Mus81 and converging forks limit the mutagenicity of replication fork breakage

Science

Volumn 349, Issue 6249, 2015, Pages 742-747

  Mayle, Ryan ^a   Campbell, Ian M ^a   Beck, Christine R ^a   Yu, Yang ^a   Wilson, Marenda ^a,d   Shaw, Chad A ^a   Bjergbaek, Lotte ^b   Lupski, James R ^a,c   Ira, Grzegorz ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c TEXAS CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; MUS81 PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE; MUS81 PROTEIN, S CEREVISIAE; POL32 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

CANCER; EUKARYOTE; GENETIC ANALYSIS; GENOME; HOMOLOGY; MUTAGENICITY;

ARTICLE; BREAK INDUCED REPLICATION; DNA REPAIR; DNA REPLICATION ORIGIN; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; FRAMESHIFT MUTATION; GENE REARRANGEMENT; GENOMIC INSTABILITY; MISMATCH REPAIR; MUTAGENICITY; MUTATION RATE; POINT MUTATION; PRIORITY JOURNAL; SISTER CHROMATID; ALU SEQUENCE; DNA REPLICATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; SACCHAROMYCES CEREVISIAE;

EUKARYOTA;

ALU ELEMENTS; BASE SEQUENCE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; ENDONUCLEASES; GENOMIC INSTABILITY; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84940205642     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa8391     Document Type: Article

References (28)

1. C. Shee, J. L. Gibson, S. M. Rosenberg, Cell Rep. 2, 714-721 (2012).
2. A. Deem et al., PLOS Biol. 9, e1000594 (2011).
3. C. E. Smith, B. Llorente, L. S. Symington, Nature 447, 102-105 (2007).
4. F. Pratto et al., Science 346, 1256442 (2014).
5. J. R. Lydeard, S. Jain, M. Yamaguchi, J. E. Haber, Nature 448, 820-823 (2007).
6. N. Saini et al., Nature 502, 389-392 (2013).
7. M. A. Wilson et al., Nature 502, 393-396 (2013).
8. C. J. Sakofsky et al., Cell Rep. 7, 1640-1648 (2014).
9. L. Costantino et al., Science 343, 88-91 (2014).
10. C. M. Carvalho et al., Nat. Genet. 45, 1319-1326 (2013).
11. I. Nielsen et al., Nat. Methods 6, 753-757 (2009).
12. S. R. McGuffee, D. J. Smith, I. Whitehouse, Mol. Cell 50, 123-135 (2013).
13. A. R. Clausen et al., Nat. Struct. Mol. Biol. 22, 185-191 (2015).
14. R. A. Donnianni, L. S. Symington, Proc. Natl. Acad. Sci. U.S.A. 110, 13475-13480 (2013).
15. K. T. Ehmsen, W. D. Heyer, Nucleic Acids Res. 36, 2182-2195 (2008).
16. A. Pepe, S. C. West, Cell Rep. 7, 1048-1055 (2014).
17. C. K. Ho, G. Mazón, A. F. Lam, L. S. Symington, Mol. Cell 40, 988-1000 (2010).
18. S. Muñoz-Galván et al., Mol. Cell. Biol. 32, 1592-1603 (2012).
19. L. Roseaulin et al., EMBO J. 27, 1378-1387 (2008).
20. Y. Doksani, R. Bermejo, S. Fiorani, J. E. Haber, M. Foiani, Cell 137, 247-258 (2009).
21. C. A. Müller et al., Nucleic Acids Res. 42, e3 (2014).
22. A. Malkova, J. E. Haber, Annu. Rev. Genet. 46, 455-473 (2012).
23. M. G. Blanco, J. Matos, U. Rass, S. C. Ip, S. C. West, DNA Repair (Amst.) 9, 394-402 (2010).
24. M. G. Blanco, J. Matos, S. C. West, Mol. Cell 54, 94-106 (2014).
25. C. L. Eissler et al., Mol. Cell 54, 80-93 (2014).
26. S. Jain et al., Genes Dev. 23, 291-303 (2009).
27. S. Gu et al., Hum. Mol. Genet. 24, 4061-4077 (2015).
28. P. M. Boone et al., Am. J. Hum. Genet. 95, 143-161 (2014).