus 로고
    • Glycolysis and the significance of lactate in traumatic brain injury
    • PID: 25904838
    • Carpenter KL, Jalloh I, Hutchinson PJ. Glycolysis and the significance of lactate in traumatic brain injury. Front Neurosci. 2015;9:112. doi:10.3389/fnins.2015.00112.
    • (2015) Front Neurosci , vol.9 , pp. 112
    • Carpenter, K.L.1    Jalloh, I.2    Hutchinson, P.J.3
  • 23
    • 67349095741 scopus 로고    scopus 로고
    • Blood lactate is an important energy source for the human brain
    • PID: 19337275
    • van Hall G, Stromstad M, Rasmussen P, Jans O, Zaar M, Gam C, et al. Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab. 2009;29(6):1121–9. doi:10.1038/jcbfm.2009.35.
    • (2009) J Cereb Blood Flow Metab , vol.29 , Issue.6 , pp. 1121-1129
    • van Hall, G.1    Stromstad, M.2    Rasmussen, P.3    Jans, O.4    Zaar, M.5    Gam, C.6
  • 24
    • 84938483649 scopus 로고    scopus 로고
    • Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate
    • Patet C, Quintard H, Suys T, Bloch J, Daniel R, Pellerin L, et al. Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate. J Neurotrauma. 2015. doi:10.1089/neu.2014.3781.
    • (2015) J Neurotrauma
    • Patet, C.1    Quintard, H.2    Suys, T.3    Bloch, J.4    Daniel, R.5    Pellerin, L.6
  • 25
    • 12544249525 scopus 로고    scopus 로고
    • Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis
    • PID: 15665601
    • Hillered L, Vespa PM, Hovda DA. Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis. J Neurotrauma. 2005;22(1):3–41. doi:10.1089/neu.2005.22.3.
    • (2005) J Neurotrauma , vol.22 , Issue.1 , pp. 3-41
    • Hillered, L.1    Vespa, P.M.2    Hovda, D.A.3
  • 26
    • 79551702749 scopus 로고    scopus 로고
    • Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    • PID: 21247930
    • Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O'Connell MT, Czosnyka M, et al. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain. 2011;134(Pt 2):484–94. doi:10.1093/brain/awq353.
    • (2011) Brain , vol.134 , pp. 484-494
    • Timofeev, I.1    Carpenter, K.L.2    Nortje, J.3    Al-Rawi, P.G.4    O'Connell, M.T.5    Czosnyka, M.6
  • 27
    • 84924345565 scopus 로고    scopus 로고
    • Cerebral metabolism following traumatic brain injury: new discoveries with implications for treatment
    • PID: 25709562
    • Brooks GA, Martin NA. Cerebral metabolism following traumatic brain injury: new discoveries with implications for treatment. Front Neurosci. 2014;8:408. doi:10.3389/fnins.2014.00408.
    • (2014) Front Neurosci , vol.8 , pp. 408
    • Brooks, G.A.1    Martin, N.A.2
  • 28
    • 84887095057 scopus 로고    scopus 로고
    • Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury
    • COI: 1:CAS:528:DC%2BC3sXhslWqur3P, PID: 23963367
    • Sala N, Suys T, Zerlauth JB, Bouzat P, Messerer M, Bloch J, et al. Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury. J Cereb Blood Flow Metab. 2013;33(11):1815–22. doi:10.1038/jcbfm.2013.142.
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.11 , pp. 1815-1822
    • Sala, N.1    Suys, T.2    Zerlauth, J.B.3    Bouzat, P.4    Messerer, M.5    Bloch, J.6
  • 29
    • 70349957926 scopus 로고    scopus 로고
    • The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
    • PID: 19700417
    • Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, et al. The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study. Brain. 2009;132(Pt 10):2839–49. doi:10.1093/brain/awp202.
    • (2009) Brain , vol.132 , pp. 2839-2849
    • Gallagher, C.N.1    Carpenter, K.L.2    Grice, P.3    Howe, D.J.4    Mason, A.5    Timofeev, I.6
  • 30
    • 84856734036 scopus 로고    scopus 로고
    • Acute feedback control of astrocytic glycolysis by lactate
    • COI: 1:STN:280:DC%2BC383hsFCgtw%3D%3D, PID: 22290492
    • Sotelo-Hitschfeld T, Fernandez-Moncada I, Barros LF. Acute feedback control of astrocytic glycolysis by lactate. Glia. 2012;60(4):674–80. doi:10.1002/glia.22304.
