Cerebral extracellular chemistry and outcome following traumatic brain injury: A microdialysis study of 223 patients

Brain

Volumn 134, Issue 2, 2011, Pages 484-494

  Timofeev, Ivan ^a   Carpenter, Keri L H ^a   Nortje, Jürgens ^a,b   Al Rawi, Pippa G ^a   O'Connell, Mark T ^a,b   Czosnyka, Marek ^a   Smielewski, Peter ^a   Pickard, John D ^a,b   Menon, David K ^a,b   Kirkpatrick, Peter J ^a   Gupta, Arun K ^b   Hutchinson, Peter J ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

brain metabolism; microdialysis; outcome; traumatic brain injury (human)

Indexed keywords

GLUCOSE; GLUTAMIC ACID; GLYCEROL; LACTIC ACID; PYRUVIC ACID;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BRAIN PERFUSION; CEREBROVASCULAR PRESSURE REACTIVITY INDEX; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GLASGOW OUTCOME SCALE; GLUCOSE BRAIN LEVEL; HUMAN; INTENSIVE CARE; INTRACRANIAL PRESSURE; MAJOR CLINICAL STUDY; MALE; MICRODIALYSIS; MORTALITY; OUTCOME ASSESSMENT; PATIENT MONITORING; PERFUSION PRESSURE; PREDICTION; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; TRAUMATIC BRAIN INJURY;

ADULT; BIOLOGICAL MARKERS; BRAIN INJURIES; CEREBRAL CORTEX; EXTRACELLULAR FLUID; FEMALE; GLASGOW COMA SCALE; GLASGOW OUTCOME SCALE; GLUCOSE; GLUTAMIC ACID; GLYCEROL; HUMANS; INTRACRANIAL PRESSURE; LACTIC ACID; MALE; MICRODIALYSIS; MIDDLE AGED; PYRUVIC ACID;

EID: 79551702749     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq353     Document Type: Article

References (44)

