Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response

FASEB Journal

Volumn 30, Issue 8, 2016, Pages 2899-2914

  Guillonneau, Maëva ^a,b,c,d   Paris, François ^a,b,c   Dutoit, Soizic ^a,b,c   Estephan, Hala ^a,b,c   Bénéteau, Elise ^a,b,c   Huot, Jacques ^d   Corre, Isabelle ^a,b,c,d,e  

^a CNRS   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d LAVAL UNIVERSITY   (Canada)

^e Team 12   (France)

Author keywords

Double strand breaks; Endothelial dysfunction; P38MAPK; Phosphatases; Reactive oxygen species

Indexed keywords

ATM PROTEIN; CYTOPLASM PROTEIN; DNA; DNA DEPENDENT PROTEIN KINASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIPROTEIN COMPLEX; NUCLEOPHOSMIN; PHOSPHOPROTEIN PHOSPHATASE 2A; NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MICROSCOPY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOCYTOPLASMIC TRANSPORT; PHOSPHORYLATION; PHYSIOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; DNA DAMAGE; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; NUCLEAR PROTEINS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCTION;

EID: 84982719976     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201500194R     Document Type: Article

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