Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics

Oncotarget

Volumn 7, Issue 31, 2016, Pages 50596-50611

  Shen, Kaikai ^a   Lu, Fangfang ^a   Xie, Jianling ^c,d   Wu, Minfeng ^a   Cai, Bo ^a   Liu, Yurong ^a   Zhang, Hong ^a,b   Tan, Hongsheng ^a,b   Pan, Yingyi ^a   Xu, Hongxi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b China State Institute of Pharmaceutical Industry   (China)

^c SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Breast cancer; Cambogin; NADPH oxidase 1; Reactive oxygen species; Thioredoxin 1 ASK1 complex

Indexed keywords

ANTINEOPLASTIC AGENT; APOCYNIN; APOPTOSIS SIGNAL REGULATING KINASE 1; CAMBOGIN; CATALASE; CYTOSOL RECEPTOR; EUK 8 PROTEIN; HYDROGEN PEROXIDE; MEMBRANE PROTEIN; ML 171; OXYGEN; P22PHOX PROTEIN; P47PHOX PROTEIN; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; THIOREDOXIN 1; UNCLASSIFIED DRUG; GARCINOL; MAP3K5 PROTEIN, HUMAN; TERPENE; THIOREDOXIN; TXN PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CELLULAR PARAMETERS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; GARCINIA; HUMAN; HUMAN CELL; IC50; IN VIVO STUDY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRO APOPTOTIC ACTIVITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ADENOCARCINOMA; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BREAST TUMOR; CELL SURVIVAL; MCF-7 CELL LINE; METABOLISM; MITOCHONDRION; NUDE MOUSE; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MAP KINASE KINASE KINASE 5; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NADPH OXIDASE 1; OXYGEN; REACTIVE OXYGEN SPECIES; TERPENES; THIOREDOXINS;

EID: 84981309683     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10585     Document Type: Article

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