메뉴 건너뛰기




Volumn 42, Issue 1, 2017, Pages 1-10

Enhancing Oral Absorption of β-Lapachone: Progress Till Date

Author keywords

[No Author keywords available]

Indexed keywords

BETA LAPACHONE; CYCLODEXTRIN; POLYMER; BETA-LAPACHONE; DRUG CARRIER; NAPHTHOQUINONE; NQO1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

EID: 84982252692     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-016-0369-7     Document Type: Article
Times cited : (5)

References (71)
  • 1
    • 84862025527 scopus 로고    scopus 로고
    • The fraction dose absorbed, in humans, and high jejunal human permeability relationship
    • COI: 1:CAS:528:DC%2BC38XlvFCqs7w%3D, PID: 22524707
    • Dahan A, Lennernas H, Amidon GL. The fraction dose absorbed, in humans, and high jejunal human permeability relationship. Mol Pharm. 2012;9(6):1847–51. doi:10.1021/mp300140h.
    • (2012) Mol Pharm , vol.9 , Issue.6 , pp. 1847-1851
    • Dahan, A.1    Lennernas, H.2    Amidon, G.L.3
  • 2
    • 0025142668 scopus 로고
    • DT-diaphorase: purification, properties, and function
    • COI: 1:CAS:528:DyaK3MXhvVSqsLg%3D, PID: 2233301
    • Lind C, Cadenas E, Hochstein P, Ernster L. DT-diaphorase: purification, properties, and function. Methods Enzymol. 1990;186:287–301.
    • (1990) Methods Enzymol , vol.186 , pp. 287-301
    • Lind, C.1    Cadenas, E.2    Hochstein, P.3    Ernster, L.4
  • 3
    • 84858005998 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones
    • COI: 1:CAS:528:DC%2BC38XjsFOhsbk%3D, PID: 22209713
    • Siegel D, Yan C, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012;83(8):1033–40. doi:10.1016/j.bcp.2011.12.017.
    • (2012) Biochem Pharmacol , vol.83 , Issue.8 , pp. 1033-1040
    • Siegel, D.1    Yan, C.2    Ross, D.3
  • 4
    • 0030979645 scopus 로고    scopus 로고
    • Quantitation of beta-lapachone and 3-hydroxy-beta-lapachone in human plasma samples by reversed-phase high-performance liquid chromatography
    • COI: 1:CAS:528:DyaK2sXisFKmurs%3D, PID: 9187398
    • Glen VL, Hutson PR, Kehrli NJ, Boothman DA, Wilding G. Quantitation of beta-lapachone and 3-hydroxy-beta-lapachone in human plasma samples by reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997;692(1):181–6.
    • (1997) J Chromatogr B Biomed Sci Appl , vol.692 , Issue.1 , pp. 181-186
    • Glen, V.L.1    Hutson, P.R.2    Kehrli, N.J.3    Boothman, D.A.4    Wilding, G.5
  • 5
    • 84885647211 scopus 로고    scopus 로고
    • Catalase abrogates beta-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers
    • COI: 1:CAS:528:DC%2BC3sXhsFOhurvI, PID: 23883585
    • Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, et al. Catalase abrogates beta-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers. Mol Cancer Ther. 2013;12(10):2110–20. doi:10.1158/1535-7163.MCT-12-0962.
    • (2013) Mol Cancer Ther , vol.12 , Issue.10 , pp. 2110-2120
    • Bey, E.A.1    Reinicke, K.E.2    Srougi, M.C.3    Varnes, M.4    Anderson, V.E.5    Pink, J.J.6
  • 6
    • 84948171903 scopus 로고    scopus 로고
    • Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, beta-lapachone
    • COI: 1:CAS:528:DC%2BC2MXhvFentL7L, PID: 26602448
    • Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, et al. Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, beta-lapachone. Sci Rep. 2015;5:17066. doi:10.1038/srep17066.
    • (2015) Sci Rep. , vol.5 , pp. 17066
    • Chakrabarti, G.1    Silvers, M.A.2    Ilcheva, M.3    Liu, Y.4    Moore, Z.R.5    Luo, X.6
  • 7
    • 22844452668 scopus 로고    scopus 로고
    • Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity
    • COI: 1:CAS:528:DC%2BD2MXjtFelsbg%3D, PID: 15753997
    • Woo HJ, Choi YH. Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity. Int J Oncol. 2005;26(4):1017–23.
    • (2005) Int J Oncol , vol.26 , Issue.4 , pp. 1017-1023
    • Woo, H.J.1    Choi, Y.H.2
  • 8
    • 84944275825 scopus 로고    scopus 로고
    • Mitochondrial targeted beta-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells
    • COI: 1:CAS:528:DC%2BC2MXhtVyht7%2FO, PID: 26159482
    • Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted beta-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett. 2015;25(21):4828–33. doi:10.1016/j.bmcl.2015.06.073.
    • (2015) Bioorg Med Chem Lett , vol.25 , Issue.21 , pp. 4828-4833
    • Ma, J.1    Lim, C.2    Sacher, J.R.3    Van Houten, B.4    Qian, W.5    Wipf, P.6
  • 9
    • 84923599041 scopus 로고    scopus 로고
    • eIF2 kinases mediate beta-lapachone toxicity in yeast and human cancer cells
    • COI: 1:CAS:528:DC%2BC2MXhslGmt73K, PID: 25590579
    • Menacho-Marquez M, Rodriguez-Hernandez CJ, Villaronga MA, Perez-Valle J, Gadea J, Belandia B, et al. eIF2 kinases mediate beta-lapachone toxicity in yeast and human cancer cells. Cell Cycle. 2015;14(4):630–40. doi:10.4161/15384101.2014.994904.
