Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

FASEB Journal

Volumn 30, Issue 8, 2016, Pages 2945-2958

  Huang, Wei Ching ^a,d   Liang, Jie ^a,e   Nagahashi, Masayuki ^a,b,f   Avni, Dorit ^a   Yamada, Akimitsu ^a,b,g   Maceyka, Michael ^a   Wolen, Aaron R ^a   Kordula, Tomasz ^a   Milstien, Sheldon ^a   Takabe, Kazuaki ^a,b   Oravecz, Tamas ^c,h   Spiegel, Sarah ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LEXICON PHARMACEUTICALS INC   (United States)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e State Key Laboratory of Cancer Biology   (China)

^f NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^g YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

^h Celgene   (United States)

Author keywords

Inflammatory bowel disease; S1P; SGPP1; SGPP2

Indexed keywords

DEXTRAN SULFATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHOSPHATASE; SPHINGOSINE 1 PHOSPHATE PHOSPHATASE 1; SPHINGOSINE 1 PHOSPHATE PHOSPHATASE 2; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; MEMBRANE PROTEIN; SGPP1 PROTEIN, HUMAN; SGPP2 PROTEIN, HUMAN; SGPP2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; COLON; COLON BIOPSY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; GASTROINTESTINAL TRACT; GENE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE MUCOSA; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SGPP1 GENE; SGPP2 GENE; SIGMOID; ULCERATIVE COLITIS; ANIMAL; CHEMICALLY INDUCED; ENZYMOLOGY; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PERMEABILITY;

ANIMALS; CADHERINS; COLITIS, ULCERATIVE; DEXTRAN SULFATE; DOWN-REGULATION; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PERMEABILITY; PHOSPHORIC MONOESTER HYDROLASES;

EID: 84982706184     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201600394R     Document Type: Article

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