Administration of the optimized β-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 84, Issue 3, 2013, Pages 497-504

  Seoane, Samuel ^a   Díaz Rodríguez, Patricia ^b   Sendon Lago, Juan ^a   Gallego, Rosalia ^b   Pérez Fernández, Román ^a   Landin, Mariana ^b  

^a Universidade de Santiago de Compostela and Instituto de Investigación Sanitaria de Santiago de Compostela   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Lapachone; Artificial neural networks; Breast cancer; Genetic algorithms; MCF 7 cells

Indexed keywords

BETA LAPACHONE; METHYL BETA CYCLODEXTRIN; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; FEMALE; GEL; GELATION; GENETIC ALGORITHM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID; LIVER TOXICITY; MOUSE; NEPHROTOXICITY; NONHUMAN; PHASE TRANSITION; ROOM TEMPERATURE; TEMPERATURE; TOXICITY TESTING; TUMOR MODEL; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLODEXTRINS; DNA DAMAGE; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MICE; MICE, SCID; NAPHTHOQUINONES; POLOXAMER; RHEOLOGY; TEMPERATURE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84879086126     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.12.019     Document Type: Article

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