    • (2015) Cell Cycle , vol.14 , Issue.4 , pp. 630-640
    • Menacho-Marquez, M.1    Rodriguez-Hernandez, C.J.2    Villaronga, M.A.3    Perez-Valle, J.4    Gadea, J.5    Belandia, B.6
  • 10
    • 0036494316 scopus 로고    scopus 로고
    • Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells
    • COI: 1:CAS:528:DC%2BD38Xit1Khur8%3D, PID: 11888914
    • Winski SL, Koutalos Y, Bentley DL, Ross D. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 2002;62(5):1420–4.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1420-1424
    • Winski, S.L.1    Koutalos, Y.2    Bentley, D.L.3    Ross, D.4
  • 11
    • 0033801337 scopus 로고    scopus 로고
    • Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
    • COI: 1:CAS:528:DC%2BD3cXnslWmtrk%3D, PID: 11035253
    • Siegel D, Ross D. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 2000;29(3–4):246–53.
    • (2000) Free Radic Biol Med , vol.29 , Issue.3-4 , pp. 246-253
    • Siegel, D.1    Ross, D.2
  • 12
    • 0031666337 scopus 로고    scopus 로고
    • Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors
    • COI: 1:CAS:528:DyaK1cXmslCjsrc%3D, PID: 9748120
    • Siegel D, Franklin WA, Ross D. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 1998;4(9):2065–70.
    • (1998) Clin Cancer Res , vol.4 , Issue.9 , pp. 2065-2070
    • Siegel, D.1    Franklin, W.A.2    Ross, D.3
  • 13
    • 0025917452 scopus 로고
    • High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin
    • COI: 1:CAS:528:DyaK3MXlsFKitb8%3D, PID: 1651729
    • Cresteil T, Jaiswal AK. High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin. Biochem Pharmacol. 1991;42(5):1021–7.
    • (1991) Biochem Pharmacol , vol.42 , Issue.5 , pp. 1021-1027
    • Cresteil, T.1    Jaiswal, A.K.2
  • 14
    • 0036156337 scopus 로고    scopus 로고
    • Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue
    • COI: 1:CAS:528:DC%2BD38Xos1OhtQ%3D%3D, PID: 11809856
    • Strassburg A, Strassburg CP, Manns MP, Tukey RH. Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue. Mol Pharmacol. 2002;61(2):320–5.
    • (2002) Mol Pharmacol , vol.61 , Issue.2 , pp. 320-325
    • Strassburg, A.1    Strassburg, C.P.2    Manns, M.P.3    Tukey, R.H.4
  • 15
    • 0025248106 scopus 로고
    • Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol
    • COI: 1:CAS:528:DyaK3cXktVWrsbg%3D, PID: 2307529
    • Schlager JJ, Powis G. Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol. Int J Cancer. 1990;45(3):403–9.
    • (1990) Int J Cancer , vol.45 , Issue.3 , pp. 403-409
    • Schlager, J.J.1    Powis, G.2
  • 16
    • 0017725357 scopus 로고
    • The activity of the D-T diaphorase in experimental hepatomas
    • COI: 1:CAS:528:DyaE2sXltFKjtr4%3D, PID: 616321
    • Schor NA, Morris HP. The activity of the D-T diaphorase in experimental hepatomas. Cancer Biochem Biophys. 1977;2(1):5–9.
    • (1977) Cancer Biochem Biophys , vol.2 , Issue.1 , pp. 5-9
    • Schor, N.A.1    Morris, H.P.2
  • 17
    • 0031870525 scopus 로고    scopus 로고
    • Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents
    • COI: 1:CAS:528:DyaK1cXktFOisr8%3D, PID: 9660542
    • Dolan ME, Frydman B, Thompson CB, Diamond AM, Garbiras BJ, Safa AR, et al. Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents. Anticancer Drugs. 1998;9(5):437–48.
    • (1998) Anticancer Drugs , vol.9 , Issue.5 , pp. 437-448
    • Dolan, M.E.1    Frydman, B.2    Thompson, C.B.3    Diamond, A.M.4    Garbiras, B.J.5    Safa, A.R.6
  • 18
    • 17544391279 scopus 로고    scopus 로고
    • Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones
    • COI: 1:CAS:528:DyaK2sXht1Ors7w%3D, PID: 9044837
    • Frydman B, Marton LJ, Sun JS, Neder K, Witiak DT, Liu AA, et al. Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res. 1997;57(4):620–7.
    • (1997) Cancer Res , vol.57 , Issue.4 , pp. 620-627
    • Frydman, B.1    Marton, L.J.2    Sun, J.S.3    Neder, K.4    Witiak, D.T.5    Liu, A.A.6
  • 19
    • 0027377069 scopus 로고
    • beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin
    • COI: 1:CAS:528:DyaK3sXlslelt7k%3D, PID: 8226754
    • Li CJ, Averboukh L, Pardee AB. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993;268(30):22463–8.
    • (1993) J Biol Chem , vol.268 , Issue.30 , pp. 22463-22468
    • Li, C.J.1    Averboukh, L.2    Pardee, A.B.3
  • 20
    • 0029360394 scopus 로고
    • Induction of apoptosis by beta-lapachone in human prostate cancer cells
    • COI: 1:CAS:528:DyaK2MXnvVelsL4%3D, PID: 7641181
    • Li CJ, Wang C, Pardee AB. Induction of apoptosis by beta-lapachone in human prostate cancer cells. Cancer Res. 1995;55(17):3712–5.
    • (1995) Cancer Res , vol.55 , Issue.17 , pp. 3712-3715
    • Li, C.J.1    Wang, C.2    Pardee, A.B.3
  • 21
    • 0033045065 scopus 로고    scopus 로고
    • Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells
    • PID: 10448645
    • Li YZ, Li CJ, Pinto AV, Pardee AB. Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells. Mol Med. 1999;5(4):232–9.
    • (1999) Mol Med , vol.5 , Issue.4 , pp. 232-239
    • Li, Y.Z.1    Li, C.J.2    Pinto, A.V.3    Pardee, A.B.4
  • 22
    • 0036348011 scopus 로고    scopus 로고
    • Cancer therapy with beta-lapachone
    • COI: 1:CAS:528:DC%2BD38XmtF2rsbo%3D, PID: 12188909
    • Pardee AB, Li YZ, Li CJ. Cancer therapy with beta-lapachone. Curr Cancer Drug Targets. 2002;2(3):227–42.
    • (2002) Curr Cancer Drug Targets , vol.2 , Issue.3 , pp. 227-242
    • Pardee, A.B.1    Li, Y.Z.2    Li, C.J.3
  • 23
    • 0028982219 scopus 로고
    • Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response
    • COI: 1:CAS:528:DyaK2MXnvVels7c%3D, PID: 7641180
    • Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, et al. Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer Res. 1995;55(17):3706–11.
    • (1995) Cancer Res , vol.55 , Issue.17 , pp. 3706-3711
    • Planchon, S.M.1    Wuerzberger, S.2    Frydman, B.3    Witiak, D.T.4    Hutson, P.5    Church, D.R.6
  • 24
    • 0033524857 scopus 로고    scopus 로고
    • A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis
    • COI: 1:CAS:528:DyaK1MXhtlOktbc%3D, PID: 10082646
    • Samali A, Nordgren H, Zhivotovsky B, Peterson E, Orrenius S. A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis. Biochem Biophys Res Commun. 1999;255(1):6–11. doi:10.1006/bbrc.1998.0139.
    • (1999) Biochem Biophys Res Commun. , vol.255 , Issue.1 , pp. 6-11
    • Samali, A.1    Nordgren, H.2    Zhivotovsky, B.3    Peterson, E.4    Orrenius, S.5
  • 25
    • 84911874658 scopus 로고    scopus 로고
    • Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent
    • COI: 1:CAS:528:DC%2BC2cXhvVGgurnK, PID: 25448047
    • Li JZ, Ke Y, Misra HP, Trush MA, Li YR, Zhu H, et al. Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent. Toxicol Appl Pharmacol. 2014;281(3):285–93. doi:10.1016/j.taap.2014.10.012.
    • (2014) Toxicol Appl Pharmacol , vol.281 , Issue.3 , pp. 285-293
    • Li, J.Z.1    Ke, Y.2    Misra, H.P.3    Trush, M.A.4    Li, Y.R.5    Zhu, H.6
  • 26
    • 84901023217 scopus 로고    scopus 로고
    • beta-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells
    • COI: 1:CAS:528:DC%2BC2cXnsl2ns7k%3D, PID: 24832602
    • Park EJ, Min KJ, Lee TJ, Yoo YH, Kim YS, Kwon TK. beta-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells. Cell Death Dis. 2014;5:e1230. doi:10.1038/cddis.2014.202.
    • (2014) Cell Death Dis , vol.5
    • Park, E.J.1    Min, K.J.2    Lee, T.J.3    Yoo, Y.H.4    Kim, Y.S.5    Kwon, T.K.6
  • 27
    • 37549056508 scopus 로고    scopus 로고
    • NQO1 expression in pancreatic cancer and its potential use as a biomarker
    • COI: 1:CAS:528:DC%2BD1cXhsVSlsLc%3D, PID: 18091324
    • Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, et al. NQO1 expression in pancreatic cancer and its potential use as a biomarker. Appl Immunohistochem Mol Morphol. 2008;16(1):24–31. doi:10.1097/PAI.0b013e31802e91d0.
    • (2008) Appl Immunohistochem Mol Morphol , vol.16 , Issue.1 , pp. 24-31
    • Awadallah, N.S.1    Dehn, D.2    Shah, R.J.3    Russell Nash, S.4    Chen, Y.K.5    Ross, D.6
  • 28
    • 84941061402 scopus 로고    scopus 로고
    • Beta-lapachone suppresses non-small cell lung cancer proliferation through the regulation of specificity protein 1
    • COI: 1:CAS:528:DC%2BC28Xjtl2isLs%3D, PID: 26328485
    • Jeon YJ, Bang W, Choi YH, Shim JH, Chae JI. Beta-lapachone suppresses non-small cell lung cancer proliferation through the regulation of specificity protein 1. Biol Pharm Bull. 2015;38(9):1302–8. doi:10.1248/bpb.b15-00159.
    • (2015) Biol Pharm Bull , vol.38 , Issue.9 , pp. 1302-1308
    • Jeon, Y.J.1    Bang, W.2    Choi, Y.H.3    Shim, J.H.4    Chae, J.I.5
  • 29
    • 0026700546 scopus 로고
    • Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl
    • COI: 1:CAS:528:DyaK38Xls1enurc%3D, PID: 1324793
    • Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, et al. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res. 1992;52(17):4752–7.
    • (1992) Cancer Res , vol.52 , Issue.17 , pp. 4752-4757
    • Malkinson, A.M.1    Siegel, D.2    Forrest, G.L.3    Gazdar, A.F.4    Oie, H.K.5    Chan, D.C.6
  • 30
    • 84978376224 scopus 로고    scopus 로고
    • Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ss-lapachone
    • PID: 26462257
    • Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, et al. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ss-lapachone. Cancer Metab. 2015;3:12. doi:10.1186/s40170-015-0137-1.
    • (2015) Cancer Metab. , vol.3 , pp. 12
    • Chakrabarti, G.1    Moore, Z.R.2    Luo, X.3    Ilcheva, M.4    Ali, A.5    Padanad, M.6
  • 31
    • 84884180331 scopus 로고    scopus 로고
    • Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species
    • PID: 23933437
    • Di Rosso ME, Barreiro Arcos ML, Elingold I, Sterle H, Baptista Ferreira S, Ferreira VF, et al. Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species. Toxicol In Vitro. 2013;27(7):2094–104. doi:10.1016/j.tiv.2013.08.002.
    • (2013) Toxicol In Vitro , vol.27 , Issue.7 , pp. 2094-2104
    • Di Rosso, M.E.1    Barreiro Arcos, M.L.2    Elingold, I.3    Sterle, H.4    Baptista Ferreira, S.5    Ferreira, V.F.6
  • 32
    • 33847189252 scopus 로고    scopus 로고
    • Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia
    • COI: 1:CAS:528:DC%2BD2sXit1Gru7o%3D, PID: 17321474
    • Moon DO, Choi YH, Kim ND, Park YM, Kim GY. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol. 2007;7(4):506–14. doi:10.1016/j.intimp.2006.12.006.
    • (2007) Int Immunopharmacol , vol.7 , Issue.4 , pp. 506-514
    • Moon, D.O.1    Choi, Y.H.2    Kim, N.D.3    Park, Y.M.4    Kim, G.Y.5
  • 33
    • 84901660459 scopus 로고    scopus 로고
    • beta-Lapachone-induced apoptosis of human gastric carcinoma AGS cells is caspase-dependent and regulated by the PI3K/Akt pathway
    • COI: 1:CAS:528:DC%2BC2cXhtlKjur3F, PID: 25009698
    • Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, et al. beta-Lapachone-induced apoptosis of human gastric carcinoma AGS cells is caspase-dependent and regulated by the PI3K/Akt pathway. Biomol Ther (Seoul). 2014;22(3):184–92. doi:10.4062/biomolther.2014.026.
    • (2014) Biomol Ther (Seoul). , vol.22 , Issue.3 , pp. 184-192
    • Yu, H.Y.1    Kim, S.O.2    Jin, C.Y.3    Kim, G.Y.4    Kim, W.J.5    Yoo, Y.H.6
  • 34
    • 84896473676 scopus 로고    scopus 로고
    • Albuquerque MC. beta-Lapachone: a naphthoquinone with promising antischistosomal properties in mice
    • Aires Ade L, Ximenes EC, Barbosa VX, Goes AJ, Souza VM, Albuquerque MC. beta-Lapachone: a naphthoquinone with promising antischistosomal properties in mice. Phytomedicine. 2014;21(3):261–7. doi:10.1016/j.phymed.2013.08.012.
    • (2014) Phytomedicine , vol.21 , Issue.3 , pp. 261-267
    • Aires Ade, L.1    Ximenes, E.C.2    Barbosa, V.X.3    Goes, A.J.4    Souza, V.M.5
  • 35
    • 84937697862 scopus 로고    scopus 로고
    • Anthelmintic activity of lapachol, beta-lapachone and its derivatives against Toxocara Canis Larvae
    • COI: 1:CAS:528:DC%2BC28XovVerurs%3D, PID: 26200958
    • Mata-Santos T, Pinto NF, Mata-Santos HA, De Moura KG, Carneiro PF, Carvalho Tdos S, et al. Anthelmintic activity of lapachol, beta-lapachone and its derivatives against Toxocara Canis Larvae. Rev Inst Med Trop Sao Paulo. 2015;57(3):197–204. doi:10.1590/S0036-46652015000300003.
    • (2015) Rev Inst Med Trop Sao Paulo , vol.57 , Issue.3 , pp. 197-204
    • Mata-Santos, T.1    Pinto, N.F.2    Mata-Santos, H.A.3    De Moura, K.G.4    Carneiro, P.F.5    Carvalho Tdos, S.6
  • 36
    • 34347264532 scopus 로고    scopus 로고
    • Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
    • PID: 17579510
    • Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arner ES, et al. Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007;4(6):e206. doi:10.1371/journal.pmed.0040206.
    • (2007) PLoS Med. , vol.4 , Issue.6
    • Kuntz, A.N.1    Davioud-Charvet, E.2    Sayed, A.A.3    Califf, L.L.4    Dessolin, J.5    Arner, E.S.6
  • 37
    • 19744373924 scopus 로고    scopus 로고
    • Sativa seeds against Schistosoma mansoni different stages
    • PID: 16021310, 10.1590/S0074-02762005000200016
    • Mohamed AM, Metwally NM, Mahmoud SS. Sativa seeds against Schistosoma mansoni different stages. Mem Inst Oswaldo Cruz. 2005;100(2):205–11. doi:10.1590/S0074-02762005000200016
    • (2005) Mem Inst Oswaldo Cruz , vol.100 , Issue.2 , pp. 205-211
    • Mohamed, A.M.1    Metwally, N.M.2    Mahmoud, S.S.3
  • 38
    • 79956101516 scopus 로고    scopus 로고
    • Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice
    • COI: 1:CAS:528:DC%2BC3MXmsVCksrk%3D, PID: 21426905
    • Seif el-Din SH, Al-Hroob AM, Ebeid FA. Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice. Exp Parasitol. 2011;128(3):230–5. doi:10.1016/j.exppara.2011.03.006.