    • (2012) Glia , vol.60 , Issue.4 , pp. 674-680
    • Sotelo-Hitschfeld, T.1    Fernandez-Moncada, I.2    Barros, L.F.3
  • 31
    • 78149425848 scopus 로고    scopus 로고
    • Glial and neuronal control of brain blood flow
    • COI: 1:CAS:528:DC%2BC3cXhsVWjsbzJ, PID: 21068832
    • Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468(7321):232–43. doi:10.1038/nature09613.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 232-243
    • Attwell, D.1    Buchan, A.M.2    Charpak, S.3    Lauritzen, M.4    Macvicar, B.A.5    Newman, E.A.6
  • 32
    • 35548995067 scopus 로고    scopus 로고
    • Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    • COI: 1:CAS:528:DC%2BD2sXht1ajsbbM, PID: 17952067
    • Vilchez D, Ros S, Cifuentes D, Pujadas L, Valles J, Garcia-Fojeda B, et al. Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat Neurosci. 2007;10(11):1407–13. doi:10.1038/nn1998.
    • (2007) Nat Neurosci , vol.10 , Issue.11 , pp. 1407-1413
    • Vilchez, D.1    Ros, S.2    Cifuentes, D.3    Pujadas, L.4    Valles, J.5    Garcia-Fojeda, B.6
  • 33
    • 78649694225 scopus 로고    scopus 로고
    • Treating hyperglycemia in neurocritical patients: benefits and perils
    • PID: 20652767
    • Godoy DA, Di Napoli M, Rabinstein AA. Treating hyperglycemia in neurocritical patients: benefits and perils. Neurocrit Care. 2010;13(3):425–38. doi:10.1007/s12028-010-9404-8.
    • (2010) Neurocrit Care , vol.13 , Issue.3 , pp. 425-438
    • Godoy, D.A.1    Di Napoli, M.2    Rabinstein, A.A.3
  • 34
    • 77950483051 scopus 로고    scopus 로고
    • Glycogen metabolism: metabolic coupling between astrocytes and neurons
    • COI: 1:CAS:528:DC%2BC3cXltV2nu7k%3D, PID: 20231669
    • Benarroch EE. Glycogen metabolism: metabolic coupling between astrocytes and neurons. Neurology. 2010;74(11):919–23. doi:10.1212/WNL.0b013e3181d3e44b.
    • (2010) Neurology , vol.74 , Issue.11 , pp. 919-923
    • Benarroch, E.E.1
  • 35
    • 84938207174 scopus 로고    scopus 로고
    • Brain glycogen decreases during intense exercise without hypoglycemia: the possible involvement of serotonin
    • COI: 1:CAS:528:DC%2BC2MXpsVyrsbw%3D, PID: 26037553
    • Matsui T, Soya S, Kawanaka K, Soya H. Brain glycogen decreases during intense exercise without hypoglycemia: the possible involvement of serotonin. Neurochem Res. 2015;40(7):1333–40. doi:10.1007/s11064-015-1594-1.
    • (2015) Neurochem Res , vol.40 , Issue.7 , pp. 1333-1340
    • Matsui, T.1    Soya, S.2    Kawanaka, K.3    Soya, H.4
  • 36
    • 84868686002 scopus 로고    scopus 로고
    • New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration
    • COI: 1:CAS:528:DC%2BC38XhvVyktL3E, PID: 23154656
    • Berthet C, Castillo X, Magistretti PJ, Hirt L. New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration. Cerebrovasc Dis. 2012;34(5–6):329–35. doi:10.1159/000343657.
    • (2012) Cerebrovasc Dis , vol.34 , Issue.5-6 , pp. 329-335
    • Berthet, C.1    Castillo, X.2    Magistretti, P.J.3    Hirt, L.4
  • 37
    • 84865208378 scopus 로고    scopus 로고
    • The neuroprotective effect of lactate is not due to improved glutamate uptake after controlled cortical impact in rats
    • PID: 22888957
    • Alessandri B, Schwandt E, Kamada Y, Nagata M, Heimann A, Kempski O. The neuroprotective effect of lactate is not due to improved glutamate uptake after controlled cortical impact in rats. J Neurotrauma. 2012;29(12):2181–91. doi:10.1089/neu.2011.2067.
