In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes

Magnetic Resonance in Medicine

Volumn 67, Issue 4, 2012, Pages 1106-1113

  Liu, Guanshu ^a,b   Moake, Matthew ^c   Har El, Yah El ^b   Long, Chris M ^d   Chan, Kannie W Y ^b,c   Cardona, Amanda ^a   Jamil, Muksit ^a   Walczak, Piotr ^b,c   Gilad, Assaf A ^a,b,c   Sgouros, George ^b   Van Zijl, Peter C M ^a,b   Bulte, Jeff W M ^a,b,c,d,e   McMahon, Michael T ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Johns Hopkins University School of Medicine   (United States)

^e Whiting School of Engineering   (United States)

Author keywords

CEST; liposome contrast agent; lymph node imaging; molecular imaging; multicolor MR imaging

Indexed keywords

AMINO ACIDS; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MAMMALS; METAL IONS; METALS;

BIODEGRADABLE COMPOUNDS; CEST; CHEMICAL EXCHANGE SATURATION TRANSFER; CONTRAST AGENT; FREQUENCY DEPENDENT; LYMPH NODE; MR IMAGING; PARAMAGNETIC CONTRASTS;

MOLECULAR IMAGING;

ARGININE; CONTRAST MEDIUM; GLYCOGEN; LIPOSOME; POLYLYSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; ENCAPSULATION; IN VIVO STUDY; LYMPH NODE; LYMPHATIC SYSTEM; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 84859104671     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.23100     Document Type: Article

References (50)

1. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB,. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 1999; 99: 2293-2352. (Pubitemid 30498114)
2. Bulte JWM, Kraitchman DL,. Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 2004; 17 (7): 484-499. (Pubitemid 39549426)
3. Yang M, Li L, Jiang P, Moossa AR, Penman S, Hoffman RM,. Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci USA 2003; 100 (24): 14259-14262. (Pubitemid 37499224)
4. Livet J, Weissman TA, Kang H, Draft RW, Lu J, Bennis RA, Sanes JR, Lichtman JW,. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature 2007; 450 (7166): 56-62. (Pubitemid 350070576)
5. Hoffman R,. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer 2005; 5 (10): 796-806. (Pubitemid 41400779)
6. Chalfie M, Tu Y, Euskirchen G, Ward W, Prasher D,. Green fluorescent protein as a marker for gene expression. Science 1994; 263 (5148): 802-805. (Pubitemid 24093206)
7. Giepmans BN, Adams SR, Ellisman MH, Tsien RY,. The fluorescent toolbox for assessing protein location and function. Science 2006; 312 (5771): 217-224.
8. Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP,. Semiconductor nanocrystals as fluorescent biological labels. Science 1998; 281 (5385): 2013-2016. (Pubitemid 28475485)
9. Gao X, Cui Y, Levenson RM, Chung LWK, Nie S,. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004; 22 (8): 969-976. (Pubitemid 39014473)
10. Keren S, Zavaleta C, Cheng Z, de la Zerda A, Gheysens O, Gambhir SS,. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc Natl Acad Sci USA 2008; 105 (15): 5844-5849. (Pubitemid 351758460)
11. Coons AH,. Histochemistry with labeled antibody. Int Rev Cytol 1956; 5: 1-23.
12. Ward KM, Aletras AH, Balaban RS,. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson Imaging 2000; 143 (1): 79-87.
13. Viswanathan S, Kovacs Z, Green K, Ratnakar S, Sherry A,. Alternatives to gadolinium-based metal chelates for magnetic resonance imaging. Chem Rev 2010; 110 (5): 2960-3018.
14. Terreno E, Castelli D, Aime S,. Encoding the frequency dependence in MRI contrast media: the emerging class of CEST agents. Contrast Media Mol Imaging 2010; 5 (2): 78-98.
15. Zhou J, Zijl P,. Chemical exchange saturation transfer imaging and spectroscopy. Prog Nucl Magn Reson Spectrosc 2006; 48 (2-3): 109-136.
16. van Zijl PC, Yadav NN,. Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 2011; 65 (4): 927-948.
17. Hama Y, Koyama Y, Urano Y, Choyke P, Kobayashi H,. Two-color lymphatic mapping using Ig-conjugated near infrared optical probes. J Invest Dermatol 2007; 127 (10): 2351-2356. (Pubitemid 47619761)
18. Castile JD, Taylor KM,. Factors affecting the size distribution of liposomes produced by freeze-thaw extrusion. Int J Pharm 1999; 188 (1): 87-95. (Pubitemid 29472463)
19. Hwang K, Merriam J, Beaumier P, Luk K,. Encapsulation, with high efficiency, of radioactive metal ions in liposomes. Biochim Biophys Acta 1982; 716 (1): 101-109. (Pubitemid 12057405)
20. Long C, van Laarhoven H, Bulte J, Levitsky H,. Magnetovaccination as a novel method to assess and quantify dendritic cell tumor antigen capture and delivery to lymph nodes. Cancer Res 2009; 69 (7): 3180-3187.
21. Liu G, Gilad AA, Bulte JW, van Zijl PC, McMahon MT,. High-throughput screening of chemical exchange saturation transfer MR contrast agents. Contrast Media Mol Imaging 2010; 5 (3): 162-170.
22. Kim M, Gillen J, Landman B, Zhou J, van Zijl PC,. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 2009; 61 (6): 1441-1450.
23. McMahon MT, Gilad AA, DeLiso MA, Berman SM, Bulte JW, van Zijl PC,. New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI. Magn Reson Med 2008; 60 (4): 803-812.
24. van Zijl P, Jones C, Ren J, Malloy C, Sherry A,. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci USA 2007; 104 (11): 4359-4364. (Pubitemid 47186231)
25. Goffeney N, Bulte JW, Duyn J, Bryant LH Jr, van Zijl PC,. Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange. J Am Chem Soc 2001; 123 (35): 8628-8629. (Pubitemid 32808097)
26. Allen TM,. Long-circulating (sterically stabilized) liposomes for targeted drug-delivery. Trends Pharmacol Sci 1994; 15 (7): 215-220. (Pubitemid 24210725)
27. Gilad AA, McMahon MT, Walczak P, Winnard PT Jr, Raman V, van Laarhoven HW, Skoglund CM, Bulte JW, van Zijl PC,. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol 2007; 25 (2): 217-219. (Pubitemid 46227121)
