Oligodendrocytes use lactate as a source of energy and as a precursor of lipids

GLIA

Volumn 36, Issue 3, 2001, Pages 321-329

  Sánchez Abarca, Luis I ^a   Tabernero, Arantxa ^a,b   Medina, José M ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

Brain; Glucose; Lipid synthesis; Metabolism; Neurons; Oxidation; Type 2 astrocytes

Indexed keywords

CARBON; GALACTOSYLCERAMIDE; GAP 43 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; LACTIC ACID; LIPID; NEUROMODULIN;

AGING; ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CYTOLOGY; ENERGY METABOLISM; FEMALE; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; NERVE CELL; OLIGODENDROGLIA; PHYSIOLOGY; RAT; RAT STRAIN;

AGING; ANIMAL; ASTROCYTES; CARBON RADIOISOTOPES; CELL CULTURE; CENTRAL NERVOUS SYSTEM; ENERGY METABOLISM; FEMALE; GALACTOSYLCERAMIDES; GAP-43 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; IMMUNOHISTOCHEMISTRY; LACTIC ACID; LIPIDS; MALE; NEURONS; OLIGODENDROGLIA; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T;

EID: 0035542983     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.1119     Document Type: Article

References (47)

1. Lactate as an oxidizable substrate for rat brain in vivo during perinatal period
2. Biology of oligodendrocyte and myelin in the mammalian central nervous system
3. Glial cell lineage in the cerebral cortex: A review and synthesis
4. Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. I. Neurons and glia
5. Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus
6. Influence of the malate-aspartate shuttle on oxidative metabolism in synaptesomes
7. Prematurity in the rat. I. Fuels and gluceneogenic enzymes
8. Glycogen in astrocytes, possible function as lactate supply for neighboring cells
9. Uptake of L-lactate by cultured rat brain neurons
10. The use of brain slices
11. Postnatal hypoglycaemia and gluconeogenesis in the newborn rat. Delayed onset of gluconeogenesis in prematurely delivered newborns
12. A simple method for the isolation and purification of total lipids from animal tissues
13. Fuels, hormones and liver metabolism at term during the early postnatal period in the rat
14. Alternative pathways of glucose utilization in brain. Changes in the pattern of glucose utilization in brain during development and the effect of phenazine methosulphate on the integration of metabolic routes
15. Alternative pathways of glucose utilization in brain; Changes in the pattern of glucose utilization in brain resulting from treatment of rats with 6-aminonicotinamide
16. Attenuation of postnatal hypoxia in the premature newborn rat by maternal treatment with dexamethasone: Its relationship with lung phospholipid content
17. Establishment of highly enriched type-2 astrocyte cultures and quantitative determination of intense glutamine synthetase activity in these cells
18. 2 data. Fallibility of a classic equation when applied to non-homogeneous tissues
19. Myelin: Delivery by raft
20. 13C]NMR spectroscopy
21. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
22. Non-gluconeogenic fate of lactate during the early neonatal period in the rat
23. Biochemical adaptations to early extrauterine life
24. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase
25. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
26. Influence of environmental temperature and acidosis on lipid mobilization in the human infant during the first two hours after birth
27. Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
28. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina
29. Mechanisms of glutamate metabolic signaling in retinal glial (Müller) cells
30. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
31. Trafficking between glia and neurons of TCA cycle intermediates and related metabolites
32. An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons
33. 13C NMR study of IGF-I- and insulin-effects on mitochondrial function in cultured brain cells
34. Regulation of Schwann cell Po expression and DNA synthesis by insulin-like growth factors in vitro
35. Glial glycogen stores affect neuronal survival during glucose deprivation in vitro
36. Relationship between the pentose-phosphate pathway and de novo synthesis of fatty acids and cholesterol in oligodendrocyte-enriched glial cultures
37. Lipogenesis from lactate in rat neurons and astrocytes in primary culture
38. Endothalin-1 regulates glucose utilization in cultured rat astrocytes by controlling intercellular communication through gap junctions
39. Lactate spares glucose as a metabolic fuel in neurons and astrocytes from primary culture
40. 2+ concentrations but by free-fatty acid sequestration
41. Transport of L-lactate by cultured rat brain astrocytes
42. Lactic acid as an energy source in perinatal brain
43. Regulation of lactate metabolism by albumin in rat neurons and astrocytes from primary culture
44. A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons
45. Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter
46. Lactate prevents the alterations in tissue amino acids, decline in ATP, and cell damage due to aglycemia in retina
47. 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes