Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 18, 2016, Pages 4120-4128

  Wang, Liping ^a,b   Wu, Rong ^a,b   Fu, Wenwei ^a,b   Lao, Yuanzhi ^a,b   Zheng, Changwu ^a,b   Tan, Hongsheng ^a,b   Xu, Hongxi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b China State Institute of Pharmaceutical Industry   (China)

Author keywords

c Met kinase inhibitor; Cytotoxicity; Derivatives; HCC827 cell line; Modification; Oblongifolin C; Structure activity relationships

Indexed keywords

BENZOPHENONE; CRIZOTINIB; OBLONGIFOLIN C; OBLONGIFOLIN C DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR RECEPTOR INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOPHENONE DERIVATIVE; MET PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; SCATTER FACTOR RECEPTOR; TERPENE;

A549 CELL LINE; AGS CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL LINE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HCC827 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; IC50; MIAPACA 2 CELL LINE; MIGRATION INHIBITION; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG SCREENING; GARCINIA; HT-29 CELL LINE; METABOLISM; NEOPLASMS; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOPHENONES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GARCINIA; HELA CELLS; HT29 CELLS; HUMANS; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

EID: 84982085334     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.06.054     Document Type: Article

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