    • (2012) J Neurotrauma , vol.29 , Issue.12 , pp. 2181-2191
    • Alessandri, B.1    Schwandt, E.2    Kamada, Y.3    Nagata, M.4    Heimann, A.5    Kempski, O.6
  • 38
    • 0035542983 scopus 로고    scopus 로고
    • Oligodendrocytes use lactate as a source of energy and as a precursor of lipids
    • COI: 1:STN:280:DC%2BD3Mnps12rug%3D%3D, PID: 11746769
    • Sanchez-Abarca LI, Tabernero A, Medina JM. Oligodendrocytes use lactate as a source of energy and as a precursor of lipids. Glia. 2001;36(3):321–9.
    • (2001) Glia , vol.36 , Issue.3 , pp. 321-329
    • Sanchez-Abarca, L.I.1    Tabernero, A.2    Medina, J.M.3
  • 39
    • 67649496586 scopus 로고    scopus 로고
    • A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
    • COI: 1:CAS:528:DC%2BD1MXovV2mt7w%3D, PID: 19457103
    • Castro MA, Beltran FA, Brauchi S, Concha II. A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid. J Neurochem. 2009;110(2):423–40. doi:10.1111/j.1471-4159.2009.06151.x.
    • (2009) J Neurochem , vol.110 , Issue.2 , pp. 423-440
    • Castro, M.A.1    Beltran, F.A.2    Brauchi, S.3    Concha, I.I.4
  • 40
    • 36448983548 scopus 로고    scopus 로고
    • Na(+)-Ca(2+) cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes
    • PID: 17924581
    • Porras OH, Ruminot I, Loaiza A, Barros LF. Na(+)-Ca(2+) cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes. Glia. 2008;56(1):59–68. doi:10.1002/glia.20589.
    • (2008) Glia , vol.56 , Issue.1 , pp. 59-68
    • Porras, O.H.1    Ruminot, I.2    Loaiza, A.3    Barros, L.F.4
  • 41
    • 39749191331 scopus 로고    scopus 로고
    • Current trends in lactate metabolism: introduction
    • COI: 1:CAS:528:DC%2BD1cXit1ynt7k%3D, PID: 18379209
    • Gladden LB. Current trends in lactate metabolism: introduction. Med Sci Sports Exerc. 2008;40(3):475–6. doi:10.1249/MSS.0b013e31816154c9.
    • (2008) Med Sci Sports Exerc , vol.40 , Issue.3 , pp. 475-476
    • Gladden, L.B.1
  • 42
    • 34548125766 scopus 로고    scopus 로고
    • Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humans
    • COI: 1:CAS:528:DC%2BD2sXptlSqtro%3D, PID: 17293841
    • Dusick JR, Glenn TC, Lee WN, Vespa PM, Kelly DF, Lee SM, et al. Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humans. J Cereb Blood Flow Metab. 2007;27(9):1593–602. doi:10.1038/sj.jcbfm.9600458.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.9 , pp. 1593-1602
    • Dusick, J.R.1    Glenn, T.C.2    Lee, W.N.3    Vespa, P.M.4    Kelly, D.F.5    Lee, S.M.6
  • 43
    • 84934441936 scopus 로고    scopus 로고
    • Is L-lactate a novel signaling molecule in the brain?
    • COI: 1:CAS:528:DC%2BC2MXnsFOqu7g%3D, PID: 25920953
    • Mosienko V, Teschemacher AG, Kasparov S. Is L-lactate a novel signaling molecule in the brain? J Cereb Blood Flow Metab. 2015;35(7):1069–75. doi:10.1038/jcbfm.2015.77.
    • (2015) J Cereb Blood Flow Metab , vol.35 , Issue.7 , pp. 1069-1075
    • Mosienko, V.1    Teschemacher, A.G.2    Kasparov, S.3
  • 44
    • 84942986567 scopus 로고    scopus 로고
    • A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia
    • This study perfusing isotopic D- and L-lactate on an animal model of transient focal cerebral ischemia revealed a strong neuronal expression of the HCA1 receptor in different parts of brain. They also observed a significant increase in HCA1 receptor following ischemia and reinforced by the intravenous injection of L-lactate
    • Castillo X, Rosafio K, Wyss MT, Drandarov K, Buck A, Pellerin L, et al. A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia. J Cereb Blood Flow Metab. 2015. doi:10.1038/jcbfm.2015.115. This study perfusing isotopic D- and L-lactate on an animal model of transient focal cerebral ischemia revealed a strong neuronal expression of the HCA1 receptor in different parts of brain. They also observed a significant increase in HCA1 receptor following ischemia and reinforced by the intravenous injection of L-lactate.