1. Balestreri M, Czosnyka M, Hutchinson P, Steiner LA, Hiler M, Smielewski P, et al. Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury. Neurocrit Care 2006; 4: 8-13. (Pubitemid 43269454)
2. Bellander BM, Cantais E, Enblad P, Hutchinson P, Nordstrom CH, Robertson C, et al. Consensus meeting on microdialysis in neurointen-sive care. Intensive Care Med 2004; 30: 2166-9. (Pubitemid 40174251)
3. Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, et al. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg 1998; 89: 507-18. (Pubitemid 28440917)
4. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34: 216-22. (Pubitemid 23111023)
5. Czosnyka M, Balestreri M, Steiner L, Smielewski P, Hutchinson PJ, Matta B, et al. Age, intracranial pressure, autoregulation, and outcome after brain trauma. J Neurosurg 2005; 102: 450-4. (Pubitemid 43194035)
6. Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery 1997; 41: 11-7; discussion 17-9.
7. Diaz-Parejo P, Stahl N, Xu W, Reinstrup P, Ungerstedt U, Nordstrom CH. Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma. Intensive Care Med 2003; 29: 544-50. (Pubitemid 36523668)
8. Fukushima M, Lee SM, Moro N, Hovda DA, Sutton RL. Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury. J Neurotrauma 2009; 26: 1095-110.
9. Gilmer LK, Roberts KN, Joy K, Sullivan PG, Scheff SW. Early mitochon-drial dysfunction after cortical contusion injury. J Neurotrauma 2009; 26: 1271-80.
10. Goodman JC, Robertson CS. Microdialysis: is it ready for prime time? Curr Opin Crit Care 2009; 15: 110-7.
11. Goodman JC, Valadka AB, Gopinath SP, Uzura M, Robertson CS. Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit Care Med 1999; 27: 1965-73. (Pubitemid 29455132)
12. Gupta AK, Zygun DA, Johnston AJ, Steiner LA, Al-Rawi PG, Chatfield D, et al. Extracellular brain pH and outcome following severe traumatic brain injury. J Neurotrauma 2004; 21: 678-84. (Pubitemid 38880240)
13. Hlatky R, Valadka AB, Goodman JC, Contant CF, Robertson CS. Patterns of energy substrates during ischemia measured in the brain by micro-dialysis. J Neurotrauma 2004; 21: 894-906. (Pubitemid 38998917)
14. Holbein M, Bechir M, Ludwig S, Sommerfeld J, Cottini SR, Keel M, et al. Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury. Crit Care 2009; 13: R13.
15. Hutchinson PJ, O'Connell MT, Al-Rawi PG, Kett-White R, Gupta AK, Kirkpatrick PJ, et al. Clinical cerebral microdialysis - determining the true extracellular concentration. Acta Neurochir Suppl 2002; 81: 359-62.
16. Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, et al. Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma 2007; 24: 1545-57. (Pubitemid 350035838)
17. Koura SS, Doppenberg EM, Marmarou A, Choi S, Young HF, Bullock R. Relationship between excitatory amino acid release and outcome after severe human head injury. Acta Neurochir Suppl 1998; 71: 244-6. (Pubitemid 128444409)
18. Lee JY, Kim YH, Koh JY. Protection by pyruvate against transient fore-brain ischaemia in rats. J Neurosci 2001; 21: RC171.
19. Marcoux J, McArthur DA, Miller C, Glenn TC, Villablanca P, Martin NA, et al. Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury. Crit Care Med 2008; 36: 2871-7.
20. Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring. J Neurosurg 1979; 50: 20-5. (Pubitemid 9157083)
21. McHugh GS, Engel DC, Butcher I, Steyerberg EW, Lu J, Mushkudiani N, et al. Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007; 24: 287-93. (Pubitemid 46492150)
22. Meierhans R, Bechir M, Ludwig S, Sommerfeld J, Brandi G, Haberthur C, et al. Brain metabolism is significantly impaired at blood glucose below 6mM and brain glucose below 1mM in patients with severe traumatic brain injury. Crit Care 2010; 14: R13.
23. Menon DK. Cerebral protection in severe brain injury: physiological determinants of outcome and their optimisation. Br Med Bull 1999; 55: 226-58. (Pubitemid 29243560)
24. Moro N, Sutton RL. Beneficial effects of sodium or ethyl pyruvate after traumatic injury in the rat. Exp Neurol 2010; 225: 391-401.
25. Murray GD, Butcher I, McHugh GS, Lu J, Mushkudiani NA, Maas AI, et al. Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007; 24: 329-37. (Pubitemid 46492154)
26. Opii WO, Nukala VN, Sultana R, Pandya JD, Day KM, Merchant ML, et al. Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. J Neurotrauma 2007; 24: 772-89. (Pubitemid 46799270)
27. Patel HC, Bouamra O, Woodford M, King AT, Yates DW, Lecky FE. Trends in head injury outcome from 1989 to 2003 and the effect of neurosurgical care: an observational study. Lancet 2005; 366: 1538-44. (Pubitemid 41540111)
28. Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ. Specialist neurocritical care and outcome from head injury. Intensive Care Med 2002; 28: 547-53. (Pubitemid 34594583)
29. Perel P, Arango M, Clayton T, Edwards P, Komolafe E, Poccock S, et al. Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. Br Med J 2008; 336: 425-9. (Pubitemid 351310887)
30. Reinert M, Andres RH, Fuhrer M, Muller A, Schaller B, Widmer H. Online correlation of spontaneous arterial and intracranial pressure fluctuations in patients with diffuse severe head injury. Neurol Res 2007; 29: 455-62. (Pubitemid 47311517)
31. Reinstrup P, Stahl N, Mellergard P, Uski T, Ungerstedt U, Nordstrom CH. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefullness, anesthesia, and neurosurgery. Neurosurgery 2000; 47: 701-9.
32. Sarrafzadeh A, Haux D, Kuchler I, Lanksch WR, Unterberg AW. Poor-grade aneurysmal subarachnoid hemorrhage: relationship of cerebral metabolism to outcome. J Neurosurg 2004; 100: 400-6. (Pubitemid 38269066)
33. Saul TG, Ducker TB. Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg 1982; 56: 498-503. (Pubitemid 12055036)
34. Singh IN, Sullivan PG, Deng Y, Mbye LH, Hall ED. Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuro-protective therapy. J Cereb Blood Flow Metab 2006; 26: 1407-18. (Pubitemid 44629888)
35. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS. Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 1998; 26: 1576-81. (Pubitemid 28450368)
36. Van den Brink WA, Van Santbrink H, Steyerberg EW, Avezaat CJ, Suazo JA, Hogesteeger C, et al. Brain oxygen tension in severe head injury. Neurosurgery 2000; 46: 868-76; discussion 76-8.
37. Van Santbrink H, Maas AI, Avezaat CJ. Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 1996; 38: 21-31. (Pubitemid 26002379)
38. Verweij BH, Muizelaar JP, Vinas FC, Peterson PL, Xiong Y, Lee CP. Impaired cerebral mitochondrial function after traumatic brain injury in humans. J Neurosurg 2000; 93: 815-20. (Pubitemid 32803405)
39. Vespa P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005; 25: 763-74. (Pubitemid 40705611)
40. Vespa PM, O'Phelan K, McArthur D, Miller C, Eliseo M, Hirt D, et al. Pericontusional brain tissue exhibits persistent elevation of lactate/ pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med 2007; 35: 1153-60. (Pubitemid 46598968)
41. Vespa PM, McArthur D, O'Phelan K, Glenn T, Etchepare M, Kelly D, et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab 2003; 23: 865-77. (Pubitemid 36818694)
42. Winter CD, Pringle AK, Clough GF, Church MK. Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain 2004; 127: 315-20. (Pubitemid 38160316)
43. Zauner A, Doppenberg E, Soukup J, Menzel M, Young HF, Bullock R. Extended neuromonitoring: new therapeutic opportunities? Neurol Res 1998; 20 (Suppl. 1): S85-90. (Pubitemid 28223677)
44. Zauner A, Doppenberg EM, Woodward JJ, Choi SC, Young HF, Bullock R. Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery 1997; 41: 1082-91; discussion 91-3.