A probable dual mode of action for both L-and D-lactate neuroprotection in cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 10, 2015, Pages 1561-1569

  Castillo, Ximena ^a   Rosafio, Katia ^b   Wyss, Matthias T ^c   Drandarov, Konstantin ^d   Buck, Alfred ^d   Pellerin, Luc ^b   Weber, Bruno ^c   Hirt, Lorenz ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d University Hospital of Psychiatry   (Switzerland)

Author keywords

energy metabolism; focal ischemia; lactate; neuron glia interactions; neuroprotection

Indexed keywords

ACETIC ACID; ALPHA RESORCYLIC ACID; CARBON 11; DEXTRO LACTIC ACID C 11; G PROTEIN COUPLED RECEPTOR; GLUCOSE; HYDROXYCARBOXYLIC ACID RECEPTOR; LACTATE SODIUM; OXYGEN; PYRUVIC ACID; UNCLASSIFIED DRUG; CARRIER PROTEIN; LACTIC ACID; MAGEE1 PROTEIN, HUMAN; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN METABOLISM; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; DRUG MECHANISM; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL SLICE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; SOMATOSENSORY CORTEX; WALKING; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; BRAIN CHEMISTRY; BRAIN HYPOXIA; CELL DEATH; DEFICIENCY; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; KINETICS; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; SIGNAL TRANSDUCTION; STEREOISOMERISM;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CARRIER PROTEINS; CELL DEATH; GLUCOSE; HIPPOCAMPUS; HYPOXIA, BRAIN; IMMUNOHISTOCHEMISTRY; KINETICS; LACTIC ACID; MALE; MICE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; SIGNAL TRANSDUCTION; STEREOISOMERISM;

EID: 84942986567     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.115     Document Type: Article

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