-
1
-
-
59649089647
-
Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
-
Becker PS, Kopecky KJ, Wilks AN, Chien S, Harlan JM, Willman CL, Petersdorf SH, Stirewalt DL, Papayannopoulou T, Appelbaum FR (2009) Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood 113: 866-874.
-
(2009)
Blood
, vol.113
, pp. 866-874
-
-
Becker, P.S.1
Kopecky, K.J.2
Wilks, A.N.3
Chien, S.4
Harlan, J.M.5
Willman, C.L.6
Petersdorf, S.H.7
Stirewalt, D.L.8
Papayannopoulou, T.9
Appelbaum, F.R.10
-
2
-
-
20444484563
-
Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway
-
Bortul R, Tazzari PL, Billi AM, Tabellini G, Mantovani I, Cappellini A, Grafone T, Martinelli G, Conte R, Martelli AM (2005) Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway. Br J Haematol 129: 677-686.
-
(2005)
Br J Haematol
, vol.129
, pp. 677-686
-
-
Bortul, R.1
Tazzari, P.L.2
Billi, A.M.3
Tabellini, G.4
Mantovani, I.5
Cappellini, A.6
Grafone, T.7
Martinelli, G.8
Conte, R.9
Martelli, A.M.10
-
3
-
-
2542496929
-
Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia
-
Carmosino I, Latagliata R, Avvisati G, Breccia M, Finolezzi E, Lo Coco F, Petti MC (2004) Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia. Haematologica 89: 615-617.
-
(2004)
Haematologica
, vol.89
, pp. 615-617
-
-
Carmosino, I.1
Latagliata, R.2
Avvisati, G.3
Breccia, M.4
Finolezzi, E.5
Lo Coco, F.6
Petti, M.C.7
-
4
-
-
48749117533
-
Leukemia stem cells in acute myeloid leukemia
-
Chan WI, Huntly BJ (2008) Leukemia stem cells in acute myeloid leukemia. Semin Oncol 35: 326-335.
-
(2008)
Semin Oncol
, vol.35
, pp. 326-335
-
-
Chan, W.I.1
Huntly, B.J.2
-
5
-
-
33845794791
-
Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and upregulation of death receptors
-
Chen D, Chan R, Waxman S, JingY(2006) Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and upregulation of death receptors. Cancer Res 66: 11416-11423.
-
(2006)
Cancer Res
, vol.66
, pp. 11416-11423
-
-
Chen, D.1
Chan, R.2
Waxman, S.3
Jing, Y.4
-
6
-
-
84879368649
-
Mesenchymal stem cells induce granulocytic differentiation of acute promyelocytic leukemic cells via IL-6 and MEK/ERK pathways
-
Chen F, Zhou K, Zhang L, Ma F, Chen D, Cui J, Feng X, Yang S, Chi Y, Han Z, Xue F, Rong L, Ge M, Wan L, Xu S, Du W, Lu S, Ren H, Han Z (2013) Mesenchymal stem cells induce granulocytic differentiation of acute promyelocytic leukemic cells via IL-6 and MEK/ERK pathways. Stem Cells Dev 22: 1955-1967.
-
(2013)
Stem Cells Dev
, vol.22
, pp. 1955-1967
-
-
Chen, F.1
Zhou, K.2
Zhang, L.3
Ma, F.4
Chen, D.5
Cui, J.6
Feng, X.7
Yang, S.8
Chi, Y.9
Han, Z.10
Xue, F.11
Rong, L.12
Ge, M.13
Wan, L.14
Xu, S.15
Du, W.16
Lu, S.17
Ren, H.18
Han, Z.19
-
7
-
-
84898836357
-
The effect to IL-3Rα, downstream PI3K/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells
-
Chen Ping, Wu Juan Y, Huang Hui F, Chen Yuan Z (2014) The effect to IL-3Rα, downstream PI3K/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells. Pharmazie 69: 297-300.
-
(2014)
Pharmazie
, vol.69
, pp. 297-300
-
-
Ping, C.1
Wu Juan, Y.2
Huang Hui, F.3
Chen Yuan, Z.4
-
8
-
-
76349103937
-
An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities
-
Funayama K, Shimane M, Nomura H, Asano S (2010) An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities. Biochem Biophys Res Commun 392: 271-276.
-
(2010)
Biochem Biophys Res Commun
, vol.392
, pp. 271-276
-
-
Funayama, K.1
Shimane, M.2
Nomura, H.3
Asano, S.4
-
9
-
-
73349123461
-
BMP4 regulates the hematopoietic stem cell niche
-
Goldman DC, Bailey AS, Pfaffle DL, Al Masri A, Christian JL, Fleming WH (2009) BMP4 regulates the hematopoietic stem cell niche. Blood 114: 4393-4401.