    • (2015) J Cereb Blood Flow Metab
    • Castillo, X.1    Rosafio, K.2    Wyss, M.T.3    Drandarov, K.4    Buck, A.5    Pellerin, L.6
  • 45
    • 84881482883 scopus 로고    scopus 로고
    • Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathway
    • COI: 1:CAS:528:DC%2BC3sXhtlaqs7rE, PID: 23951229
    • Bozzo L, Puyal J, Chatton JY. Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathway. PLoS One. 2013;8(8), e71721. doi:10.1371/journal.pone.0071721.
    • (2013) PLoS One , vol.8 , Issue.8
    • Bozzo, L.1    Puyal, J.2    Chatton, J.Y.3
  • 46
    • 84930335880 scopus 로고    scopus 로고
    • Endogenous nutritive support after traumatic brain injury: peripheral lactate production for glucose supply via gluconeogenesis
    • PID: 25279664, This study extended the ANLS hypothesis to the whole body. The authors evaluated systemic lactate metabolism using isotope tracers of glucose and lactate and sampling blood from the brain through arterial and jugular bulb catheters. They determined that lactate clearance accounted for 67.1% of glucose rate of appearance in TBI patients and concluded that blood lactate is the major precursor of glucose through gluconeogenesis
    • Glenn TC, Martin NA, McArthur DL, Hovda DA, Vespa P, Johnson ML, et al. Endogenous nutritive support after traumatic brain injury: peripheral lactate production for glucose supply via gluconeogenesis. J Neurotrauma. 2015;32(11):811–9. doi:10.1089/neu.2014.3482. This study extended the ANLS hypothesis to the whole body. The authors evaluated systemic lactate metabolism using isotope tracers of glucose and lactate and sampling blood from the brain through arterial and jugular bulb catheters. They determined that lactate clearance accounted for 67.1% of glucose rate of appearance in TBI patients and concluded that blood lactate is the major precursor of glucose through gluconeogenesis.
    • (2015) J Neurotrauma , vol.32 , Issue.11 , pp. 811-819
    • Glenn, T.C.1    Martin, N.A.2    McArthur, D.L.3    Hovda, D.A.4    Vespa, P.5    Johnson, M.L.6
  • 47
    • 84924455174 scopus 로고    scopus 로고
    • Channel-mediated lactate release by K(+)-stimulated astrocytes
    • COI: 1:CAS:528:DC%2BC2MXhtVCktLrL, PID: 25762664
    • Sotelo-Hitschfeld T, Niemeyer MI, Machler P, Ruminot I, Lerchundi R, Wyss MT, et al. Channel-mediated lactate release by K(+)-stimulated astrocytes. J Neurosci. 2015;35(10):4168–78. doi:10.1523/JNEUROSCI.5036-14.2015.
    • (2015) J Neurosci , vol.35 , Issue.10 , pp. 4168-4178
    • Sotelo-Hitschfeld, T.1    Niemeyer, M.I.2    Machler, P.3    Ruminot, I.4    Lerchundi, R.5    Wyss, M.T.6
  • 48
    • 0034575201 scopus 로고    scopus 로고
    • Evidence for lactate uptake after rat fluid percussion brain injury
    • COI: 1:CAS:528:DC%2BD3MXlsV2qsbY%3D, PID: 11450045
    • Chen T, Qian YZ, Di X, Zhu JP, Bullock R. Evidence for lactate uptake after rat fluid percussion brain injury. Acta Neurochir Suppl. 2000;76:359–64.
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 359-364
    • Chen, T.1    Qian, Y.Z.2    Di, X.3    Zhu, J.P.4    Bullock, R.5
  • 49
    • 77958528666 scopus 로고    scopus 로고
    • The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy
    • COI: 1:CAS:528:DC%2BC3cXhtlyqtLvM, PID: 20962220
    • Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, et al. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci. 2010;30(42):13983–91. doi:10.1523/JNEUROSCI.2040-10.2010.
