CEST theranostics: Label-free MR imaging of anticancer drugs

Oncotarget

Volumn 7, Issue 6, 2016, Pages 6369-6378

  Li, Yuguo ^a,b   Chen, Hanwei ^b,c,d   Xu, Jiadi ^a,b   Yadav, Nirbhay N ^a,b   Chan, Kannie W Y ^a,b   Luo, Liangping ^d   McMahon, Michael T ^a,b   Vogelstein, Bert ^e   Van Zijl, Peter C M ^a,b   Zhou, Shibin ^e   Liu, Guanshu ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Dept of Neurology Panyu Central Hospital   (China)

^d THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERSITY   (China)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

CEST; Chemotherapy; Image guided drug delivery; MRI; Theranostics

Indexed keywords

AZACITIDINE; CYTARABINE; DECITABINE; DEOXYCYTIDINE; FLUDARABINE; FOLINIC ACID; GEMCITABINE; LIPOSOME; METHOTREXATE; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC ANTIMETABOLITE; CONTRAST MEDIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL EXCHANGE SATURATION TRANSFER MAGNETIC RESONANCE IMAGING; CONTRAST TO NOISE RATIO; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG RELEASE; DRUG STRUCTURE; DRUG UPTAKE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; MOUSE; NANOENCAPSULATION; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; SENSITIVITY ANALYSIS; THERANOSTIC NANOMEDICINE; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; COLORECTAL NEOPLASMS; COMPUTER ASSISTED DIAGNOSIS; DRUG SCREENING; ENZYME IMMUNOASSAY; FLUORESCENCE; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; PROCEDURES; TUMOR CELL CULTURE;

ADENOCARCINOMA; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; COLORECTAL NEOPLASMS; CONTRAST MEDIA; DEOXYCYTIDINE; DRUG DELIVERY SYSTEMS; FEMALE; FLUORESCENCE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, NUDE; THERANOSTIC NANOMEDICINE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84981161238     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7141     Document Type: Article

References (33)

