p38 MAPK mediates γ-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 43352-43360

  Kumar, Pawan ^a   Miller, April I ^b   Polverini, Peter J ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; ENZYMES; GAMMA RAYS; GROWTH KINETICS; RADIOTHERAPY; TUMORS;

SIGNALING PATHWAYS; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

CELLS;

2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; VASCULOTROPIN;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GAMMA IRRADIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; SKIN CELL; TUMOR VASCULARIZATION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELLS, CULTURED; CHROMONES; DNA; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FLOW CYTOMETRY; GAMMA RAYS; GENES, DOMINANT; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MICROCIRCULATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; MORPHOLINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; RETROVIRIDAE; SIGNAL TRANSDUCTION; SKIN; TIME FACTORS; TRANSFECTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 5644271454     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405777200     Document Type: Article

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