    • (2011) Exp Parasitol , vol.128 , Issue.3 , pp. 230-235
    • Seif el-Din, S.H.1    Al-Hroob, A.M.2    Ebeid, F.A.3
  • 39
    • 84900543413 scopus 로고    scopus 로고
    • Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via regulation of HIF-1alpha
    • COI: 1:CAS:528:DC%2BC2cXotFOnsrg%3D, PID: 24533641
    • Park SW, Kim JH, Kim KE, Jeong MH, Park H, Park B, et al. Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via regulation of HIF-1alpha. J Cell Mol Med. 2014;18(5):875–84. doi:10.1111/jcmm.12235.
    • (2014) J Cell Mol Med , vol.18 , Issue.5 , pp. 875-884
    • Park, S.W.1    Kim, J.H.2    Kim, K.E.3    Jeong, M.H.4    Park, H.5    Park, B.6
  • 40
    • 84883211697 scopus 로고    scopus 로고
    • NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats
    • COI: 1:CAS:528:DC%2BC3sXht1yrsrfJ, PID: 23749777
    • Kim YH, Hwang JH, Kim KS, Noh JR, Gang GT, Kim SW, et al. NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats. Cardiovasc Res. 2013;99(4):743–50. doi:10.1093/cvr/cvt147.
    • (2013) Cardiovasc Res , vol.99 , Issue.4 , pp. 743-750
    • Kim, Y.H.1    Hwang, J.H.2    Kim, K.S.3    Noh, J.R.4    Gang, G.T.5    Kim, S.W.6
  • 41
    • 84884733372 scopus 로고    scopus 로고
    • Synthesis of quinoidal molecules: strategies towards bioactive compounds with an emphasis on lapachones
    • PID: 24095760
    • de Castro SL, Emery FS, da Silva Junior EN. Synthesis of quinoidal molecules: strategies towards bioactive compounds with an emphasis on lapachones. Eur J Med Chem. 2013;69:678–700. doi:10.1016/j.ejmech.2013.07.057.
    • (2013) Eur J Med Chem , vol.69 , pp. 678-700
    • de Castro, S.L.1    Emery, F.S.2    da Silva Junior, E.N.3
  • 42
    • 24644432026 scopus 로고    scopus 로고
    • Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1
    • COI: 1:CAS:528:DC%2BD28XhvFOmsrk%3D, PID: 15662131
    • Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, Bornmann W, et al. Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biol Ther. 2005;4(1):95–102.
    • (2005) Cancer Biol Ther , vol.4 , Issue.1 , pp. 95-102
    • Ough, M.1    Lewis, A.2    Bey, E.A.3    Gao, J.4    Ritchie, J.M.5    Bornmann, W.6
  • 43
    • 0142074305 scopus 로고    scopus 로고
    • Enhancement of solubility and bioavailability of beta-lapachone using cyclodextrin inclusion complexes
    • COI: 1:CAS:528:DC%2BD3sXotFCls70%3D, PID: 14620518
    • Nasongkla N, Wiedmann AF, Bruening A, Beman M, Ray D, Bornmann WG, et al. Enhancement of solubility and bioavailability of beta-lapachone using cyclodextrin inclusion complexes. Pharm Res. 2003;20(10):1626–33.
    • (2003) Pharm Res , vol.20 , Issue.10 , pp. 1626-1633
    • Nasongkla, N.1    Wiedmann, A.F.2    Bruening, A.3    Beman, M.4    Ray, D.5    Bornmann, W.G.6
  • 44
    • 84928993766 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic evaluation of beta-lapachone: characteristics of oral bioavailability and first-pass metabolism in rats
    • COI: 1:CAS:528:DC%2BC2MXhs1Sgt73P, PID: 25995830
    • Kim I, Kim H, Ro J, Jo K, Karki S, Khadka P, et al. Preclinical pharmacokinetic evaluation of beta-lapachone: characteristics of oral bioavailability and first-pass metabolism in rats. Biomol Ther (Seoul). 2015;23(3):296–300. doi:10.4062/biomolther.2015.029.
    • (2015) Biomol Ther (Seoul). , vol.23 , Issue.3 , pp. 296-300
    • Kim, I.1    Kim, H.2    Ro, J.3    Jo, K.4    Karki, S.5    Khadka, P.6
  • 45
    • 84957848480 scopus 로고    scopus 로고
    • Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: design, synthesis, and in vivo antitumor evaluation
    • COI: 1:CAS:528:DC%2BC28XhtF2ks7w%3D, PID: 26803578
    • Li X, Bian J, Wang N, Qian X, Gu J, Mu T, et al. Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: design, synthesis, and in vivo antitumor evaluation. Bioorg Med Chem. 2016;24(5):1006–13. doi:10.1016/j.bmc.2016.01.024.
    • (2016) Bioorg Med Chem. , vol.24 , Issue.5 , pp. 1006-1013
    • Li, X.1    Bian, J.2    Wang, N.3    Qian, X.4    Gu, J.5    Mu, T.6
  • 46
    • 85011735082 scopus 로고    scopus 로고
    • https://disco.chemaxon.com/apps/demos/logd/. 2016.
