POLD3 Is Haploinsufficient for DNA Replication in Mice

Molecular Cell

Volumn 63, Issue 5, 2016, Pages 877-883

  Murga, Matilde ^a   Lecona, Emilio ^a   Kamileri, Irene ^b   Díaz, Marcos ^a   Lugli, Natalia ^b   Sotiriou, Sotirios K ^b   Anton, Marta E ^a   Méndez, Juan ^a   Halazonetis, Thanos D ^b   Fernandez Capetillo, Oscar ^a,c  

^a Centro Nacional de Investigations Oncológicas   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA DIRECTED DNA POLYMERASE DELTA; CHECKPOINT KINASE 1; CHEK1 PROTEIN, MOUSE; DNA DIRECTED DNA POLYMERASE GAMMA; H2AX PROTEIN, MOUSE; HISTONE; POLD3 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; DNA REPLICATION; EMBRYO; ENZYME STABILITY; GENE; GENE DELETION; GENE EXPRESSION; HAPLOINSUFFICIENCY; HYDROCEPHALUS; LETHALITY; LIFESPAN; MOUSE; NONHUMAN; POLD3 GENE; ANIMAL; BRAIN; DEFICIENCY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOMOZYGOTE; KNOCKOUT MOUSE; LONGEVITY; LUNG; METABOLISM; MORTALITY; PATHOLOGY; PHOSPHORYLATION; SURVIVAL ANALYSIS;

ANIMALS; B-LYMPHOCYTES; BRAIN; CELL DEATH; CHECKPOINT KINASE 1; DNA DAMAGE; DNA POLYMERASE III; DNA REPLICATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAPLOINSUFFICIENCY; HISTONES; HOMOZYGOTE; HYDROCEPHALUS; LONGEVITY; LUNG; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; SURVIVAL ANALYSIS;

EID: 84981743036     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.07.007     Document Type: Article

References (27)

1. Costantino, L., Sotiriou, S.K., Rantala, J.K., Magin, S., Mladenov, E., Helleday, T., Haber, J.E., Iliakis, G., Kallioniemi, O.P., Halazonetis, T.D., Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science 343 (2014), 88–91.
2. Ducoux, M., Urbach, S., Baldacci, G., Hübscher, U., Koundrioukoff, S., Christensen, J., Hughes, P., Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. J. Biol. Chem. 276 (2001), 49258–49266.
3. Gerik, K.J., Li, X., Pautz, A., Burgers, P.M., Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta. J. Biol. Chem. 273 (1998), 19747–19755.
4. Hirota, K., Yoshikiyo, K., Guilbaud, G., Tsurimoto, T., Murai, J., Tsuda, M., Phillips, L.G., Narita, T., Nishihara, K., Kobayashi, K., et al. The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ. Nucleic Acids Res. 43 (2015), 1671–1683.
5. Hirota, K., Tsuda, M., Mohiuddin, Tsurimoto, T., Cohen, I.S., Livneh, Z., Kobayashi, K., Narita, T., Nishihara, K., Murai, J., et al. In vivo evidence for translesion synthesis by the replicative DNA polymerase δ. Nucleic Acids Res., 2016, 10.1093/nar/gkw439 Published May 16, 2016.
6. Hughes, P., Tratner, I., Ducoux, M., Piard, K., Baldacci, G., Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Nucleic Acids Res. 27 (1999), 2108–2114.
7. Jacome, A., Gutierrez-Martinez, P., Schiavoni, F., Tenaglia, E., Martinez, P., Rodríguez-Acebes, S., Lecona, E., Murga, M., Méndez, J., Blasco, M.A., Fernandez-Capetillo, O., NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 34 (2015), 2604–2619.
8. Johansson, E., Dixon, N., Replicative DNA polymerases. Cold Spring Harb. Perspect. Biol., 5, 2013, a012799.
9. Johnson, R.E., Klassen, R., Prakash, L., Prakash, S., A major role of DNA polymerase δ in replication of both the leading and lagging DNA strands. Mol. Cell 59 (2015), 163–175.
10. Lakso, M., Pichel, J.G., Gorman, J.R., Sauer, B., Okamoto, Y., Lee, E., Alt, F.W., Westphal, H., Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93 (1996), 5860–5865.
11. Lee, M.Y., Tan, C.K., Downey, K.M., So, A.G., Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedure. Biochemistry 23 (1984), 1906–1913.
12. Lee, Y.S., Gregory, M.T., Yang, W., Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass. Proc. Natl. Acad. Sci. USA 111 (2014), 2954–2959.
13. Liu, L., Mo, J., Rodriguez-Belmonte, E.M., Lee, M.Y., Identification of a fourth subunit of mammalian DNA polymerase delta. J. Biol. Chem. 275 (2000), 18739–18744.
14. Lydeard, J.R., Jain, S., Yamaguchi, M., Haber, J.E., Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 448 (2007), 820–823.
15. MacNeill, S.A., Moreno, S., Reynolds, N., Nurse, P., Fantes, P.A., The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27. EMBO J. 15 (1996), 4613–4628.
16. Makarova, A.V., Stodola, J.L., Burgers, P.M., A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis. Nucleic Acids Res. 40 (2012), 11618–11626.
17. Mayle, R., Campbell, I.M., Beck, C.R., Yu, Y., Wilson, M., Shaw, C.A., Bjergbaek, L., Lupski, J.R., Ira, G., DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage. Science 349 (2015), 742–747.
18. Minocherhomji, S., Ying, S., Bjerregaard, V.A., Bursomanno, S., Aleliunaite, A., Wu, W., Mankouri, H.W., Shen, H., Liu, Y., Hickson, I.D., Replication stress activates DNA repair synthesis in mitosis. Nature 528 (2015), 286–290.
19. Mo, J., Liu, L., Leon, A., Mazloum, N., Lee, M.Y., Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. Biochemistry 39 (2000), 7245–7254.
20. Murga, M., Bunting, S., Montaña, M.F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P.J., Nussenzweig, A., Fernandez-Capetillo, O., A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat. Genet. 41 (2009), 891–898.
21. Ng, L., Tan, C.K., Downey, K.M., Fisher, P.A., Enzymologic mechanism of calf thymus DNA polymerase delta. J. Biol. Chem. 266 (1991), 11699–11704.
22. Ogi, T., Limsirichaikul, S., Overmeer, R.M., Volker, M., Takenaka, K., Cloney, R., Nakazawa, Y., Niimi, A., Miki, Y., Jaspers, N.G., et al. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol. Cell 37 (2010), 714–727.
23. Rickert, R.C., Roes, J., Rajewsky, K., B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25 (1997), 1317–1318.
24. Rodríguez, C.I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A.F., Dymecki, S.M., High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat. Genet. 25 (2000), 139–140.
25. Ruzankina, Y., Pinzon-Guzman, C., Asare, A., Ong, T., Pontano, L., Cotsarelis, G., Zediak, V.P., Velez, M., Bhandoola, A., Brown, E.J., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1 (2007), 113–126.
26. Shikata, K., Ohta, S., Yamada, K., Obuse, C., Yoshikawa, H., Tsurimoto, T., The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta. J. Biochem. 129 (2001), 699–708.
27. Zuo, S., Gibbs, E., Kelman, Z., Wang, T.S., O'Donnell, M., MacNeill, S.A., Hurwitz, J., DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits. Proc. Natl. Acad. Sci. USA 94 (1997), 11244–11249.