-
(2009)
Blood
, vol.114
, pp. 4393-4401
-
-
Goldman, D.C.1
Bailey, A.S.2
Pfaffle, D.L.3
Al Masri, A.4
Christian, J.L.5
Fleming, W.H.6
-
10
-
-
77953504466
-
Arsenic trioxide overcomes cell adhesion-mediated drug resistance through down-regulating the expression of beta (1)-integrin in K562 chronic myelogenous leukemia cell line
-
Guo-Bao W, Xiao-Qin C, Qi-Rong G, Jie L, Gui-Nan L, Yue L (2010) Arsenic trioxide overcomes cell adhesion-mediated drug resistance through down-regulating the expression of beta (1)-integrin in K562 chronic myelogenous leukemia cell line. Leuk Lymphoma 51: 1090-1097.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 1090-1097
-
-
Guo-Bao, W.1
Xiao-Qin, C.2
Qi-Rong, G.3
Jie, L.4
Gui-Nan, L.5
Yue, L.6
-
11
-
-
84877281667
-
Direct contact with bone stromal HS-5 cells reduces the sensitivity of HEL to drugs
-
Huang HF, Lu R, Chen P, Lin ZX, Wu Y, Chen YZ (2012) Direct contact with bone stromal HS-5 cells reduces the sensitivity of HEL to drugs. Zhongguo Shi Yan Xue Ye Xue Za Zhi 20: 818-822.
-
(2012)
Zhongguo Shi Yan Xue Ye Xue Za Zhi
, vol.20
, pp. 818-822
-
-
Huang, H.F.1
Lu, R.2
Chen, P.3
Lin, Z.X.4
Wu, Y.5
Chen, Y.Z.6
-
12
-
-
16844378799
-
Leukemia stem cells and the evolution of cancer-stem-cell research
-
Huntly BJ, Gilliland DG (2005) Leukemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 5: 311-321.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 311-321
-
-
Huntly, B.J.1
Gilliland, D.G.2
-
13
-
-
79951678828
-
FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling
-
Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Kaibuchi K, Senga T, Kojima T, Kohno T, Hamaguchi M, Naoe T (2011) FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling. Eur J Haematol 86: 191-198.
-
(2011)
Eur J Haematol
, vol.86
, pp. 191-198
-
-
Katsumi, A.1
Kiyoi, H.2
Abe, A.3
Tanizaki, R.4
Iwasaki, T.5
Kobayashi, M.6
Matsushita, T.7
Kaibuchi, K.8
Senga, T.9
Kojima, T.10
Kohno, T.11
Hamaguchi, M.12
Naoe, T.13
-
14
-
-
0036738149
-
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
-
Konopleva M, Konoplev S, Hu W, Zaritskey AY, Afanasiev BV, Andreeff M (2002) Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 16: 1713-1724.
-
(2002)
Leukemia
, vol.16
, pp. 1713-1724
-
-
Konopleva, M.1
Konoplev, S.2
Hu, W.3
Zaritskey, A.Y.4
Afanasiev, B.V.5
Andreeff, M.6
-
15
-
-
84887424411
-
Differential regulation of myeloid leukemias by the bone marrow microenvironment
-
Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT (2013) Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med 19: 1513-1517.
-
(2013)
Nat Med
, vol.19
, pp. 1513-1517
-
-
Krause, D.S.1
Fulzele, K.2
Catic, A.3
Sun, C.C.4
Dombkowski, D.5
Hurley, M.P.6
Lezeau, S.7
Attar, E.8
Wu, J.Y.9
Lin, H.Y.10
Divieti-Pajevic, P.11
Hasserjian, R.P.12
Schipani, E.13
Van Etten, R.A.14
Scadden, D.T.15
-
16
-
-
4344653856
-
Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells:direct evidence of PI3K activation
-
Kubota Y, Ohnishi H, Kitanaka A, Ishida T, Tanaka T (2004) Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells:direct evidence of PI3K activation. Leukemia 18: 1438-1440.
-
(2004)
Leukemia
, vol.18
, pp. 1438-1440
-
-
Kubota, Y.1
Ohnishi, H.2
Kitanaka, A.3
Ishida, T.4
Tanaka, T.5
-
17
-
-
0036090647
-
Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: A bridge to transplantation
-
Leoni F, Gianfaldoni G, Annunziata M, Fanci R, Ciolli S, Nozzoli C, Ferrara F (2002) Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation. Haematologica 87: 485-489.