    • (2016)
  • 47
    • 77952866189 scopus 로고    scopus 로고
    • Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy
    • COI: 1:CAS:528:DC%2BC3cXlvFyrtLc%3D, PID: 20460521
    • Blanco E, Bey EA, Khemtong C, Yang SG, Setti-Guthi J, Chen H, et al. Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. Cancer Res. 2010;70(10):3896–904. doi:10.1158/0008-5472.CAN-09-3995.
    • (2010) Cancer Res , vol.70 , Issue.10 , pp. 3896-3904
    • Blanco, E.1    Bey, E.A.2    Khemtong, C.3    Yang, S.G.4    Setti-Guthi, J.5    Chen, H.6
  • 49
    • 0033751958 scopus 로고    scopus 로고
    • Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones
    • COI: 1:CAS:528:DC%2BD3cXnvVygsbk%3D, PID: 11015685
    • Sanchez-Castano G, Ruiz-Garcia A, Banon N, Bermejo M, Merino V, Freixas J, et al. Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones. J Pharm Sci. 2000;89(11):1395–403.
    • (2000) J Pharm Sci , vol.89 , Issue.11 , pp. 1395-1403
    • Sanchez-Castano, G.1    Ruiz-Garcia, A.2    Banon, N.3    Bermejo, M.4    Merino, V.5    Freixas, J.6
  • 50
    • 0030799001 scopus 로고    scopus 로고
    • The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data
    • COI: 1:CAS:528:DyaK2sXmslCltr0%3D, PID: 9336307
    • Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, et al. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J Pharmacol Exp Ther. 1997;283(1):46–58.
    • (1997) J Pharmacol Exp Ther , vol.283 , Issue.1 , pp. 46-58
    • Obach, R.S.1    Baxter, J.G.2    Liston, T.E.3    Silber, B.M.4    Jones, B.C.5    MacIntyre, F.6
  • 51
    • 0030806348 scopus 로고    scopus 로고
    • Physiological parameter values for physiologically based pharmacokinetic models
    • COI: 1:CAS:528:DyaK2sXltl2itrk%3D, PID: 9249929
    • Brown RP, Delp MD, Lindstedt SL, Rhomberg LR, Beliles RP. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health. 1997;13(4):407–84.
    • (1997) Toxicol Ind Health , vol.13 , Issue.4 , pp. 407-484
    • Brown, R.P.1    Delp, M.D.2    Lindstedt, S.L.3    Rhomberg, L.R.4    Beliles, R.P.5
  • 52
    • 58049131225 scopus 로고    scopus 로고
    • Red Lapacho (Tabebuia impetiginosa)–a global ethnopharmacological commodity?
    • COI: 1:CAS:528:DC%2BD1MXhsV2rsA%3D%3D, PID: 18992801
    • Gomez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)–a global ethnopharmacological commodity? J Ethnopharmacol. 2009;121(1):1–13. doi:10.1016/j.jep.2008.10.004.
    • (2009) J Ethnopharmacol , vol.121 , Issue.1 , pp. 1-13
    • Gomez Castellanos, J.R.1    Prieto, J.M.2    Heinrich, M.3
  • 53
    • 42149145178 scopus 로고    scopus 로고
    • Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice
    • COI: 1:CAS:528:DC%2BD1cXkvFGks78%3D, PID: 18343063
    • Queiroz ML, Valadares MC, Torello CO, Ramos AL, Oliveira AB, Rocha FD, et al. Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice. J Ethnopharmacol. 2008;117(2):228–35. doi:10.1016/j.jep.2008.01.034.
    • (2008) J Ethnopharmacol , vol.117 , Issue.2 , pp. 228-235
    • Queiroz, M.L.1    Valadares, M.C.2    Torello, C.O.3    Ramos, A.L.4    Oliveira, A.B.5    Rocha, F.D.6
  • 54
    • 0029684560 scopus 로고    scopus 로고
    • Human and bovine tuberculosis in the Monze District of Zambia–a cross-sectional study
    • COI: 1:STN:280:DyaK283hsVKgsg%3D%3D, PID: 8634864
    • Cook AJ, Tuchili LM, Buve A, Foster SD, Godfrey-Fausett P, Pandey GS, et al. Human and bovine tuberculosis in the Monze District of Zambia–a cross-sectional study. Br Vet J. 1996;152(1):37–46.
    • (1996) Br Vet J , vol.152 , Issue.1 , pp. 37-46
    • Cook, A.J.1    Tuchili, L.M.2    Buve, A.3    Foster, S.D.4    Godfrey-Fausett, P.5    Pandey, G.S.6
  • 55
    • 35548987490 scopus 로고    scopus 로고
    • Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients
    • COI: 1:CAS:528:DC%2BD2sXht1Grs7vN, PID: 17890039
    • Cunha-Filho MS, Martinez-Pacheco R, Landin M. Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients. J Pharm Biomed Anal. 2007;45(4):590–8. doi:10.1016/j.jpba.2007.08.016.
    • (2007) J Pharm Biomed Anal , vol.45 , Issue.4 , pp. 590-598
    • Cunha-Filho, M.S.1    Martinez-Pacheco, R.2    Landin, M.3
  • 56
    • 84858039015 scopus 로고    scopus 로고
    • The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugs
    • COI: 1:CAS:528:DC%2BC38Xlslantr0%3D, PID: 22391790
    • Dahan A, Miller JM. The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugs. Aaps J. 2012;14(2):244–51. doi:10.1208/s12248-012-9337-6.
