Adhesion-induced drug resistance in leukemia stem cells

Pharmacology

Volumn 86, Issue 2, 2010, Pages 79-84

  Funayama, Keiji ^a   Murai, Fumihiko ^a   Shimane, Miyuki ^a   Nomura, Hitoshi ^a   Asano, Shigetaka ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

BCL2; MDR 1; p16INK4A; p21CIP1

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BREAST CANCER RESISTANCE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2;

ARTICLE; CELL ADHESION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG SENSITIVITY; GENE SEQUENCE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; STROMA CELL; UPREGULATION;

ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; CYTARABINE; DAUNORUBICIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; LEUKEMIA; LYSOSOMES; NEOPLASTIC STEM CELLS; OSMOLAR CONCENTRATION; PROTO-ONCOGENE PROTEINS C-BCL-2; STEM CELL NICHE; STROMAL CELLS; UP-REGULATION; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 77955101301     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000305344     Document Type: Article

References (18)

1. Tallman MS, Gilliland DG, Rowe JM: Drug therapy for acute myeloid leukemia. Blood 2005; 106: 1154-1163.
2. Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz LD: Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 2007; 25: 1315-1321.
3. Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE: Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006; 12: 1167-1174.
4. Krause DS, Lazarides K, von Andrian UH, Van Etten RA: Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 2006; 12: 1175-1180.
5. Itoh K, Tezuka H, Sakoda H, Konno M, Nagata K, Uchiyama T, Uchino H, Mori KJ: Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. Exp Hematol 1989; 17: 145-153.
6. Krishan A: Rapid flow cytofluorometric analysis of cell cycle by propidium iodide staining. J Cell Biol 1975; 66: 188.
7. Funayama K, Shimane M, Nomura H, Asano S: An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities. Biochem Biophys Res Commun 2010;392:271-276.
8. Vidal A, Koff A: Cell-cycle inhibitors: three families united by a common cause. Gene 2000; 247: 1-15.
9. Park DS, Morris EJ, Padmanabhan J, Shelanski ML, Geller HM, Greene LA: Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 1998; 143: 457-467.
10. Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S: Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1- - D -arabinofuranosylcytosineinduced apoptosis in human leukemia cells that overexpress Bcl-2. Mol Pharmacol 1997; 52: 1000-1009.
11. Mahoney BP, Raghunand N, Baggett B, Gillies RJ: Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol 2003; 66: 1207-1218.
12. Gong Y, Duvvuri M, Krise JP: Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. J Biol Chem 2003; 278: 50234-50239.
13. Kawada M, Usami I, Ohba S, Someno T, Kim J, Hayakawa Y, Nose K, Ishizuka M: Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Biochem Biophys Res Commun 2002; 298: 178-183.
14. Sasazawa Y, Futamura Y, Tashiro E, Imoto M: Vacuolar H + -ATPase inhibitors overcome Bcl-x L -mediated chemoresistance through restoration of a caspase-independent apoptotic pathway. Cancer Sci 2009; 100: 1460-1467.
15. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-659.
16. Zeng Z, Samudio IJ, Munsell M, An J, Huang Z, Estey E, Andreeff M, Konopleva M: Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Mol Cancer Ther 2006; 5: 3113-3121.
17. Hazlehurst LA, Damiano JS, Buyuksal I, Pledger WJ, Dalton WS: Adhesion to fibronectin via- 1 integrins regulates p27KIP1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene 2000; 19: 4319-4327.
18. Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, Akiyama T, Kuroda H, Kawano Y, Kobune M, Kato J, Hirayama Y, Sakamaki S, Kohda K, Miyake K, Niitsu Y: Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med 2003; 9: 1158-1165.