28. McMahon MT, Gilad AA, Zhou J, Sun PZ, Bulte JW, van Zijl PC,. Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): pH calibration for poly- L -lysine and a starburst dendrimer. Magn Reson Med 2006; 55 (4): 836-847.
29. Frank J, Miller B, Arbab A, Zywicke H, Jordan E, Lewis B, Bryant L, Bulte J,. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003; 228 (2): 480-487. (Pubitemid 36910091)
30. Wagner V, Dullaart A, Bock AK, Zweck A,. The emerging nanomedicine landscape. Nat Biotechnol 2006; 24 (10): 1211-1217. (Pubitemid 44564760)
31. Tilcock C, Ahkong QF, Koenig SH, Brown RD III, Davis M, Kabalka G,. The design of liposomal paramagnetic MR agents: effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates. Magn Reson Med 1992; 27 (1): 44-51.
32. Bogdanov AA, Martin C, Weissleder R, Brady TJ,. Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipidpreparation of ferrosomes. Biochim Biophys Acta: Biomembr 1994; 1193 (1): 212-218. (Pubitemid 24234196)
33. Bulte JWM, de Cuyper M, Despres D, Frank JA,. Short- vs. long-circulating magnetoliposomes as bone marrow-seeking MR contrast agents. J Magn Reson Imaging 1999; 9 (2): 329-335. (Pubitemid 29115361)
34. Bacic G, Niesman MR, Bennett HF, Magin RL, Swartz HM,. Modulation of water proton relaxation rates by liposomes containing paramagnetic materials. Magn Reson Med 1988; 6 (4): 445-458.
35. Mulder WJ, Strijkers GJ, van Tilborg GA, Griffioen AW, Nicolay K,. Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging. NMR Biomed 2006; 19 (1): 142-164. (Pubitemid 43250800)
36. Ikomi F, Hanna G, Schmid-Schönbein G,. Mechanism of colloidal particle uptake into the lymphatic system: basic study with percutaneous lymphography. Radiology 1995; 196 (1): 107-113.
37. Wolf G, Rogowska J, Hanna G, Halpern E,. Percutaneous CT lymphography with perflubron: imaging efficacy in rabbits and monkeys. Radiology 1994; 191 (2): 501-505. (Pubitemid 24141057)
38. Velinova M, Read N, Kirby C, Gregoriadis G,. Morphological observations on the fate of liposomes in the regional lymph nodes after footpad injection into rats. Biochim Biophys Acta 1996; 1299 (2): 207-215.
39. Delli Castelli D, Dastr W, Terreno E, Cittadino E, Mainini F, Torres E, Spadaro M, Aime S,. In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes. J Control Release 2010; 144 (3): 271-279.
40. Terreno E, Sanino A, Carrera C, Castelli DD, Giovenzana GB, Lombardi A, Mazzon R, Milone L, Visigalli M, Aime S,. Determination of water permeability of paramagnetic liposomes of interest in MRI field. J Inorg Biochem 2008; 102 (5-6): 1112-1119.
41. Zhao JM, Har-el YE, McMahon MT, Zhou J, Sherry AD, Sgouros G, Bulte JW, van Zijl PC,. Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. J Am Chem Soc 2008; 130: 5178-5184. (Pubitemid 351537078)
42. 3+-DOTAM- glycine (Gly)-phenylalanine (Phe). Magn Reson Med 2008; 59 (2): 374-381. (Pubitemid 351220101)
43. Zhang S, Winter P, Wu K, Sherry AD,. A novel europium(III)-based MRI contrast agent. J Am Chem Soc 2001; 123 (7): 1517-1518. (Pubitemid 32167350)
44. Aime S, Carrera C, Delli Castelli D, Geninatti Crich S, Terreno E,. Tunable imaging of cells labeled with MRI-PARACEST agents. Angew Chem Int Ed 2005; 44 (12): 1813-1815.
45. Wu Y, Zhou Y, Ouari O, Woods M, Zhao P, Soesbe TC, Kiefer GE, Sherry AD,. Polymeric PARACEST agents for enhancing MRI contrast sensitivity. J Am Chem Soc 2008; 130 (42): 13854-13855.
46. Ali MM, Yoo B, Pagel MD,. Tracking the relative in vivo pharmacokinetics of nanoparticles with PARACEST MRI. Mol Pharm 2009; 6 (5): 1409-1416.
47. Pikkemaat JA, Wegh RT, Lamerichs R, van de Molengraaf RA, Langereis S, Burdinski D, Raymond AY, Janssen HM, de Waal BF, Willard NP, Meijer EW, Grull H,. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol Imaging 2007; 2 (5): 229-239. (Pubitemid 351166059)
48. Aime S, Delli Castelli D, Terreno E,. Highly sensitive MRI chemical exchange saturation transfer agents using liposomes. Angew Chem 2005; 117 (34): 5649-5651.
49. Winter PM, Cai K, Chen J, Adair CR, Kiefer GE, Athey PS, Gaffney PJ, Buff CE, Robertson JD, Caruthers SD, Wickline SA, Lanza GM,. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin. Magn Reson Med 2006; 56 (6): 1384-1388. (Pubitemid 44865324)
50. Partlow KC, Chen JJ, Brant JA, Neubauer AM, Meyerrose TE, Creer MH, Nolta JA, Caruthers SD, Lanza GM, Wickline SA,. F-19 magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 2007; 21: 1647-1654. (Pubitemid 46855610)