    • (2012) Aaps J. , vol.14 , Issue.2 , pp. 244-251
    • Dahan, A.1    Miller, J.M.2
  • 57
    • 84876754894 scopus 로고    scopus 로고
    • Impact of micellar vehicles on in situ intestinal absorption properties of beta-lapachone in rats
    • COI: 1:CAS:528:DC%2BC3sXktVOgs7s%3D, PID: 23440944
    • Jang SB, Kim D, Kim SY, Park C, Jeong JH, Kuh HJ, et al. Impact of micellar vehicles on in situ intestinal absorption properties of beta-lapachone in rats. Korean J Physiol Pharmacol. 2013;17(1):9–13. doi:10.4196/kjpp.2013.17.1.9.
    • (2013) Korean J Physiol Pharmacol. , vol.17 , Issue.1 , pp. 9-13
    • Jang, S.B.1    Kim, D.2    Kim, S.Y.3    Park, C.4    Jeong, J.H.5    Kuh, H.J.6
  • 58
    • 33750144064 scopus 로고    scopus 로고
    • Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract
    • COI: 1:CAS:528:DC%2BD28XhtFentr3N, PID: 16876987
    • Masaoka Y, Tanaka Y, Kataoka M, Sakuma S, Yamashita S. Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract. Eur J Pharm Sci. 2006;29(3–4):240–50. doi:10.1016/j.ejps.2006.06.004.
    • (2006) Eur J Pharm Sci , vol.29 , Issue.3-4 , pp. 240-250
    • Masaoka, Y.1    Tanaka, Y.2    Kataoka, M.3    Sakuma, S.4    Yamashita, S.5
  • 59
    • 84939264285 scopus 로고    scopus 로고
    • In situ perfusion model in rat colon for drug absorption studies: comparison with small intestine and Caco-2 cell model
    • COI: 1:CAS:528:DC%2BC2MXms1GqsL4%3D, PID: 25891783
    • Lozoya-Agullo I, Gonzalez-Alvarez I, Gonzalez-Alvarez M, Merino-Sanjuan M, Bermejo M. In situ perfusion model in rat colon for drug absorption studies: comparison with small intestine and Caco-2 cell model. J Pharm Sci. 2015;104(9):3136–45. doi:10.1002/jps.24447.
    • (2015) J Pharm Sci , vol.104 , Issue.9 , pp. 3136-3145
    • Lozoya-Agullo, I.1    Gonzalez-Alvarez, I.2    Gonzalez-Alvarez, M.3    Merino-Sanjuan, M.4    Bermejo, M.5
  • 60
    • 84861073235 scopus 로고    scopus 로고
    • Temperature-sensitive gels for intratumoral delivery of beta-lapachone: effect of cyclodextrins and ethanol
    • PID: 22629119
    • Cunha-Filho MS, Alvarez-Lorenzo C, Martinez-Pacheco R, Landin M. Temperature-sensitive gels for intratumoral delivery of beta-lapachone: effect of cyclodextrins and ethanol. ScientificWorldJournal. 2012;2012:126723. doi:10.1100/2012/126723.
    • (2012) ScientificWorldJournal. , vol.2012 , pp. 126723
    • Cunha-Filho, M.S.1    Alvarez-Lorenzo, C.2    Martinez-Pacheco, R.3    Landin, M.4
  • 61
    • 80053918074 scopus 로고    scopus 로고
    • The encapsulation of beta-lapachone in 2-hydroxypropyl-beta-cyclodextrin inclusion complex into liposomes: a physicochemical evaluation and molecular modeling approach
    • COI: 1:CAS:528:DC%2BC3MXht12rt7fJ, PID: 21888967
    • Cavalcanti IM, Mendonca EA, Lira MC, Honrato SB, Camara CA, Amorim RV, et al. The encapsulation of beta-lapachone in 2-hydroxypropyl-beta-cyclodextrin inclusion complex into liposomes: a physicochemical evaluation and molecular modeling approach. Eur J Pharm Sci. 2011;44(3):332–40. doi:10.1016/j.ejps.2011.08.011.
    • (2011) Eur J Pharm Sci , vol.44 , Issue.3 , pp. 332-340
    • Cavalcanti, I.M.1    Mendonca, E.A.2    Lira, M.C.3    Honrato, S.B.4    Camara, C.A.5    Amorim, R.V.6
  • 62
    • 84870163047 scopus 로고    scopus 로고
    • Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique
    • PID: 23103351
    • Sjoberg A, Lutz M, Tannergren C, Wingolf C, Borde A, Ungell AL. Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique. Eur J Pharm Sci. 2013;48(1–2):166–80. doi:10.1016/j.ejps.2012.10.007.
    • (2013) Eur J Pharm Sci , vol.48 , Issue.1-2 , pp. 166-180
    • Sjoberg, A.1    Lutz, M.2    Tannergren, C.3    Wingolf, C.4    Borde, A.5    Ungell, A.L.6
  • 63
    • 48149090217 scopus 로고    scopus 로고
    • Dissolution rate enhancement of the novel antitumoral beta-lapachone by solvent change precipitation of microparticles
    • COI: 1:CAS:528:DC%2BD1cXpt1Gqt70%3D, PID: 18395431
    • Cunha-Filho MS, Martinez-Pacheco R, Landin M. Dissolution rate enhancement of the novel antitumoral beta-lapachone by solvent change precipitation of microparticles. Eur J Pharm Biopharm. 2008;69(3):871–7. doi:10.1016/j.ejpb.2008.02.014.