-
(2002)
Haematologica
, vol.87
, pp. 485-489
-
-
Leoni, F.1
Gianfaldoni, G.2
Annunziata, M.3
Fanci, R.4
Ciolli, S.5
Nozzoli, C.6
Ferrara, F.7
-
18
-
-
84879789176
-
Cytosine- arabinoside stimulates the capability of human marrow stromal cells to support normal hematopoiesis
-
Li H, Koh KR, Toramoto T, Nakamae H, Yamane T, Ohta K, HinoM(2010) Cytosine- arabinoside stimulates the capability of human marrow stromal cells to support normal hematopoiesis. Osaka City Med J 56: 11-20.
-
(2010)
Osaka City Med J
, vol.56
, pp. 11-20
-
-
Li, H.1
Koh, K.R.2
Toramoto, T.3
Nakamae, H.4
Yamane, T.5
Ohta, K.6
Hino, M.7
-
19
-
-
64049091680
-
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo
-
Li Y, Chen S, Yuan J, Yang Y, Li J, Ma J, Wu X, Freund M, Pollok K, Hanenberg H, Goebel WS, Yang FC (2009) Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo. Blood 113: 2342-2351.
-
(2009)
Blood
, vol.113
, pp. 2342-2351
-
-
Li, Y.1
Chen, S.2
Yuan, J.3
Yang, Y.4
Li, J.5
Ma, J.6
Wu, X.7
Freund, M.8
Pollok, K.9
Hanenberg, H.10
Goebel, W.S.11
Yang, F.C.12
-
20
-
-
38349107623
-
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
-
Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG (2008) The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 111: 846-855.
-
(2008)
Blood
, vol.111
, pp. 846-855
-
-
Longo, P.G.1
Laurenti, L.2
Gobessi, S.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
21
-
-
84861316751
-
Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis
-
Macanas-Pirard P1, Leisewitz A, Broekhuizen R, Cautivo K, Barriga FM, Leisewitz F, GidiV, Riquelme E, MontecinosVP, Swett P, Besa P, Ramirez P, Ocqueteau M, Kalergis AM, Holt M, Rettig M, DiPersio JF, Nervi B (2012) Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. PLoS One 7: e37203.
-
(2012)
PLoS One
, vol.7
, pp. e37203
-
-
Macanas-Pirard, P.1
Leisewitz, A.2
Broekhuizen, R.3
Cautivo, K.4
Barriga, F.M.5
Leisewitz, F.6
Gidiv Riquelme, E.7
Montecinos, V.P.8
Swett, P.9
Besa, P.10
Ramirez, P.11
Ocqueteau, M.12
Kalergis, A.M.13
Holt, M.14
Rettig, M.15
Dipersio, J.F.16
Nervi, B.17
-
22
-
-
33744457653
-
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
-
Martelli AM, Nyåkern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L (2006) Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20: 911-928.
-
(2006)
Leukemia
, vol.20
, pp. 911-928
-
-
Martelli, A.M.1
Nyåkern, M.2
Tabellini, G.3
Bortul, R.4
Tazzari, P.L.5
Evangelisti, C.6
Cocco, L.7
-
23
-
-
66149183002
-
Beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
-
Nemeth MJ, Mak KK, Yang Y, Bodine DM (2009) beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells 27: 1109-1119.
-
(2009)
Stem Cells
, vol.27
, pp. 1109-1119
-
-
Nemeth, M.J.1
Mak, K.K.2
Yang, Y.3
Bodine, D.M.4
-
24
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki M, Oshimura M. Ito H (2004) PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9: 667-676.
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
25
-
-
79959891134
-
Stromal niche cells protect early leukemic FLT3-ITD + progenitor cells against first-generation FLT3 tyrosine kinase inhibitors
-
Parmar A, Marz S, Rushton S, Holzwarth C, Lind K, Kayser S, Döhner K, Peschel C, Oostendorp RA, Götze KS (2011) Stromal niche cells protect early leukemic FLT3-ITD + progenitor cells against first-generation FLT3 tyrosine kinase inhibitors.Cancer Res 71: 4696-4706.
-
(2011)
Cancer Res
, vol.71
, pp. 4696-4706
-
-
Parmar, A.1
Marz, S.2
Rushton, S.3
Holzwarth, C.4
Lind, K.5
Kayser, S.6
Döhner, K.7
Peschel, C.8
Oostendorp, R.A.9
Götze, K.S.10
-
26
-
-
18544374589
-
Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
-
Ramos AM, Fernández C, Amrán D, Sancho P, de Blas E, Aller P (2005) Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105: 4013-4020.
-
(2005)
Blood
, vol.105
, pp. 4013-4020
-
-
Ramos, A.M.1
Fernández, C.2
Amrán, D.3
Sancho, P.4
De Blas, E.5
Aller, P.6
-
27
-
-
0035884639
-
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
-
Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, Stone RM, Kalaycio M, Scheinberg DA, Steinherz P, Sievers EL, Coutré S, Dahlberg S, Ellison R, Warrell RP Jr. (2001) United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol 19: 3852-3860.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3852-3860
-
-
Soignet, S.L.1
Frankel, J.R.2
Douer, D.3
Tallman, M.S.4
Kantarjian, H.5
Calleja, E.6
Stone, R.M.7
Kalaycio, M.8
Scheinberg, D.A.9
Steinherz, P.10
Sievers, E.L.11
Coutré, S.12
Dahlberg, S.13
Ellison, R.14
Warrell, R.P.15
-
28
-
-
33846666657
-
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells
-
Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M (2007) Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res 67: 684-694.
-
(2007)
Cancer Res
, vol.67
, pp. 684-694
-
-
Tabe, Y.1
Jin, L.2
Tsutsumi-Ishii, Y.3
Xu, Y.4
McQueen, T.5
Priebe, W.6
Mills, G.B.7
Ohsaka, A.8
Nagaoka, I.9
Andreeff, M.10
Konopleva, M.11
-
29
-
-
11144324517
-
Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells
-
Tabellini G, Cappellini A, Tazzari PL, Falà F, Billi AM, Manzoli L, Cocco L, Martelli AM (2005) Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J Cell Physiol 202: 623-634.
-
(2005)
J Cell Physiol
, vol.202
, pp. 623-634
-
-
Tabellini, G.1
Cappellini, A.2
Tazzari, P.L.3
Falà, F.4
Billi, A.M.5
Manzoli, L.6
Cocco, L.7
Martelli, A.M.8
-
30
-
-
77950451485
-
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction
-
Taussig DC, Vargaftig J, Miraki-Moud F, Griessinger E, Sharrock K, Luke T, Lillington D, Oakervee H, Cavenagh J, Agrawal SG, Lister TA, Gribben JG, Bonnet D (2010) Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood 115: 1976-1984.
-
(2010)
Blood
, vol.115
, pp. 1976-1984
-
-
Taussig, D.C.1
Vargaftig, J.2
Miraki-Moud, F.3
Griessinger, E.4
Sharrock, K.5
Luke, T.6
Lillington, D.7
Oakervee, H.8
Cavenagh, J.9
Agrawal, S.G.10
Lister, T.A.11
Gribben, J.G.12
Bonnet, D.13
-
31
-
-
33847225602
-
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts
-
Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, MartelliAM(2007) Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. Leukemia 21: 427-438.
-
(2007)
Leukemia
, vol.21
, pp. 427-438
-
-
Tazzari, P.L.1
Cappellini, A.2
Ricci, F.3
Evangelisti, C.4
Papa, V.5
Grafone, T.6
Martinelli, G.7
Conte, R.8
Cocco, L.9
McCubrey, J.A.10
Martelli, A.M.11
-
32
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West KA, Castillo SS, Dennis PA(2002) Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updates 5: 234-248.
-
(2002)
Drug Resist Updates
, vol.5
, pp. 234-248
-
-
West, K.A.1
Castillo, S.S.2
Dennis, P.A.3
-
33
-
-
0042744837
-
Survival of acute myeloid leukemia cells requires PI3 kinase activation
-
Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M (2003) Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 102: 972-980.
-
(2003)
Blood
, vol.102
, pp. 972-980
-
-
Xu, Q.1
Simpson, S.E.2
Scialla, T.J.3
Bagg, A.4
Carroll, M.5
-
34
-
-
67650367598
-
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
-
Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, Konoplev S, AndreeffM, KonoplevaM(2009) Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 113: 6215-6224.
-
(2009)
Blood
, vol.113
, pp. 6215-6224
-
-
Zeng, Z.1
Shi, Y.X.2
Samudio, I.J.3
Wang, R.Y.4
Ling, X.5
Frolova, O.6
Levis, M.7
Rubin, J.B.8
Negrin, R.R.9
Estey, E.H.10
Konoplev, S.11
Konoplevam, A.12
|