1. Tredan O, Galmarini CM, Patel K and Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst. 2007; 99:1441-1454.
2. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009; 324:1457-1461.
3. Ginsburg GS and McCarthy JJ. Personalized medicine: revolutionizing drug discovery and patient care. Trends Biotechnol. 2001; 19:491-496.
4. Nunn AD. Update: Molecular Imaging and Personalized Medicine: An Uncertain Future. Cancer Biother Radiopharm. 2007; 22:722-739.
5. Ward KM, Aletras AH and Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson. 2000; 143:79-87.
6. Liu G, Song X, Chan KW and McMahon MT. Nuts and bolts of chemical exchange saturation transfer MRI. NMR Biomed. 2013; 26:810-828.
7. van Zijl PC and Yadav NN. Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med. 2011; 65:927-948.
8. Walker-Samuel S, Ramasawmy R, Torrealdea F, Rega M, Rajkumar V, Johnson SP, Richardson S, Goncalves M, Parkes HG, Arstad E, Thomas DL, Pedley RB, Lythgoe MF and Golay X. In vivo imaging of glucose uptake and metabolism in tumors. Nat Med. 2013; 19:1067-1072.
9. Chan KW, McMahon MT, Kato Y, Liu G, Bulte JW, Bhujwalla ZM, Artemov D and van Zijl PC. Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn Reson Med. 2012; 68:1764-1773.
10. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA and Reddy R. Magnetic resonance imaging of glutamate. Nat Med. 2012; 18:302-306.
11. Goffeney N, Bulte JW, Duyn J, Bryant LH, Jr. and van Zijl PC. Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange. J Am Chem Soc. 2001; 123:8628-8629.
12. Zhou J, Payen JF, Wilson DA, Traystman RJ and van Zijl PC. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med. 2003; 9:1085-1090.
13. Liu G, Liang Y, Bar-Shir A, Chan KW, Galpoththawela CS, Bernard SM, Tse T, Yadav NN, Walczak P, McMahon MT, Bulte JW, van Zijl PC and Gilad AA. Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. J Am Chem Soc. 2011; 133:16326-16329.
14. Liu G, Bettegowda C, Qiao Y, Staedtke V, Chan KW, Bai R, Li Y, Riggins GJ, Kinzler KW, Bulte JW, McMahon MT, Gilad AA, Vogelstein B, Zhou S and van Zijl PC. Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. Magn Reson Med. 2013; 70:1690-1698.
15. Friedman JI, McMahon MT, Stivers JT and Van Zijl PC. Indirect detection of labile solute proton spectra via the water signal using frequency-labeled exchange (FLEX) transfer. J Am Chem Soc. 2010; 132:1813-1815.
16. Liu G, Ali MM, Yoo B, Griswold MA, Tkach JA and Pagel MD. PARACEST MRI with improved temporal resolution. Magn Reson Med. 2009; 61:399-408.
17. Laprie A, Catalaa I, Cassol E, McKnight TR, Berchery D, Marre D, Bachaud JM, Berry I and Moyal EC. Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study. Int J Radiat Oncol Biol Phys. 2008; 70:773-781.
18. Verdun FR, Denys A, Valley JF, Schnyder P and Meuli RA. Detection of low-contrast objects: experimental comparison of single- and multi-detector row CT with a phantom. Radiology. 2002; 223:426-431.
19. Aime S, Castelli DD, Crich SG, Gianolio E and Terreno E. Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications. Acc Chem Res. 2009; 42:822-831.
20. Ruiz-Cabello J, Walczak P, Kedziorek DA, Chacko VP, Schmieder AH, Wickline SA, Lanza GM and Bulte JW. In vivo "hot spot" MR imaging of neural stem cells using fluorinated nanoparticles. Magn Reson Med. 2008; 60:1506-1511.
21. Federico C, Morittu VM, Britti D, Trapasso E and Cosco D. Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives. Int J Nanomedicine. 2012; 7:5423-5436.
22. Grazia Calvagno M, Celia C, Paolino D, Cosco D, Iannone M, Castelli F, Doldo P and Fresta M. Effects of lipid composition and preparation conditions on physical-chemical properties, technological parameters and in vitro biological activity of gemcitabine-loaded liposomes. Curr Drug Deliv. 2007; 4:89-101.
23. Liu G, Moake M, Har-el YE, Long CM, Chan KW, Cardona A, Jamil M, Walczak P, Gilad AA, Sgouros G, van Zijl PC, Bulte JW and McMahon MT. In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magn Reson Med. 2012; 67:1106-1113.
24. Chan KW, Liu G, Song X, Kim H, Yu T, Arifin DR, Gilad AA, Hanes J, Walczak P, van Zijl PC, Bulte JW and McMahon MT. MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat Mater. 2013; 12:268-275.
25. Chan KW, Yu T, Qiao Y, Liu Q, Yang M, Patel H, Liu G, Kinzler KW, Vogelstein B, Bulte JW, van Zijl PC, Hanes J, Zhou S and McMahon MT. A diaCEST MRI approach for monitoring liposomal accumulation in tumors. J Control Release. 2014; 180:51-59.
26. Ma X, Song Y, Zhang K, Shang L, Gao Y, Zhang W, Xue X, Jia H, Geng J, Zhou W, Dang Y, Li E, Ti X, Fan F, Zhang Y and Li M. Recombinant mutated human TNF in combination with chemotherapy for stage IIIB/IV non-small cell lung cancer: a randomized, phase III study. Sci Rep. 2015; 4:9918.
27. Davis ME, Chen ZG and Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008; 7:771-782.
28. Sumer B and Gao J. Theranostic nanomedicine for cancer. Nanomedicine (Lond). 2008; 3:137-140.
29. Liu Z, Dimitrov IE, Lenkinski RE, Hajibeigi A and Vinogradov E. UCEPR: Ultrafast localized CEST-spectroscopy with PRESS in phantoms and in vivo. Magn Reson Med. 2015.
30. Liu G, Chan KW, Song X, Zhang J, Gilad AA, Bulte JW, van Zijl PC and McMahon MT. NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps. Magn Reson Med. 2013; 69:516-523.
31. Chen LQ, Howison CM, Jeffery JJ, Robey IF, Kuo PH and Pagel MD. Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI. Magn Reson Med. 2014; 72:1408-1417.
32. Liu G, Gilad AA, Bulte JW, van Zijl PC and McMahon MT. High-throughput screening of chemical exchange saturation transfer MR contrast agents. Contrast Media Mol Imaging. 2010; 5:162-170.
33. Kim M, Gillen J, Landman BA, Zhou J and van Zijl PC. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med. 2009; 61:1441-1450.