    • (2008) Eur J Pharm Biopharm , vol.69 , Issue.3 , pp. 871-877
    • Cunha-Filho, M.S.1    Martinez-Pacheco, R.2    Landin, M.3
  • 64
    • 0022579970 scopus 로고
    • Pluronic F-127 gels as a novel vehicle for rectal administration of indomethacin
    • COI: 1:CAS:528:DyaL28Xkt12qt70%3D, PID: 3719880
    • Miyazaki S, Yokouchi C, Nakamura T, Hashiguchi N, Hou WM, Takada M. Pluronic F-127 gels as a novel vehicle for rectal administration of indomethacin. Chem Pharm Bull (Tokyo). 1986;34(4):1801–8.
    • (1986) Chem Pharm Bull (Tokyo). , vol.34 , Issue.4 , pp. 1801-1808
    • Miyazaki, S.1    Yokouchi, C.2    Nakamura, T.3    Hashiguchi, N.4    Hou, W.M.5    Takada, M.6
  • 65
    • 3242680503 scopus 로고    scopus 로고
    • Comparative in vitro-in vivo study of two quinine rectal gel formulations
    • COI: 1:CAS:528:DC%2BD2cXlslGhsL8%3D, PID: 15265555
    • Fawaz F, Koffi A, Guyot M, Millet P. Comparative in vitro-in vivo study of two quinine rectal gel formulations. Int J Pharm. 2004;280(1–2):151–62. doi:10.1016/j.ijpharm.2004.05.002.
    • (2004) Int J Pharm , vol.280 , Issue.1-2 , pp. 151-162
    • Fawaz, F.1    Koffi, A.2    Guyot, M.3    Millet, P.4
  • 66
    • 84987642034 scopus 로고    scopus 로고
    • Beta-lapachone prevents diet-induced obesity by increasing energy expenditure and stimulating the browning of white adipose tissue via down-regulation of miR-382 expression
    • Choi WH, Ahn J, Jung CH, Jang YJ, Ha TY. Beta-lapachone prevents diet-induced obesity by increasing energy expenditure and stimulating the browning of white adipose tissue via down-regulation of miR-382 expression. Diabetes. 2016;. doi:10.2337/db15-1423.
    • (2016) Diabetes
    • Choi, W.H.1    Ahn, J.2    Jung, C.H.3    Jang, Y.J.4    Ha, T.Y.5
  • 67
    • 33749996935 scopus 로고    scopus 로고
    • Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation
    • COI: 1:CAS:528:DC%2BD28XhtVChur7P, PID: 16883563
    • Wang F, Blanco E, Ai H, Boothman DA, Gao J. Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation. J Pharm Sci. 2006;95(10):2309–19. doi:10.1002/jps.20721.
    • (2006) J Pharm Sci , vol.95 , Issue.10 , pp. 2309-2319
    • Wang, F.1    Blanco, E.2    Ai, H.3    Boothman, D.A.4    Gao, J.5
  • 68
    • 20244386984 scopus 로고    scopus 로고
    • Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels
    • COI: 1:CAS:528:DC%2BD2MXjtlejtbw%3D, PID: 15837761
    • Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, et al. Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res. 2005;11(8):3055–64. doi:10.1158/1078-0432.CCR-04-2185.
    • (2005) Clin Cancer Res , vol.11 , Issue.8 , pp. 3055-3064
    • Reinicke, K.E.1    Bey, E.A.2    Bentle, M.S.3    Pink, J.J.4    Ingalls, S.T.5    Hoppel, C.L.6
  • 69
    • 84906096952 scopus 로고    scopus 로고
    • Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of beta-Lapachone
    • COI: 1:CAS:528:DC%2BC2cXhtlKjtrfE, PID: 24532286
    • Ma X, Huang X, Huang G, Li L, Wang Y, Luo X, et al. Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of beta-Lapachone. Adv Healthc Mater. 2014;3(8):1210–6. doi:10.1002/adhm.201300590.
    • (2014) Adv Healthc Mater. , vol.3 , Issue.8 , pp. 1210-1216
    • Ma, X.1    Huang, X.2    Huang, G.3    Li, L.4    Wang, Y.5    Luo, X.6
  • 70
    • 41549101628 scopus 로고    scopus 로고
    • Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals
    • COI: 1:CAS:528:DC%2BD1cXktVelur4%3D, PID: 18227145
    • Savage RE, Tyler AN, Miao XS, Chan TC. Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals. Drug Metab Dispos. 2008;36(4):753–8. doi:10.1124/dmd.107.018655.
    • (2008) Drug Metab Dispos , vol.36 , Issue.4 , pp. 753-758
    • Savage, R.E.1    Tyler, A.N.2    Miao, X.S.3    Chan, T.C.4
  • 71
    • 84879086126 scopus 로고    scopus 로고
    • Administration of the optimized beta-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model
    • COI: 1:CAS:528:DC%2BC3sXisVGrsr8%3D, PID: 23333901
    • Seoane S, Diaz-Rodriguez P, Sendon-Lago J, Gallego R, Perez-Fernandez R, Landin M. Administration of the optimized beta-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model. Eur J Pharm Biopharm. 2013;84(3):497–504. doi:10.1016/j.ejpb.2012.12.019.
    • (2013) Eur J Pharm Biopharm , vol.84 , Issue.3 , pp. 497-504
    • Seoane, S.1    Diaz-Rodriguez, P.2    Sendon-Lago, J.3    Gallego, R.4    Perez-Fernandez, R.5    Landin, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.