    • (2010) J Neurosci , vol.30 , Issue.42 , pp. 13983-13991
    • Boumezbeur, F.1    Petersen, K.F.2    Cline, G.W.3    Mason, G.F.4    Behar, K.L.5    Shulman, G.I.6
  • 50
    • 54049143854 scopus 로고    scopus 로고
    • Lactate fuels the human brain during exercise
    • COI: 1:CAS:528:DC%2BD1cXht1SqsrnO, PID: 18653766
    • Quistorff B, Secher NH, Van Lieshout JJ. Lactate fuels the human brain during exercise. FASEB J. 2008;22(10):3443–9. doi:10.1096/fj.08-106104.
    • (2008) FASEB J , vol.22 , Issue.10 , pp. 3443-3449
    • Quistorff, B.1    Secher, N.H.2    Van Lieshout, J.J.3
  • 51
    • 0037782010 scopus 로고    scopus 로고
    • Lactate: a preferred fuel for human brain metabolism in vivo
    • COI: 1:CAS:528:DC%2BD3sXks1yqsLg%3D, PID: 12796713
    • Smith D, Pernet A, Hallett WA, Bingham E, Marsden PK, Amiel SA. Lactate: a preferred fuel for human brain metabolism in vivo. J Cereb Blood Flow Metab. 2003;23(6):658–64. doi:10.1097/01.WCB.0000063991.19746.11.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.6 , pp. 658-664
    • Smith, D.1    Pernet, A.2    Hallett, W.A.3    Bingham, E.4    Marsden, P.K.5    Amiel, S.A.6
  • 52
    • 0026592560 scopus 로고
    • Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury
    • COI: 1:STN:280:DyaK38%2FnvFSntQ%3D%3D, PID: 1727174
    • Shackford SR, Zhuang J, Schmoker J. Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury. J Neurosurg. 1992;76(1):91–8. doi:10.3171/jns.1992.76.1.0091.
    • (1992) J Neurosurg , vol.76 , Issue.1 , pp. 91-98
    • Shackford, S.R.1    Zhuang, J.2    Schmoker, J.3
  • 53
    • 84927586918 scopus 로고    scopus 로고
    • Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock
    • PID: 25125153
    • Duburcq T, Favory R, Mathieu D, Hubert T, Mangalaboyi J, Gmyr V, et al. Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock. Crit Care. 2014;18(4):467. doi:10.1186/s13054-014-0467-3.
    • (2014) Crit Care , vol.18 , Issue.4 , pp. 467
    • Duburcq, T.1    Favory, R.2    Mathieu, D.3    Hubert, T.4    Mangalaboyi, J.5    Gmyr, V.6
  • 54
    • 60449118292 scopus 로고    scopus 로고
    • Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients
    • COI: 1:CAS:528:DC%2BD1MXhvV2jsLo%3D, PID: 18807008
    • Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med. 2009;35(3):471–9. doi:10.1007/s00134-008-1283-5.
    • (2009) Intensive Care Med , vol.35 , Issue.3 , pp. 471-479
    • Ichai, C.1    Armando, G.2    Orban, J.C.3    Berthier, F.4    Rami, L.5    Samat-Long, C.6
  • 55
    • 84880298733 scopus 로고    scopus 로고
    • Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC3sXhtFajtb7I, PID: 23749153
    • Ichai C, Payen JF, Orban JC, Quintard H, Roth H, Legrand R, et al. Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial. Intensive Care Med. 2013;39(8):1413–22. doi:10.1007/s00134-013-2978-9.
    • (2013) Intensive Care Med , vol.39 , Issue.8 , pp. 1413-1422
    • Ichai, C.1    Payen, J.F.2    Orban, J.C.3    Quintard, H.4    Roth, H.5    Legrand, R.6
  • 56
    • 84929655740 scopus 로고    scopus 로고
    • Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects
    • PID: 25594628
    • Glenn TC, Martin NA, Horning MA, McArthur DL, Hovda DA, Vespa P, et al. Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. J Neurotrauma. 2015;32(11):820–32. doi:10.1089/neu.2014.3483.
    • (2015) J Neurotrauma , vol.32 , Issue.11 , pp. 820-832
    • Glenn, T.C.1    Martin, N.A.2    Horning, M.A.3    McArthur, D.L.4    Hovda, D.A.5    Vespa, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.