Effects of lipid composition and preparation conditions on physical-chemical properties, technological parameters and in vitro biological activity of gemcitabine-loaded liposomes

Current Drug Delivery

Volumn 4, Issue 1, 2007, Pages 89-101

  Calvagno, Maria Grazia ^a   Celia, Christian ^a   Paolino, Donatella ^a,b   Cosco, Donato ^a   Iannone, Michelangelo ^c   Castelli, Francesco ^b   Doldo, Patrizia ^a   Fresta, Massimo ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

Author keywords

Caco 2 cells; Drug release; Gemcitabine; in vitro anticancer activity; Intracellular drug uptake; Liposomes; MTT assay

Indexed keywords

(4,5 DIMETHYLTHIAZOL 2 YL) 3,5 DIPHENYLTETRAZOLIUM BROMIDE; CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLSERINE; GEMCITABINE; LIPOSOME; MACROGOL; N (CARBONYLMETHOXYPOLYETHYLENE GLYCOL 2000); OLEIC ACID; PHOSPHATIDYLSERINE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL ACTIVITY; CELL TRANSPORT; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG UPTAKE; ENCAPSULATION; EVAPORATION; FREEZE THAWING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; LIPID COMPOSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ZETA POTENTIAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL SURVIVAL; CHOLESTEROL; COLLOIDS; DEOXYCYTIDINE; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; OLEIC ACID; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; PRODRUGS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33846061242     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720107779314749     Document Type: Article

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